GREMLIN Database
Utp11 - Utp11 protein
PFAM: PF03998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 227 (223)
Sequences: 622 (486)
Seq/√Len: 32.5
META: 0.17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_H36_Q6.5221.00
22_H26_V6.2141.00
26_V30_R4.6381.00
175_E179_R3.9301.00
34_K38_T3.3441.00
100_R190_E3.1511.00
135_V144_F3.1321.00
81_T84_Q3.0691.00
152_T162_N3.0411.00
179_R182_R2.8531.00
152_T163_R2.6691.00
31_D35_K2.3540.99
9_Q21_K2.2010.99
13_R21_K2.1860.99
25_Y29_A2.0950.98
150_F162_N2.0730.98
11_A14_K2.0400.98
32_Y36_Q2.0040.98
144_F150_F1.9970.98
161_E164_P1.9640.97
203_G221_W1.9610.97
105_K108_E1.9200.97
144_F149_H1.9040.97
133_V150_F1.7920.96
131_H134_F1.7650.95
4_H23_K1.7540.95
88_L91_Q1.7460.95
113_E172_L1.7150.94
207_K219_Y1.6960.94
181_E185_E1.6430.93
24_D28_R1.6390.93
25_Y33_H1.6170.92
108_E112_S1.6150.92
159_R164_P1.6150.92
100_R104_R1.6140.92
144_F152_T1.5910.92
146_P149_H1.5850.92
151_D165_R1.5830.92
44_E48_E1.5720.91
211_G217_P1.5530.91
63_T67_V1.5470.91
57_G205_K1.5200.90
152_T157_L1.4890.89
159_R163_R1.4850.89
114_L173_Y1.4710.88
150_F163_R1.4630.88
130_K140_E1.4220.86
96_V186_L1.4030.86
107_I176_L1.3740.84
115_H173_Y1.3650.84
145_D150_F1.3510.83
211_G216_G1.3460.83
40_K186_L1.3400.83
149_H152_T1.3320.83
148_K151_D1.3220.82
145_D156_L1.3090.81
146_P150_F1.3070.81
147_A159_R1.3070.81
94_G97_R1.2700.79
137_D140_E1.2650.79
109_K113_E1.2630.79
96_V193_L1.2490.78
103_E182_R1.2390.78
6_E9_Q1.2360.77
80_L85_V1.2310.77
145_D149_H1.2210.77
87_L96_V1.2190.76
89_K200_M1.2110.76
205_K223_A1.2070.76
107_I199_L1.2000.75
91_Q95_Y1.2000.75
9_Q19_L1.1910.75
36_Q39_L1.1810.74
147_A152_T1.1800.74
130_K136_D1.1800.74
156_L163_R1.1760.74
13_R19_L1.1550.72
85_V89_K1.1530.72
97_R190_E1.1500.72
33_H37_D1.1310.71
100_R183_E1.1220.70
31_D92_D1.1110.69
95_Y182_R1.1060.69
74_D77_N1.1040.69
29_A35_K1.0980.69
8_S12_S1.0970.68
99_K129_N1.0960.68
82_P85_V1.0850.68
107_I172_L1.0830.67
198_A201_G1.0810.67
85_V91_Q1.0800.67
15_K203_G1.0790.67
149_H157_L1.0770.67
88_L94_G1.0690.66
131_H162_N1.0690.66
110_L175_E1.0680.66
111_K180_I1.0680.66
145_D152_T1.0670.66
199_L219_Y1.0650.66
144_F148_K1.0640.66
150_F159_R1.0640.66
189_A193_L1.0580.66
10_P16_L1.0550.65
84_Q189_A1.0520.65
195_L199_L1.0450.65
20_E28_R1.0440.65
89_K196_Q1.0380.64
5_K8_S1.0270.63
10_P94_G1.0260.63
182_R219_Y1.0130.62
49_R60_N0.9920.61
25_Y28_R0.9650.58
