GREMLIN Database
Sulf_transp - Sulphur transport
PFAM: PF04143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 310 (305)
Sequences: 7970 (5961)
Seq/√Len: 341.3
META: 0.774

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_V265_L4.2941.00
35_G191_V4.0161.00
58_I303_A3.9011.00
99_G269_L3.6661.00
13_L19_G3.2121.00
82_L90_L2.6881.00
2_G182_G2.6091.00
146_A150_A2.5241.00
91_V261_L2.3181.00
129_L134_A2.2041.00
242_F246_L2.1831.00
124_S127_G2.1631.00
57_A300_A2.1511.00
246_L251_F2.1141.00
244_A248_A2.0631.00
82_L93_L2.0181.00
38_L42_L2.0171.00
286_G301_L1.9931.00
200_L203_P1.9631.00
298_W302_A1.9431.00
131_L134_A1.8751.00
28_A287_L1.8581.00
78_T93_L1.8471.00
201_G204_W1.8401.00
95_V268_G1.8351.00
290_I298_W1.7961.00
50_S54_W1.7861.00
13_L22_L1.7801.00
209_T275_A1.7561.00
210_A214_D1.7531.00
145_L149_A1.7521.00
198_G203_P1.7431.00
61_G303_A1.7401.00
127_G131_L1.7231.00
63_L270_L1.7171.00
290_I301_L1.7111.00
126_P129_L1.7111.00
62_L307_G1.6871.00
198_G202_R1.6871.00
95_V99_G1.5931.00
300_A304_I1.5931.00
181_L185_V1.5901.00
147_L150_A1.5881.00
39_L44_L1.5861.00
51_P54_W1.5781.00
71_A268_G1.5751.00
150_A153_R1.5651.00
57_A296_G1.5601.00
121_V124_S1.5541.00
122_A125_L1.5521.00
134_A138_A1.5511.00
62_L306_A1.5411.00
128_L131_L1.5411.00
221_L225_A1.5331.00
211_P214_D1.5301.00
184_L188_L1.5271.00
146_A149_A1.5211.00
152_L155_G1.5171.00
199_H203_P1.4931.00
151_A154_A1.4821.00
115_L118_P1.4821.00
14_V309_A1.4821.00
238_I242_F1.4511.00
200_L204_W1.4451.00
83_G238_I1.4441.00
129_L132_P1.4331.00
123_L126_P1.4271.00
38_L41_A1.4191.00
63_L273_F1.4131.00
221_L224_S1.4131.00
223_T226_F1.4041.00
142_L146_A1.3961.00
127_G130_G1.3961.00
121_V125_L1.3941.00
245_A251_F1.3931.00
259_R263_R1.3881.00
246_L249_G1.3861.00
132_P135_L1.3851.00
283_I287_L1.3781.00
188_L192_A1.3781.00
134_A137_A1.3741.00
199_H202_R1.3731.00
301_L305_F1.3661.00
123_L128_L1.3621.00
111_W115_L1.3491.00
215_T219_L1.3471.00
99_G273_F1.3411.00
82_L238_I1.3401.00
193_G205_S1.3361.00
106_G109_A1.3351.00
225_A228_T1.3341.00
3_R250_E1.3321.00
303_A306_A1.3311.00
208_F237_V1.3291.00
143_A147_L1.3221.00
8_G21_R1.3121.00
164_L167_A1.3001.00
215_T235_L1.2871.00
195_L199_H1.2851.00
75_G96_F1.2761.00
193_G197_T1.2721.00
26_L29_I1.2581.00
19_G22_L1.2551.00
130_G134_A1.2441.00
40_L47_L1.2421.00
303_A307_G1.2321.00
120_V123_L1.2301.00
253_W262_L1.2251.00
214_D218_Y1.2241.00
135_L139_L1.2191.00
79_L238_I1.2161.00
71_A92_V1.2151.00
