GREMLIN Database
CD20 - CD20-like family
PFAM: PF04103 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (144)
Sequences: 1098 (792)
Seq/√Len: 66.0
META: 0.026

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_S50_A4.7961.00
10_G38_G3.6291.00
10_G42_I3.3881.00
146_C150_S3.1731.00
107_T110_C3.0881.00
1_V5_V2.8441.00
120_C123_C2.6511.00
14_L38_G2.5741.00
135_S139_I2.2531.00
33_Y37_G2.1701.00
105_L108_C2.1601.00
61_Q65_G2.0401.00
144_E151_S1.9481.00
34_P38_G1.9181.00
33_Y77_G1.8891.00
33_Y41_F1.8621.00
9_L65_G1.7861.00
118_E123_C1.7811.00
118_E121_S1.7711.00
33_Y141_S1.7181.00
106_P109_S1.7130.99
82_S86_A1.6970.99
32_G36_W1.6260.99
84_S130_L1.6230.99
119_C123_C1.6130.99
7_I49_I1.5750.99
85_L138_L1.5600.99
17_G32_G1.5480.99
48_S63_S1.5400.99
105_L109_S1.5230.99
38_G55_P1.4920.99
106_P110_C1.4610.98
35_F70_S1.4240.98
10_G45_G1.4090.98
115_Y118_E1.3580.97
149_L153_V1.3410.97
115_Y119_C1.3350.97
40_L44_S1.3280.97
114_S118_E1.2910.96
54_K74_A1.2780.96
79_I83_I1.2740.96
122_Y125_S1.2610.96
50_A59_L1.2360.95
53_K136_V1.2220.95
133_I140_L1.2180.95
119_C125_S1.2050.95
97_S106_P1.1970.95
105_L110_C1.1910.94
6_Q44_S1.1840.94
49_I63_S1.1760.94
37_G138_L1.1750.94
97_S105_L1.1180.92
120_C125_S1.0820.91
42_I63_S1.0780.91
29_F43_I1.0620.90
117_E122_Y1.0410.89
11_L62_G1.0400.89
75_L135_S1.0380.89
97_S110_C1.0360.89
44_S56_T1.0330.89
17_G34_P1.0280.89
35_F52_E1.0260.88
44_S70_S1.0200.88
16_L20_L1.0180.88
112_E121_S1.0170.88
122_Y126_L1.0170.88
73_L151_S1.0110.88
14_L52_E0.9850.86
66_L151_S0.9800.86
131_T135_S0.9790.86
48_S69_L0.9750.86
65_G143_L0.9710.86
67_N145_L0.9660.85
118_E122_Y0.9630.85
78_I142_V0.9590.85
21_L35_F0.9570.85
54_K69_L0.9380.84
106_P111_Y0.9380.84
62_G65_G0.9360.83
9_L149_L0.9300.83
115_Y121_S0.9280.83
5_V16_L0.9280.83
76_A83_I0.9270.83
38_G81_L0.9250.83
74_A145_L0.9200.82
2_L66_L0.9100.82
97_S109_S0.9080.82
13_I67_N0.9060.81
47_L140_L0.8990.81
121_S125_S0.8980.81
117_E123_C0.8970.81
113_S116_E0.8950.81
78_I113_S0.8870.80
64_L155_G0.8860.80
45_G49_I0.8850.80
75_L86_A0.8810.80
73_L94_C0.8780.79
134_L155_G0.8770.79
48_S52_E0.8640.78
14_L59_L0.8630.78
2_L113_S0.8500.77
81_L141_S0.8500.77
121_S124_Y0.8500.77
112_E115_Y0.8500.77
44_S49_I0.8310.75
17_G36_W0.8230.75
110_C113_S0.8200.74
35_F65_G0.8180.74
120_C124_Y0.8170.74
38_G93_Y0.8100.74
4_V15_A0.8010.73
119_C124_Y0.8000.73
15_A68_I0.7900.72
43_I47_L0.7740.70
114_S124_Y0.7740.70
