GREMLIN Database
Iron_permease - Low affinity iron permease
PFAM: PF04120 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (119)
Sequences: 14317 (8925)
Seq/√Len: 818.1
META: 0.958

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V48_G3.0231.00
31_T34_L2.9231.00
78_L82_V2.5211.00
96_S99_E2.5001.00
7_A10_R2.4081.00
31_T35_F2.2971.00
7_A11_A2.2391.00
62_N66_R2.2301.00
71_I75_L2.2231.00
79_I87_N2.2081.00
107_Y110_L2.0341.00
14_S17_A1.9741.00
20_L24_V1.9671.00
69_A104_R1.9161.00
86_R107_Y1.7881.00
13_G65_N1.7641.00
68_S71_I1.7411.00
94_D104_R1.7131.00
69_A101_E1.6981.00
45_I50_T1.6961.00
94_D108_E1.6741.00
89_L107_Y1.6651.00
3_R7_A1.6381.00
101_E105_K1.6311.00
76_D80_R1.6021.00
68_S72_Q1.5961.00
86_R106_E1.5851.00
23_L27_V1.5491.00
25_I45_I1.5131.00
12_T56_M1.5011.00
70_A93_E1.4681.00
80_R86_R1.4171.00
95_L103_L1.3911.00
104_R108_E1.3871.00
87_N90_I1.3601.00
21_A54_F1.3491.00
62_N97_E1.3381.00
77_E85_A1.3101.00
6_K10_R1.3011.00
2_E6_K1.2861.00
42_Q47_T1.2771.00
70_A92_L1.2641.00
81_A84_G1.2531.00
102_E106_E1.2171.00
105_K108_E1.2071.00
49_T54_F1.1951.00
2_E9_A1.1831.00
97_E101_E1.1341.00
101_E104_R1.0981.00
42_Q46_N1.0891.00
11_A17_A1.0811.00
105_K109_R1.0561.00
48_G51_I1.0501.00
24_V45_I1.0451.00
12_T16_W1.0431.00
43_L46_N1.0061.00
66_R80_R1.0051.00
108_E112_E0.9851.00
109_R112_E0.9821.00
111_A115_R0.9811.00
10_R69_A0.9761.00
81_A85_A0.9761.00
73_L89_L0.9751.00
12_T17_A0.9721.00
45_I49_T0.9711.00
67_D71_I0.9681.00
113_R117_E0.9671.00
52_V56_M0.9641.00
67_D72_Q0.9631.00
112_E116_E0.9611.00
32_G38_S0.9561.00
81_A87_N0.9471.00
2_E14_S0.9331.00
32_G37_F0.9331.00
53_T57_V0.9261.00
93_E104_R0.9261.00
40_T43_L0.9131.00
57_V60_I0.9061.00
8_V12_T0.9021.00
80_R90_I0.9001.00
11_A14_S0.8941.00
2_E15_P0.8871.00
8_V59_L0.8821.00
91_D107_Y0.8771.00
82_V86_R0.8661.00
25_I44_V0.8621.00
77_E80_R0.8471.00
102_E105_K0.8471.00
9_A12_T0.8401.00
89_L92_L0.8341.00
95_L99_E0.8281.00
82_V87_N0.8181.00
73_L91_D0.7971.00
2_E12_T0.7971.00
76_D90_I0.7891.00
21_A55_L0.7861.00
33_P38_S0.7811.00
20_L27_V0.7801.00
104_R111_A0.7751.00
64_Q67_D0.7751.00
114_A118_L0.7721.00
24_V27_V0.7701.00
34_L37_F0.7591.00
69_A96_S0.7561.00
46_N50_T0.7421.00
21_A58_F0.7381.00
45_I48_G0.7381.00
68_S73_L0.7261.00
73_L107_Y0.7091.00
109_R113_R0.7081.00
82_V85_A0.7051.00
9_A15_P0.7041.00
80_R110_L0.6991.00
4_F8_V0.6931.00
99_E102_E0.6901.00
106_E109_R0.6861.00
106_E113_R0.6851.00
82_V90_I0.6801.00
51_I56_M0.6731.00
38_S41_W0.6711.00
46_N49_T0.6631.00
77_E86_R0.6581.00
31_T41_W0.6551.00
18_F55_L0.6551.00
50_T54_F0.6521.00
33_P37_F0.6511.00
18_F22_V0.6411.00
31_T44_V0.6311.00
24_V39_D0.6261.00
91_D94_D0.6261.00
19_L23_L0.6201.00
25_I50_T0.6171.00
35_F44_V0.6161.00
16_W20_L0.6091.00
9_A14_S0.6061.00
76_D91_D0.6061.00
8_V11_A0.6051.00
29_A48_G0.6041.00
92_L95_L0.6031.00
91_D110_L0.6021.00
36_G39_D0.5991.00
107_Y111_A0.5981.00
33_P41_W0.5981.00
82_V88_R0.5891.00
11_A20_L0.5891.00
91_D111_A0.5891.00
11_A15_P0.5881.00
26_V29_A0.5871.00
66_R106_E0.5861.00
10_R14_S0.5831.00
54_F58_F0.5751.00
103_L106_E0.5731.00
62_N86_R0.5721.00
25_I52_V0.5691.00
42_Q49_T0.5691.00
47_T50_T0.5651.00
2_E5_A0.5611.00
86_R118_L0.5601.00
15_P62_N0.5601.00
69_A72_Q0.5581.00
21_A25_I0.5561.00
2_E10_R0.5481.00
88_R106_E0.5471.00
6_K12_T0.5441.00
4_F18_F0.5441.00
78_L88_R0.5431.00
18_F59_L0.5421.00
23_L30_V0.5401.00
1_F4_F0.5321.00
46_N51_I0.5311.00
98_E101_E0.5291.00
50_T53_T0.5151.00
20_L23_L0.5151.00
104_R118_L0.5121.00
32_G41_W0.5101.00
92_L110_L0.5031.00
73_L110_L0.5011.00
98_E102_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f95B 2 0.3228 22.7 0.914 Contact Map
4rngA 2 0.4882 12.2 0.924 Contact Map
4pypA 1 0.4961 10.4 0.927 Contact Map
3wdoA 1 0.9449 10.1 0.927 Contact Map
2yfkA 3 0.4331 9.3 0.928 Contact Map
4gycB 2 0.3858 9.1 0.929 Contact Map
3vouA 4 0.8189 8.3 0.93 Contact Map
3q98A 3 0.4094 7.4 0.931 Contact Map
4q4hA 1 0.9764 7.2 0.932 Contact Map
4bgnA 3 0.5197 7.1 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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