Got1 - PFAM28P - GREMLIN Contacts

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Got1 - Got1/Sft2-like family

PFAM:	PF04178	Sequences: FGILFSFLGFLLLPVLLLKPRKFALLYTLGNILFLASTAFLIGPKKQLKFMFSPERLPATIVYLGSLVLTLYFALVLKSYLLTLLGIILQFLALLWYFLSYIPGGRTFLRKCC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	113 (111)
Sequences:	1980 (1319)
Seq/√Len:	125.2
META:	0.411

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
2_G	6_S	2.902	1.00
66_S	89_L	2.554	1.00
2_G	30_G	2.467	1.00
45_K	49_K	2.349	1.00
99_L	109_L	2.333	1.00
68_V	72_Y	2.288	1.00
31_N	63_Y	2.260	1.00
71_L	75_L	2.120	1.00
73_F	77_L	2.090	1.00
72_Y	76_V	2.066	1.00
54_P	57_L	2.061	1.00
6_S	30_G	2.029	1.00
70_T	90_Q	2.027	1.00
45_K	48_L	1.892	1.00
19_K	22_K	1.858	1.00
69_L	86_G	1.772	1.00
22_K	26_L	1.756	1.00
24_A	70_T	1.755	1.00
38_T	47_Q	1.658	1.00
73_F	76_V	1.591	1.00
92_L	96_W	1.534	1.00
28_T	70_T	1.516	1.00
21_R	80_Y	1.482	1.00
50_F	101_Y	1.448	1.00
73_F	86_G	1.444	1.00
39_A	44_P	1.431	1.00
57_L	61_I	1.416	1.00
15_V	18_L	1.396	1.00
47_Q	97_Y	1.324	1.00
10_F	13_L	1.317	1.00
81_L	85_L	1.296	1.00
96_W	100_S	1.276	1.00
14_P	18_L	1.268	1.00
37_S	42_I	1.263	1.00
47_Q	51_M	1.234	0.99
60_T	64_L	1.215	0.99
48_L	52_F	1.186	0.99
8_L	12_L	1.178	0.99
63_Y	94_L	1.174	0.99
52_F	61_I	1.172	0.99
36_A	39_A	1.170	0.99
24_A	87_I	1.165	0.99
22_K	105_G	1.156	0.99
50_F	53_S	1.127	0.99
52_F	57_L	1.125	0.99
108_F	111_K	1.123	0.99
61_I	65_G	1.120	0.99
5_F	33_L	1.111	0.99
77_L	83_T	1.111	0.99
23_F	27_Y	1.104	0.99
46_K	50_F	1.103	0.99
28_T	67_L	1.085	0.99
31_N	90_Q	1.081	0.99
2_G	34_F	1.066	0.98
28_T	71_L	1.063	0.98
100_S	103_P	1.049	0.98
43_G	56_R	1.043	0.98
6_S	34_F	1.040	0.98
56_R	101_Y	1.022	0.98
106_R	109_L	1.020	0.98
4_L	8_L	0.998	0.98
107_T	110_R	0.991	0.98
69_L	73_F	0.990	0.98
104_G	108_F	0.976	0.97
46_K	56_R	0.961	0.97
52_F	60_T	0.955	0.97
74_A	83_T	0.951	0.97
62_V	92_L	0.950	0.97
46_K	49_K	0.948	0.97
43_G	60_T	0.942	0.97
91_F	95_L	0.941	0.97
63_Y	67_L	0.932	0.96
102_I	105_G	0.924	0.96
16_L	20_P	0.919	0.96
14_P	22_K	0.918	0.96
104_G	107_T	0.908	0.96
73_F	83_T	0.906	0.96
93_A	97_Y	0.903	0.96
96_W	106_R	0.901	0.96
84_L	88_I	0.900	0.96
37_S	94_L	0.890	0.95
29_L	58_P	0.888	0.95
12_L	15_V	0.885	0.95
45_K	57_L	0.871	0.95
14_P	37_S	0.859	0.94
