GREMLIN Database
SCAMP - SCAMP family
PFAM: PF04144 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (169)
Sequences: 710 (422)
Seq/√Len: 32.5
META: 0.197

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_W150_T4.4551.00
13_H81_Y4.2021.00
4_W31_Y4.0621.00
14_D17_V3.9921.00
116_G121_G3.9211.00
128_A146_A3.8361.00
30_A84_L3.6911.00
21_E24_Q3.3561.00
137_A141_F3.2631.00
45_L69_F3.1151.00
34_W76_S3.1131.00
132_F143_L2.3220.99
69_F73_T2.0880.98
77_F81_Y2.0810.98
136_V140_I2.0650.98
113_Q149_F2.0470.98
99_F103_F1.9840.98
47_A145_G1.9240.97
93_S101_F1.8670.97
161_K165_R1.8130.96
96_F100_F1.7860.95
114_A150_T1.7780.95
164_H167_Y1.7740.95
125_W146_A1.7600.95
66_I90_S1.7530.95
113_Q122_L1.6810.94
84_L159_V1.6700.94
80_W106_Q1.5480.91
143_L147_G1.5430.90
12_Y17_V1.5340.90
100_F103_F1.4670.88
42_F69_F1.4620.88
49_L53_I1.4470.87
45_L105_F1.4110.86
12_Y18_E1.3820.85
36_G40_T1.3670.84
49_L62_F1.3560.84
45_L65_S1.3490.83
25_R29_R1.3470.83
128_A132_F1.3400.83
156_S165_R1.2940.81
35_L39_L1.2910.80
76_S83_P1.2520.78
67_L154_V1.2390.78
76_S80_W1.2250.77
79_C102_F1.2160.76
47_A123_C1.2040.76
91_D96_F1.1900.75
102_F112_I1.1900.75
135_N139_G1.1630.73
15_I19_I1.1560.72
77_F85_Y1.1490.72
51_A127_A1.1460.72
47_A141_F1.1370.71
54_V135_N1.1350.71
13_H19_I1.1330.71
46_I50_A1.1330.71
15_I28_K1.1170.70
96_F99_F1.1100.69
73_T77_F1.1050.69
152_E155_L1.0970.68
164_H168_R1.0950.68
49_L52_F1.0940.68
131_L135_N1.0650.66
31_Y34_W1.0540.65
83_P87_A1.0520.65
40_T142_M1.0510.65
132_F135_N1.0490.65
71_L125_W1.0490.65
57_G137_A1.0480.65
43_L119_G1.0380.64
26_L103_F1.0370.64
55_G58_G1.0360.64
111_I115_I1.0360.64
41_L75_C1.0070.62
63_G117_I1.0040.61
4_W129_I0.9990.61
103_F106_Q0.9960.61
114_A146_A0.9940.61
63_G66_I0.9810.60
4_W14_D0.9750.59
116_G122_L0.9710.59
115_I118_P0.9670.58
97_F101_F0.9650.58
91_D102_F0.9490.57
54_V138_V0.9440.57
63_G121_G0.9430.57
13_H31_Y0.9410.56
99_F106_Q0.9360.56
33_L103_F0.9340.56
27_V139_G0.9240.55
131_L139_G0.9240.55
9_P34_W0.9230.55
10_C13_H0.9220.55
27_V88_F0.9120.54
30_A159_V0.9090.54
92_S96_F0.8930.52
158_W162_K0.8920.52
91_D97_F0.8910.52
51_A68_Y0.8870.52
42_F154_V0.8810.51
32_Y46_I0.8790.51
7_F11_F0.8770.51
29_R33_L0.8720.51
81_Y108_V0.8630.50
7_F29_R0.8590.50
68_Y109_F0.8540.49
166_Y169_G0.8450.48
20_P24_Q0.8270.47
107_I156_S0.8260.47
64_L68_Y0.8260.47
80_W83_P0.8250.47
87_A99_F0.8240.47
56_G123_C0.8210.47
4_W35_L0.8170.46
50_A141_F0.8150.46
14_D34_W0.8140.46
78_V150_T0.8060.45
111_I153_A0.8060.45
134_G139_G0.8020.45
107_I110_C0.8020.45
47_A118_P0.7980.45
26_L29_R0.7970.45
12_Y33_L0.7950.44
107_I155_L0.7900.44
90_S104_F0.7900.44
72_F102_F0.7890.44
120_W151_L0.7870.44
16_S24_Q0.7830.43
89_R95_N0.7790.43
108_V137_A0.7760.43
108_V160_L0.7750.43
42_F143_L0.7740.43
149_F155_L0.7730.43
138_V143_L0.7650.42
