Las1 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Las1 - Las1-like

PFAM:	PF04031	Sequences: VPWRSWAEWLQVRDWLYSDSSDPDSRRRALARVSAWRSRGNSKLPHAVESTALLLEAILLDESGSNSSSSELALRLAYSMAIIRFVNGLVDPLQKGAYARSIASLAKQLGLPAWLVELRHEATHEELPSLEVLREAAREALEWLWDNYWEH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	151 (148)
Sequences:	592 (479)
Seq/√Len:	39.4
META:	0.255

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_D	78_Y	5.390	1.00
61_D	134_R	4.894	1.00
78_Y	134_R	3.903	1.00
12_V	36_W	3.876	1.00
79_S	122_A	3.825	1.00
33_V	52_A	2.967	1.00
16_L	33_V	2.871	1.00
94_Q	99_A	2.687	1.00
15_W	28_R	2.533	1.00
56_E	70_S	2.495	1.00
33_V	55_L	2.440	1.00
115_L	140_A	2.355	1.00
3_W	36_W	2.320	1.00
90_V	102_I	2.262	1.00
85_F	140_A	2.077	0.99
6_W	9_W	1.955	0.99
37_R	49_E	1.885	0.98
51_T	149_W	1.801	0.98
74_L	78_Y	1.795	0.98
16_L	55_L	1.742	0.97
89_L	109_L	1.712	0.97
57_A	74_L	1.709	0.97
22_D	25_S	1.695	0.97
85_F	143_W	1.614	0.95
5_S	8_E	1.587	0.95
91_D	125_E	1.554	0.94
12_V	48_V	1.549	0.94
11_Q	15_W	1.491	0.93
94_Q	105_L	1.487	0.93
39_R	149_W	1.481	0.93
83_I	123_T	1.449	0.92
87_N	123_T	1.425	0.91
37_R	44_L	1.405	0.91
57_A	77_A	1.393	0.90
101_S	105_L	1.373	0.90
27_R	63_S	1.361	0.89
113_A	117_E	1.355	0.89
91_D	111_L	1.345	0.89
106_A	116_V	1.339	0.88
83_I	122_A	1.315	0.88
99_A	105_L	1.313	0.87
75_R	91_D	1.302	0.87
82_I	118_L	1.290	0.87
13_R	145_W	1.278	0.86
46_H	88_G	1.253	0.85
102_I	132_V	1.223	0.83
80_M	87_N	1.222	0.83
6_W	85_F	1.221	0.83
92_P	102_I	1.217	0.83
94_Q	98_Y	1.213	0.83
87_N	120_H	1.212	0.83
115_L	136_A	1.184	0.81
13_R	17_Y	1.175	0.81
102_I	125_E	1.154	0.80
41_N	44_L	1.151	0.79
127_L	148_Y	1.147	0.79
83_I	87_N	1.139	0.79
89_L	111_L	1.132	0.78
78_Y	137_A	1.131	0.78
36_W	112_P	1.090	0.76
62_E	142_E	1.089	0.76
94_Q	123_T	1.070	0.74
106_A	143_W	1.066	0.74
88_G	91_D	1.057	0.73
114_W	136_A	1.031	0.71
15_W	32_R	1.022	0.71
2_P	40_G	1.016	0.70
58_I	61_D	1.011	0.70
113_A	136_A	1.000	0.69
9_W	148_Y	0.967	0.66
130_L	134_R	0.961	0.66
115_L	139_E	0.944	0.65
118_L	138_R	0.940	0.64
75_R	127_L	0.927	0.63
104_S	107_K	0.926	0.63
90_V	106_A	0.922	0.63
57_A	60_L	0.917	0.62
81_A	86_V	0.914	0.62
76_L	87_N	0.897	0.61
118_L	143_W	0.895	0.60
82_I	115_L	0.893	0.60
9_W	46_H	0.890	0.60
84_R	109_L	0.868	0.58
48_V	149_W	0.859	0.57
47_A	144_L	0.854	0.57
15_W	25_S	0.853	0.57
19_D	25_S	0.841	0.56
91_D	123_T	0.840	0.55
76_L	80_M	0.832	0.55
28_R	35_A	0.831	0.55
115_L	121_E	0.831	0.55
31_A	71_E	0.830	0.55
52_A	55_L	0.829	0.55
82_I	140_A	0.826	0.54
114_W	139_E	0.812	0.53
72_L	76_L	0.801	0.52
37_R	121_E	0.800	0.52
95_K	117_E	0.798	0.52
86_V	91_D	0.795	0.51
26_R	55_L	0.794	0.51
101_S	108_Q	0.792	0.51
52_A	88_G	0.788	0.51
37_R	85_F	0.788	0.51
94_Q	116_V	0.786	0.51
137_A	141_L	0.785	0.51
9_W	125_E	0.775	0.50
54_L	137_A	0.775	0.50
46_H	91_D	0.774	0.50
116_V	122_A	0.757	0.48
140_A	143_W	0.750	0.47
73_A	77_A	0.747	0.47
