Sulf_transp - PFAM28P - GREMLIN Contacts

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Sulf_transp - Sulphur transport

PFAM:	PF04143	Sequences: RGRFCFMGAVRDLVNMGDGRRLRAWLLAIAVAILGFQLLLALGLIDLSGSPFPWLGAIVGGLLFGIGMVLAGGCGSGTLVRLGGGNLRSLVVLLVFGIGAYATLRGLLAPWRVALLDPPVVALSLPGLLGLPPALLAALLALAALALLAAALRAGALAPAAALLAFAFASRLFRGSWPLLLGGLVIGLLVVAGWLVTGHLGRPWSLTFTAPGADTLQYLMLGTSAFLTFGIVLVLGVILGAFLAALLAGEFRWEFPSARDLLRALIGGLLMGFGAVLALGCTIGQGLSGISTLSLGSWLALAAIFAGAAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	310 (305)
Sequences:	7970 (5961)
Seq/√Len:	341.3
META:	0.774

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
95_V	265_L	4.294	1.00
35_G	191_V	4.016	1.00
58_I	303_A	3.901	1.00
99_G	269_L	3.666	1.00
13_L	19_G	3.212	1.00
82_L	90_L	2.688	1.00
2_G	182_G	2.609	1.00
146_A	150_A	2.524	1.00
91_V	261_L	2.318	1.00
129_L	134_A	2.204	1.00
242_F	246_L	2.183	1.00
124_S	127_G	2.163	1.00
57_A	300_A	2.151	1.00
246_L	251_F	2.114	1.00
244_A	248_A	2.063	1.00
82_L	93_L	2.018	1.00
38_L	42_L	2.017	1.00
286_G	301_L	1.993	1.00
200_L	203_P	1.963	1.00
298_W	302_A	1.943	1.00
131_L	134_A	1.875	1.00
28_A	287_L	1.858	1.00
78_T	93_L	1.847	1.00
201_G	204_W	1.840	1.00
95_V	268_G	1.835	1.00
290_I	298_W	1.796	1.00
50_S	54_W	1.786	1.00
13_L	22_L	1.780	1.00
209_T	275_A	1.756	1.00
210_A	214_D	1.753	1.00
145_L	149_A	1.752	1.00
198_G	203_P	1.743	1.00
61_G	303_A	1.740	1.00
127_G	131_L	1.723	1.00
63_L	270_L	1.717	1.00
290_I	301_L	1.711	1.00
126_P	129_L	1.711	1.00
62_L	307_G	1.687	1.00
198_G	202_R	1.687	1.00
95_V	99_G	1.593	1.00
300_A	304_I	1.593	1.00
181_L	185_V	1.590	1.00
147_L	150_A	1.588	1.00
39_L	44_L	1.586	1.00
51_P	54_W	1.578	1.00
71_A	268_G	1.575	1.00
150_A	153_R	1.565	1.00
57_A	296_G	1.560	1.00
121_V	124_S	1.554	1.00
122_A	125_L	1.552	1.00
134_A	138_A	1.551	1.00
62_L	306_A	1.541	1.00
128_L	131_L	1.541	1.00
221_L	225_A	1.533	1.00
211_P	214_D	1.530	1.00
184_L	188_L	1.527	1.00
146_A	149_A	1.521	1.00
152_L	155_G	1.517	1.00
199_H	203_P	1.493	1.00
151_A	154_A	1.482	1.00
115_L	118_P	1.482	1.00
14_V	309_A	1.482	1.00
238_I	242_F	1.451	1.00
200_L	204_W	1.445	1.00
83_G	238_I	1.444	1.00
129_L	132_P	1.433	1.00
123_L	126_P	1.427	1.00
38_L	41_A	1.419	1.00
63_L	273_F	1.413	1.00
221_L	224_S	1.413	1.00
223_T	226_F	1.404	1.00
142_L	146_A	1.396	1.00
127_G	130_G	1.396	1.00
121_V	125_L	1.394	1.00
