GREMLIN Database
DUF370 - Domain of unknown function (DUF370)
PFAM: PF04025 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (72)
Sequences: 5916 (3514)
Seq/√Len: 414.1
META: 0.877

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_R55_D4.3131.00
32_E36_E2.8151.00
54_T60_I2.3981.00
18_I50_S2.1601.00
65_S68_T2.0191.00
29_L53_I2.0191.00
40_I58_H1.9761.00
21_P51_V1.9311.00
26_I51_V1.8221.00
25_P28_R1.6441.00
15_I52_I1.5881.00
38_R57_G1.5091.00
4_I10_V1.4841.00
33_A59_V1.4701.00
24_A28_R1.4311.00
6_F63_A1.4201.00
16_I54_T1.4071.00
21_P48_T1.3631.00
19_V53_I1.2861.00
41_D45_G1.2811.00
68_T72_R1.2651.00
39_L61_L1.2611.00
19_V26_I1.2551.00
4_I42_A1.2531.00
30_I51_V1.2471.00
65_S71_K1.2411.00
19_V42_A1.2401.00
51_V61_L1.2181.00
6_F46_R1.2041.00
31_Q35_E1.1911.00
48_T61_L1.1831.00
8_N44_Y1.1791.00
32_E35_E1.1731.00
9_V70_A1.1591.00
2_L12_A1.1461.00
35_E38_R1.1351.00
26_I30_I1.1341.00
28_R32_E1.0581.00
43_T46_R1.0481.00
3_H68_T1.0131.00
53_I59_V0.9761.00
65_S69_L0.9651.00
3_H64_I0.9551.00
50_S66_P0.9421.00
41_D61_L0.9361.00
19_V51_V0.9061.00
49_R65_S0.8981.00
64_I72_R0.8951.00
62_S69_L0.8881.00
51_V59_V0.8871.00
20_S44_Y0.8671.00
11_S14_R0.8581.00
43_T48_T0.8561.00
68_T71_K0.8541.00
10_V60_I0.8491.00
64_I68_T0.8461.00
14_R56_S0.8461.00
34_R41_D0.8311.00
32_E38_R0.8261.00
16_I55_D0.8261.00
3_H9_V0.8091.00
41_D48_T0.7891.00
34_R39_L0.7781.00
23_S26_I0.7781.00
54_T57_G0.7691.00
18_I66_P0.7671.00
22_D25_P0.7341.00
2_L69_L0.7311.00
29_L59_V0.7231.00
31_Q34_R0.7151.00
43_T47_K0.6911.00
21_P50_S0.6771.00
42_A60_I0.6771.00
4_I60_I0.6761.00
30_I39_L0.6700.99
1_L9_V0.6520.99
38_R58_H0.6480.99
10_V52_I0.6220.99
3_H16_I0.6200.99
1_L11_S0.6170.99
22_D47_K0.6140.99
42_A62_S0.6110.99
8_N42_A0.6050.99
20_S66_P0.6050.99
3_H65_S0.5940.99
22_D31_Q0.5920.99
47_K67_E0.5700.98
50_S62_S0.5590.98
26_I29_L0.5570.98
27_K34_R0.5510.98
7_G12_A0.5480.98
10_V33_A0.5440.98
4_I62_S0.5420.98
12_A15_I0.5340.97
25_P29_L0.5340.97
14_R57_G0.5320.97
34_R61_L0.5220.97
3_H44_Y0.5190.97
4_I15_I0.5170.97
27_K33_A0.5160.97
1_L42_A0.5150.97
17_A60_I0.5110.97
30_I34_R0.5060.97
27_K31_Q0.5040.96
4_I19_V0.5030.96
23_S30_I0.5020.96
38_R56_S0.5020.96
33_A39_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jwkA 2 0.3973 15.5 0.856 Contact Map
1rypK 2 0.9178 13.6 0.86 Contact Map
4lb6B 2 0.7534 11.4 0.865 Contact Map
2o0mA 1 0.1233 10.8 0.866 Contact Map
1j2qH 5 1 9.4 0.87 Contact Map
3nzjK 1 1 9.3 0.87 Contact Map
3tgnA 2 0.9863 9.2 0.87 Contact Map
1jgsA 2 1 8.8 0.872 Contact Map
4iqzA 4 0.3014 8.6 0.872 Contact Map
3h4pa 5 1 7.9 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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