GREMLIN Database
FxsA - FxsA cytoplasmic membrane protein
PFAM: PF04186 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (108)
Sequences: 16065 (10267)
Seq/√Len: 987.9
META: 0.869

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_A60_R3.5231.00
54_A58_Q2.4781.00
92_L102_L2.4611.00
68_D103_R2.4521.00
55_A65_E2.4461.00
13_L85_L2.2571.00
16_Q20_A2.2321.00
16_Q19_S2.2311.00
95_L98_T2.0661.00
9_L85_L1.9371.00
75_A93_L1.9171.00
21_I25_P1.8941.00
29_L84_F1.8281.00
50_R54_A1.7981.00
47_R51_R1.7921.00
101_L105_L1.7441.00
71_L93_L1.7431.00
33_T87_D1.7131.00
23_A27_I1.6581.00
17_V84_F1.5901.00
12_Y16_Q1.5481.00
98_T101_L1.5451.00
53_Q57_A1.5371.00
39_W43_R1.5181.00
64_R103_R1.4751.00
88_A92_L1.4261.00
17_V21_I1.4121.00
92_L98_T1.3801.00
12_Y23_A1.3741.00
13_L16_Q1.3721.00
64_R100_R1.3531.00
54_A57_A1.3461.00
97_P100_R1.3191.00
64_R107_R1.3051.00
41_L76_G1.2951.00
77_A81_T1.2911.00
6_V86_T1.2611.00
68_D99_R1.2331.00
50_R53_Q1.2281.00
68_D100_R1.2261.00
100_R103_R1.2191.00
14_L26_T1.2131.00
71_L103_R1.1771.00
28_L32_L1.1761.00
105_L109_R1.1751.00
74_V77_A1.1711.00
64_R68_D1.1671.00
51_R65_E1.1631.00
32_L36_L1.1611.00
33_T91_L1.1591.00
14_L30_V1.1561.00
24_L28_L1.1181.00
15_I18_G1.1111.00
52_L70_A1.0811.00
94_L98_T1.0681.00
97_P101_L1.0671.00
75_A90_G1.0631.00
44_Q47_R1.0531.00
34_A80_L1.0471.00
4_I7_P1.0231.00
51_R54_A0.9971.00
30_V33_T0.9961.00
5_L9_L0.9951.00
36_L39_W0.9761.00
20_A24_L0.9741.00
67_L71_L0.9721.00
75_A98_T0.9611.00
55_A58_Q0.9411.00
15_I19_S0.9351.00
6_V81_T0.9341.00
6_V85_L0.9311.00
47_R50_R0.9121.00
14_L84_F0.8921.00
105_L108_R0.8821.00
48_T51_R0.8711.00
51_R55_A0.8661.00
101_L104_R0.8631.00
75_A94_L0.8611.00
22_G26_T0.8421.00
103_R107_R0.8171.00
11_I15_I0.8141.00
20_A25_P0.8131.00
33_T90_G0.8121.00
25_P32_L0.8021.00
41_L72_I0.8011.00
16_Q23_A0.8011.00
41_L73_L0.8001.00
21_I29_L0.7891.00
52_L56_L0.7631.00
18_G23_A0.7611.00
29_L33_T0.7561.00
100_R104_R0.7511.00
49_L53_Q0.7411.00
71_L75_A0.7391.00
48_T72_I0.7371.00
7_P11_I0.7331.00
44_Q72_I0.7271.00
17_V29_L0.7241.00
106_L109_R0.7211.00
18_G22_G0.7171.00
64_R67_L0.7061.00
41_L94_L0.7051.00
42_R46_L0.7051.00
17_V26_T0.7031.00
46_L50_R0.6991.00
63_A66_L0.6901.00
6_V9_L0.6811.00
104_R107_R0.6811.00
104_R109_R0.6761.00
89_L92_L0.6701.00
38_A80_L0.6611.00
33_T79_L0.6581.00
65_E68_D0.6571.00
48_T55_A0.6541.00
34_A38_A0.6531.00
22_G25_P0.6481.00
49_L73_L0.6451.00
42_R45_G0.6421.00
84_F88_A0.6391.00
104_R108_R0.6301.00
93_L102_L0.6241.00
98_T102_L0.6201.00
38_A81_T0.6181.00
62_P66_L0.6171.00
21_I26_T0.6091.00
3_F7_P0.5991.00
40_L76_G0.5951.00
51_R68_D0.5921.00
56_L62_P0.5911.00
43_R47_R0.5901.00
31_I38_A0.5831.00
75_A79_L0.5611.00
2_L5_L0.5611.00
68_D72_I0.5561.00
3_F81_T0.5541.00
52_L65_E0.5531.00
18_G21_I0.5511.00
15_I23_A0.5491.00
68_D71_L0.5471.00
13_L26_T0.5441.00
45_G49_L0.5401.00
25_P28_L0.5391.00
76_G79_L0.5391.00
61_L67_L0.5371.00
102_L109_R0.5371.00
84_F87_D0.5321.00
47_R54_A0.5311.00
11_I30_V0.5291.00
34_A41_L0.5271.00
70_A73_L0.5261.00
18_G26_T0.5251.00
85_L89_L0.5241.00
67_L107_R0.5231.00
35_V38_A0.5201.00
55_A63_A0.5191.00
10_E14_L0.5171.00
81_T91_L0.5091.00
26_T84_F0.5071.00
49_L52_L0.5041.00
17_V20_A0.5031.00
64_R104_R0.5011.00
67_L103_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mt1A 3 0.9196 7.8 0.889 Contact Map
3aqpA 1 0.9911 5 0.899 Contact Map
4dx5A 3 0.9732 4 0.904 Contact Map
3giaA 1 0.4821 3.5 0.906 Contact Map
4k0jA 3 0.8929 2.8 0.911 Contact Map
3w4tA 1 0.4911 2.6 0.912 Contact Map
1ciyA 1 0.4286 2.5 0.914 Contact Map
4ev6A 3 0.4196 2.2 0.916 Contact Map
4i0uA 4 0.4018 2.1 0.916 Contact Map
4w6vA 1 0.4375 2 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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