Iron_permease - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Iron_permease - Low affinity iron permease

PFAM:	PF04120	Sequences: FERFAKAVARATGSPWAFLLAVLVIVVWAVTGPLFGFSDTWQLVINTGTTIVTFLMVFLIQNTQNRDSAAIQLKLDELIRAVEGARNRLIDLEDLSEEELEELRKEYERLAERAREELDLTESHSIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	127 (119)
Sequences:	14317 (8925)
Seq/√Len:	818.1
META:	0.958

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
24_V	48_G	3.023	1.00
31_T	34_L	2.923	1.00
78_L	82_V	2.521	1.00
96_S	99_E	2.500	1.00
7_A	10_R	2.408	1.00
31_T	35_F	2.297	1.00
7_A	11_A	2.239	1.00
62_N	66_R	2.230	1.00
71_I	75_L	2.223	1.00
79_I	87_N	2.208	1.00
107_Y	110_L	2.034	1.00
14_S	17_A	1.974	1.00
20_L	24_V	1.967	1.00
69_A	104_R	1.916	1.00
86_R	107_Y	1.788	1.00
13_G	65_N	1.764	1.00
68_S	71_I	1.741	1.00
94_D	104_R	1.713	1.00
69_A	101_E	1.698	1.00
45_I	50_T	1.696	1.00
94_D	108_E	1.674	1.00
89_L	107_Y	1.665	1.00
3_R	7_A	1.638	1.00
101_E	105_K	1.631	1.00
76_D	80_R	1.602	1.00
68_S	72_Q	1.596	1.00
86_R	106_E	1.585	1.00
23_L	27_V	1.549	1.00
25_I	45_I	1.513	1.00
12_T	56_M	1.501	1.00
70_A	93_E	1.468	1.00
80_R	86_R	1.417	1.00
95_L	103_L	1.391	1.00
104_R	108_E	1.387	1.00
87_N	90_I	1.360	1.00
21_A	54_F	1.349	1.00
62_N	97_E	1.338	1.00
77_E	85_A	1.310	1.00
6_K	10_R	1.301	1.00
2_E	6_K	1.286	1.00
42_Q	47_T	1.277	1.00
70_A	92_L	1.264	1.00
81_A	84_G	1.253	1.00
102_E	106_E	1.217	1.00
105_K	108_E	1.207	1.00
49_T	54_F	1.195	1.00
2_E	9_A	1.183	1.00
97_E	101_E	1.134	1.00
101_E	104_R	1.098	1.00
42_Q	46_N	1.089	1.00
11_A	17_A	1.081	1.00
105_K	109_R	1.056	1.00
48_G	51_I	1.050	1.00
24_V	45_I	1.045	1.00
12_T	16_W	1.043	1.00
43_L	46_N	1.006	1.00
66_R	80_R	1.005	1.00
108_E	112_E	0.985	1.00
109_R	112_E	0.982	1.00
111_A	115_R	0.981	1.00
10_R	69_A	0.976	1.00
81_A	85_A	0.976	1.00
73_L	89_L	0.975	1.00
12_T	17_A	0.972	1.00
45_I	49_T	0.971	1.00
67_D	71_I	0.968	1.00
113_R	117_E	0.967	1.00
52_V	56_M	0.964	1.00
67_D	72_Q	0.963	1.00
112_E	116_E	0.961	1.00
32_G	38_S	0.956	1.00
81_A	87_N	0.947	1.00
2_E	14_S	0.933	1.00
32_G	37_F	0.933	1.00
53_T	57_V	0.926	1.00
93_E	104_R	0.926	1.00
40_T	43_L	0.913	1.00
57_V	60_I	0.906	1.00
8_V	12_T	0.902	1.00
80_R	90_I	0.900	1.00
11_A	14_S	0.894	1.00
2_E	15_P	0.887	1.00
8_V	59_L	0.882	1.00
91_D	107_Y	0.877	1.00
82_V	86_R	0.866	1.00
25_I	44_V	0.862	1.00
77_E	80_R	0.847	1.00
102_E	105_K	0.847	1.00
9_A	12_T	0.840	1.00
