Utp11 - PFAM28P - GREMLIN Contacts

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Utp11 - Utp11 protein

PFAM:	PF03998	Sequences: RRTHKERSQPASRKKLGLLEKHKDYVLRARDYHKKQDTLKALREKAAERNPDEFYFGMINSKTKDGVHVEKRKDRGNEALTPDQVKLLKTQDLGYVRTKRQVERKKIEKLKSELHLLDALGKPEEDKKNKHTVFVDDEEEAKEFDPAKHFDTDPELLDRRENRPRAKKREKLYKELEARIEREKELTKAEQKLELQRALMGKGRKKKVVGGTNKSGPVYKWRAERKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	227 (223)
Sequences:	622 (486)
Seq/√Len:	32.5
META:	0.17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_H	36_Q	6.522	1.00
22_H	26_V	6.214	1.00
26_V	30_R	4.638	1.00
175_E	179_R	3.930	1.00
34_K	38_T	3.344	1.00
100_R	190_E	3.151	1.00
135_V	144_F	3.132	1.00
81_T	84_Q	3.069	1.00
152_T	162_N	3.041	1.00
179_R	182_R	2.853	1.00
152_T	163_R	2.669	1.00
31_D	35_K	2.354	0.99
9_Q	21_K	2.201	0.99
13_R	21_K	2.186	0.99
25_Y	29_A	2.095	0.98
150_F	162_N	2.073	0.98
11_A	14_K	2.040	0.98
32_Y	36_Q	2.004	0.98
144_F	150_F	1.997	0.98
161_E	164_P	1.964	0.97
203_G	221_W	1.961	0.97
105_K	108_E	1.920	0.97
144_F	149_H	1.904	0.97
133_V	150_F	1.792	0.96
131_H	134_F	1.765	0.95
4_H	23_K	1.754	0.95
88_L	91_Q	1.746	0.95
113_E	172_L	1.715	0.94
207_K	219_Y	1.696	0.94
181_E	185_E	1.643	0.93
24_D	28_R	1.639	0.93
25_Y	33_H	1.617	0.92
108_E	112_S	1.615	0.92
159_R	164_P	1.615	0.92
100_R	104_R	1.614	0.92
144_F	152_T	1.591	0.92
146_P	149_H	1.585	0.92
151_D	165_R	1.583	0.92
44_E	48_E	1.572	0.91
211_G	217_P	1.553	0.91
63_T	67_V	1.547	0.91
57_G	205_K	1.520	0.90
152_T	157_L	1.489	0.89
159_R	163_R	1.485	0.89
114_L	173_Y	1.471	0.88
150_F	163_R	1.463	0.88
130_K	140_E	1.422	0.86
96_V	186_L	1.403	0.86
107_I	176_L	1.374	0.84
115_H	173_Y	1.365	0.84
145_D	150_F	1.351	0.83
211_G	216_G	1.346	0.83
40_K	186_L	1.340	0.83
149_H	152_T	1.332	0.83
148_K	151_D	1.322	0.82
145_D	156_L	1.309	0.81
146_P	150_F	1.307	0.81
147_A	159_R	1.307	0.81
94_G	97_R	1.270	0.79
137_D	140_E	1.265	0.79
109_K	113_E	1.263	0.79
96_V	193_L	1.249	0.78
103_E	182_R	1.239	0.78
6_E	9_Q	1.236	0.77
80_L	85_V	1.231	0.77
145_D	149_H	1.221	0.77
87_L	96_V	1.219	0.76
89_K	200_M	1.211	0.76
205_K	223_A	1.207	0.76
107_I	199_L	1.200	0.75
91_Q	95_Y	1.200	0.75
9_Q	19_L	1.191	0.75
36_Q	39_L	1.181	0.74
147_A	152_T	1.180	0.74
130_K	136_D	1.180	0.74
156_L	163_R	1.176	0.74
13_R	19_L	1.155	0.72
85_V	89_K	1.153	0.72
97_R	190_E	1.150	0.72
33_H	37_D	1.131	0.71
100_R	183_E	1.122	0.70
31_D	92_D	1.111	0.69
95_Y	182_R	1.106	0.69
74_D	77_N	1.104	0.69
29_A	35_K	1.098	0.69
8_S	12_S	1.097	0.68
99_K	129_N	1.096	0.68
82_P	85_V	1.085	0.68
107_I	172_L	1.083	0.67
198_A	201_G	1.081	0.67
85_V	91_Q	1.080	0.67
15_K	203_G	1.079	0.67
149_H	157_L	1.077	0.67
88_L	94_G	1.069	0.66
131_H	162_N	1.069	0.66
110_L	175_E	1.068	0.66
111_K	180_I	1.068	0.66
145_D	152_T	1.067	0.66
199_L	219_Y	1.065	0.66
144_F	148_K	1.064	0.66
150_F	159_R	1.064	0.66
189_A	193_L	1.058	0.66
