GREMLIN Database
TIP41 - TIP41-like family
PFAM: PF04176 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (170)
Sequences: 543 (371)
Seq/√Len: 28.4
META: 0.221

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_N25_D4.9291.00
104_D107_A4.6531.00
12_H15_S4.0331.00
85_E88_K3.8861.00
29_R65_D3.6541.00
114_L129_L3.5871.00
165_A169_E3.3901.00
86_K148_Y3.0041.00
140_V170_L2.8971.00
25_D69_T2.8731.00
12_H16_G2.7351.00
91_D123_S2.7221.00
98_E115_S2.5750.99
78_T157_L2.4860.99
97_D117_K2.3250.99
86_K150_E2.3040.99
10_L127_L2.2230.98
124_C148_Y2.1570.98
9_R20_E2.1320.98
125_F149_H2.0990.97
141_R164_E2.0840.97
24_L61_T2.0500.97
143_R162_A1.9730.96
87_L93_I1.9010.95
11_E18_K1.8690.95
4_G167_Y1.7140.92
83_P150_E1.6660.91
98_E116_V1.6350.90
37_K45_K1.6220.90
40_Y137_G1.5800.88
31_D34_G1.5530.87
63_T139_L1.5500.87
24_L41_A1.5410.87
107_A112_S1.4380.83
64_T102_Y1.4270.82
67_K158_R1.3930.81
116_V129_L1.3890.81
104_D167_Y1.3790.80
40_Y109_N1.3660.80
8_L125_F1.3040.76
94_L151_F1.3030.76
108_D136_D1.2860.75
39_A112_S1.2690.74
166_T169_E1.2630.74
97_D100_V1.2590.74
67_K160_Y1.2100.71
19_I147_V1.1990.70
29_R64_T1.1940.70
43_E46_K1.1900.69
108_D134_R1.1690.68
86_K89_R1.1470.66
141_R145_T1.1430.66
102_Y120_V1.1380.66
80_E157_L1.1370.66
22_N111_I1.1290.65
64_T114_L1.1280.65
126_F144_D1.1210.65
76_E79_D1.1170.64
44_W48_R1.1020.63
143_R160_Y1.1020.63
72_G77_P1.1020.63
66_Y69_T1.0860.62
22_N69_T1.0780.62
30_V57_P1.0560.60
75_W78_T1.0460.59
78_T81_R1.0390.59
119_R146_R1.0300.58
40_Y126_F1.0300.58
135_V163_R1.0270.58
3_F62_Y1.0200.57
24_L169_E1.0110.57
82_I144_D1.0060.56
30_V33_T0.9960.55
80_E155_Y0.9870.55
96_Y117_K0.9740.54
105_E133_L0.9640.53
8_L12_H0.9610.53
2_I23_A0.9500.52
74_K77_P0.9470.52
19_I102_Y0.9450.51
102_Y141_R0.9440.51
153_T170_L0.9380.51
5_D62_Y0.9360.51
114_L140_V0.9340.51
37_K133_L0.9210.50
89_R92_P0.9170.49
53_E137_G0.9000.48
107_A138_V0.8980.48
23_A137_G0.8980.48
82_I157_L0.8830.47
30_V41_A0.8790.46
93_I121_M0.8770.46
9_R18_K0.8760.46
61_T135_V0.8750.46
86_K132_F0.8740.46
16_G157_L0.8700.46
77_P80_E0.8660.45
144_D148_Y0.8620.45
64_T94_L0.8530.44
40_Y47_S0.8510.44
61_T86_K0.8300.43
3_F103_E0.8230.42
97_D107_A0.8220.42
125_F155_Y0.8220.42
40_Y83_P0.8120.41
110_G134_R0.8110.41
85_E115_S0.8110.41
105_E138_V0.8070.41
118_I131_F0.8050.41
84_L144_D0.8050.41
31_D129_L0.8010.40
42_E46_K0.8000.40
111_I132_F0.7980.40
41_A90_R0.7960.40
98_E117_K0.7950.40
120_V151_F0.7920.40
39_A138_V0.7920.40
62_Y83_P0.7870.39
37_K142_I0.7860.39
139_L142_I0.7840.39
97_D132_F0.7780.39
88_K163_R0.7760.39
109_N138_V0.7730.38
97_D163_R0.7720.38
84_L148_Y0.7610.38
84_L123_S0.7570.37
72_G139_L0.7570.37
48_R57_P0.7550.37
103_E138_V0.7510.37
7_S19_I0.7500.37
43_E121_M0.7490.37
104_D125_F0.7480.37
45_K125_F0.7430.36
48_R151_F0.7420.36
