GREMLIN Database
Got1 - Got1/Sft2-like family
PFAM: PF04178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (111)
Sequences: 1980 (1319)
Seq/√Len: 125.2
META: 0.411

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_G6_S2.9021.00
66_S89_L2.5541.00
2_G30_G2.4671.00
45_K49_K2.3491.00
99_L109_L2.3331.00
68_V72_Y2.2881.00
31_N63_Y2.2601.00
71_L75_L2.1201.00
73_F77_L2.0901.00
72_Y76_V2.0661.00
54_P57_L2.0611.00
6_S30_G2.0291.00
70_T90_Q2.0271.00
45_K48_L1.8921.00
19_K22_K1.8581.00
69_L86_G1.7721.00
22_K26_L1.7561.00
24_A70_T1.7551.00
38_T47_Q1.6581.00
73_F76_V1.5911.00
92_L96_W1.5341.00
28_T70_T1.5161.00
21_R80_Y1.4821.00
50_F101_Y1.4481.00
73_F86_G1.4441.00
39_A44_P1.4311.00
57_L61_I1.4161.00
15_V18_L1.3961.00
47_Q97_Y1.3241.00
10_F13_L1.3171.00
81_L85_L1.2961.00
96_W100_S1.2761.00
14_P18_L1.2681.00
37_S42_I1.2631.00
47_Q51_M1.2340.99
60_T64_L1.2150.99
48_L52_F1.1860.99
8_L12_L1.1780.99
63_Y94_L1.1740.99
52_F61_I1.1720.99
36_A39_A1.1700.99
24_A87_I1.1650.99
22_K105_G1.1560.99
50_F53_S1.1270.99
52_F57_L1.1250.99
108_F111_K1.1230.99
61_I65_G1.1200.99
5_F33_L1.1110.99
77_L83_T1.1110.99
23_F27_Y1.1040.99
46_K50_F1.1030.99
28_T67_L1.0850.99
31_N90_Q1.0810.99
2_G34_F1.0660.98
28_T71_L1.0630.98
100_S103_P1.0490.98
43_G56_R1.0430.98
6_S34_F1.0400.98
56_R101_Y1.0220.98
106_R109_L1.0200.98
4_L8_L0.9980.98
107_T110_R0.9910.98
69_L73_F0.9900.98
104_G108_F0.9760.97
46_K56_R0.9610.97
52_F60_T0.9550.97
74_A83_T0.9510.97
62_V92_L0.9500.97
46_K49_K0.9480.97
43_G60_T0.9420.97
91_F95_L0.9410.97
63_Y67_L0.9320.96
102_I105_G0.9240.96
16_L20_P0.9190.96
14_P22_K0.9180.96
104_G107_T0.9080.96
73_F83_T0.9060.96
93_A97_Y0.9030.96
96_W106_R0.9010.96
84_L88_I0.9000.96
37_S94_L0.8900.95
29_L58_P0.8880.95
12_L15_V0.8850.95
45_K57_L0.8710.95
14_P37_S0.8590.94
77_L82_L0.8420.94
51_M64_L0.8410.94
21_R26_L0.8390.94
41_L47_Q0.8390.94
96_W102_I0.8240.93
83_T86_G0.8160.93
39_A47_Q0.8070.92
9_G14_P0.7890.92
31_N67_L0.7890.92
40_F102_I0.7880.91
73_F79_S0.7880.91
97_Y100_S0.7810.91
62_V96_W0.7700.91
79_S82_L0.7650.90
26_L35_L0.7630.90
104_G111_K0.7600.90
58_P62_V0.7580.90
42_I46_K0.7530.90
10_F20_P0.7450.89
42_I50_F0.7440.89
8_L22_K0.7390.89
73_F78_K0.7370.89
37_S66_S0.7340.88
52_F58_P0.7030.86
55_E106_R0.6980.86
41_L56_R0.6960.86
78_K85_L0.6930.85
11_L14_P0.6900.85
64_L68_V0.6900.85
77_L80_Y0.6900.85
40_F44_P0.6870.85
68_V73_F0.6860.85
7_F11_L0.6810.84
28_T31_N0.6780.84
84_L89_L0.6720.83
70_T103_P0.6710.83
5_F9_G0.6690.83
100_S106_R0.6630.83
44_P48_L0.6600.82
88_I92_L0.6560.82
33_L37_S0.6380.80
7_F12_L0.6310.79
78_K83_T0.6300.79
39_A63_Y0.6280.79
72_Y77_L0.6270.79
17_L20_P0.6200.78
92_L100_S0.6190.78
11_L20_P0.6120.77
51_M60_T0.6060.77
109_L112_C0.6000.76
52_F64_L0.5970.76
9_G61_I0.5950.75
45_K72_Y0.5900.75
12_L22_K0.5880.75
26_L33_L0.5800.74
76_V81_L0.5750.73
97_Y101_Y0.5670.72
24_A28_T0.5630.71
71_L94_L0.5540.70
78_K86_G0.5540.70
5_F19_K0.5530.70
31_N37_S0.5480.69
69_L82_L0.5470.69
19_K73_F0.5420.69
18_L22_K0.5410.68
96_W110_R0.5310.67
3_I88_I0.5280.67
100_S104_G0.5270.66
40_F47_Q0.5260.66
34_F64_L0.5220.66
24_A83_T0.5180.65
27_Y94_L0.5170.65
98_F109_L0.5150.65
10_F14_P0.5140.64
26_L30_G0.5070.63
27_Y90_Q0.5050.63
77_L90_Q0.5030.63
66_S69_L0.5020.63
96_W109_L0.5020.63
49_K53_S0.5000.62
66_S79_S0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1loiA 1 0.2212 1.7 0.929 Contact Map
3x29A 1 0.6814 1.7 0.93 Contact Map
3wo6A 1 0.3451 1.2 0.935 Contact Map
4pxzA 1 0.646 1.1 0.938 Contact Map
3dinE 1 0.5752 1 0.938 Contact Map
3j45G 1 0.5752 0.9 0.94 Contact Map
2akhX 1 0.646 0.8 0.943 Contact Map
2a65A 2 0.9912 0.8 0.944 Contact Map
4pd6A 3 0.4779 0.7 0.944 Contact Map
4xp4A 1 1 0.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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