9_W	126_E	0.744	0.47
76_L	105_L	0.729	0.45
119_R	124_H	0.728	0.45
145_W	150_E	0.725	0.45
60_L	73_A	0.724	0.45
76_L	82_I	0.723	0.45
98_Y	129_S	0.723	0.45
83_I	102_I	0.716	0.44
108_Q	136_A	0.716	0.44
102_I	114_W	0.709	0.44
87_N	99_A	0.709	0.44
46_H	125_E	0.705	0.43
97_A	147_N	0.695	0.42
84_R	99_A	0.694	0.42
5_S	89_L	0.690	0.42
57_A	81_A	0.687	0.42
93_L	108_Q	0.683	0.41
17_Y	26_R	0.682	0.41
96_G	100_R	0.681	0.41
50_S	125_E	0.679	0.41
15_W	29_A	0.676	0.41
94_Q	101_S	0.673	0.40
60_L	77_A	0.671	0.40
17_Y	143_W	0.670	0.40
1_V	9_W	0.670	0.40
81_A	144_L	0.669	0.40
40_G	115_L	0.669	0.40
31_A	77_A	0.668	0.40
56_E	71_E	0.665	0.40
105_L	123_T	0.664	0.40
46_H	89_L	0.662	0.39
118_L	136_A	0.659	0.39
102_I	115_L	0.657	0.39
27_R	59_L	0.656	0.39
1_V	4_R	0.653	0.39
92_P	105_L	0.652	0.39
91_D	94_Q	0.651	0.39
13_R	26_R	0.647	0.38
95_K	100_R	0.644	0.38
5_S	27_R	0.642	0.38
89_L	143_W	0.638	0.37
56_E	60_L	0.638	0.37
2_P	110_G	0.637	0.37
14_D	65_S	0.635	0.37
143_W	148_Y	0.635	0.37
3_W	12_V	0.634	0.37
123_T	127_L	0.633	0.37
33_V	82_I	0.629	0.37
29_A	77_A	0.628	0.37
118_L	123_T	0.627	0.36
74_L	77_A	0.625	0.36
5_S	14_D	0.622	0.36
41_N	69_S	0.622	0.36
10_L	14_D	0.614	0.35
80_M	129_S	0.613	0.35
96_G	99_A	0.612	0.35
117_E	125_E	0.608	0.35
74_L	130_L	0.607	0.35
27_R	57_A	0.601	0.34
61_D	130_L	0.597	0.34
25_S	79_S	0.595	0.34
19_D	22_D	0.595	0.34
61_D	137_A	0.593	0.34
87_N	102_I	0.584	0.33
27_R	32_R	0.584	0.33
54_L	141_L	0.583	0.33
48_V	134_R	0.582	0.33
79_S	129_S	0.580	0.33
62_E	73_A	0.580	0.33
78_Y	130_L	0.569	0.32
57_A	76_L	0.567	0.32
57_A	133_L	0.562	0.31
54_L	60_L	0.560	0.31
82_I	136_A	0.560	0.31
7_A	60_L	0.558	0.31
99_A	123_T	0.556	0.31
83_I	125_E	0.556	0.31
106_A	112_P	0.555	0.31
16_L	39_R	0.552	0.30
106_A	144_L	0.551	0.30
115_L	125_E	0.551	0.30
2_P	126_E	0.550	0.30
85_F	144_L	0.547	0.30
124_H	128_P	0.544	0.30
6_W	20_S	0.543	0.30
31_A	82_I	0.541	0.30
143_W	147_N	0.540	0.30
46_H	121_E	0.538	0.29
29_A	116_V	0.535	0.29
56_E	73_A	0.533	0.29
87_N	94_Q	0.532	0.29
7_A	11_Q	0.525	0.28
16_L	77_A	0.523	0.28
29_A	51_T	0.523	0.28
26_R	29_A	0.521	0.28
86_V	96_G	0.521	0.28
59_L	70_S	0.520	0.28
117_E	121_E	0.520	0.28
120_H	123_T	0.520	0.28
11_Q	64_G	0.519	0.28
58_I	78_Y	0.517	0.28
61_D	74_L	0.516	0.28
65_S	68_S	0.512	0.27
40_G	44_L	0.512	0.27
89_L	115_L	0.512	0.27
88_G	113_A	0.509	0.27
22_D	65_S	0.509	0.27
34_S	59_L	0.506	0.27
103_A	113_A	0.501	0.27
25_S	28_R	0.500	0.27
90_V	107_K	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3f1xA	6	0.3841	24.6	0.933	Contact Map
2yxlA	1	0.9603	18.6	0.936	Contact Map
3n0fA	1	1	7.9	0.946	Contact Map
1sqgA	1	0.947	7	0.947	Contact Map
3ix3A	2	0.4106	7	0.948	Contact Map
3sggA	1	0.6887	6.8	0.948	Contact Map
2ongA	2	0.9801	6.5	0.948	Contact Map
2j5cA	1	0.9669	5.9	0.949	Contact Map
3oq9A	3	0.4503	5.8	0.949	Contact Map
4jioA	1	0.5497	5.3	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.