GREMLIN Database
DUF367 - Domain of unknown function (DUF367)
PFAM: PF04034 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (126)
Sequences: 2613 (1511)
Seq/√Len: 134.6
META: 0.776

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A69_T4.0551.00
98_T101_E3.4131.00
19_I80_L3.2761.00
70_V93_F3.1991.00
4_N47_H2.9141.00
83_K111_A2.5311.00
104_K108_E2.3241.00
109_A126_Y2.3121.00
97_H101_E2.2741.00
74_A90_L2.2661.00
114_K118_E2.1721.00
52_Y64_P2.0581.00
113_A122_I1.9311.00
34_A38_P1.9081.00
83_K87_E1.9031.00
70_V90_L1.8401.00
60_N66_K1.8321.00
78_Y83_K1.8171.00
115_D118_E1.7471.00
49_A123_Q1.6871.00
120_V123_Q1.6241.00
83_K108_E1.6001.00
56_A102_L1.5771.00
20_E82_F1.5671.00
16_R20_E1.5561.00
77_L85_Q1.5311.00
32_A66_K1.5271.00
121_E125_E1.4891.00
10_A120_V1.4511.00
11_L76_A1.4351.00
56_A98_T1.4271.00
10_A116_S1.4241.00
33_R36_E1.4221.00
9_K14_A1.3961.00
52_Y65_F1.3661.00
121_E124_K1.3361.00
70_V89_L1.3241.00
122_I126_Y1.3181.00
70_V100_L1.2821.00
88_E92_K1.2801.00
54_V62_G1.2731.00
108_E111_A1.2541.00
118_E121_E1.2521.00
13_P16_R1.2421.00
70_V92_K1.2291.00
106_L126_Y1.2141.00
116_S120_V1.2091.00
68_S95_W1.2041.00
84_E87_E1.2011.00
61_Y102_L1.1810.99
6_F34_A1.1750.99
53_L75_A1.1610.99
87_E100_L1.1480.99
29_C34_A1.1450.99
11_L80_L1.1360.99
109_A122_I1.1300.99
59_V62_G1.1170.99
15_D48_R1.1020.99
78_Y107_L1.0980.99
10_A49_A1.0960.99
117_E121_E1.0910.99
120_V124_K1.0820.99
54_V106_L1.0650.99
94_K97_H1.0510.99
82_F85_Q1.0470.99
18_L46_I1.0430.99
26_A73_L1.0220.98
60_N63_K1.0220.98
109_A125_E1.0040.98
9_K116_S1.0020.98
17_E20_E0.9760.98
49_A65_F0.9720.98
78_Y108_E0.9690.98
24_L76_A0.9660.98
2_V45_G0.9650.98
85_Q88_E0.9630.98
87_E97_H0.9370.97
12_S116_S0.9290.97
105_E109_A0.9280.97
73_L89_L0.9230.97
16_R19_I0.8970.96
10_A119_V0.8940.96
16_R82_F0.8890.96
26_A32_A0.8780.96
107_L111_A0.8740.96
4_N27_L0.8730.96
112_K122_I0.8670.96
122_I125_E0.8670.96
4_N7_A0.8540.95
101_E104_K0.8510.95
88_E91_S0.8450.95
59_V68_S0.8380.95
10_A123_Q0.8250.94
49_A52_Y0.8010.93
19_I24_L0.7920.93
2_V44_G0.7820.93
108_E112_K0.7780.92
25_V69_T0.7720.92
98_T102_L0.7610.92
113_A118_E0.7580.91
102_L106_L0.7550.91
16_R80_L0.7370.90
61_Y98_T0.7220.89
5_P28_D0.7120.89
49_A69_T0.7090.88
63_K66_K0.7080.88
70_V96_G0.7020.88
24_L77_L0.7000.88
63_K68_S0.7000.88
53_L107_L0.6980.88
13_P115_D0.6960.88
118_E122_I0.6940.87
117_E120_V0.6790.86
4_N25_V0.6770.86
7_A11_L0.6680.85
104_K121_E0.6540.84
55_A65_F0.6540.84
29_C37_V0.6530.84
13_P114_K0.6520.84
56_A97_H0.6520.84
10_A65_F0.6450.83
39_F42_L0.6370.83
69_T73_L0.6350.82
86_A100_L0.6330.82
91_S94_K0.6330.82
58_P95_W0.6160.80
58_P94_K0.6160.80
77_L89_L0.6150.80
26_A68_S0.6060.79
27_L61_Y0.6030.79
27_L42_L0.6000.79
32_A63_K0.6000.79
24_L73_L0.5980.78
14_A116_S0.5980.78
41_K45_G0.5960.78
54_V81_G0.5930.78
12_S15_D0.5920.78
74_A89_L0.5920.78
92_K95_W0.5890.77
101_E106_L0.5840.77
58_P70_V0.5800.76
29_C38_P0.5800.76
56_A100_L0.5750.76
74_A96_G0.5720.75
116_S119_V0.5710.75
59_V66_K0.5700.75
52_Y55_A0.5690.75
21_K125_E0.5650.74
60_N95_W0.5630.74
65_F123_Q0.5610.74
35_E83_K0.5600.74
19_I82_F0.5600.74
29_C33_R0.5570.73
27_L37_V0.5560.73
27_L38_P0.5540.73
11_L19_I0.5540.73
55_A63_K0.5510.73
88_E115_D0.5500.72
13_P81_G0.5470.72
116_S123_Q0.5470.72
107_L110_Y0.5440.72
38_P41_K0.5420.71
10_A52_Y0.5420.71
10_A14_A0.5400.71
59_V106_L0.5400.71
52_Y123_Q0.5400.71
14_A115_D0.5340.70
109_A113_A0.5300.70
79_I119_V0.5300.70
30_S68_S0.5300.70
90_L93_F0.5300.70
28_D120_V0.5280.69
100_L104_K0.5280.69
68_S94_K0.5250.69
28_D94_K0.5250.69
1_I15_D0.5200.68
106_L125_E0.5190.68
78_Y100_L0.5180.68
12_S119_V0.5180.68
7_A47_H0.5150.68
25_V38_P0.5120.67
78_Y86_A0.5120.67
56_A62_G0.5080.66
12_S64_P0.5040.66
4_N38_P0.5040.66
6_F35_E0.5020.66
117_E125_E0.5020.66
3_L28_D0.5010.65
108_E126_Y0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2raaA 1 0.8504 45.6 0.933 Contact Map
3on3A 2 0.8346 29.2 0.94 Contact Map
1yt5A 4 0.7559 25.7 0.941 Contact Map
1y9jA 1 0.7795 20.1 0.944 Contact Map
2c42A 2 0.9528 18.8 0.945 Contact Map
3oqcA 1 0.3701 17.6 0.945 Contact Map
3bdnA 2 0.5433 9.7 0.951 Contact Map
4ccaA 1 0.7717 7 0.955 Contact Map
2f02A 2 0.7795 6.2 0.955 Contact Map
3g2eA 4 0.8661 6 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.