GREMLIN Database
Sof1 - Sof1-like domain
PFAM: PF04158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (87)
Sequences: 755 (506)
Seq/√Len: 54.3
META: 0.419

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_E69_R3.4901.00
2_N22_E3.2281.00
63_R67_N3.2061.00
17_A21_R3.1751.00
25_K38_A2.8661.00
26_E29_K2.6931.00
2_N5_E2.5741.00
69_R78_P2.3961.00
22_E25_K2.1241.00
55_R59_E2.0481.00
51_A55_R1.8940.99
57_M60_A1.8720.99
53_I57_M1.8690.99
56_E60_A1.8300.99
54_K58_L1.8240.99
57_M61_I1.7800.99
36_R40_H1.7120.99
60_A64_K1.6750.99
23_A26_E1.6590.99
48_K52_K1.5600.98
72_S75_G1.5600.98
11_S14_E1.4500.97
66_E70_K1.4340.97
27_R46_A1.3970.96
43_V47_I1.3380.95
15_R19_E1.3060.94
46_A50_A1.3040.94
18_L84_K1.2160.92
48_K57_M1.2050.91
50_A53_I1.1510.89
49_K52_K1.1460.89
34_I41_R1.1200.88
62_K66_E1.0940.87
82_E86_H1.0620.85
62_K65_E1.0450.84
82_E85_K1.0310.83
8_G14_E1.0290.83
23_A60_A1.0250.83
80_V84_K1.0020.81
53_I56_E0.9950.81
5_E8_G0.9880.80
65_E68_R0.9530.78
58_L62_K0.9210.76
27_R67_N0.9030.74
66_E79_R0.8850.73
62_K71_H0.8840.72
32_P67_N0.8770.72
28_Y77_V0.8670.71
69_R79_R0.8640.71
72_S76_S0.8630.71
6_K14_E0.8590.70
73_K81_P0.8540.70
1_A5_E0.8460.69
32_P53_I0.8420.69
10_L14_E0.8410.69
21_R53_I0.8310.68
50_A71_H0.8230.67
22_E34_I0.8140.66
20_Y70_K0.8020.65
64_K71_H0.7970.64
3_A83_R0.7870.63
5_E56_E0.7790.63
71_H74_P0.7640.61
33_E36_R0.7590.61
36_R42_H0.7580.61
74_P77_V0.7520.60
25_K28_Y0.7500.60
65_E77_V0.7490.60
8_G56_E0.7470.59
40_H64_K0.7440.59
35_R84_K0.7410.59
64_K68_R0.7360.58
7_L29_K0.7260.57
29_K50_A0.7240.57
68_R72_S0.7160.56
49_K62_K0.7120.56
81_P84_K0.6920.54
23_A61_I0.6900.53
56_E59_E0.6870.53
4_S18_L0.6820.53
67_N71_H0.6810.53
73_K76_S0.6640.51
29_K56_E0.6610.50
41_R83_R0.6590.50
12_P16_A0.6530.50
81_P85_K0.6520.49
50_A57_M0.6520.49
53_I60_A0.6460.49
13_R39_R0.6450.49
24_L38_A0.6320.47
35_R39_R0.6280.47
80_V87_V0.6250.47
14_E26_E0.6090.45
16_A19_E0.6080.45
46_A49_K0.6080.45
50_A54_K0.5990.44
31_M48_K0.5940.43
7_L64_K0.5860.42
42_H52_K0.5860.42
48_K51_A0.5850.42
56_E63_R0.5790.42
15_R69_R0.5720.41
27_R49_K0.5700.41
27_R60_A0.5650.40
56_E80_V0.5630.40
33_E66_E0.5610.40
20_Y24_L0.5600.40
30_H49_K0.5600.40
60_A67_N0.5510.39
24_L73_K0.5460.38
37_I87_V0.5420.38
46_A53_I0.5410.38
17_A31_M0.5390.38
43_V51_A0.5310.37
5_E32_P0.5290.37
79_R87_V0.5280.37
21_R61_I0.5260.36
47_I75_G0.5230.36
40_H43_V0.5210.36
6_K31_M0.5200.36
2_N10_L0.5190.36
33_E80_V0.5170.35
29_K45_K0.5160.35
18_L25_K0.5150.35
9_V30_H0.5130.35
66_E69_R0.5110.35
22_E39_R0.5080.35
7_L51_A0.5040.34
28_Y52_K0.5010.34
56_E79_R0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uerb 1 0.092 5.6 0.914 Contact Map
3flvA 1 0.3333 5 0.916 Contact Map
4z29A 1 0.3563 2.8 0.926 Contact Map
4flaA 2 0.3678 2.6 0.927 Contact Map
2zaiA 2 0.6207 2.4 0.929 Contact Map
2jpfA 1 0.3333 2.3 0.929 Contact Map
3vu1A 2 0.6782 2.2 0.93 Contact Map
1ji8A 1 0.8391 2 0.932 Contact Map
3b5mA 2 0.3218 1.5 0.936 Contact Map
2lbbA 1 0.3333 1.4 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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