GREMLIN Database
Las1 - Las1-like
PFAM: PF04031 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 151 (148)
Sequences: 592 (479)
Seq/√Len: 39.4
META: 0.255

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_D78_Y5.3901.00
61_D134_R4.8941.00
78_Y134_R3.9031.00
12_V36_W3.8761.00
79_S122_A3.8251.00
33_V52_A2.9671.00
16_L33_V2.8711.00
94_Q99_A2.6871.00
15_W28_R2.5331.00
56_E70_S2.4951.00
33_V55_L2.4401.00
115_L140_A2.3551.00
3_W36_W2.3201.00
90_V102_I2.2621.00
85_F140_A2.0770.99
6_W9_W1.9550.99
37_R49_E1.8850.98
51_T149_W1.8010.98
74_L78_Y1.7950.98
16_L55_L1.7420.97
89_L109_L1.7120.97
57_A74_L1.7090.97
22_D25_S1.6950.97
85_F143_W1.6140.95
5_S8_E1.5870.95
91_D125_E1.5540.94
12_V48_V1.5490.94
11_Q15_W1.4910.93
94_Q105_L1.4870.93
39_R149_W1.4810.93
83_I123_T1.4490.92
87_N123_T1.4250.91
37_R44_L1.4050.91
57_A77_A1.3930.90
101_S105_L1.3730.90
27_R63_S1.3610.89
113_A117_E1.3550.89
91_D111_L1.3450.89
106_A116_V1.3390.88
83_I122_A1.3150.88
99_A105_L1.3130.87
75_R91_D1.3020.87
82_I118_L1.2900.87
13_R145_W1.2780.86
46_H88_G1.2530.85
102_I132_V1.2230.83
80_M87_N1.2220.83
6_W85_F1.2210.83
92_P102_I1.2170.83
94_Q98_Y1.2130.83
87_N120_H1.2120.83
115_L136_A1.1840.81
13_R17_Y1.1750.81
102_I125_E1.1540.80
41_N44_L1.1510.79
127_L148_Y1.1470.79
83_I87_N1.1390.79
89_L111_L1.1320.78
78_Y137_A1.1310.78
36_W112_P1.0900.76
62_E142_E1.0890.76
94_Q123_T1.0700.74
106_A143_W1.0660.74
88_G91_D1.0570.73
114_W136_A1.0310.71
15_W32_R1.0220.71
2_P40_G1.0160.70
58_I61_D1.0110.70
113_A136_A1.0000.69
9_W148_Y0.9670.66
130_L134_R0.9610.66
115_L139_E0.9440.65
118_L138_R0.9400.64
75_R127_L0.9270.63
104_S107_K0.9260.63
90_V106_A0.9220.63
57_A60_L0.9170.62
81_A86_V0.9140.62
76_L87_N0.8970.61
118_L143_W0.8950.60
82_I115_L0.8930.60
9_W46_H0.8900.60
84_R109_L0.8680.58
48_V149_W0.8590.57
47_A144_L0.8540.57
15_W25_S0.8530.57
19_D25_S0.8410.56
91_D123_T0.8400.55
76_L80_M0.8320.55
28_R35_A0.8310.55
115_L121_E0.8310.55
31_A71_E0.8300.55
52_A55_L0.8290.55
82_I140_A0.8260.54
114_W139_E0.8120.53
72_L76_L0.8010.52
37_R121_E0.8000.52
95_K117_E0.7980.52
86_V91_D0.7950.51
26_R55_L0.7940.51
101_S108_Q0.7920.51
52_A88_G0.7880.51
37_R85_F0.7880.51
94_Q116_V0.7860.51
137_A141_L0.7850.51
9_W125_E0.7750.50
54_L137_A0.7750.50
46_H91_D0.7740.50
116_V122_A0.7570.48
140_A143_W0.7500.47
73_A77_A0.7470.47
9_W126_E0.7440.47
76_L105_L0.7290.45
119_R124_H0.7280.45
145_W150_E0.7250.45
60_L73_A0.7240.45
76_L82_I0.7230.45
98_Y129_S0.7230.45
