GREMLIN Database
Utp12 - Dip2/Utp12 Family
PFAM: PF04003 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (101)
Sequences: 1994 (1435)
Seq/√Len: 142.8
META: 0.337

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_P28_Y3.7501.00
9_L49_L3.5941.00
10_E45_H3.0611.00
53_L77_L2.6681.00
37_A80_A2.2591.00
6_L39_R2.2161.00
96_G101_Y2.2051.00
7_R11_S2.1591.00
28_Y31_R2.1431.00
41_E76_S1.9951.00
13_P16_D1.9161.00
21_L56_L1.8701.00
8_V11_S1.8321.00
55_F59_T1.7321.00
26_F63_Y1.7101.00
24_L29_V1.6831.00
37_A76_S1.6171.00
5_L35_F1.5761.00
61_G65_V1.5371.00
78_Q82_R1.5031.00
16_D19_L1.4961.00
94_L98_R1.4881.00
98_R101_Y1.4461.00
47_E51_R1.4341.00
2_E38_E1.4021.00
98_R102_L1.3731.00
62_G66_S1.3621.00
21_L59_T1.3291.00
86_K90_D1.3201.00
18_E55_F1.2951.00
63_Y67_N1.2751.00
20_T84_R1.2671.00
45_H48_L1.2641.00
35_F39_R1.2631.00
37_A53_L1.2571.00
29_V70_L1.2521.00
72_P81_L1.2131.00
16_D47_E1.1871.00
40_L84_R1.1851.00
73_V83_R1.1591.00
2_E12_I1.1560.99
36_L53_L1.1450.99
10_E48_L1.1100.99
22_L59_T1.1040.99
83_R87_E1.0990.99
64_L67_N1.0980.99
21_L55_F1.0770.99
57_L84_R1.0440.99
95_N98_R1.0350.99
17_I52_W1.0150.99
4_L8_V1.0040.99
45_H52_W1.0040.99
46_L84_R0.9940.98
91_L98_R0.9920.98
40_L53_L0.9870.98
93_G98_R0.9840.98
18_E51_R0.9710.98
6_L45_H0.9710.98
89_K93_G0.9350.98
5_L14_P0.9120.97
14_P18_E0.9100.97
57_L91_L0.9060.97
80_A88_L0.8960.97
9_L101_Y0.8950.97
13_P79_K0.8870.97
12_I15_S0.8800.97
6_L17_I0.8680.96
3_A7_R0.8660.96
31_R35_F0.8580.96
64_L74_L0.8540.96
7_R10_E0.8520.96
53_L102_L0.8430.96
46_L95_N0.8350.96
10_E72_P0.8340.95
5_L8_V0.8170.95
26_F60_H0.8120.95
90_D99_L0.8120.95
47_E102_L0.8020.94
26_F67_N0.7930.94
48_L95_N0.7920.94
47_E95_N0.7920.94
4_L17_I0.7890.94
11_S81_L0.7850.94
83_R99_L0.7840.94
6_L10_E0.7770.93
22_L55_F0.7750.93
85_L98_R0.7690.93
44_S66_S0.7680.93
22_L100_D0.7670.93
43_P87_E0.7510.92
27_S58_K0.7510.92
15_S22_L0.7490.92
18_E58_K0.7400.92
37_A61_G0.7210.91
85_L88_L0.7190.91
34_R80_A0.7100.90
38_E69_P0.7030.90
2_E11_S0.7000.89
8_V69_P0.6990.89
12_I47_E0.6960.89
29_V56_L0.6900.89
35_F62_G0.6850.88
55_F58_K0.6840.88
23_R29_V0.6790.88
5_L39_R0.6780.88
43_P49_L0.6730.87
13_P20_T0.6450.85
8_V12_I0.6440.85
48_L65_V0.6420.85
32_L96_G0.6400.85
73_V76_S0.6370.84
59_T63_Y0.6370.84
42_S78_Q0.6290.84
11_S15_S0.6220.83
37_A88_L0.6200.83
40_L50_L0.6080.82
2_E83_R0.6070.81
24_L32_L0.6050.81
22_L99_L0.6020.81
80_A84_R0.6000.81
3_A16_D0.5880.79
61_G81_L0.5860.79
96_G100_D0.5850.79
77_L80_A0.5850.79
22_L36_L0.5840.79
92_L97_A0.5750.78
86_K96_G0.5720.77
17_I31_R0.5650.77
45_H49_L0.5630.76
27_S76_S0.5590.76
29_V60_H0.5570.76
41_E44_S0.5530.75
28_Y102_L0.5490.75
64_L69_P0.5480.74
90_D93_G0.5430.74
96_G99_L0.5420.74
36_L49_L0.5420.74
37_A41_E0.5290.72
84_R91_L0.5280.72
94_L99_L0.5270.72
41_E50_L0.5260.71
63_Y70_L0.5180.70
10_E49_L0.5170.70
75_R82_R0.5170.70
12_I84_R0.5110.69
8_V54_K0.5060.69
52_W61_G0.5030.68
89_K95_N0.5020.68
25_P31_R0.5020.68
31_R34_R0.5010.68
4_L7_R0.5000.68
71_L75_R0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vu2F 1 0.9615 73.1 0.787 Contact Map
3s6n2 1 0.9135 70.3 0.791 Contact Map
3dwlG 1 0.6731 51.8 0.814 Contact Map
4bzjA 2 0.9904 46.4 0.82 Contact Map
1k8kG 1 0.7404 42.8 0.824 Contact Map
4rh7A 1 0.9423 14.1 0.861 Contact Map
3re2A 1 0.9423 10.1 0.869 Contact Map
2vxgA 1 0.9231 9.8 0.87 Contact Map
3wuqA 1 0.9615 9.3 0.872 Contact Map
1ybkA 3 0.4038 8.7 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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