242_F251_F1.2061.00
12_D16_M1.2051.00
183_G187_G1.1911.00
302_A306_A1.1881.00
124_S128_L1.1791.00
78_T89_S1.1731.00
220_M223_T1.1661.00
95_V269_L1.1631.00
129_L133_P1.1611.00
95_V98_I1.1611.00
126_P131_L1.1591.00
220_M227_L1.1591.00
50_S53_P1.1471.00
31_V187_G1.1451.00
209_T212_G1.1441.00
83_G241_A1.1401.00
190_V194_W1.1261.00
206_L233_L1.1251.00
84_G245_A1.1241.00
147_L151_A1.1101.00
257_S260_D1.1071.00
52_F299_L1.1031.00
228_T231_I1.1031.00
139_L143_A1.1021.00
225_A229_F1.0991.00
126_P130_G1.0971.00
220_M228_T1.0971.00
37_Q40_L1.0961.00
220_M229_F1.0931.00
141_A144_A1.0931.00
193_G233_L1.0931.00
285_Q297_S1.0921.00
119_P122_A1.0881.00
133_P136_L1.0821.00
178_P181_L1.0811.00
62_L66_I1.0781.00
137_A140_L1.0761.00
46_D49_G1.0761.00
10_V14_V1.0741.00
115_L119_P1.0741.00
57_A299_L1.0711.00
22_L26_L1.0701.00
105_R109_A1.0701.00
133_P138_A1.0681.00
182_G186_I1.0641.00
231_I235_L1.0631.00
117_D120_V1.0611.00
153_R156_A1.0581.00
168_F180_L1.0571.00
33_I37_Q1.0571.00
187_G190_V1.0551.00
214_D217_Q1.0551.00
62_L303_A1.0531.00
128_L134_A1.0401.00
110_P113_V1.0401.00
11_R16_M1.0371.00
39_L191_V1.0351.00
133_P137_A1.0241.00
1_R248_A1.0171.00
149_A153_R1.0171.00
177_W181_L1.0081.00
88_R260_D1.0051.00
226_F229_F1.0011.00
31_V184_L1.0001.00
130_G133_P1.0001.00
300_A303_A0.9961.00
144_A148_L0.9901.00
103_T106_G0.9901.00
131_L135_L0.9871.00
112_R117_D0.9831.00
116_L119_P0.9821.00
102_A107_L0.9801.00
142_L145_L0.9771.00
8_G12_D0.9731.00
212_G215_T0.9721.00
140_L143_A0.9671.00
194_W197_T0.9661.00
189_L192_A0.9631.00
151_A155_G0.9621.00
179_L183_G0.9611.00
223_T228_T0.9611.00
111_W114_A0.9601.00
220_M225_A0.9541.00
222_G225_A0.9511.00
135_L142_L0.9421.00
110_P115_L0.9411.00
69_V73_G0.9361.00
208_F211_P0.9361.00
126_P132_P0.9341.00
286_G290_I0.9291.00
152_L157_L0.9271.00
113_V117_D0.9261.00
127_G134_A0.9191.00
190_V193_G0.9191.00
12_D18_D0.9181.00
258_A262_L0.9111.00
91_V265_L0.9101.00
10_V305_F0.9101.00
133_P139_L0.9041.00
127_G132_P0.9021.00
186_I190_V0.8981.00
289_G297_S0.8951.00
114_A118_P0.8901.00
220_M226_F0.8891.00
198_G201_G0.8891.00
109_A112_R0.8881.00
67_G270_L0.8871.00
150_A154_A0.8851.00
202_R205_S0.8841.00
296_G300_A0.8831.00
278_A300_A0.8811.00
52_F57_A0.8791.00
122_A126_P0.8751.00
103_T107_L0.8711.00
213_A219_L0.8711.00
207_T211_P0.8701.00
155_G158_A0.8681.00
138_A142_L0.8641.00
190_V287_L0.8631.00
36_F40_L0.8551.00
152_L156_A0.8551.00
186_I189_L0.8551.00
154_A157_L0.8511.00