10_P	16_L	1.055	0.65
84_Q	189_A	1.052	0.65
195_L	199_L	1.045	0.65
20_E	28_R	1.044	0.65
89_K	196_Q	1.038	0.64
5_K	8_S	1.027	0.63
10_P	94_G	1.026	0.63
182_R	219_Y	1.013	0.62
49_R	60_N	0.992	0.61
25_Y	28_R	0.965	0.58
64_K	69_V	0.961	0.58
24_D	29_A	0.960	0.58
203_G	207_K	0.958	0.58
50_N	53_E	0.958	0.58
110_L	129_N	0.954	0.57
44_E	143_E	0.950	0.57
211_G	215_S	0.939	0.56
162_N	165_R	0.934	0.56
23_K	95_Y	0.930	0.56
62_K	112_S	0.925	0.55
152_T	156_L	0.923	0.55
149_H	154_P	0.923	0.55
83_D	91_Q	0.919	0.55
152_T	165_R	0.915	0.54
4_H	7_R	0.907	0.54
85_V	97_R	0.900	0.53
144_F	163_R	0.899	0.53
4_H	19_L	0.897	0.53
210_G	226_K	0.896	0.53
61_S	70_E	0.895	0.53
132_T	135_V	0.895	0.53
76_G	79_A	0.892	0.52
144_F	147_A	0.891	0.52
8_S	11_A	0.887	0.52
214_K	221_W	0.887	0.52
152_T	164_P	0.887	0.52
20_E	25_Y	0.870	0.51
194_E	198_A	0.865	0.50
7_R	20_E	0.864	0.50
2_R	44_E	0.862	0.50
147_A	154_P	0.857	0.50
160_R	164_P	0.846	0.49
30_R	38_T	0.845	0.49
149_H	163_R	0.845	0.49
33_H	40_K	0.845	0.49
1_R	49_R	0.843	0.48
35_K	91_Q	0.840	0.48
13_R	20_E	0.838	0.48
192_K	196_Q	0.836	0.48
33_H	49_R	0.834	0.48
6_E	20_E	0.828	0.47
42_L	90_T	0.828	0.47
106_K	175_E	0.825	0.47
101_Q	105_K	0.825	0.47
17_G	20_E	0.822	0.47
96_V	190_E	0.822	0.47
149_H	155_E	0.817	0.46
34_K	207_K	0.813	0.46
7_R	13_R	0.812	0.46
51_P	217_P	0.809	0.46
1_R	84_Q	0.808	0.45
156_L	162_N	0.808	0.45
177_E	180_I	0.800	0.45
79_A	85_V	0.793	0.44
103_E	179_R	0.790	0.44
1_R	15_K	0.788	0.44
212_T	221_W	0.786	0.44
102_V	108_E	0.785	0.44
77_N	96_V	0.784	0.44
92_D	95_Y	0.781	0.43
159_R	162_N	0.779	0.43
179_R	186_L	0.779	0.43
140_E	144_F	0.777	0.43
109_K	212_T	0.774	0.43
7_R	19_L	0.774	0.43
81_T	103_E	0.772	0.43
87_L	177_E	0.770	0.42
194_E	197_R	0.767	0.42
6_E	13_R	0.767	0.42
8_S	21_K	0.762	0.42
83_D	105_K	0.760	0.42
150_F	156_L	0.760	0.42
168_K	172_L	0.758	0.41
150_F	153_D	0.755	0.41
212_T	216_G	0.752	0.41
133_V	149_H	0.748	0.41
83_D	90_T	0.744	0.40
45_K	56_F	0.743	0.40
18_L	21_K	0.739	0.40
6_E	19_L	0.738	0.40
150_F	157_L	0.731	0.39
42_L	195_L	0.729	0.39
140_E	143_E	0.720	0.38
63_T	203_G	0.718	0.38
29_A	105_K	0.716	0.38
57_G	61_S	0.716	0.38
161_E	165_R	0.707	0.37
200_M	204_R	0.706	0.37
118_D	173_Y	0.706	0.37
22_H	30_R	0.705	0.37
84_Q	87_L	0.700	0.37
156_L	164_P	0.700	0.37
206_K	222_R	0.700	0.37
145_D	162_N	0.697	0.37
1_R	47_A	0.695	0.36
145_D	154_P	0.693	0.36
103_E	183_E	0.692	0.36
2_R	41_A	0.691	0.36
45_K	200_M	0.688	0.36
198_A	205_K	0.687	0.36
224_E	227_R	0.687	0.36
167_K	171_K	0.687	0.36
111_K	114_L	0.684	0.36
30_R	43_R	0.683	0.36
7_R	24_D	0.682	0.35
100_R	107_I	0.678	0.35
4_H	21_K	0.676	0.35
68_H	179_R	0.676	0.35
144_F	151_D	0.676	0.35
149_H	162_N	0.675	0.35
135_V	141_A	0.674	0.35
106_K	179_R	0.672	0.35
132_T	150_F	0.672	0.35
89_K	201_G	0.670	0.35
153_D	163_R	0.668	0.34
20_E	24_D	0.663	0.34
138_E	151_D	0.663	0.34
