GREMLIN Database
GtrA - GtrA-like protein
PFAM: PF04138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (117)
Sequences: 81657 (61323)
Seq/√Len: 5669.3
META: 0.904

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_L42_V2.7751.00
48_R63_E2.7561.00
70_V111_L2.5721.00
112_S116_V2.3991.00
5_V46_L2.3851.00
47_N51_T2.3701.00
42_V46_L2.3491.00
37_L68_L2.1841.00
12_V42_V2.1011.00
9_G43_N2.0681.00
33_A79_L2.0431.00
16_V38_V2.0181.00
83_A87_E1.9771.00
18_A22_E1.9281.00
41_L64_L1.9251.00
110_L114_L1.8771.00
29_L83_A1.8691.00
13_D32_N1.8171.00
28_Y82_L1.7951.00
29_L79_L1.7791.00
13_D97_K1.7581.00
81_L100_A1.7241.00
45_L49_R1.6491.00
92_P95_L1.5541.00
14_L18_A1.5191.00
85_L96_A1.4681.00
9_G42_V1.4601.00
64_L68_L1.4461.00
32_N97_K1.4451.00
84_L88_L1.4421.00
32_N79_L1.4341.00
100_A104_V1.3891.00
62_R66_R1.3841.00
32_N82_L1.3681.00
40_V68_L1.3481.00
40_V71_S1.3421.00
79_L83_A1.3341.00
21_L93_Y1.3241.00
66_R115_W1.2901.00
27_P30_L1.2891.00
54_D63_E1.2751.00
18_A94_L1.2231.00
33_A75_L1.1781.00
97_K101_I1.1731.00
77_L107_W1.1601.00
106_V110_L1.1431.00
36_F75_L1.1391.00
13_D78_N1.1311.00
17_L97_K1.0971.00
37_L41_L1.0901.00
52_F113_R1.0891.00
73_V107_W1.0791.00
9_G13_D1.0751.00
36_F40_V1.0641.00
16_V20_L1.0631.00
61_L65_L1.0531.00
28_Y86_V1.0421.00
5_V51_T1.0411.00
66_R116_V1.0341.00
20_L34_I1.0221.00
19_L23_L1.0191.00
35_A39_A1.0131.00
18_A21_L1.0121.00
17_L93_Y1.0111.00
74_G108_N1.0091.00
75_L79_L1.0001.00
10_T101_I0.9851.00
44_F63_E0.9841.00
107_W111_L0.9741.00
17_L35_A0.9731.00
20_L26_L0.9671.00
10_T14_L0.9631.00
48_R117_F0.9621.00
48_R56_G0.9381.00
74_G107_W0.9231.00
83_A88_L0.9111.00
82_L86_V0.9001.00
65_L68_L0.8991.00
81_L85_L0.8981.00
32_N78_N0.8961.00
30_L33_A0.8951.00
26_L30_L0.8901.00
41_L45_L0.8771.00
3_A105_T0.8641.00
71_S112_S0.8621.00
102_A106_V0.8421.00
24_L31_A0.8391.00
41_L68_L0.8311.00
4_L8_L0.8201.00
40_V64_L0.8131.00
37_L40_V0.7961.00
62_R65_L0.7961.00
44_F67_F0.7921.00
7_G11_L0.7831.00
87_E90_G0.7761.00
21_L31_A0.7761.00
4_L7_G0.7731.00
101_I105_T0.7701.00
88_L91_L0.7561.00
111_L114_L0.7551.00
13_D39_A0.7471.00
98_L102_A0.7371.00
107_W110_L0.7361.00
22_E93_Y0.7321.00
24_L27_P0.7251.00
18_A23_L0.7161.00
17_L82_L0.7121.00
9_G46_L0.7111.00
76_L80_G0.7031.00
78_N97_K0.6961.00
108_N112_S0.6921.00
80_G84_L0.6871.00
3_A7_G0.6821.00
8_L11_L0.6791.00
101_I104_V0.6771.00
96_A100_A0.6761.00
72_L76_L0.6751.00
67_F71_S0.6671.00
80_G83_A0.6661.00
70_V116_V0.6661.00
14_L97_K0.6631.00
85_L89_L0.6631.00
61_L64_L0.6621.00
33_A37_L0.6611.00
87_E91_L0.6571.00
29_L33_A0.6571.00
28_Y87_E0.6551.00
65_L69_L0.6531.00
17_L21_L0.6471.00
22_E25_G0.6431.00
48_R54_D0.6381.00
70_V74_G0.6331.00
111_L115_W0.6291.00
31_A35_A0.6271.00
70_V112_S0.6271.00
73_V76_L0.6121.00
1_R50_W0.6061.00
11_L15_G0.6021.00
20_L31_A0.6011.00
85_L88_L0.5981.00
19_L24_L0.5961.00
12_V39_A0.5911.00
68_L72_L0.5851.00
13_D35_A0.5811.00
21_L28_Y0.5811.00
91_L95_L0.5801.00
81_L103_V0.5721.00
20_L24_L0.5701.00
26_L31_A0.5701.00
29_L87_E0.5651.00
14_L98_L0.5641.00
46_L49_R0.5641.00
9_G12_V0.5591.00
22_E94_L0.5581.00
16_V35_A0.5581.00
59_G62_R0.5561.00
56_G63_E0.5551.00
20_L38_V0.5531.00
15_G19_L0.5461.00
15_G18_A0.5461.00
58_R63_E0.5431.00
33_A36_F0.5321.00
8_L12_V0.5321.00
86_V96_A0.5321.00
63_E66_R0.5271.00
43_N47_N0.5191.00
85_L91_L0.5141.00
43_N71_S0.5141.00
96_A99_I0.5111.00
6_G105_T0.5111.00
16_V39_A0.5081.00
57_R60_L0.5081.00
7_G10_T0.5061.00
5_V50_W0.5041.00
81_L84_L0.5031.00
2_F108_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4tA 1 0.4872 5.4 0.879 Contact Map
3mktA 1 0.547 4.2 0.885 Contact Map
4lz6A 1 0.4872 3.4 0.89 Contact Map
4humA 1 0.547 3.3 0.891 Contact Map
3aqpA 1 1 3.1 0.893 Contact Map
4k0jA 3 0.9744 2.6 0.897 Contact Map
4il3A 1 0.9915 1.8 0.905 Contact Map
4av3A 2 0.7265 1.5 0.91 Contact Map
3iyzA 3 0.8547 1.4 0.911 Contact Map
2voyD 1 0.1368 1.3 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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