GREMLIN Database
DUF359 - Protein of unknown function (DUF359)
PFAM: PF04019 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (123)
Sequences: 3261 (2367)
Seq/√Len: 213.4
META: 0.924

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_L83_L5.2941.00
22_K103_G3.7421.00
101_Q107_V3.2931.00
48_K77_D3.0431.00
50_P55_T2.9461.00
115_K118_K2.7001.00
2_T15_A2.3471.00
3_E7_K2.1901.00
93_E116_K2.0761.00
45_L72_V2.0691.00
47_V76_V1.9261.00
59_W90_L1.8961.00
46_R75_V1.8141.00
17_V73_L1.7891.00
96_V108_V1.7671.00
46_R77_D1.7261.00
87_A91_A1.6561.00
109_V115_K1.6331.00
92_P95_S1.6001.00
63_K90_L1.5801.00
98_V108_V1.5611.00
97_V111_V1.5481.00
61_A74_I1.5301.00
19_G75_V1.5251.00
88_I119_A1.4851.00
42_E71_P1.4761.00
65_A74_I1.4121.00
47_V61_A1.4041.00
98_V106_V1.3921.00
44_V75_V1.3881.00
16_I62_I1.3791.00
101_Q104_E1.3791.00
88_I97_V1.3771.00
61_A65_A1.3661.00
5_L98_V1.3491.00
120_R124_K1.3211.00
16_I87_A1.3041.00
93_E113_E1.3011.00
15_A73_L1.2971.00
12_P15_A1.2871.00
65_A72_V1.2621.00
91_A95_S1.2361.00
84_V88_I1.2341.00
1_V4_N1.2161.00
66_L91_A1.2131.00
54_I83_L1.1961.00
112_T115_K1.1571.00
50_P53_T1.1531.00
45_L61_A1.1471.00
117_E121_E1.1431.00
85_L119_A1.1421.00
6_L12_P1.1001.00
87_A97_V1.0811.00
17_V75_V1.0771.00
66_L87_A1.0521.00
44_V73_L1.0411.00
62_I87_A1.0351.00
1_V106_V1.0241.00
84_V97_V1.0241.00
1_V98_V1.0151.00
41_F73_L1.0141.00
115_K119_A1.0061.00
121_E125_R1.0051.00
93_E112_T1.0041.00
4_N7_K1.0041.00
14_L65_A0.9991.00
99_Y107_V0.9931.00
4_N106_V0.9811.00
16_I74_I0.9781.00
89_L120_R0.9751.00
3_E26_V0.9701.00
88_I109_V0.9691.00
4_N8_A0.9461.00
13_D71_P0.9340.99
48_K57_E0.9320.99
13_D95_S0.9280.99
89_L123_L0.9270.99
43_K70_E0.9180.99
47_V55_T0.8910.99
21_T24_K0.8870.99
26_V30_V0.8870.99
57_E61_A0.8690.99
20_K25_P0.8640.99
123_L126_M0.8640.99
10_I13_D0.8550.99
54_I62_I0.8540.99
117_E120_R0.8530.99
21_T26_V0.8510.99
56_E60_E0.8470.99
43_K72_V0.8280.99
20_K51_P0.8260.99
118_K122_L0.8220.99
55_T58_L0.8000.98
84_V101_Q0.7950.98
121_E124_K0.7810.98
86_P89_L0.7780.98
61_A64_E0.7720.98
14_L62_I0.7520.98
5_L106_V0.7520.98
47_V58_L0.7520.98
45_L65_A0.7520.98
54_I59_W0.7510.98
9_G12_P0.7480.97
62_I74_I0.7180.97
88_I111_V0.7080.96
91_A111_V0.7000.96
89_L119_A0.7000.96
55_T83_L0.6960.96
6_L41_F0.6930.96
82_L101_Q0.6920.96
101_Q105_G0.6900.96
5_L8_A0.6890.96
54_I86_P0.6890.96
47_V57_E0.6870.96
14_L87_A0.6830.96
85_L89_L0.6750.95
49_N65_A0.6720.95
11_I71_P0.6710.95
85_L88_I0.6710.95
114_E117_E0.6700.95
14_L66_L0.6680.95
59_W86_P0.6530.94
5_L12_P0.6520.94
17_V42_E0.6510.94
6_L11_I0.6510.94
29_E32_I0.6470.94
15_A106_V0.6470.94
94_G111_V0.6430.94
84_V89_L0.6410.94
52_G105_G0.6400.94
47_V65_A0.6400.94
94_G110_K0.6400.94
97_V109_V0.6390.94
39_S42_E0.6370.94
76_V80_E0.6310.93
113_E116_K0.6300.93
22_K102_P0.6260.93
5_L10_I0.6220.93
102_P105_G0.6170.93
42_E73_L0.6060.92
6_L15_A0.6040.92
84_V87_A0.5930.91
122_L126_M0.5910.91
21_T80_E0.5880.91
40_K46_R0.5850.91
60_E70_E0.5750.90
43_K68_S0.5720.90
57_E60_E0.5710.89
3_E30_V0.5700.89
60_E64_E0.5660.89
111_V116_K0.5630.89
77_D96_V0.5610.89
84_V109_V0.5610.89
8_A103_G0.5610.89
111_V119_A0.5560.88
84_V119_A0.5540.88
102_P107_V0.5530.88
39_S46_R0.5510.88
11_I15_A0.5440.87
27_D44_V0.5440.87
67_K114_E0.5430.87
16_I83_L0.5420.87
72_V75_V0.5400.87
45_L64_E0.5390.87
88_I116_K0.5360.86
8_A106_V0.5350.86
44_V62_I0.5340.86
88_I115_K0.5340.86
8_A21_T0.5340.86
3_E104_E0.5270.85
49_N98_V0.5240.85
84_V122_L0.5240.85
49_N53_T0.5200.85
2_T6_L0.5160.84
9_G121_E0.5140.84
4_N96_V0.5140.84
5_L13_D0.5100.84
104_E107_V0.5070.83
110_K126_M0.5070.83
50_P65_A0.5060.83
114_E126_M0.5060.83
64_E68_S0.5060.83
68_S72_V0.5030.83
93_E111_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oryA 3 0.9685 87.6 0.869 Contact Map
1rxwA 1 0.9449 86.1 0.872 Contact Map
4wa8A 1 0.7323 85 0.874 Contact Map
2izoA 1 0.6693 82.8 0.878 Contact Map
1a76A 1 0.9685 77.9 0.883 Contact Map
1b43A 2 0.9606 61.6 0.896 Contact Map
4q0wA 1 0.8661 39.8 0.909 Contact Map
1ul1X 1 0.8031 31.9 0.914 Contact Map
3q8kA 1 0.9685 31.6 0.914 Contact Map
2p62A 2 0.4173 31.4 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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