GREMLIN Database
PDCD2_C - Programmed cell death protein 2, C-terminal putative domain
PFAM: PF04194 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (166)
Sequences: 868 (697)
Seq/√Len: 54.1
META: 0.156

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_A146_S4.1201.00
95_I138_G3.9821.00
94_W141_A3.4771.00
145_C149_C3.1391.00
6_I83_V3.1291.00
109_C112_C2.9561.00
140_L162_V2.7591.00
95_I139_T2.5521.00
90_G118_F2.4781.00
31_E35_Y2.4491.00
111_N158_V2.4161.00
109_C145_C2.3651.00
112_C145_C2.3261.00
112_C149_C2.2281.00
82_Q123_M2.2121.00
115_K146_S2.1911.00
109_C149_C2.1811.00
27_N31_E2.1571.00
28_E31_E2.1161.00
72_F124_P2.1161.00
66_D69_F2.0671.00
110_S159_E2.0311.00
75_R78_A1.9731.00
82_Q85_R1.9271.00
88_R144_T1.9221.00
56_E61_Y1.9161.00
84_L148_S1.8700.99
57_E61_Y1.8610.99
58_L61_Y1.7000.99
108_N115_K1.6680.99
113_G116_R1.6650.99
107_P161_F1.6360.98
32_L35_Y1.5240.98
4_Y8_V1.5220.98
114_A147_K1.5060.97
89_G117_V1.4990.97
125_Q157_Y1.4820.97
107_P116_R1.4630.97
120_F142_V1.4310.96
99_I103_E1.4140.96
79_N94_W1.3280.95
87_S90_G1.3170.94
125_Q128_N1.2980.94
125_Q129_Y1.2830.93
96_S116_R1.2710.93
3_E122_L1.2680.93
74_K90_G1.2590.93
123_M139_T1.2580.93
71_K135_L1.2060.91
22_S25_P1.1980.91
95_I123_M1.1810.90
41_Q44_E1.1730.90
37_E40_E1.1650.90
28_E32_L1.1600.89
42_E45_G1.1550.89
116_R161_F1.1430.89
5_E120_F1.1180.88
18_D21_S1.1120.87
127_L164_V1.1120.87
56_E83_V1.1050.87
3_E9_E1.0980.87
20_D23_E1.0960.87
143_Y161_F1.0950.87
72_F82_Q1.0890.86
23_E27_N1.0860.86
11_E75_R1.0780.86
24_D27_N1.0770.86
27_N30_I1.0770.86
76_I123_M1.0710.85
34_D83_V1.0640.85
127_L140_L1.0580.85
96_S130_L1.0420.84
49_E53_S1.0410.84
88_R148_S1.0300.83
59_E74_K1.0250.83
76_I142_V0.9970.81
122_L140_L0.9870.80
17_V20_D0.9730.79
14_E18_D0.9720.79
106_I161_F0.9710.79
27_N32_L0.9660.79
41_Q46_A0.9650.79
54_E58_L0.9490.78
69_F92_P0.9380.77
20_D24_D0.9370.77
158_V162_V0.9350.76
95_I164_V0.9340.76
49_E52_E0.9180.75
29_E32_L0.9130.75
134_S137_W0.9110.75
88_R95_I0.9010.74
87_S143_Y0.8910.73
54_E61_Y0.8910.73
30_I34_D0.8890.73
139_T159_E0.8880.73
70_Q74_K0.8850.72
9_E96_S0.8820.72
130_L138_G0.8660.71
71_K75_R0.8630.71
82_Q93_L0.8630.71
31_E34_D0.8510.69
34_D39_S0.8480.69
67_K80_P0.8430.69
140_L164_V0.8360.68
88_R136_D0.8360.68
57_E60_K0.8230.67
106_I116_R0.8230.67
67_K73_K0.8220.67
71_K74_K0.8210.67
36_E39_S0.8190.66
79_N127_L0.8110.66
147_K150_W0.8040.65
77_A132_V0.8040.65
19_P27_N0.7950.64
69_F96_S0.7930.64
29_E52_E0.7910.64
52_E135_L0.7910.64
127_L163_W0.7900.64
1_F154_G0.7860.63
123_M137_W0.7850.63
69_F80_P0.7850.63
35_Y38_L0.7830.63
85_R93_L0.7820.63
120_F140_L0.7820.63
26_D30_I0.7770.62
8_V81_E0.7760.62
88_R117_V0.7750.62
88_R127_L0.7750.62
84_L138_G0.7740.62
64_S162_V0.7630.61
55_E61_Y0.7630.61