64_K69_V0.9610.58
24_D29_A0.9600.58
203_G207_K0.9580.58
50_N53_E0.9580.58
110_L129_N0.9540.57
44_E143_E0.9500.57
211_G215_S0.9390.56
162_N165_R0.9340.56
23_K95_Y0.9300.56
62_K112_S0.9250.55
152_T156_L0.9230.55
149_H154_P0.9230.55
83_D91_Q0.9190.55
152_T165_R0.9150.54
4_H7_R0.9070.54
85_V97_R0.9000.53
144_F163_R0.8990.53
4_H19_L0.8970.53
210_G226_K0.8960.53
61_S70_E0.8950.53
132_T135_V0.8950.53
76_G79_A0.8920.52
144_F147_A0.8910.52
8_S11_A0.8870.52
214_K221_W0.8870.52
152_T164_P0.8870.52
20_E25_Y0.8700.51
194_E198_A0.8650.50
7_R20_E0.8640.50
2_R44_E0.8620.50
147_A154_P0.8570.50
160_R164_P0.8460.49
30_R38_T0.8450.49
149_H163_R0.8450.49
33_H40_K0.8450.49
1_R49_R0.8430.48
35_K91_Q0.8400.48
13_R20_E0.8380.48
192_K196_Q0.8360.48
33_H49_R0.8340.48
6_E20_E0.8280.47
42_L90_T0.8280.47
106_K175_E0.8250.47
101_Q105_K0.8250.47
17_G20_E0.8220.47
96_V190_E0.8220.47
149_H155_E0.8170.46
34_K207_K0.8130.46
7_R13_R0.8120.46
51_P217_P0.8090.46
1_R84_Q0.8080.45
156_L162_N0.8080.45
177_E180_I0.8000.45
79_A85_V0.7930.44
103_E179_R0.7900.44
1_R15_K0.7880.44
212_T221_W0.7860.44
102_V108_E0.7850.44
77_N96_V0.7840.44
92_D95_Y0.7810.43
159_R162_N0.7790.43
179_R186_L0.7790.43
140_E144_F0.7770.43
109_K212_T0.7740.43
7_R19_L0.7740.43
81_T103_E0.7720.43
87_L177_E0.7700.42
194_E197_R0.7670.42
6_E13_R0.7670.42
8_S21_K0.7620.42
83_D105_K0.7600.42
150_F156_L0.7600.42
168_K172_L0.7580.41
150_F153_D0.7550.41
212_T216_G0.7520.41
133_V149_H0.7480.41
83_D90_T0.7440.40
45_K56_F0.7430.40
18_L21_K0.7390.40
6_E19_L0.7380.40
150_F157_L0.7310.39
42_L195_L0.7290.39
140_E143_E0.7200.38
63_T203_G0.7180.38
29_A105_K0.7160.38
57_G61_S0.7160.38
161_E165_R0.7070.37
200_M204_R0.7060.37
118_D173_Y0.7060.37
22_H30_R0.7050.37
84_Q87_L0.7000.37
156_L164_P0.7000.37
206_K222_R0.7000.37
145_D162_N0.6970.37
1_R47_A0.6950.36
145_D154_P0.6930.36
103_E183_E0.6920.36
2_R41_A0.6910.36
45_K200_M0.6880.36
198_A205_K0.6870.36
224_E227_R0.6870.36
167_K171_K0.6870.36
111_K114_L0.6840.36
30_R43_R0.6830.36
7_R24_D0.6820.35
100_R107_I0.6780.35
4_H21_K0.6760.35
68_H179_R0.6760.35
144_F151_D0.6760.35
149_H162_N0.6750.35
135_V141_A0.6740.35
106_K179_R0.6720.35
132_T150_F0.6720.35
89_K201_G0.6700.35
153_D163_R0.6680.34
20_E24_D0.6630.34
138_E151_D0.6630.34
127_K142_K0.6620.34
93_L193_L0.6600.34
2_R169_R0.6580.34
6_E24_D0.6510.33
52_D58_M0.6460.33
60_N74_D0.6430.33
185_E224_E0.6430.33
