GREMLIN Database
DUF384 - Domain of unknown function (DUF384)
PFAM: PF04064 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (54)
Sequences: 671 (445)
Seq/√Len: 60.6
META: 0.411

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_L30_W2.7351.00
19_G22_P2.6351.00
9_R13_E2.4181.00
8_T11_G2.2841.00
28_H41_E2.2721.00
26_E29_L2.2251.00
6_C46_V2.1721.00
13_E17_E2.0851.00
41_E45_Q2.0211.00
14_Y18_K1.9601.00
15_L20_V1.6610.99
22_P25_R1.6450.99
19_G23_I1.5340.98
7_T42_R1.5040.98
50_D54_E1.4180.97
27_L31_E1.4010.97
3_L43_L1.3720.97
22_P26_E1.3610.97
45_Q49_R1.2520.95
14_Y17_E1.1710.92
40_C44_V1.1700.92
24_L43_L1.1130.90
2_L43_L1.1000.90
16_R21_Y1.0210.86
18_K23_I1.0070.85
3_L44_V0.9860.84
49_R54_E0.9540.82
12_R16_R0.9320.80
36_V44_V0.9300.80
1_T5_L0.9260.80
34_E38_E0.8770.76
27_L36_V0.8530.74
10_E17_E0.8430.73
4_L44_V0.8410.73
43_L46_V0.8350.73
28_H37_R0.8350.73
23_I41_E0.8280.72
21_Y28_H0.8170.71
27_L40_C0.8140.71
12_R51_E0.8120.70
2_L15_L0.7830.68
20_V44_V0.7790.67
6_C15_L0.7670.66
34_E37_R0.7510.64
6_C37_R0.7470.64
11_G15_L0.7260.62
39_A46_V0.7110.60
31_E37_R0.7030.59
4_L42_R0.6990.59
19_G29_L0.6970.59
9_R50_D0.6820.57
30_W40_C0.6790.57
31_E41_E0.6780.56
21_Y51_E0.6690.55
28_H42_R0.6610.55
37_R41_E0.6420.52
7_T46_V0.6350.52
29_L40_C0.6310.51
20_V24_L0.6220.50
22_P48_I0.6150.49
8_T46_V0.6080.49
49_R53_E0.6030.48
4_L23_I0.5900.47
13_E16_R0.5880.46
1_T42_R0.5760.45
19_G54_E0.5730.45
24_L46_V0.5670.44
13_E32_E0.5620.43
16_R49_R0.5610.43
36_V40_C0.5510.42
16_R51_E0.5460.42
17_E47_L0.5410.41
49_R52_E0.5390.41
21_Y25_R0.5310.40
32_E36_V0.5240.39
7_T47_L0.5130.38
1_T33_D0.5130.38
26_E40_C0.5100.38
39_A43_L0.5060.37
1_T54_E0.5010.37
32_E35_D0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dkaA 1 0.7636 29.6 0.829 Contact Map
3tpoA 1 0.8545 23 0.837 Contact Map
1wa5B 1 0.9273 22.3 0.839 Contact Map
3nowA 3 1 19.7 0.843 Contact Map
2f7lA 4 0.8727 18.9 0.844 Contact Map
4ev8A 1 0.8364 17.7 0.846 Contact Map
4bjuA 1 0.9455 16.9 0.847 Contact Map
4uafB 1 0.8545 16.4 0.848 Contact Map
2jdqA 2 0.9455 14.1 0.853 Contact Map
3nmzA 2 1 14 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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