245_A	251_F	1.393	1.00
259_R	263_R	1.388	1.00
246_L	249_G	1.386	1.00
132_P	135_L	1.385	1.00
283_I	287_L	1.378	1.00
188_L	192_A	1.378	1.00
134_A	137_A	1.374	1.00
199_H	202_R	1.373	1.00
301_L	305_F	1.366	1.00
123_L	128_L	1.362	1.00
111_W	115_L	1.349	1.00
215_T	219_L	1.347	1.00
99_G	273_F	1.341	1.00
82_L	238_I	1.340	1.00
193_G	205_S	1.336	1.00
106_G	109_A	1.335	1.00
225_A	228_T	1.334	1.00
3_R	250_E	1.332	1.00
303_A	306_A	1.331	1.00
208_F	237_V	1.329	1.00
143_A	147_L	1.322	1.00
8_G	21_R	1.312	1.00
164_L	167_A	1.300	1.00
215_T	235_L	1.287	1.00
195_L	199_H	1.285	1.00
75_G	96_F	1.276	1.00
193_G	197_T	1.272	1.00
26_L	29_I	1.258	1.00
19_G	22_L	1.255	1.00
130_G	134_A	1.244	1.00
40_L	47_L	1.242	1.00
303_A	307_G	1.232	1.00
120_V	123_L	1.230	1.00
253_W	262_L	1.225	1.00
214_D	218_Y	1.224	1.00
135_L	139_L	1.219	1.00
79_L	238_I	1.216	1.00
71_A	92_V	1.215	1.00
242_F	251_F	1.206	1.00
12_D	16_M	1.205	1.00
183_G	187_G	1.191	1.00
302_A	306_A	1.188	1.00
124_S	128_L	1.179	1.00
78_T	89_S	1.173	1.00
220_M	223_T	1.166	1.00
95_V	269_L	1.163	1.00
129_L	133_P	1.161	1.00
95_V	98_I	1.161	1.00
126_P	131_L	1.159	1.00
220_M	227_L	1.159	1.00
50_S	53_P	1.147	1.00
31_V	187_G	1.145	1.00
209_T	212_G	1.144	1.00
83_G	241_A	1.140	1.00
190_V	194_W	1.126	1.00
206_L	233_L	1.125	1.00
84_G	245_A	1.124	1.00
147_L	151_A	1.110	1.00
257_S	260_D	1.107	1.00
52_F	299_L	1.103	1.00
228_T	231_I	1.103	1.00
139_L	143_A	1.102	1.00
225_A	229_F	1.099	1.00
126_P	130_G	1.097	1.00
220_M	228_T	1.097	1.00
37_Q	40_L	1.096	1.00
220_M	229_F	1.093	1.00
141_A	144_A	1.093	1.00
193_G	233_L	1.093	1.00
285_Q	297_S	1.092	1.00
119_P	122_A	1.088	1.00
133_P	136_L	1.082	1.00
178_P	181_L	1.081	1.00
62_L	66_I	1.078	1.00
137_A	140_L	1.076	1.00
46_D	49_G	1.076	1.00
10_V	14_V	1.074	1.00
115_L	119_P	1.074	1.00
57_A	299_L	1.071	1.00
22_L	26_L	1.070	1.00
105_R	109_A	1.070	1.00
133_P	138_A	1.068	1.00
182_G	186_I	1.064	1.00
231_I	235_L	1.063	1.00
117_D	120_V	1.061	1.00
153_R	156_A	1.058	1.00
168_F	180_L	1.057	1.00
33_I	37_Q	1.057	1.00
187_G	190_V	1.055	1.00
214_D	217_Q	1.055	1.00
62_L	303_A	1.053	1.00
128_L	134_A	1.040	1.00
110_P	113_V	1.040	1.00
11_R	16_M	1.037	1.00
39_L	191_V	1.035	1.00
133_P	137_A	1.024	1.00
1_R	248_A	1.017	1.00
149_A	153_R	1.017	1.00
177_W	181_L	1.008	1.00
88_R	260_D	1.005	1.00
226_F	229_F	1.001	1.00
31_V	184_L	1.000	1.00
