GREMLIN Database
DUF397 - Domain of unknown function (DUF397)
PFAM: PF04149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (52)
Sequences: 27894 (18768)
Seq/√Len: 2602.7
META: 0.663

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_E29_R2.9141.00
20_A27_A2.8781.00
27_A40_V2.4881.00
22_L27_A2.1521.00
33_D36_G2.0531.00
5_K18_E1.9161.00
19_V46_W1.8091.00
4_R21_A1.6681.00
31_S34_P1.5411.00
5_K9_S1.5321.00
4_R19_V1.4531.00
2_A20_A1.4431.00
47_A51_A1.3701.00
9_S16_C1.3641.00
46_W49_F1.3511.00
42_T45_E1.3011.00
10_G15_N1.2061.00
18_E31_S1.1911.00
33_D37_P1.1851.00
48_A52_G1.1471.00
16_C31_S1.1401.00
30_D39_L1.0801.00
50_L53_V1.0671.00
45_E48_A1.0601.00
41_F45_E1.0541.00
44_A48_A1.0171.00
11_G15_N1.0161.00
10_G13_G1.0041.00
34_P37_P0.9961.00
8_Y51_A0.9831.00
5_K16_C0.9731.00
25_A40_V0.9711.00
2_A21_A0.9471.00
35_D38_V0.9031.00
43_P47_A0.8981.00
9_S32_K0.8911.00
41_F49_F0.8861.00
28_V41_F0.8661.00
12_N15_N0.8621.00
44_A47_A0.8581.00
5_K34_P0.8471.00
27_A38_V0.8391.00
21_A43_P0.8301.00
49_F53_V0.8001.00
28_V46_W0.7821.00
50_L54_K0.7731.00
22_L25_A0.7661.00
9_S15_N0.7511.00
48_A51_A0.7421.00
36_G39_L0.7361.00
47_A50_L0.7351.00
15_N32_K0.7071.00
2_A22_L0.7051.00
45_E52_G0.7051.00
23_P27_A0.6981.00
34_P38_V0.6961.00
19_V49_F0.6901.00
3_W20_A0.6641.00
28_V39_L0.6301.00
4_R20_A0.6271.00
13_G16_C0.6071.00
30_D41_F0.6071.00
19_V26_V0.5951.00
6_S9_S0.5731.00
9_S31_S0.5701.00
18_E34_P0.5531.00
30_D45_E0.5531.00
7_S10_G0.5471.00
16_C28_V0.5441.00
46_W50_L0.5421.00
30_D33_D0.5371.00
16_C32_K0.5341.00
21_A27_A0.5301.00
9_S30_D0.5231.00
37_P41_F0.5111.00
21_A26_V0.5101.00
25_A43_P0.5061.00
4_R10_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jp6A 1 0.8889 9.1 0.85 Contact Map
1n10A 1 0.9259 6.5 0.86 Contact Map
2xb0X 1 0.3519 5.9 0.862 Contact Map
4jcwA 2 0.9074 5.6 0.863 Contact Map
3e49A 3 0.9444 5.5 0.864 Contact Map
3e02A 3 0.9444 5.4 0.864 Contact Map
4hd4A 1 0.4444 5.3 0.865 Contact Map
2hczX 1 0.9259 5.3 0.865 Contact Map
3l6wA 2 0.4259 5.1 0.866 Contact Map
3fqmA 2 0.8889 4.8 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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