GREMLIN Database
DUF378 - Domain of unknown function (DUF378)
PFAM: PF04070 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (56)
Sequences: 12649 (8035)
Seq/√Len: 1073.7
META: 0.926

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_G52_A3.2121.00
23_L46_I2.9091.00
26_F31_A2.4351.00
30_A41_S2.3431.00
11_V55_L2.3221.00
4_D54_Y2.0381.00
25_N42_R1.8181.00
8_L55_L1.7861.00
11_V15_G1.7731.00
27_D30_A1.7071.00
2_T6_I1.5611.00
38_S41_S1.5481.00
22_G46_I1.5161.00
14_G48_V1.4871.00
39_A43_I1.4771.00
7_A55_L1.2921.00
7_A54_Y1.2651.00
20_L28_L1.2451.00
18_W45_Y1.2221.00
12_I52_A1.2191.00
19_G49_G1.1941.00
55_L58_L1.1601.00
2_T5_K1.1491.00
10_L51_A1.0601.00
21_V27_D1.0211.00
24_F42_R1.0191.00
17_N27_D0.9971.00
5_K55_L0.9801.00
5_K9_I0.9731.00
33_F38_S0.9401.00
20_L26_F0.9381.00
37_M41_S0.9231.00
27_D41_S0.9201.00
4_D55_L0.9201.00
54_Y57_V0.9131.00
7_A51_A0.9081.00
53_L57_V0.8931.00
25_N37_M0.8901.00
30_A45_Y0.8641.00
42_R46_I0.8421.00
50_L54_Y0.8131.00
5_K57_V0.8061.00
17_N28_L0.7911.00
22_G49_G0.7791.00
29_V44_V0.7761.00
22_G42_R0.7761.00
14_G18_W0.7631.00
4_D8_L0.7521.00
5_K8_L0.7311.00
29_V41_S0.7311.00
8_L12_I0.7281.00
30_A36_S0.7251.00
31_A39_A0.7131.00
18_W29_V0.7071.00
8_L58_L0.7061.00
4_D57_V0.6981.00
33_F40_L0.6761.00
13_I48_V0.6611.00
16_L52_A0.6571.00
27_D45_Y0.6441.00
18_W48_V0.6441.00
33_F44_V0.6421.00
34_G38_S0.6331.00
33_F41_S0.6321.00
47_L51_A0.6271.00
36_S41_S0.6221.00
11_V52_A0.6141.00
39_A42_R0.6031.00
30_A38_S0.6001.00
3_L54_Y0.5851.00
51_A55_L0.5811.00
12_I55_L0.5731.00
12_I16_L0.5561.00
4_D9_I0.5461.00
40_L44_V0.5421.00
21_V36_S0.5371.00
17_N20_L0.5341.00
40_L43_I0.5341.00
17_N48_V0.5311.00
34_G41_S0.5231.00
18_W44_V0.5141.00
10_L47_L0.5081.00
29_V33_F0.5061.00
12_I56_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1rA 5 0.4167 2.1 0.877 Contact Map
1oahA 2 0 2 0.88 Contact Map
3pjzA 2 0.8833 1.6 0.885 Contact Map
4ev6A 3 0.8667 1.4 0.889 Contact Map
4q4hB 1 0.9667 1.4 0.889 Contact Map
4pl0A 2 1 1.3 0.891 Contact Map
3zdqA 2 1 1.2 0.893 Contact Map
3j9pD 4 1 1.2 0.895 Contact Map
3bz1X 1 0.5 1.1 0.896 Contact Map
4i0uA 4 0.8667 1 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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