130_G	133_P	1.000	1.00
300_A	303_A	0.996	1.00
144_A	148_L	0.990	1.00
103_T	106_G	0.990	1.00
131_L	135_L	0.987	1.00
112_R	117_D	0.983	1.00
116_L	119_P	0.982	1.00
102_A	107_L	0.980	1.00
142_L	145_L	0.977	1.00
8_G	12_D	0.973	1.00
212_G	215_T	0.972	1.00
140_L	143_A	0.967	1.00
194_W	197_T	0.966	1.00
189_L	192_A	0.963	1.00
151_A	155_G	0.962	1.00
179_L	183_G	0.961	1.00
223_T	228_T	0.961	1.00
111_W	114_A	0.960	1.00
220_M	225_A	0.954	1.00
222_G	225_A	0.951	1.00
135_L	142_L	0.942	1.00
110_P	115_L	0.941	1.00
69_V	73_G	0.936	1.00
208_F	211_P	0.936	1.00
126_P	132_P	0.934	1.00
286_G	290_I	0.929	1.00
152_L	157_L	0.927	1.00
113_V	117_D	0.926	1.00
127_G	134_A	0.919	1.00
190_V	193_G	0.919	1.00
12_D	18_D	0.918	1.00
258_A	262_L	0.911	1.00
91_V	265_L	0.910	1.00
10_V	305_F	0.910	1.00
133_P	139_L	0.904	1.00
127_G	132_P	0.902	1.00
186_I	190_V	0.898	1.00
289_G	297_S	0.895	1.00
114_A	118_P	0.890	1.00
220_M	226_F	0.889	1.00
198_G	201_G	0.889	1.00
109_A	112_R	0.888	1.00
67_G	270_L	0.887	1.00
150_A	154_A	0.885	1.00
202_R	205_S	0.884	1.00
296_G	300_A	0.883	1.00
278_A	300_A	0.881	1.00
52_F	57_A	0.879	1.00
122_A	126_P	0.875	1.00
103_T	107_L	0.871	1.00
213_A	219_L	0.871	1.00
207_T	211_P	0.870	1.00
155_G	158_A	0.868	1.00
138_A	142_L	0.864	1.00
190_V	287_L	0.863	1.00
36_F	40_L	0.855	1.00
152_L	156_A	0.855	1.00
186_I	189_L	0.855	1.00
154_A	157_L	0.851	1.00
179_L	182_G	0.849	1.00
127_G	135_L	0.848	1.00
203_P	206_L	0.848	1.00
68_M	308_A	0.846	1.00
9_A	21_R	0.846	1.00
124_S	130_G	0.837	1.00
197_T	203_P	0.832	1.00
136_L	140_L	0.831	1.00
165_A	169_A	0.829	1.00
8_G	11_R	0.827	1.00
136_L	147_L	0.825	1.00
154_A	158_A	0.821	1.00
103_T	273_F	0.812	1.00
32_A	291_S	0.810	1.00
96_F	99_G	0.809	1.00
215_T	218_Y	0.809	1.00
188_L	191_V	0.806	1.00
141_A	146_A	0.803	1.00
123_L	127_G	0.802	1.00
12_D	21_R	0.800	1.00
131_L	137_A	0.800	1.00
224_S	227_L	0.799	1.00
290_I	297_S	0.797	1.00
55_L	59_V	0.795	1.00
131_L	136_L	0.793	1.00
143_A	146_A	0.792	1.00
36_F	47_L	0.791	1.00
28_A	183_G	0.790	1.00
75_G	237_V	0.789	1.00
30_A	34_L	0.789	1.00
34_L	38_L	0.787	1.00
37_Q	41_A	0.787	1.00
211_P	215_T	0.784	1.00
129_L	137_A	0.771	1.00
141_A	145_L	0.771	1.00
145_L	150_A	0.770	1.00
185_V	189_L	0.770	1.00
224_S	228_T	0.765	1.00
212_G	234_V	0.760	1.00
48_S	51_P	0.755	1.00
78_T	92_V	0.753	1.00
306_A	309_A	0.752	1.00
