GREMLIN Database
MtrA - Tetrahydromethanopterin S-methyltransferase, subunit A
PFAM: PF04208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 173 (152)
Sequences: 1531 (944)
Seq/√Len: 76.5
META: 0.933

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_N104_G4.3951.00
87_S102_I3.6461.00
89_L131_D3.2471.00
121_E125_K3.0491.00
92_H129_L2.9311.00
86_Q106_K2.8861.00
121_E124_R2.8381.00
144_K147_E2.7621.00
132_L144_K2.5771.00
27_C49_L2.3601.00
92_H123_F2.3521.00
89_L129_L2.2911.00
128_E151_K2.2601.00
86_Q90_A2.0791.00
92_H124_R2.0351.00
71_F130_V1.9851.00
52_E82_H1.9621.00
137_D140_E1.9361.00
117_K121_E1.9171.00
63_V123_F1.9051.00
135_E140_E1.8711.00
74_L129_L1.8661.00
63_V72_L1.8111.00
52_E110_P1.7711.00
61_A119_A1.7441.00
83_L106_K1.7151.00
87_S105_A1.6841.00
27_C59_I1.6541.00
52_E81_G1.6311.00
116_P119_A1.5931.00
122_R126_Q1.5730.99
96_V120_I1.5710.99
60_I115_L1.5560.99
26_V43_A1.5510.99
49_L59_I1.4820.99
59_I88_L1.4560.99
74_L89_L1.4480.99
71_F148_L1.4320.99
140_E144_K1.4030.99
51_T114_N1.4020.99
28_T31_S1.3540.98
91_L123_F1.3430.98
23_P153_P1.3210.98
30_G79_S1.3170.98
73_I132_L1.3080.98
86_Q105_A1.3060.98
8_W17_V1.2950.98
27_C75_C1.2820.98
49_L75_C1.2640.97
56_I102_I1.2600.97
100_G117_K1.2450.97
140_E143_A1.2240.97
87_S90_A1.1900.96
86_Q107_G1.1860.96
18_G22_S1.1690.96
34_L38_L1.1670.96
11_V58_K1.1280.95
50_K109_I1.1270.95
73_I148_L1.1100.95
57_E114_N1.0900.94
23_P71_F1.0770.94
71_F154_G1.0750.94
75_C135_E1.0730.93
132_L141_I1.0660.93
25_A45_I1.0640.93
51_T54_L1.0580.93
144_K148_L1.0530.93
42_G146_K1.0530.93
72_L127_V1.0450.93
96_V117_K1.0440.93
96_V100_G1.0420.92
143_A147_E1.0320.92
41_A142_R1.0220.92
142_R145_I1.0190.92
62_N66_N0.9990.91
26_V145_I0.9950.91
54_L114_N0.9920.90
22_S149_A0.9870.90
151_K156_F0.9780.90
142_R146_K0.9660.89
89_L92_H0.9600.89
75_C141_I0.9570.89
52_E108_A0.9560.89
64_I119_A0.9440.88
89_L93_E0.9410.88
73_I130_V0.9290.87
29_L133_I0.9200.87
21_K68_N0.9170.87
52_E85_G0.8910.85
94_N103_I0.8890.85
13_G57_E0.8880.85
81_G108_A0.8870.85
34_L39_A0.8860.85
85_G133_I0.8810.84
70_R128_E0.8680.84
87_S106_K0.8640.83
59_I63_V0.8450.82
33_L37_P0.8450.82
69_I126_Q0.8430.82
72_L91_L0.8400.81
45_I53_N0.8390.81
151_K154_G0.8150.79
43_A46_V0.8130.79
118_E128_E0.8090.79
70_R126_Q0.8070.79
77_K136_E0.7970.78
15_Y45_I0.7780.76
98_E117_K0.7780.76
69_I143_A0.7760.76
7_G117_K0.7700.76
50_K54_L0.7690.75
64_I115_L0.7670.75
64_I126_Q0.7650.75
13_G51_T0.7650.75
100_G112_L0.7640.75
29_L85_G0.7640.75
23_P42_G0.7620.75
60_I92_H0.7550.74
100_G120_I0.7500.74
60_I63_V0.7470.73
