GREMLIN Database
DUF374 - Domain of unknown function (DUF374)
PFAM: PF04028 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (67)
Sequences: 19423 (11166)
Seq/√Len: 1364.2
META: 0.97

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_E34_R3.4511.00
9_A56_R2.3961.00
52_L58_V2.2301.00
9_A31_G2.2161.00
19_E23_R2.1381.00
9_A51_A2.1121.00
49_L53_R1.7711.00
14_R43_R1.7581.00
22_A32_T1.7551.00
11_L44_A1.7521.00
51_A56_R1.7031.00
66_R69_R1.5271.00
31_G56_R1.5161.00
46_R50_R1.4661.00
14_R40_G1.4511.00
22_A34_R1.4481.00
48_L58_V1.4291.00
43_R46_R1.4231.00
31_G51_A1.4191.00
40_G43_R1.2971.00
51_A54_E1.2951.00
11_L48_L1.2941.00
38_S66_R1.2661.00
42_A46_R1.2411.00
10_V25_L1.2401.00
3_F6_R1.2271.00
46_R49_L1.2191.00
12_I18_G1.2121.00
35_G44_A1.1791.00
12_I21_I1.0881.00
26_E32_T1.0691.00
12_I25_L1.0561.00
7_G56_R1.0461.00
21_I61_T1.0461.00
64_G68_P1.0431.00
9_A33_V1.0241.00
64_G67_G0.9971.00
10_V30_F0.9951.00
8_I57_D0.9741.00
23_R26_E0.9441.00
8_I59_A0.9181.00
48_L52_L0.9121.00
37_S65_P0.9091.00
23_R27_R0.8891.00
12_I34_R0.8831.00
21_I25_L0.8671.00
10_V59_A0.8631.00
37_S64_G0.8461.00
19_E22_A0.8411.00
38_S65_P0.8271.00
50_R53_R0.8201.00
35_G41_G0.8171.00
33_V51_A0.8091.00
47_E51_A0.7881.00
50_R54_E0.7791.00
33_V44_A0.7781.00
13_S18_G0.7761.00
40_G47_E0.7711.00
45_L49_L0.7641.00
41_G44_A0.7421.00
14_R38_S0.7361.00
17_D36_S0.7351.00
7_G31_G0.7311.00
33_V47_E0.7271.00
24_V28_F0.7161.00
22_A26_E0.7031.00
13_S17_D0.7001.00
21_I24_V0.7001.00
25_L30_F0.6941.00
11_L33_V0.6841.00
36_S39_R0.6831.00
33_V48_L0.6641.00
41_G45_L0.6641.00
12_I32_T0.6481.00
11_L60_I0.6451.00
16_R20_L0.6391.00
5_G8_I0.6301.00
12_I22_A0.6251.00
24_V27_R0.6201.00
43_R47_E0.6161.00
20_L24_V0.6151.00
14_R34_R0.6101.00
3_F8_I0.6051.00
6_R57_D0.5891.00
3_F7_G0.5851.00
18_G21_I0.5841.00
38_S41_G0.5801.00
15_S38_S0.5751.00
20_L23_R0.5721.00
45_L48_L0.5641.00
47_E50_R0.5541.00
10_V32_T0.5521.00
17_D35_G0.5321.00
17_D65_P0.5291.00
52_L55_G0.5281.00
12_I60_I0.5261.00
4_R7_G0.5151.00
65_P68_P0.5071.00
62_P69_R0.5041.00
26_E31_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g8lA 2 1 40.2 0.83 Contact Map
1uz5A 1 0.942 37.8 0.832 Contact Map
3kbqA 2 0.971 35.6 0.834 Contact Map
1uuyA 3 0.971 35.4 0.835 Contact Map
1y5eA 4 1 34.8 0.835 Contact Map
3iwtA 4 0.971 34.6 0.835 Contact Map
1mkzA 2 1 32.3 0.838 Contact Map
1wu2A 2 0.913 30.7 0.84 Contact Map
1iuqA 1 1 30.4 0.84 Contact Map
2is8A 3 0.942 30.3 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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