127_K	142_K	0.662	0.34
93_L	193_L	0.660	0.34
2_R	169_R	0.658	0.34
6_E	24_D	0.651	0.33
52_D	58_M	0.646	0.33
60_N	74_D	0.643	0.33
185_E	224_E	0.643	0.33
60_N	73_K	0.642	0.33
107_I	183_E	0.641	0.32
7_R	17_G	0.640	0.32
160_R	163_R	0.639	0.32
121_G	127_K	0.638	0.32
4_H	95_Y	0.633	0.32
144_F	157_L	0.632	0.32
154_P	159_R	0.632	0.32
101_Q	227_R	0.631	0.32
19_L	24_D	0.630	0.32
169_R	190_E	0.627	0.31
148_K	159_R	0.625	0.31
113_E	134_F	0.623	0.31
213_N	216_G	0.619	0.31
53_E	58_M	0.619	0.31
4_H	13_R	0.618	0.31
175_E	218_V	0.617	0.31
84_Q	185_E	0.616	0.31
137_D	158_D	0.613	0.30
1_R	5_K	0.607	0.30
6_E	17_G	0.605	0.30
1_R	22_H	0.601	0.30
220_K	224_E	0.600	0.30
13_R	17_G	0.598	0.29
101_Q	111_K	0.598	0.29
98_T	101_Q	0.598	0.29
199_L	221_W	0.596	0.29
30_R	85_V	0.594	0.29
31_D	55_Y	0.593	0.29
131_H	156_L	0.592	0.29
86_K	112_S	0.590	0.29
37_D	105_K	0.588	0.29
42_L	53_E	0.586	0.29
35_K	52_D	0.583	0.28
21_K	24_D	0.578	0.28
23_K	136_D	0.577	0.28
81_T	189_A	0.575	0.28
77_N	82_P	0.574	0.28
46_A	50_N	0.573	0.28
22_H	182_R	0.572	0.28
91_Q	197_R	0.571	0.28
69_V	171_K	0.571	0.28
102_V	186_L	0.571	0.28
9_Q	20_E	0.570	0.28
148_K	154_P	0.569	0.27
92_D	103_E	0.569	0.27
38_T	47_A	0.566	0.27
179_R	218_V	0.566	0.27
181_E	184_K	0.566	0.27
156_L	185_E	0.563	0.27
26_V	33_H	0.562	0.27
196_Q	211_G	0.562	0.27
7_R	21_K	0.559	0.27
107_I	180_I	0.559	0.27
59_I	140_E	0.557	0.27
27_L	46_A	0.556	0.27
4_H	45_K	0.556	0.27
105_K	158_D	0.554	0.26
87_L	122_K	0.553	0.26
37_D	40_K	0.553	0.26
17_G	23_K	0.549	0.26
115_H	118_D	0.549	0.26
103_E	107_I	0.547	0.26
146_P	157_L	0.547	0.26
96_V	171_K	0.547	0.26
13_R	24_D	0.546	0.26
210_G	222_R	0.546	0.26
2_R	103_E	0.542	0.26
57_G	70_E	0.542	0.26
96_V	189_A	0.541	0.26
106_K	114_L	0.540	0.26
30_R	37_D	0.539	0.26
145_D	163_R	0.538	0.25
17_G	29_A	0.536	0.25
119_A	214_K	0.535	0.25
42_L	45_K	0.533	0.25
101_Q	107_I	0.531	0.25
108_E	227_R	0.531	0.25
116_L	173_Y	0.529	0.25
51_P	164_P	0.525	0.25
49_R	71_K	0.524	0.25
106_K	115_H	0.524	0.25
61_S	75_R	0.524	0.25
68_H	175_E	0.523	0.25
9_Q	13_R	0.522	0.24
106_K	221_W	0.522	0.24
6_E	21_K	0.520	0.24
50_N	58_M	0.520	0.24
54_F	166_A	0.518	0.24
150_F	161_E	0.518	0.24
209_V	214_K	0.518	0.24
2_R	6_E	0.517	0.24
18_L	96_V	0.515	0.24
154_P	202_K	0.510	0.24
186_L	196_Q	0.508	0.24
4_H	18_L	0.507	0.24
208_V	221_W	0.504	0.23
17_G	21_K	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1iqoA	1	0.3877	3.2	0.971	Contact Map
3tweA	2	0.1145	2.6	0.972	Contact Map
4c5iC	1	0.0705	1.8	0.975	Contact Map
4c5eE	2	0.1322	1.6	0.975	Contact Map
4g3bA	3	0.1013	1.6	0.975	Contact Map
2jwsA	1	0.2423	1.3	0.977	Contact Map
2dgcA	2	0.1982	1.2	0.977	Contact Map
4g9jC	1	0.0573	1	0.978	Contact Map
2m5wA	1	0.3965	1	0.979	Contact Map
4cc9C	1	0.0837	0.9	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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