163_R166_T0.7420.36
65_D143_R0.7390.36
19_I24_L0.7360.36
8_L112_S0.7350.36
140_V167_Y0.7320.35
105_E109_N0.7310.35
5_D12_H0.7300.35
87_L119_R0.7290.35
40_Y147_V0.7240.35
27_L30_V0.7170.34
20_E25_D0.7150.34
102_Y151_F0.7140.34
73_L79_D0.7090.34
103_E108_D0.7080.34
104_D110_G0.7080.34
155_Y166_T0.7070.34
47_S151_F0.6980.33
87_L146_R0.6960.33
74_K80_E0.6900.33
149_H152_G0.6900.33
87_L121_M0.6880.32
105_E108_D0.6820.32
29_R58_Y0.6800.32
63_T141_R0.6750.32
112_S131_F0.6730.31
8_L129_L0.6730.31
32_K156_V0.6720.31
162_A170_L0.6710.31
28_K32_K0.6710.31
103_E106_L0.6710.31
129_L170_L0.6700.31
125_F167_Y0.6690.31
102_Y116_V0.6680.31
95_F132_F0.6660.31
124_C149_H0.6640.31
92_P109_N0.6530.30
50_D129_L0.6430.29
30_V34_G0.6420.29
110_G136_D0.6410.29
62_Y148_Y0.6390.29
147_V156_V0.6380.29
132_F145_T0.6300.29
75_W80_E0.6290.29
65_D162_A0.6230.28
106_L133_L0.6230.28
70_L137_G0.6170.28
38_V138_V0.6170.28
70_L75_W0.6160.28
148_Y153_T0.6150.28
6_N56_K0.6150.28
132_F142_I0.6140.28
63_T162_A0.6140.28
99_V116_V0.6120.27
11_E99_V0.6120.27
99_V118_I0.6110.27
14_P55_V0.6080.27
154_N168_E0.6040.27
44_W108_D0.6030.27
12_H72_G0.6030.27
75_W79_D0.6030.27
18_K42_E0.6020.27
83_P88_K0.6010.27
1_M105_E0.5990.27
58_Y97_D0.5990.27
139_L164_E0.5980.27
26_A38_V0.5970.27
4_G58_Y0.5920.26
25_D142_I0.5920.26
102_Y143_R0.5910.26
101_L141_R0.5900.26
75_W156_V0.5890.26
99_V157_L0.5840.26
23_A113_M0.5830.26
71_E147_V0.5820.26
42_E76_E0.5790.25
4_G99_V0.5780.25
34_G102_Y0.5750.25
99_V127_L0.5720.25
86_K156_V0.5710.25
130_R144_D0.5700.25
81_R112_S0.5680.25
70_L147_V0.5670.25
8_L100_V0.5670.25
38_V141_R0.5660.25
153_T156_V0.5650.25
98_E118_I0.5610.24
48_R95_F0.5600.24
132_F170_L0.5570.24
18_K152_G0.5570.24
65_D160_Y0.5510.24
4_G151_F0.5490.24
73_L102_Y0.5490.24
43_E48_R0.5470.24
149_H153_T0.5420.23
45_K116_V0.5410.23
67_K80_E0.5390.23
51_S55_V0.5340.23
103_E134_R0.5340.23
16_G46_K0.5330.23
81_R152_G0.5330.23
45_K163_R0.5290.23
70_L78_T0.5240.22
48_R82_I0.5240.22
117_K123_S0.5240.22
96_Y153_T0.5230.22
61_T116_V0.5220.22
30_V105_E0.5210.22
41_A96_Y0.5180.22
3_F16_G0.5180.22
77_P168_E0.5150.22
117_K146_R0.5130.22
24_L98_E0.5100.22
83_P149_H0.5090.22
31_D114_L0.5080.22
94_L98_E0.5050.21
40_Y107_A0.5040.21
83_P91_D0.5020.21
81_R117_K0.5020.21
161_T166_T0.5020.21
114_L131_F0.5010.21
126_F149_H0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rydA 4 0.4561 4.1 0.969 Contact Map
3wbzA 5 0.3509 3.5 0.97 Contact Map
2kvkA 1 0.2807 3.3 0.97 Contact Map
2gibA 3 0.3216 3.1 0.971 Contact Map
4kgmA 5 0.3158 2.9 0.971 Contact Map
1t3yA 1 0.2398 2.9 0.971 Contact Map
1sr4A 1 0.3333 2.8 0.971 Contact Map
1sa3A 1 0.4035 2.8 0.971 Contact Map
4cknA 2 0.3801 2.8 0.971 Contact Map
3pimA 2 0.3392 2.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0167 seconds.