179_L182_G0.8491.00
127_G135_L0.8481.00
203_P206_L0.8481.00
68_M308_A0.8461.00
9_A21_R0.8461.00
124_S130_G0.8371.00
197_T203_P0.8321.00
136_L140_L0.8311.00
165_A169_A0.8291.00
8_G11_R0.8271.00
136_L147_L0.8251.00
154_A158_A0.8211.00
103_T273_F0.8121.00
32_A291_S0.8101.00
96_F99_G0.8091.00
215_T218_Y0.8091.00
188_L191_V0.8061.00
141_A146_A0.8031.00
123_L127_G0.8021.00
12_D21_R0.8001.00
131_L137_A0.8001.00
224_S227_L0.7991.00
290_I297_S0.7971.00
55_L59_V0.7951.00
131_L136_L0.7931.00
143_A146_A0.7921.00
36_F47_L0.7911.00
28_A183_G0.7901.00
75_G237_V0.7891.00
30_A34_L0.7891.00
34_L38_L0.7871.00
37_Q41_A0.7871.00
211_P215_T0.7841.00
129_L137_A0.7711.00
141_A145_L0.7711.00
145_L150_A0.7701.00
185_V189_L0.7701.00
224_S228_T0.7651.00
212_G234_V0.7601.00
48_S51_P0.7551.00
78_T92_V0.7531.00
306_A309_A0.7521.00
212_G217_Q0.7501.00
88_R264_A0.7501.00
145_L148_L0.7451.00
199_H204_W0.7431.00
205_S288_S0.7420.99
140_L145_L0.7400.99
125_L129_L0.7400.99
120_V124_S0.7310.99
197_T200_L0.7290.99
78_T82_L0.7260.99
67_G274_G0.7260.99
103_T277_L0.7250.99
29_I290_I0.7240.99
110_P114_A0.7220.99
102_A269_L0.7210.99
130_G136_L0.7200.99
167_A170_S0.7190.99
35_G38_L0.7180.99
139_L142_L0.7150.99
196_V200_L0.7140.99
27_L31_V0.7120.99
81_R86_N0.7100.99
196_V199_H0.7090.99
112_R115_L0.7090.99
143_A150_A0.7080.99
140_L149_A0.7060.99
96_F209_T0.7050.99
112_R116_L0.7050.99
165_A168_F0.7030.99
244_A247_L0.7030.99
53_P57_A0.7030.99
114_A117_D0.7030.99
129_L135_L0.7020.99
265_L269_L0.7020.99
84_G254_E0.7010.99
144_A147_L0.7000.99
149_A152_L0.6940.99
134_A141_A0.6930.99
116_L120_V0.6920.99
106_G112_R0.6910.99
148_L152_L0.6910.99
129_L136_L0.6900.99
57_A61_G0.6870.99
36_F45_I0.6860.99
107_L111_W0.6850.99
132_P138_A0.6830.99
102_A219_L0.6820.99
222_G228_T0.6820.99
73_G77_G0.6820.99
221_L226_F0.6800.99
11_R15_N0.6770.99
46_D50_S0.6770.99
176_S179_L0.6760.99
111_W117_D0.6710.99
134_A139_L0.6700.99
125_L128_L0.6680.99
208_F212_G0.6670.99
35_G39_L0.6590.99
150_A155_G0.6580.99
61_G304_I0.6570.99
210_A213_A0.6560.99
49_G53_P0.6560.99
257_S263_R0.6560.99
101_Y105_R0.6540.99
211_P218_Y0.6540.99
281_C284_G0.6530.99
153_R158_A0.6480.99
110_P116_L0.6470.99
70_L263_R0.6450.99
109_A113_V0.6450.99
87_L253_W0.6430.99
185_V188_L0.6420.99
121_V126_P0.6370.98
166_F169_A0.6370.98
284_G288_S0.6370.98
243_L247_L0.6350.98
183_G188_L0.6340.98
99_G102_A0.6340.98
72_G264_A0.6330.98
212_G216_L0.6300.98
153_R157_L0.6300.98
183_G189_L0.6280.98
