GREMLIN Database
DUF389 - Domain of unknown function (DUF389)
PFAM: PF04087 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 142 (138)
Sequences: 11742 (7213)
Seq/√Len: 614.0
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_G25_L3.7961.00
36_V133_F3.0371.00
40_I114_A3.0291.00
114_A130_L2.9641.00
117_G125_L2.7041.00
47_G116_I2.6251.00
44_A118_L2.3691.00
65_I113_T2.2651.00
44_A48_L2.2641.00
114_A126_A2.2461.00
26_R30_K2.2431.00
118_L126_A2.2201.00
30_K34_V2.2041.00
13_L25_L2.1231.00
122_N125_L2.1221.00
40_I111_L2.0751.00
23_R27_R2.0331.00
22_R26_R1.9981.00
113_T117_G1.9931.00
64_E68_R1.9841.00
44_A119_A1.9441.00
66_L69_T1.9101.00
62_T65_I1.8671.00
16_G24_L1.7731.00
111_L133_F1.7071.00
82_A105_V1.6401.00
43_S112_A1.5801.00
36_V111_L1.5621.00
76_L139_A1.5451.00
130_L134_L1.5301.00
27_R30_K1.5281.00
33_L37_L1.4781.00
16_G28_S1.4311.00
12_G28_S1.4031.00
46_L50_L1.4021.00
96_S99_P1.3941.00
123_W127_L1.3581.00
133_F137_L1.3551.00
131_L135_T1.3541.00
113_T129_A1.3441.00
39_A108_V1.3061.00
118_L123_W1.2731.00
124_S127_L1.2701.00
126_A130_L1.2601.00
15_L19_L1.2561.00
31_T35_G1.2311.00
117_G126_A1.2241.00
63_S67_A1.2201.00
73_L77_L1.2051.00
3_I97_A1.2041.00
127_L131_L1.1971.00
47_G119_A1.1851.00
23_R26_R1.1821.00
37_L41_A1.1591.00
13_L32_L1.1471.00
58_L61_P1.1391.00
13_L29_L1.1301.00
108_V112_A1.1221.00
21_D24_L1.1191.00
127_L130_L1.1141.00
86_G101_V1.1011.00
114_A129_A1.0971.00
40_I118_L1.0941.00
59_E62_T1.0861.00
32_L137_L1.0701.00
95_S99_P1.0391.00
22_R27_R1.0351.00
68_R132_L1.0281.00
48_L119_A1.0241.00
76_L135_T1.0211.00
64_E67_A1.0181.00
23_R30_K1.0091.00
41_A45_L0.9791.00
40_I44_A0.9731.00
80_L84_A0.9651.00
135_T140_I0.9591.00
65_I117_G0.9581.00
34_V37_L0.9341.00
123_W126_A0.9181.00
80_L139_A0.9161.00
2_L7_M0.9161.00
138_V141_V0.9131.00
13_L28_S0.8911.00
7_M11_L0.8831.00
4_A107_L0.8691.00
41_A44_A0.8661.00
115_G119_A0.8651.00
10_I141_V0.8591.00
13_L141_V0.8491.00
29_L33_L0.8401.00
106_A109_P0.8351.00
74_L77_L0.8301.00
65_I68_R0.8231.00
87_A91_T0.8191.00
69_T117_G0.8091.00
88_L92_R0.8091.00
79_A136_N0.8091.00
131_L134_L0.8081.00
134_L138_V0.8061.00
71_P75_D0.7961.00
74_L78_V0.7931.00
80_L83_G0.7901.00
4_A102_A0.7901.00
43_S115_G0.7851.00
8_G11_L0.7641.00
14_G141_V0.7561.00
114_A117_G0.7511.00
121_G124_S0.7511.00
100_G109_P0.7511.00
65_I125_L0.7451.00
45_L48_L0.7451.00
75_D135_T0.7361.00
90_L99_P0.7361.00
40_I115_G0.7341.00
66_L70_S0.7271.00
17_L141_V0.7211.00
116_I120_L0.7211.00
50_L53_G0.7191.00
68_R106_A0.7151.00
43_S47_G0.7141.00
61_P65_I0.7111.00
63_S66_L0.7071.00
40_I43_S0.7071.00
15_L21_D0.7071.00
79_A82_A0.7061.00
7_M102_A0.7021.00
50_L74_L0.6981.00
71_P128_G0.6881.00
58_L63_S0.6861.00
6_L10_I0.6841.00
67_A75_D0.6811.00
11_L90_L0.6811.00
76_L80_L0.6731.00
27_R31_T0.6691.00
45_L49_L0.6581.00
103_I108_V0.6561.00
53_G59_E0.6491.00
78_V82_A0.6471.00
48_L51_P0.6371.00
68_R107_L0.6361.00
128_G132_L0.6331.00
4_A7_M0.6321.00
1_M4_A0.6311.00
101_V104_A0.6281.00
117_G122_N0.6261.00
68_R113_T0.6251.00
11_L86_G0.6211.00
3_I102_A0.6201.00
10_I102_A0.6181.00
25_L29_L0.6171.00
69_T129_A0.6161.00
11_L87_A0.6151.00
112_A115_G0.6081.00
106_A110_P0.6031.00
92_R97_A0.6021.00
121_G126_A0.6011.00
44_A121_G0.5981.00
26_R29_L0.5911.00
6_L110_P0.5881.00
66_L125_L0.5871.00
25_L32_L0.5851.00
106_A132_L0.5821.00
74_L88_L0.5791.00
7_M86_G0.5781.00
89_A99_P0.5761.00
32_L36_V0.5751.00
42_V45_L0.5751.00
2_L6_L0.5741.00
34_V38_L0.5741.00
3_I85_A0.5711.00
77_L81_A0.5701.00
114_A118_L0.5681.00
39_A133_F0.5681.00
64_E69_T0.5681.00
47_G50_L0.5671.00
126_A129_A0.5661.00
82_A94_K0.5661.00
35_G99_P0.5661.00
124_S128_G0.5651.00
48_L121_G0.5601.00
102_A106_A0.5581.00
34_V121_G0.5561.00
90_L96_S0.5521.00
13_L16_G0.5511.00
71_P135_T0.5500.99
35_G38_L0.5500.99
61_P66_L0.5480.99
79_A109_P0.5480.99
62_T66_L0.5470.99
135_T139_A0.5470.99
22_R41_A0.5370.99
9_P35_G0.5340.99
12_G105_V0.5280.99
14_G18_V0.5280.99
29_L32_L0.5280.99
129_A132_L0.5280.99
79_A106_A0.5240.99
86_G100_G0.5210.99
48_L52_L0.5190.99
83_G87_A0.5160.99
105_V139_A0.5150.99
104_A108_V0.5110.99
137_L141_V0.5050.99
68_R71_P0.5040.99
58_L62_T0.5040.99
69_T113_T0.5030.99
85_A97_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.9014 5.4 0.92 Contact Map
2zy9A 2 0.5915 1.5 0.94 Contact Map
2nq2A 2 0.8099 1.5 0.94 Contact Map
3trkA 1 0.3521 1.3 0.942 Contact Map
4httA 1 0.9296 1.1 0.945 Contact Map
4m5bA 1 0.7887 1 0.945 Contact Map
2j5dA 2 0.1831 1 0.946 Contact Map
1afoA 2 0.2817 1 0.946 Contact Map
2mgyA 1 0.7817 1 0.946 Contact Map
4p79A 1 0.6127 1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.