77_L	82_L	0.842	0.94
51_M	64_L	0.841	0.94
21_R	26_L	0.839	0.94
41_L	47_Q	0.839	0.94
96_W	102_I	0.824	0.93
83_T	86_G	0.816	0.93
39_A	47_Q	0.807	0.92
9_G	14_P	0.789	0.92
31_N	67_L	0.789	0.92
40_F	102_I	0.788	0.91
73_F	79_S	0.788	0.91
97_Y	100_S	0.781	0.91
62_V	96_W	0.770	0.91
79_S	82_L	0.765	0.90
26_L	35_L	0.763	0.90
104_G	111_K	0.760	0.90
58_P	62_V	0.758	0.90
42_I	46_K	0.753	0.90
10_F	20_P	0.745	0.89
42_I	50_F	0.744	0.89
8_L	22_K	0.739	0.89
73_F	78_K	0.737	0.89
37_S	66_S	0.734	0.88
52_F	58_P	0.703	0.86
55_E	106_R	0.698	0.86
41_L	56_R	0.696	0.86
78_K	85_L	0.693	0.85
11_L	14_P	0.690	0.85
64_L	68_V	0.690	0.85
77_L	80_Y	0.690	0.85
40_F	44_P	0.687	0.85
68_V	73_F	0.686	0.85
7_F	11_L	0.681	0.84
28_T	31_N	0.678	0.84
84_L	89_L	0.672	0.83
70_T	103_P	0.671	0.83
5_F	9_G	0.669	0.83
100_S	106_R	0.663	0.83
44_P	48_L	0.660	0.82
88_I	92_L	0.656	0.82
33_L	37_S	0.638	0.80
7_F	12_L	0.631	0.79
78_K	83_T	0.630	0.79
39_A	63_Y	0.628	0.79
72_Y	77_L	0.627	0.79
17_L	20_P	0.620	0.78
92_L	100_S	0.619	0.78
11_L	20_P	0.612	0.77
51_M	60_T	0.606	0.77
109_L	112_C	0.600	0.76
52_F	64_L	0.597	0.76
9_G	61_I	0.595	0.75
45_K	72_Y	0.590	0.75
12_L	22_K	0.588	0.75
26_L	33_L	0.580	0.74
76_V	81_L	0.575	0.73
97_Y	101_Y	0.567	0.72
24_A	28_T	0.563	0.71
71_L	94_L	0.554	0.70
78_K	86_G	0.554	0.70
5_F	19_K	0.553	0.70
31_N	37_S	0.548	0.69
69_L	82_L	0.547	0.69
19_K	73_F	0.542	0.69
18_L	22_K	0.541	0.68
96_W	110_R	0.531	0.67
3_I	88_I	0.528	0.67
100_S	104_G	0.527	0.66
40_F	47_Q	0.526	0.66
34_F	64_L	0.522	0.66
24_A	83_T	0.518	0.65
27_Y	94_L	0.517	0.65
98_F	109_L	0.515	0.65
10_F	14_P	0.514	0.64
26_L	30_G	0.507	0.63
27_Y	90_Q	0.505	0.63
77_L	90_Q	0.503	0.63
66_S	69_L	0.502	0.63
96_W	109_L	0.502	0.63
49_K	53_S	0.500	0.62
66_S	79_S	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1loiA	1	0.2212	1.7	0.929	Contact Map
3x29A	1	0.6814	1.7	0.93	Contact Map
3wo6A	1	0.3451	1.2	0.935	Contact Map
4pxzA	1	0.646	1.1	0.938	Contact Map
3dinE	1	0.5752	1	0.938	Contact Map
3j45G	1	0.5752	0.9	0.94	Contact Map
2akhX	1	0.646	0.8	0.943	Contact Map
2a65A	2	0.9912	0.8	0.944	Contact Map
4pd6A	3	0.4779	0.7	0.944	Contact Map
4xp4A	1	1	0.7	0.945	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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