83_I102_I0.7160.44
108_Q136_A0.7160.44
102_I114_W0.7090.44
87_N99_A0.7090.44
46_H125_E0.7050.43
97_A147_N0.6950.42
84_R99_A0.6940.42
5_S89_L0.6900.42
57_A81_A0.6870.42
93_L108_Q0.6830.41
17_Y26_R0.6820.41
96_G100_R0.6810.41
50_S125_E0.6790.41
15_W29_A0.6760.41
94_Q101_S0.6730.40
60_L77_A0.6710.40
17_Y143_W0.6700.40
1_V9_W0.6700.40
81_A144_L0.6690.40
40_G115_L0.6690.40
31_A77_A0.6680.40
56_E71_E0.6650.40
105_L123_T0.6640.40
46_H89_L0.6620.39
118_L136_A0.6590.39
102_I115_L0.6570.39
27_R59_L0.6560.39
1_V4_R0.6530.39
92_P105_L0.6520.39
91_D94_Q0.6510.39
13_R26_R0.6470.38
95_K100_R0.6440.38
5_S27_R0.6420.38
89_L143_W0.6380.37
56_E60_L0.6380.37
2_P110_G0.6370.37
14_D65_S0.6350.37
143_W148_Y0.6350.37
3_W12_V0.6340.37
123_T127_L0.6330.37
33_V82_I0.6290.37
29_A77_A0.6280.37
118_L123_T0.6270.36
74_L77_A0.6250.36
5_S14_D0.6220.36
41_N69_S0.6220.36
10_L14_D0.6140.35
80_M129_S0.6130.35
96_G99_A0.6120.35
117_E125_E0.6080.35
74_L130_L0.6070.35
27_R57_A0.6010.34
61_D130_L0.5970.34
25_S79_S0.5950.34
19_D22_D0.5950.34
61_D137_A0.5930.34
87_N102_I0.5840.33
27_R32_R0.5840.33
54_L141_L0.5830.33
48_V134_R0.5820.33
79_S129_S0.5800.33
62_E73_A0.5800.33
78_Y130_L0.5690.32
57_A76_L0.5670.32
57_A133_L0.5620.31
54_L60_L0.5600.31
82_I136_A0.5600.31
7_A60_L0.5580.31
99_A123_T0.5560.31
83_I125_E0.5560.31
106_A112_P0.5550.31
16_L39_R0.5520.30
106_A144_L0.5510.30
115_L125_E0.5510.30
2_P126_E0.5500.30
85_F144_L0.5470.30
124_H128_P0.5440.30
6_W20_S0.5430.30
31_A82_I0.5410.30
143_W147_N0.5400.30
46_H121_E0.5380.29
29_A116_V0.5350.29
56_E73_A0.5330.29
87_N94_Q0.5320.29
7_A11_Q0.5250.28
16_L77_A0.5230.28
29_A51_T0.5230.28
26_R29_A0.5210.28
86_V96_G0.5210.28
59_L70_S0.5200.28
117_E121_E0.5200.28
120_H123_T0.5200.28
11_Q64_G0.5190.28
58_I78_Y0.5170.28
61_D74_L0.5160.28
65_S68_S0.5120.27
40_G44_L0.5120.27
89_L115_L0.5120.27
88_G113_A0.5090.27
22_D65_S0.5090.27
34_S59_L0.5060.27
103_A113_A0.5010.27
25_S28_R0.5000.27
90_V107_K0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f1xA 6 0.3841 24.6 0.933 Contact Map
2yxlA 1 0.9603 18.6 0.936 Contact Map
3n0fA 1 1 7.9 0.946 Contact Map
1sqgA 1 0.947 7 0.947 Contact Map
3ix3A 2 0.4106 7 0.948 Contact Map
3sggA 1 0.6887 6.8 0.948 Contact Map
2ongA 2 0.9801 6.5 0.948 Contact Map
2j5cA 1 0.9669 5.9 0.949 Contact Map
3oq9A 3 0.4503 5.8 0.949 Contact Map
4jioA 1 0.5497 5.3 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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