140_L153_V0.7710.70
24_S29_F0.7690.70
38_G155_G0.7680.70
108_C111_Y0.7540.68
105_L112_E0.7530.68
5_V51_A0.7510.68
141_S147_I0.7480.67
8_L41_F0.7470.67
76_A85_L0.7460.67
72_L76_A0.7460.67
6_Q34_P0.7390.67
60_V155_G0.7340.66
48_S68_I0.7330.66
28_L33_Y0.7310.66
69_L130_L0.7280.65
10_G122_Y0.7260.65
9_L13_I0.7180.64
89_S147_I0.7160.64
78_I82_S0.7140.64
70_S85_L0.7130.64
76_A142_V0.7100.63
107_T111_Y0.7080.63
7_I74_A0.7080.63
111_Y114_S0.7070.63
88_L92_Y0.6960.62
75_L89_S0.6950.62
12_L24_S0.6940.62
52_E81_L0.6910.61
54_K60_V0.6900.61
47_L120_C0.6900.61
59_L145_L0.6900.61
4_V140_L0.6870.61
93_Y124_Y0.6820.60
63_S72_L0.6810.60
25_S130_L0.6800.60
48_S85_L0.6750.60
20_L91_Y0.6750.60
119_C122_Y0.6630.58
42_I46_S0.6620.58
137_L153_V0.6600.58
7_I67_N0.6580.58
10_G139_I0.6570.57
20_L29_F0.6540.57
44_S52_E0.6520.57
16_L24_S0.6520.57
56_T72_L0.6460.56
72_L131_T0.6460.56
85_L148_A0.6440.56
115_Y122_Y0.6420.56
89_S124_Y0.6410.56
133_I137_L0.6370.55
13_I42_I0.6340.55
19_I77_G0.6300.54
109_S117_E0.6280.54
66_L71_A0.6270.54
138_L144_E0.6260.54
97_S108_C0.6160.53
49_I141_S0.6150.53
7_I46_S0.6140.52
19_I147_I0.6120.52
78_I138_L0.6100.52
78_I141_S0.6070.52
40_L85_L0.6050.51
67_N150_S0.6030.51
38_G124_Y0.6000.51
49_I53_K0.5990.51
32_G37_G0.5990.51
4_V13_I0.5930.50
5_V92_Y0.5870.49
142_V146_C0.5860.49
130_L152_S0.5860.49
32_G84_S0.5850.49
38_G54_K0.5850.49
86_A131_T0.5760.48
132_G144_E0.5760.48
72_L80_L0.5680.47
52_E63_S0.5670.47
15_A55_P0.5660.47
114_S122_Y0.5650.47
135_S138_L0.5600.46
44_S63_S0.5550.46
84_S88_L0.5540.45
56_T63_S0.5530.45
51_A60_V0.5440.44
28_L34_P0.5440.44
47_L70_S0.5430.44
8_L11_L0.5410.44
55_P80_L0.5380.44
19_I23_V0.5370.43
86_A94_C0.5360.43
150_S153_V0.5360.43
84_S134_L0.5340.43
42_I53_K0.5310.43
136_V139_I0.5170.41
10_G14_L0.5150.41
117_E120_C0.5140.41
20_L35_F0.5130.41
43_I71_A0.5100.40
23_V73_L0.5050.40
90_S151_S0.5030.40
10_G81_L0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p79A 1 0.5641 11.7 0.904 Contact Map
3x29A 1 0.5192 10.2 0.906 Contact Map
4o6yA 2 0.5513 6.1 0.916 Contact Map
4ev6A 3 0.3654 5.8 0.916 Contact Map
4i0uA 4 0.3526 5.3 0.918 Contact Map
2i68A 2 0.3846 3.3 0.926 Contact Map
3rvyA 3 0.5321 3.2 0.926 Contact Map
3pjsK 4 0.8141 3.1 0.926 Contact Map
4mqsA 1 0.1987 3.1 0.927 Contact Map
4xesA 1 0.2692 2.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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