115_I127_A0.7650.42
154_V158_W0.7620.42
2_N12_Y0.7620.42
43_L145_G0.7560.41
53_I65_S0.7480.41
72_F88_F0.7400.40
87_A103_F0.7380.40
12_Y15_I0.7360.40
132_F139_G0.7360.40
91_D162_K0.7350.40
82_R106_Q0.7330.39
94_F98_V0.7300.39
134_G147_G0.7250.39
100_F106_Q0.7170.38
111_I166_Y0.7160.38
81_Y107_I0.7150.38
34_W83_P0.7100.38
46_I65_S0.7050.37
15_I31_Y0.7030.37
89_R103_F0.6990.37
24_Q159_V0.6980.37
93_S100_F0.6980.37
9_P15_I0.6900.36
2_N8_F0.6870.36
77_F82_R0.6860.36
128_A142_M0.6860.36
46_I98_V0.6810.35
81_Y114_A0.6800.35
136_V139_G0.6760.35
67_L168_R0.6750.35
74_P80_W0.6720.35
147_G151_L0.6710.35
46_I119_G0.6710.35
102_F106_Q0.6700.35
109_F122_L0.6690.34
2_N13_H0.6690.34
79_C109_F0.6680.34
133_S138_V0.6660.34
116_G126_I0.6640.34
52_F149_F0.6610.34
18_E27_V0.6590.34
22_E29_R0.6560.34
41_L83_P0.6550.33
18_E28_K0.6500.33
83_P96_F0.6470.33
86_K95_N0.6320.32
43_L69_F0.6250.31
107_I140_I0.6250.31
36_G101_F0.6240.31
93_S97_F0.6230.31
91_D100_F0.6180.31
152_E158_W0.6140.30
133_S160_L0.6110.30
122_L169_G0.6100.30
9_P83_P0.6060.30
107_I111_I0.6050.30
9_P12_Y0.6030.30
137_A140_I0.5990.29
163_V168_R0.5980.29
27_V32_Y0.5920.29
1_E165_R0.5920.29
80_W100_F0.5900.29
88_F96_F0.5860.29
86_K90_S0.5860.29
9_P31_Y0.5850.29
90_S102_F0.5840.28
108_V111_I0.5760.28
39_L57_G0.5720.28
68_Y75_C0.5710.28
48_C75_C0.5690.27
15_I24_Q0.5660.27
148_L151_L0.5650.27
120_W123_C0.5650.27
21_E29_R0.5640.27
7_F125_W0.5640.27
46_I134_G0.5630.27
4_W144_I0.5610.27
86_K89_R0.5610.27
14_D36_G0.5580.27
75_C125_W0.5580.27
37_L156_S0.5560.27
38_V73_T0.5550.27
38_V140_I0.5530.26
61_F123_C0.5530.26
125_W154_V0.5520.26
108_V140_I0.5500.26
70_L133_S0.5500.26
150_T154_V0.5460.26
148_L155_L0.5420.26
95_N101_F0.5410.26
46_I160_L0.5400.26
104_F108_V0.5400.26
41_L144_I0.5370.25
79_C106_Q0.5370.25
17_V71_L0.5360.25
64_L138_V0.5350.25
52_F126_I0.5340.25
50_A155_L0.5330.25
131_L169_G0.5300.25
9_P100_F0.5260.25
120_W149_F0.5220.24
28_K32_Y0.5210.24
127_A163_V0.5180.24
2_N11_F0.5170.24
28_K119_G0.5130.24
46_I136_V0.5110.24
133_S150_T0.5100.24
129_I132_F0.5090.24
114_A153_A0.5090.24
75_C157_I0.5080.24
25_R132_F0.5070.24
44_N87_A0.5050.23
114_A143_L0.5050.23
140_I144_I0.5040.23
66_I74_P0.5040.23
40_T152_E0.5030.23
52_F55_G0.5020.23
62_F160_L0.5000.23
144_I148_L0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftC 1 0.8412 10 0.94 Contact Map
2jlnA 1 0.9353 10 0.94 Contact Map
4bbjA 1 0.8471 5.2 0.948 Contact Map
1m56C 2 0.6647 4.8 0.948 Contact Map
3mktA 1 0.9059 3.7 0.951 Contact Map
4humA 1 0.9118 3.3 0.953 Contact Map
2wmyA 3 0.2941 2.8 0.954 Contact Map
3j08A 2 0.6882 2.7 0.955 Contact Map
3j1zP 8 0.8118 2.4 0.956 Contact Map
1v54C 1 0.9412 2.3 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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