212_G	217_Q	0.750	1.00
88_R	264_A	0.750	1.00
145_L	148_L	0.745	1.00
199_H	204_W	0.743	1.00
205_S	288_S	0.742	0.99
140_L	145_L	0.740	0.99
125_L	129_L	0.740	0.99
120_V	124_S	0.731	0.99
197_T	200_L	0.729	0.99
78_T	82_L	0.726	0.99
67_G	274_G	0.726	0.99
103_T	277_L	0.725	0.99
29_I	290_I	0.724	0.99
110_P	114_A	0.722	0.99
102_A	269_L	0.721	0.99
130_G	136_L	0.720	0.99
167_A	170_S	0.719	0.99
35_G	38_L	0.718	0.99
139_L	142_L	0.715	0.99
196_V	200_L	0.714	0.99
27_L	31_V	0.712	0.99
81_R	86_N	0.710	0.99
196_V	199_H	0.709	0.99
112_R	115_L	0.709	0.99
143_A	150_A	0.708	0.99
140_L	149_A	0.706	0.99
96_F	209_T	0.705	0.99
112_R	116_L	0.705	0.99
165_A	168_F	0.703	0.99
244_A	247_L	0.703	0.99
53_P	57_A	0.703	0.99
114_A	117_D	0.703	0.99
129_L	135_L	0.702	0.99
265_L	269_L	0.702	0.99
84_G	254_E	0.701	0.99
144_A	147_L	0.700	0.99
149_A	152_L	0.694	0.99
134_A	141_A	0.693	0.99
116_L	120_V	0.692	0.99
106_G	112_R	0.691	0.99
148_L	152_L	0.691	0.99
129_L	136_L	0.690	0.99
57_A	61_G	0.687	0.99
36_F	45_I	0.686	0.99
107_L	111_W	0.685	0.99
132_P	138_A	0.683	0.99
102_A	219_L	0.682	0.99
222_G	228_T	0.682	0.99
73_G	77_G	0.682	0.99
221_L	226_F	0.680	0.99
11_R	15_N	0.677	0.99
46_D	50_S	0.677	0.99
176_S	179_L	0.676	0.99
111_W	117_D	0.671	0.99
134_A	139_L	0.670	0.99
125_L	128_L	0.668	0.99
208_F	212_G	0.667	0.99
35_G	39_L	0.659	0.99
150_A	155_G	0.658	0.99
61_G	304_I	0.657	0.99
210_A	213_A	0.656	0.99
49_G	53_P	0.656	0.99
257_S	263_R	0.656	0.99
101_Y	105_R	0.654	0.99
211_P	218_Y	0.654	0.99
281_C	284_G	0.653	0.99
153_R	158_A	0.648	0.99
110_P	116_L	0.647	0.99
70_L	263_R	0.645	0.99
109_A	113_V	0.645	0.99
87_L	253_W	0.643	0.99
185_V	188_L	0.642	0.99
121_V	126_P	0.637	0.98
166_F	169_A	0.637	0.98
284_G	288_S	0.637	0.98
243_L	247_L	0.635	0.98
183_G	188_L	0.634	0.98
99_G	102_A	0.634	0.98
72_G	264_A	0.633	0.98
212_G	216_L	0.630	0.98
153_R	157_L	0.630	0.98
183_G	189_L	0.628	0.98
130_G	135_L	0.625	0.98
258_A	261_L	0.621	0.98
223_T	227_L	0.621	0.98
60_G	274_G	0.620	0.98
49_G	52_F	0.619	0.98
122_A	130_G	0.619	0.98
183_G	186_I	0.618	0.98
131_L	138_A	0.617	0.98
125_L	132_P	0.614	0.98
81_R	88_R	0.613	0.98
33_I	138_A	0.611	0.98
72_G	81_R	0.609	0.98
33_I	293_L	0.607	0.98
138_A	141_A	0.606	0.98
63_L	277_L	0.605	0.98
136_L	143_A	0.604	0.98
170_S	174_R	0.603	0.98
111_W	116_L	0.603	0.98
221_L	228_T	0.602	0.98
