GREMLIN Database
zf-like - Cysteine-rich small domain
PFAM: PF04071 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (75)
Sequences: 2121 (1561)
Seq/√Len: 180.3
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_K65_D3.7341.00
57_L66_Y3.6331.00
42_V54_D3.3851.00
60_R63_N2.4001.00
71_L74_I2.3501.00
57_L63_N2.3001.00
70_K73_E2.2331.00
71_L75_L2.2151.00
32_P77_E2.1341.00
6_Q13_F1.9871.00
56_T60_R1.9421.00
63_N66_Y1.7951.00
40_N54_D1.7791.00
19_E56_T1.7571.00
38_G70_K1.6901.00
64_Y68_I1.4961.00
32_P74_I1.4821.00
13_F21_E1.3491.00
18_G56_T1.3251.00
57_L60_R1.3241.00
3_K61_P1.2901.00
73_E76_E1.2761.00
17_K21_E1.2661.00
27_Y68_I1.2411.00
42_V51_D1.2361.00
42_V45_E1.2341.00
58_P67_I1.1291.00
38_G41_F1.1091.00
61_P64_Y1.0771.00
36_E77_E1.0651.00
23_C28_C1.0591.00
66_Y69_E1.0501.00
33_L74_I1.0451.00
37_C50_K1.0150.99
32_P71_L0.9970.99
5_F27_Y0.9870.99
7_N11_E0.9640.99
19_E60_R0.9430.99
72_K75_L0.9370.99
31_Y49_V0.9290.99
57_L67_I0.9180.99
35_D77_E0.9180.99
8_K21_E0.9020.99
30_L58_P0.9000.99
18_G21_E0.8890.99
44_T47_G0.8880.99
52_C55_C0.8610.98
30_L38_G0.8510.98
55_C59_H0.8500.98
71_L77_E0.8420.98
30_L50_K0.8390.98
5_F9_E0.8370.98
23_C26_C0.8250.98
6_Q22_N0.8230.98
35_D43_Y0.7890.97
74_I77_E0.7870.97
58_P63_N0.7740.97
34_G41_F0.7450.96
22_N37_C0.7400.95
24_L68_I0.7370.95
17_K54_D0.7350.95
37_C41_F0.7340.95
30_L67_I0.7220.95
62_E65_D0.7050.94
24_L64_Y0.6960.94
4_F18_G0.6920.94
46_N49_V0.6890.93
17_K56_T0.6880.93
25_F37_C0.6850.93
43_Y46_N0.6810.93
25_F64_Y0.6790.93
49_V71_L0.6770.93
25_F29_P0.6680.92
2_Y11_E0.6640.92
9_E72_K0.6610.92
27_Y31_Y0.6580.92
22_N61_P0.6570.92
34_G77_E0.6450.91
25_F68_I0.6370.90
64_Y67_I0.6160.89
30_L70_K0.6120.89
69_E73_E0.6050.88
66_Y70_K0.6040.88
5_F24_L0.6020.88
33_L70_K0.5920.87
11_E47_G0.5900.87
17_K20_D0.5890.87
40_N51_D0.5770.86
38_G58_P0.5680.85
52_C59_H0.5670.85
6_Q18_G0.5670.85
20_D61_P0.5640.84
51_D54_D0.5560.83
15_C26_C0.5520.83
69_E75_L0.5470.82
24_L50_K0.5400.82
35_D39_G0.5370.81
34_G38_G0.5340.81
65_D76_E0.5300.80
53_S56_T0.5290.80
40_N56_T0.5280.80
67_I70_K0.5270.80
27_Y51_D0.5270.80
2_Y12_Y0.5180.79
23_C31_Y0.5170.79
42_V53_S0.5170.79
34_G37_C0.5150.79
65_D75_L0.5140.78
22_N64_Y0.5090.78
72_K77_E0.5050.77
28_C31_Y0.5020.77
65_D68_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1co4A 1 0.4444 9.5 0.914 Contact Map
3zj1A 1 0.8025 6.4 0.921 Contact Map
2ebrA 1 0.5309 5.8 0.922 Contact Map
2ebqA 1 0.5309 5.2 0.924 Contact Map
2hgoA 1 0.3333 5.1 0.924 Contact Map
2mjgA 2 0.5679 5 0.925 Contact Map
2d9gA 1 0.5309 5 0.925 Contact Map
2j7aC 2 0.7284 4.7 0.926 Contact Map
3gj5B 1 0.321 4 0.928 Contact Map
2c2xA 2 0.3457 3.8 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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