89_L	92_L	0.834	1.00
95_L	99_E	0.828	1.00
82_V	87_N	0.818	1.00
73_L	91_D	0.797	1.00
2_E	12_T	0.797	1.00
76_D	90_I	0.789	1.00
21_A	55_L	0.786	1.00
33_P	38_S	0.781	1.00
20_L	27_V	0.780	1.00
104_R	111_A	0.775	1.00
64_Q	67_D	0.775	1.00
114_A	118_L	0.772	1.00
24_V	27_V	0.770	1.00
34_L	37_F	0.759	1.00
69_A	96_S	0.756	1.00
46_N	50_T	0.742	1.00
21_A	58_F	0.738	1.00
45_I	48_G	0.738	1.00
68_S	73_L	0.726	1.00
73_L	107_Y	0.709	1.00
109_R	113_R	0.708	1.00
82_V	85_A	0.705	1.00
9_A	15_P	0.704	1.00
80_R	110_L	0.699	1.00
4_F	8_V	0.693	1.00
99_E	102_E	0.690	1.00
106_E	109_R	0.686	1.00
106_E	113_R	0.685	1.00
82_V	90_I	0.680	1.00
51_I	56_M	0.673	1.00
38_S	41_W	0.671	1.00
46_N	49_T	0.663	1.00
77_E	86_R	0.658	1.00
31_T	41_W	0.655	1.00
18_F	55_L	0.655	1.00
50_T	54_F	0.652	1.00
33_P	37_F	0.651	1.00
18_F	22_V	0.641	1.00
31_T	44_V	0.631	1.00
24_V	39_D	0.626	1.00
91_D	94_D	0.626	1.00
19_L	23_L	0.620	1.00
25_I	50_T	0.617	1.00
35_F	44_V	0.616	1.00
16_W	20_L	0.609	1.00
9_A	14_S	0.606	1.00
76_D	91_D	0.606	1.00
8_V	11_A	0.605	1.00
29_A	48_G	0.604	1.00
92_L	95_L	0.603	1.00
91_D	110_L	0.602	1.00
36_G	39_D	0.599	1.00
107_Y	111_A	0.598	1.00
33_P	41_W	0.598	1.00
82_V	88_R	0.589	1.00
11_A	20_L	0.589	1.00
91_D	111_A	0.589	1.00
11_A	15_P	0.588	1.00
26_V	29_A	0.587	1.00
66_R	106_E	0.586	1.00
10_R	14_S	0.583	1.00
54_F	58_F	0.575	1.00
103_L	106_E	0.573	1.00
62_N	86_R	0.572	1.00
25_I	52_V	0.569	1.00
42_Q	49_T	0.569	1.00
47_T	50_T	0.565	1.00
2_E	5_A	0.561	1.00
86_R	118_L	0.560	1.00
15_P	62_N	0.560	1.00
69_A	72_Q	0.558	1.00
21_A	25_I	0.556	1.00
2_E	10_R	0.548	1.00
88_R	106_E	0.547	1.00
6_K	12_T	0.544	1.00
4_F	18_F	0.544	1.00
78_L	88_R	0.543	1.00
18_F	59_L	0.542	1.00
23_L	30_V	0.540	1.00
1_F	4_F	0.532	1.00
46_N	51_I	0.531	1.00
98_E	101_E	0.529	1.00
50_T	53_T	0.515	1.00
20_L	23_L	0.515	1.00
104_R	118_L	0.512	1.00
32_G	41_W	0.510	1.00
92_L	110_L	0.503	1.00
73_L	110_L	0.501	1.00
98_E	102_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2f95B	2	0.3228	22.7	0.914	Contact Map
4rngA	2	0.4882	12.2	0.924	Contact Map
4pypA	1	0.4961	10.4	0.927	Contact Map
3wdoA	1	0.9449	10.1	0.927	Contact Map
2yfkA	3	0.4331	9.3	0.928	Contact Map
4gycB	2	0.3858	9.1	0.929	Contact Map
3vouA	4	0.8189	8.3	0.93	Contact Map
3q98A	3	0.4094	7.4	0.931	Contact Map
4q4hA	1	0.9764	7.2	0.932	Contact Map
4bgnA	3	0.5197	7.1	0.932	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.