56_G	279_L	0.602	0.98
101_Y	213_A	0.602	0.98
127_G	133_P	0.600	0.98
266_I	270_L	0.597	0.98
213_A	217_Q	0.597	0.98
260_D	264_A	0.597	0.98
134_A	140_L	0.596	0.98
24_A	182_G	0.592	0.98
18_D	23_R	0.590	0.98
9_A	25_W	0.590	0.98
73_G	78_T	0.589	0.97
129_L	139_L	0.588	0.97
23_R	27_L	0.588	0.97
126_P	134_A	0.587	0.97
75_G	78_T	0.584	0.97
132_P	140_L	0.584	0.97
221_L	227_L	0.583	0.97
170_S	173_F	0.581	0.97
260_D	263_R	0.578	0.97
107_L	110_P	0.577	0.97
223_T	229_F	0.575	0.97
39_L	45_I	0.575	0.97
7_M	11_R	0.574	0.97
122_A	128_L	0.574	0.97
124_S	129_L	0.572	0.97
177_W	180_L	0.570	0.97
28_A	190_V	0.569	0.97
210_A	217_Q	0.564	0.97
86_N	89_S	0.564	0.97
256_P	261_L	0.563	0.97
198_G	204_W	0.562	0.97
171_R	175_G	0.561	0.97
142_L	149_A	0.557	0.96
222_G	226_F	0.555	0.96
121_V	127_G	0.555	0.96
134_A	149_A	0.555	0.96
125_L	133_P	0.554	0.96
217_Q	221_L	0.553	0.96
139_L	147_L	0.551	0.96
173_F	179_L	0.550	0.96
29_I	301_L	0.548	0.96
128_L	132_P	0.546	0.96
128_L	133_P	0.545	0.96
172_L	177_W	0.545	0.96
119_P	124_S	0.543	0.96
10_V	309_A	0.540	0.96
145_L	153_R	0.540	0.96
135_L	138_A	0.538	0.96
136_L	139_L	0.537	0.96
255_F	258_A	0.535	0.96
98_I	216_L	0.534	0.96
278_A	281_C	0.534	0.96
149_A	154_A	0.534	0.96
28_A	32_A	0.533	0.95
140_L	150_A	0.532	0.95
151_A	156_A	0.532	0.95
48_S	54_W	0.531	0.95
200_L	205_S	0.530	0.95
1_R	244_A	0.528	0.95
108_L	111_W	0.527	0.95
187_G	193_G	0.525	0.95
180_L	183_G	0.521	0.95
239_L	242_F	0.520	0.95
292_T	296_G	0.520	0.95
77_G	80_V	0.519	0.95
182_G	192_A	0.517	0.95
59_V	277_L	0.517	0.95
103_T	276_V	0.517	0.95
100_A	276_V	0.515	0.95
207_T	212_G	0.514	0.95
40_L	45_I	0.514	0.95
305_F	309_A	0.513	0.94
135_L	141_A	0.511	0.94
84_G	241_A	0.511	0.94
5_C	12_D	0.506	0.94
132_P	137_A	0.506	0.94
32_A	287_L	0.505	0.94
141_A	152_L	0.503	0.94
142_L	150_A	0.502	0.94
12_D	15_N	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3o7qA	1	0.8516	28.2	0.951	Contact Map
4ikvA	1	0.4516	19	0.955	Contact Map
4xnjA	1	0.4323	18.6	0.955	Contact Map
4uvmA	1	0.4871	16.4	0.956	Contact Map
4tphA	2	0.8484	12.9	0.958	Contact Map
2gfpA	2	0.7935	12	0.959	Contact Map
4q65A	1	0.4065	11.2	0.959	Contact Map
2yktA	2	0.1258	9.9	0.96	Contact Map
4fc4A	3	0.2387	5.6	0.964	Contact Map
1pw4A	1	0.4548	5.2	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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