GREMLIN Database
DUF350 - Domain of Unknown Function (DUF350)
PFAM: PF03994 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (54)
Sequences: 22210 (12615)
Seq/√Len: 1716.7
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_K30_E3.4381.00
12_A47_I2.6171.00
27_E32_N2.5171.00
23_D26_K2.5131.00
20_T24_L2.0941.00
25_W29_R1.6801.00
37_A41_G1.6631.00
13_F25_W1.6631.00
14_F18_K1.6431.00
13_F40_L1.4631.00
49_L52_A1.4371.00
27_E30_E1.3891.00
26_K31_G1.3731.00
39_V42_G1.3521.00
13_F44_L1.3421.00
12_A43_V1.2781.00
2_G6_L1.2601.00
14_F25_W1.2191.00
45_I49_L1.2191.00
9_L44_L1.1961.00
33_N38_I1.1761.00
27_E36_A1.1371.00
9_L48_A1.1311.00
32_N36_A1.1241.00
16_Y43_V1.1181.00
30_E33_N1.0981.00
14_F17_D1.0571.00
18_K23_D1.0541.00
48_A52_A1.0271.00
17_D25_W1.0151.00
16_Y39_V1.0031.00
24_L40_L0.9991.00
28_I36_A0.9831.00
27_E31_G0.9481.00
24_L36_A0.9291.00
46_G50_I0.9081.00
10_L14_F0.8791.00
17_D24_L0.8761.00
6_L10_L0.8711.00
11_L15_I0.8501.00
17_D20_T0.8431.00
29_R32_N0.8391.00
26_K29_R0.8311.00
5_G51_I0.8131.00
32_N35_A0.8111.00
11_L14_F0.8101.00
33_N37_A0.8051.00
16_Y40_L0.7871.00
3_V7_V0.7871.00
18_K21_P0.7511.00
45_I48_A0.7401.00
41_G45_I0.7121.00
40_L44_L0.6981.00
42_G46_G0.6901.00
16_Y20_T0.6861.00
44_L48_A0.6681.00
14_F23_D0.6661.00
17_D23_D0.6411.00
8_L47_I0.6381.00
22_Y36_A0.6251.00
2_G5_G0.6251.00
49_L53_A0.6151.00
38_I41_G0.6091.00
47_I51_I0.6031.00
41_G44_L0.6001.00
19_L39_V0.5951.00
44_L54_A0.5861.00
29_R33_N0.5641.00
1_Y6_L0.5501.00
31_G35_A0.5491.00
2_G8_L0.5441.00
39_V43_V0.5401.00
7_V11_L0.5271.00
43_V47_I0.5221.00
5_G9_L0.5221.00
12_A16_Y0.5211.00
37_A44_L0.5211.00
4_V7_V0.5181.00
1_Y44_L0.5081.00
1_Y53_A0.5041.00
1_Y8_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.9818 2.5 0.83 Contact Map
3mk7C 2 1 1.9 0.84 Contact Map
2wswA 3 1 1.9 0.84 Contact Map
3l1lA 2 0.9455 1.9 0.842 Contact Map
4rp9A 2 0.4909 1.9 0.842 Contact Map
2ww8A 1 0 1.8 0.843 Contact Map
2nq2A 2 1 1.8 0.843 Contact Map
4g1uA 2 1 1.8 0.844 Contact Map
4c7rA 3 1 1.7 0.845 Contact Map
4od4A 1 1 1.6 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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