71_F151_K0.7410.73
51_T58_K0.7360.72
34_L37_P0.7360.72
50_K108_A0.7310.72
82_H108_A0.7240.71
97_D101_R0.7160.70
58_K72_L0.7160.70
83_L108_A0.7140.70
53_N110_P0.7140.70
84_S88_L0.7100.69
57_E110_P0.7100.69
146_K149_A0.7090.69
64_I122_R0.7080.69
99_N125_K0.7080.69
93_E131_D0.7080.69
54_L58_K0.7070.69
54_L57_E0.7060.69
150_A154_G0.7040.69
152_D155_A0.7020.69
102_I106_K0.6950.68
18_G44_A0.6930.68
13_G58_K0.6900.67
27_C108_A0.6890.67
43_A114_N0.6870.67
139_E150_A0.6870.67
31_S136_E0.6830.66
66_N69_I0.6830.66
115_L119_A0.6830.66
139_E147_E0.6820.66
33_L38_L0.6760.66
132_L140_E0.6730.65
13_G126_Q0.6730.65
81_G126_Q0.6700.65
126_Q156_F0.6640.64
101_R111_F0.6610.64
14_E50_K0.6540.63
49_L128_E0.6490.63
18_G75_C0.6440.62
57_E115_L0.6400.61
19_N22_S0.6390.61
86_Q104_G0.6320.61
85_G123_F0.6250.60
42_G68_N0.6190.59
25_A53_N0.6180.59
52_E105_A0.6170.59
31_S79_S0.6170.59
14_E109_I0.6150.58
27_C58_K0.6100.58
118_E141_I0.6060.57
48_T54_L0.6000.57
138_P142_R0.6000.57
60_I124_R0.5930.56
55_G85_G0.5900.55
77_K131_D0.5880.55
69_I84_S0.5880.55
30_G50_K0.5880.55
82_H85_G0.5800.54
97_D142_R0.5790.54
51_T57_E0.5780.54
152_D156_F0.5780.54
118_E122_R0.5750.53
79_S84_S0.5710.53
13_G114_N0.5710.53
32_H35_E0.5700.53
6_E121_E0.5700.53
30_G77_K0.5670.52
81_G113_E0.5670.52
22_S68_N0.5620.52
62_N65_S0.5620.52
141_I145_I0.5590.51
70_R130_V0.5550.51
13_G107_G0.5540.51
62_N69_I0.5530.51
5_A10_P0.5530.51
20_P78_E0.5510.50
82_H110_P0.5490.50
29_L75_C0.5490.50
52_E87_S0.5470.50
147_E150_A0.5460.50
98_E139_E0.5440.49
13_G62_N0.5430.49
10_P81_G0.5430.49
17_V20_P0.5420.49
72_L88_L0.5400.49
6_E96_V0.5370.49
42_G142_R0.5350.48
27_C46_V0.5340.48
27_C105_A0.5330.48
12_P23_P0.5320.48
84_S129_L0.5320.48
50_K113_E0.5300.48
149_A152_D0.5220.47
63_V70_R0.5220.47
15_Y44_A0.5190.46
148_L153_P0.5180.46
74_L80_K0.5180.46
74_L134_G0.5160.46
36_K145_I0.5130.46
119_A122_R0.5120.45
49_L88_L0.5110.45
63_V69_I0.5110.45
15_Y57_E0.5100.45
22_S43_A0.5060.45
149_A153_P0.5060.45
90_A93_E0.5050.45
17_V68_N0.5020.44
78_E108_A0.5020.44
50_K79_S0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ghfA 2 0.3064 41.5 0.942 Contact Map
1wteA 2 0.7861 20 0.951 Contact Map
2i32A 1 0.4104 11.3 0.956 Contact Map
2dykA 1 0.4913 7.9 0.959 Contact Map
4ileA 1 0.6069 7.6 0.959 Contact Map
2h9aA 1 0.5491 7.5 0.959 Contact Map
1a9xA 3 0.8728 7.5 0.959 Contact Map
4um9B 2 0.8786 7.3 0.96 Contact Map
1rocA 1 0.4104 6.7 0.96 Contact Map
4f0hB 3 0.3815 6.7 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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