GREMLIN Database
Mpv17_PMP22 - Mpv17 / PMP22 family
PFAM: PF04117 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (64)
Sequences: 4652 (3460)
Seq/√Len: 432.5
META: 0.56

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K18_D2.5651.00
29_V53_V2.5191.00
23_L27_W2.4541.00
33_V49_F2.3911.00
33_V53_V2.3281.00
7_S10_E2.2231.00
37_N49_F2.1641.00
20_W24_K2.1461.00
12_K16_K1.9731.00
24_K28_K1.9561.00
25_A28_K1.6621.00
13_E17_R1.5821.00
52_V56_F1.5081.00
16_K20_W1.4551.00
22_T64_L1.4281.00
8_L11_I1.4211.00
8_L12_K1.4151.00
55_L59_T1.3791.00
41_V49_F1.3651.00
48_L51_N1.3521.00
60_Y64_L1.3351.00
15_L19_F1.2961.00
19_F23_L1.2851.00
47_V51_N1.2521.00
57_W60_Y1.1791.00
36_I49_F1.1321.00
29_V56_F1.1201.00
28_K32_P1.1091.00
6_K10_E1.1081.00
27_W31_P1.1041.00
11_I15_L1.0791.00
24_K27_W1.0531.00
9_E13_E1.0431.00
35_L39_R1.0331.00
25_A60_Y1.0311.00
14_K65_N0.9901.00
23_L26_N0.9881.00
59_T63_Y0.9661.00
12_K15_L0.9561.00
37_N46_R0.9301.00
37_N41_V0.8831.00
34_Q38_F0.8781.00
9_E12_K0.8671.00
6_K14_K0.8521.00
18_D22_T0.8361.00
45_L48_L0.8211.00
35_L40_F0.8071.00
26_N58_N0.8011.00
54_S58_N0.7811.00
34_Q37_N0.7771.00
36_I40_F0.7671.00
33_V37_N0.7611.00
2_L8_L0.7571.00
21_P64_L0.7391.00
10_E13_E0.7281.00
51_N54_S0.7271.00
34_Q50_V0.7151.00
43_L46_R0.7151.00
50_V54_S0.7011.00
26_N54_S0.6941.00
13_E16_K0.6931.00
7_S11_I0.6831.00
2_L11_I0.6731.00
29_V33_V0.6691.00
37_N40_F0.6681.00
60_Y63_Y0.6560.99
32_P35_L0.6550.99
18_D65_N0.6410.99
29_V60_Y0.6290.99
34_Q51_N0.6270.99
26_N57_W0.6250.99
29_V32_P0.6170.99
38_F46_R0.6170.99
25_A29_V0.5990.99
6_K11_I0.5980.99
17_R21_P0.5900.99
57_W61_L0.5890.99
34_Q58_N0.5810.99
20_W23_L0.5800.99
59_T62_S0.5760.99
21_P25_A0.5690.99
46_R50_V0.5620.98
2_L6_K0.5600.98
9_E16_K0.5590.98
56_F60_Y0.5510.98
4_E65_N0.5500.98
7_S12_K0.5420.98
26_N30_W0.5410.98
22_T25_A0.5340.98
2_L7_S0.5320.98
22_T61_L0.5310.98
34_Q47_V0.5100.97
42_P45_L0.5060.97
20_W27_W0.5040.97
53_V56_F0.5020.97
37_N50_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qufA 1 0.3485 6.1 0.867 Contact Map
3g3dA 2 0.4242 5.2 0.872 Contact Map
3oo8A 1 0.3636 4.7 0.874 Contact Map
4c1uA 1 0.3333 4.5 0.875 Contact Map
4rjzA 1 0.3636 4.4 0.875 Contact Map
3tr2A 2 0.3333 4.2 0.877 Contact Map
4rk2A 1 0.3485 4 0.878 Contact Map
3f3fC 2 0.9091 4 0.878 Contact Map
4g68A 1 0.303 3.9 0.879 Contact Map
1rpxA 4 0.3333 3.9 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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