GREMLIN Database
MnhB - Domain related to MnhB subunit of Na+/H+ antiporter
PFAM: PF04039 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (121)
Sequences: 16829 (10420)
Seq/√Len: 947.3
META: 0.841

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_G115_G3.0121.00
17_G38_L2.8851.00
58_L61_R2.8741.00
54_A58_L2.8191.00
21_L34_G2.6761.00
21_L115_G2.4341.00
79_G87_F2.3571.00
38_L115_G2.3001.00
104_L108_L2.2851.00
20_V37_I2.2481.00
94_P101_E2.2091.00
74_L113_G1.9941.00
96_G101_E1.7881.00
73_L77_G1.7691.00
38_L119_A1.7661.00
81_A85_L1.6891.00
71_G113_G1.6701.00
104_L107_I1.6551.00
14_L41_A1.6451.00
67_L120_G1.6451.00
6_A48_A1.6431.00
13_I41_A1.5901.00
77_G81_A1.5871.00
106_T110_F1.5421.00
78_T109_L1.5381.00
21_L112_L1.5031.00
72_L117_T1.4961.00
105_G108_L1.4781.00
68_E117_T1.4711.00
100_G103_H1.4661.00
23_H27_S1.4541.00
54_A57_V1.4291.00
3_R49_F1.4151.00
61_R65_R1.3471.00
94_P103_H1.3321.00
42_F123_L1.3101.00
94_P97_L1.2941.00
36_V122_L1.2911.00
92_F103_H1.2831.00
79_G82_G1.2781.00
16_F19_Y1.2511.00
56_R61_R1.2201.00
8_L11_P1.2191.00
33_Q36_V1.2171.00
79_G88_L1.2031.00
14_L38_L1.1721.00
105_G109_L1.1711.00
70_L74_L1.1581.00
10_L45_L1.1381.00
10_L41_A1.1231.00
53_A56_R1.1231.00
111_D117_T1.0921.00
4_T7_R1.0651.00
117_T121_A1.0601.00
69_G73_L1.0571.00
3_R7_R1.0381.00
75_A79_G1.0321.00
39_A122_L1.0131.00
91_A94_P0.9871.00
39_A121_A0.9831.00
45_L53_A0.9791.00
51_L55_R0.9771.00
61_R66_L0.9741.00
50_G53_A0.9631.00
91_A95_L0.9601.00
66_L70_L0.9581.00
75_A110_F0.9571.00
45_L49_F0.9291.00
46_Y51_L0.9261.00
10_L13_I0.9251.00
11_P15_L0.9211.00
67_L116_L0.9211.00
31_G35_G0.9111.00
25_H107_I0.9091.00
80_L83_L0.8941.00
13_I16_F0.8921.00
5_V9_L0.8841.00
7_R49_F0.8811.00
105_G111_D0.8791.00
68_E121_A0.8731.00
95_L100_G0.8711.00
107_I111_D0.8661.00
88_L110_F0.8601.00
119_A122_L0.8591.00
75_A88_L0.8561.00
70_L116_L0.8481.00
1_I4_T0.8351.00
16_F20_V0.8271.00
17_G34_G0.8221.00
106_T109_L0.8141.00
54_A59_P0.8101.00
95_L98_L0.8091.00
66_L69_G0.8091.00
117_T120_G0.8021.00
21_L38_L0.8011.00
77_G82_G0.8011.00
18_L22_L0.8001.00
114_V117_T0.8001.00
7_R11_P0.7951.00
2_L6_A0.7891.00
6_A41_A0.7871.00
19_Y23_H0.7871.00
82_G85_L0.7851.00
6_A44_L0.7771.00
57_V60_V0.7711.00
87_F90_Y0.7711.00
2_L48_A0.7701.00
39_A123_L0.7651.00
25_H31_G0.7651.00
45_L48_A0.7531.00
108_L111_D0.7481.00
55_R58_L0.7461.00
9_L13_I0.7371.00
119_A123_L0.7321.00
98_L101_E0.7301.00
86_G89_T0.7291.00
75_A78_T0.7271.00
98_L103_H0.7211.00
74_L78_T0.7141.00
55_R60_V0.7111.00
56_R60_V0.7011.00
23_H36_V0.6991.00
45_L54_A0.6951.00
10_L14_L0.6911.00
82_G89_T0.6791.00
97_L100_G0.6781.00
107_I110_F0.6771.00
4_T8_L0.6761.00
99_L102_L0.6721.00
14_L17_G0.6681.00
81_A91_A0.6651.00
26_N103_H0.6621.00
96_G103_H0.6551.00
52_E56_R0.6521.00
83_L87_F0.6461.00
78_T81_A0.6451.00
72_L75_A0.6431.00
92_F105_G0.6421.00
49_F52_E0.6361.00
76_A87_F0.6361.00
41_A45_L0.6351.00
97_L101_E0.6341.00
54_A61_R0.6321.00
90_Y107_I0.6291.00
81_A84_L0.6261.00
59_P62_L0.6251.00
53_A57_V0.6141.00
78_T108_L0.6081.00
36_V50_G0.6061.00
18_L21_L0.6011.00
42_F119_A0.6001.00
95_L103_H0.5951.00
56_R59_P0.5931.00
110_F114_V0.5891.00
33_Q40_A0.5831.00
9_L12_L0.5821.00
82_G86_G0.5801.00
6_A10_L0.5791.00
112_L116_L0.5781.00
110_F113_G0.5721.00
80_L84_L0.5721.00
72_L76_A0.5691.00
55_R59_P0.5681.00
79_G110_F0.5681.00
71_G74_L0.5671.00
55_R61_R0.5631.00
88_L91_A0.5561.00
97_L102_L0.5491.00
76_A82_G0.5471.00
71_G120_G0.5441.00
111_D114_V0.5401.00
19_Y37_I0.5381.00
12_L16_F0.5351.00
68_E82_G0.5231.00
95_L99_L0.5201.00
71_G79_G0.5191.00
51_L54_A0.5151.00
115_G119_A0.5111.00
93_L104_L0.5051.00
40_A43_I0.5041.00
69_G72_L0.5021.00
46_Y50_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.4113 3.8 0.919 Contact Map
4ev6A 3 0.4274 3.5 0.921 Contact Map
2ks1B 1 0.2984 1.9 0.931 Contact Map
2a65A 2 0.4597 1.7 0.932 Contact Map
4us3A 1 0.8387 1.6 0.933 Contact Map
2jlnA 1 0.9919 1.5 0.934 Contact Map
3qbgA 3 0.2339 1.4 0.936 Contact Map
3pjzA 2 0.8226 1.3 0.937 Contact Map
1xioA 2 0.1855 1.1 0.94 Contact Map
2k1aA 1 0.3387 1.1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0052 seconds.