60_N73_K0.6420.33
107_I183_E0.6410.32
7_R17_G0.6400.32
160_R163_R0.6390.32
121_G127_K0.6380.32
4_H95_Y0.6330.32
144_F157_L0.6320.32
154_P159_R0.6320.32
101_Q227_R0.6310.32
19_L24_D0.6300.32
169_R190_E0.6270.31
148_K159_R0.6250.31
113_E134_F0.6230.31
213_N216_G0.6190.31
53_E58_M0.6190.31
4_H13_R0.6180.31
175_E218_V0.6170.31
84_Q185_E0.6160.31
137_D158_D0.6130.30
1_R5_K0.6070.30
6_E17_G0.6050.30
1_R22_H0.6010.30
220_K224_E0.6000.30
13_R17_G0.5980.29
101_Q111_K0.5980.29
98_T101_Q0.5980.29
199_L221_W0.5960.29
30_R85_V0.5940.29
31_D55_Y0.5930.29
131_H156_L0.5920.29
86_K112_S0.5900.29
37_D105_K0.5880.29
42_L53_E0.5860.29
35_K52_D0.5830.28
21_K24_D0.5780.28
23_K136_D0.5770.28
81_T189_A0.5750.28
77_N82_P0.5740.28
46_A50_N0.5730.28
22_H182_R0.5720.28
91_Q197_R0.5710.28
69_V171_K0.5710.28
102_V186_L0.5710.28
9_Q20_E0.5700.28
148_K154_P0.5690.27
92_D103_E0.5690.27
38_T47_A0.5660.27
179_R218_V0.5660.27
181_E184_K0.5660.27
156_L185_E0.5630.27
26_V33_H0.5620.27
196_Q211_G0.5620.27
7_R21_K0.5590.27
107_I180_I0.5590.27
59_I140_E0.5570.27
27_L46_A0.5560.27
4_H45_K0.5560.27
105_K158_D0.5540.26
87_L122_K0.5530.26
37_D40_K0.5530.26
17_G23_K0.5490.26
115_H118_D0.5490.26
103_E107_I0.5470.26
146_P157_L0.5470.26
96_V171_K0.5470.26
13_R24_D0.5460.26
210_G222_R0.5460.26
2_R103_E0.5420.26
57_G70_E0.5420.26
96_V189_A0.5410.26
106_K114_L0.5400.26
30_R37_D0.5390.26
145_D163_R0.5380.25
17_G29_A0.5360.25
119_A214_K0.5350.25
42_L45_K0.5330.25
101_Q107_I0.5310.25
108_E227_R0.5310.25
116_L173_Y0.5290.25
51_P164_P0.5250.25
49_R71_K0.5240.25
106_K115_H0.5240.25
61_S75_R0.5240.25
68_H175_E0.5230.25
9_Q13_R0.5220.24
106_K221_W0.5220.24
6_E21_K0.5200.24
50_N58_M0.5200.24
54_F166_A0.5180.24
150_F161_E0.5180.24
209_V214_K0.5180.24
2_R6_E0.5170.24
18_L96_V0.5150.24
154_P202_K0.5100.24
186_L196_Q0.5080.24
4_H18_L0.5070.24
208_V221_W0.5040.23
17_G21_K0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iqoA 1 0.3877 3.2 0.971 Contact Map
3tweA 2 0.1145 2.6 0.972 Contact Map
4c5iC 1 0.0705 1.8 0.975 Contact Map
4c5eE 2 0.1322 1.6 0.975 Contact Map
4g3bA 3 0.1013 1.6 0.975 Contact Map
2jwsA 1 0.2423 1.3 0.977 Contact Map
2dgcA 2 0.1982 1.2 0.977 Contact Map
4g9jC 1 0.0573 1 0.978 Contact Map
2m5wA 1 0.3965 1 0.979 Contact Map
4cc9C 1 0.0837 0.9 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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