98_N101_S0.7600.61
42_E51_D0.7590.61
72_F138_G0.7560.60
15_D108_N0.7510.60
66_D95_I0.7490.60
86_Y119_E0.7490.60
42_E49_E0.7480.59
73_K130_L0.7430.59
62_E87_S0.7430.59
18_D22_S0.7420.59
59_E117_V0.7360.58
1_F126_L0.7350.58
63_K130_L0.7340.58
126_L143_Y0.7340.58
110_S116_R0.7290.57
106_I143_Y0.7280.57
31_E36_E0.7280.57
93_L147_K0.7210.57
124_P161_F0.7210.57
94_W127_L0.7180.56
160_E165_Q0.7140.56
76_I82_Q0.7120.56
137_W163_W0.7100.55
38_L44_E0.7090.55
127_L166_D0.7030.55
69_F138_G0.7020.55
113_G149_C0.7010.55
135_L166_D0.6990.54
4_Y17_V0.6980.54
83_V138_G0.6910.53
140_L155_V0.6870.53
124_P135_L0.6860.53
100_P115_K0.6850.53
45_G49_E0.6830.53
61_Y64_S0.6820.52
29_E33_S0.6800.52
9_E13_E0.6760.52
69_F117_V0.6730.52
155_V162_V0.6720.51
109_C113_G0.6670.51
18_D103_E0.6630.50
79_N148_S0.6590.50
65_L127_L0.6580.50
101_S105_D0.6540.50
87_S118_F0.6500.49
54_E57_E0.6430.48
126_L148_S0.6430.48
155_V158_V0.6420.48
25_P29_E0.6410.48
95_I125_Q0.6380.48
80_P94_W0.6380.48
87_S144_T0.6370.48
82_Q106_I0.6360.48
95_I135_L0.6330.47
6_I91_K0.6330.47
100_P105_D0.6260.47
113_G145_C0.6240.46
41_Q45_G0.6240.46
144_T157_Y0.6200.46
7_V95_I0.6180.46
88_R134_S0.6170.46
127_L134_S0.6140.45
55_E71_K0.6130.45
42_E46_A0.6120.45
27_N33_S0.6120.45
88_R125_Q0.6110.45
70_Q73_K0.6090.45
136_D150_W0.6070.45
47_D53_S0.6060.44
48_G55_E0.6060.44
98_N137_W0.6000.44
5_E125_Q0.5990.44
85_R121_Q0.5990.44
100_P114_A0.5970.43
22_S27_N0.5960.43
75_R159_E0.5860.42
22_S26_D0.5780.41
43_E49_E0.5750.41
11_E84_L0.5750.41
61_Y65_L0.5740.41
25_P28_E0.5670.40
107_P124_P0.5640.40
29_E35_Y0.5630.40
61_Y140_L0.5620.40
63_K153_G0.5580.39
34_D37_E0.5550.39
85_R119_E0.5550.39
149_C160_E0.5510.39
29_E76_I0.5510.39
84_L125_Q0.5510.39
96_S118_F0.5500.39
64_S111_N0.5490.39
124_P148_S0.5480.38
8_V95_I0.5420.38
44_E49_E0.5410.38
70_Q129_Y0.5380.37
19_P22_S0.5360.37
17_V21_S0.5360.37
25_P30_I0.5300.37
16_E21_S0.5300.37
73_K79_N0.5240.36
11_E85_R0.5230.36
57_E158_V0.5220.36
37_E45_G0.5180.35
62_E81_E0.5170.35
35_Y39_S0.5160.35
59_E100_P0.5160.35
56_E122_L0.5130.35
79_N157_Y0.5120.35
68_T123_M0.5100.35
21_S24_D0.5100.35
59_E63_K0.5060.34
35_Y44_E0.5030.34
139_T165_Q0.5020.34
132_V135_L0.5020.34
63_K151_D0.5010.34
30_I35_Y0.5010.34
69_F73_K0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qypA 1 0.3434 43.6 0.931 Contact Map
4e2xA 1 0.3614 32.1 0.936 Contact Map
4rv9A 1 0.3795 28.1 0.938 Contact Map
4h9dA 3 0.5301 19.4 0.943 Contact Map
1tfiA 1 0.3012 18.4 0.943 Contact Map
2f4mA 2 0.6687 15.7 0.945 Contact Map
2k5cA 1 0.3072 11.6 0.948 Contact Map
1pv5A 1 0.6386 10.2 0.949 Contact Map
2dj8A 1 0.3554 9.3 0.95 Contact Map
3o9xA 2 0.3313 8.9 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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