GREMLIN Database
PspC - PspC domain
PFAM: PF04024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (51)
Sequences: 52957 (30165)
Seq/√Len: 4223.9
META: 0.926

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_A47_W3.9821.00
16_C34_F2.2931.00
16_C30_V2.1771.00
7_R52_E2.0931.00
6_S9_D2.0181.00
6_S21_E1.8591.00
6_S17_G1.8121.00
46_L50_I1.8071.00
23_F30_V1.7481.00
9_D17_G1.5911.00
3_L50_I1.5521.00
26_D29_L1.5511.00
34_F38_T1.5301.00
25_I30_V1.4321.00
8_D11_M1.3631.00
10_R17_G1.2961.00
9_D27_P1.2821.00
45_I49_V1.2681.00
19_L30_V1.1921.00
10_R52_E1.1821.00
20_A27_P1.1531.00
34_F39_G1.1491.00
17_G27_P1.1411.00
29_L33_L1.1141.00
5_R52_E1.0621.00
5_R13_A1.0331.00
28_T32_L1.0001.00
18_G22_Y0.9791.00
3_L22_Y0.9731.00
6_S10_R0.9511.00
17_G21_E0.9121.00
34_F46_L0.9111.00
7_R10_R0.9051.00
5_R47_W0.8861.00
20_A30_V0.8481.00
4_Y50_I0.8261.00
25_I29_L0.8121.00
4_Y21_E0.7871.00
15_V50_I0.7831.00
19_L23_F0.7791.00
9_D21_E0.7661.00
35_V38_T0.7551.00
15_V47_W0.7491.00
15_V46_L0.7461.00
20_A25_I0.7461.00
42_A46_L0.7161.00
2_R22_Y0.6961.00
39_G42_A0.6811.00
8_D21_E0.6761.00
19_L34_F0.6681.00
36_L42_A0.6561.00
18_G50_I0.6291.00
19_L46_L0.6231.00
32_L36_L0.6141.00
7_R11_M0.6071.00
3_L19_L0.6061.00
11_M28_T0.6051.00
13_A44_L0.5961.00
33_L37_L0.5941.00
41_L44_L0.5921.00
3_L46_L0.5891.00
42_A45_I0.5811.00
25_I33_L0.5691.00
38_T42_A0.5631.00
34_F42_A0.5621.00
40_I44_L0.5571.00
16_C39_G0.5541.00
29_L32_L0.5461.00
7_R21_E0.5311.00
44_L48_I0.5301.00
16_C37_L0.5291.00
5_R15_V0.5191.00
47_W50_I0.5111.00
11_M31_R0.5061.00
46_L49_V0.5011.00
4_Y22_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3czxA 2 0.5283 7.4 0.849 Contact Map
3l51B 1 0.9057 7 0.85 Contact Map
1jwqA 1 0.4906 5.9 0.855 Contact Map
4dw1A 3 0.3774 5.5 0.857 Contact Map
3ne8A 2 0.6226 5.2 0.86 Contact Map
4x0eA 1 0.0755 5.1 0.86 Contact Map
2xq2A 2 0.9434 4.2 0.865 Contact Map
4rsiB 1 0.9057 4.2 0.865 Contact Map
3nd0A 2 1 4 0.866 Contact Map
3m3pA 1 0.9623 4 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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