130_G135_L0.6250.98
258_A261_L0.6210.98
223_T227_L0.6210.98
60_G274_G0.6200.98
49_G52_F0.6190.98
122_A130_G0.6190.98
183_G186_I0.6180.98
131_L138_A0.6170.98
125_L132_P0.6140.98
81_R88_R0.6130.98
33_I138_A0.6110.98
72_G81_R0.6090.98
33_I293_L0.6070.98
138_A141_A0.6060.98
63_L277_L0.6050.98
136_L143_A0.6040.98
170_S174_R0.6030.98
111_W116_L0.6030.98
221_L228_T0.6020.98
56_G279_L0.6020.98
101_Y213_A0.6020.98
127_G133_P0.6000.98
266_I270_L0.5970.98
213_A217_Q0.5970.98
260_D264_A0.5970.98
134_A140_L0.5960.98
24_A182_G0.5920.98
18_D23_R0.5900.98
9_A25_W0.5900.98
73_G78_T0.5890.97
129_L139_L0.5880.97
23_R27_L0.5880.97
126_P134_A0.5870.97
75_G78_T0.5840.97
132_P140_L0.5840.97
221_L227_L0.5830.97
170_S173_F0.5810.97
260_D263_R0.5780.97
107_L110_P0.5770.97
223_T229_F0.5750.97
39_L45_I0.5750.97
7_M11_R0.5740.97
122_A128_L0.5740.97
124_S129_L0.5720.97
177_W180_L0.5700.97
28_A190_V0.5690.97
210_A217_Q0.5640.97
86_N89_S0.5640.97
256_P261_L0.5630.97
198_G204_W0.5620.97
171_R175_G0.5610.97
142_L149_A0.5570.96
222_G226_F0.5550.96
121_V127_G0.5550.96
134_A149_A0.5550.96
125_L133_P0.5540.96
217_Q221_L0.5530.96
139_L147_L0.5510.96
173_F179_L0.5500.96
29_I301_L0.5480.96
128_L132_P0.5460.96
128_L133_P0.5450.96
172_L177_W0.5450.96
119_P124_S0.5430.96
10_V309_A0.5400.96
145_L153_R0.5400.96
135_L138_A0.5380.96
136_L139_L0.5370.96
255_F258_A0.5350.96
98_I216_L0.5340.96
278_A281_C0.5340.96
149_A154_A0.5340.96
28_A32_A0.5330.95
140_L150_A0.5320.95
151_A156_A0.5320.95
48_S54_W0.5310.95
200_L205_S0.5300.95
1_R244_A0.5280.95
108_L111_W0.5270.95
187_G193_G0.5250.95
180_L183_G0.5210.95
239_L242_F0.5200.95
292_T296_G0.5200.95
77_G80_V0.5190.95
182_G192_A0.5170.95
59_V277_L0.5170.95
103_T276_V0.5170.95
100_A276_V0.5150.95
207_T212_G0.5140.95
40_L45_I0.5140.95
305_F309_A0.5130.94
135_L141_A0.5110.94
84_G241_A0.5110.94
5_C12_D0.5060.94
132_P137_A0.5060.94
32_A287_L0.5050.94
141_A152_L0.5030.94
142_L150_A0.5020.94
12_D15_N0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.8516 28.2 0.951 Contact Map
4ikvA 1 0.4516 19 0.955 Contact Map
4xnjA 1 0.4323 18.6 0.955 Contact Map
4uvmA 1 0.4871 16.4 0.956 Contact Map
4tphA 2 0.8484 12.9 0.958 Contact Map
2gfpA 2 0.7935 12 0.959 Contact Map
4q65A 1 0.4065 11.2 0.959 Contact Map
2yktA 2 0.1258 9.9 0.96 Contact Map
4fc4A 3 0.2387 5.6 0.964 Contact Map
1pw4A 1 0.4548 5.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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