GREMLIN Database
DUF347 - Repeat of Unknown Function (DUF347)
PFAM: PF03988 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (50)
Sequences: 31332 (11631)
Seq/√Len: 1644.8
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A48_R3.1641.00
7_I10_T2.1931.00
33_L37_A2.0811.00
19_F23_G1.9621.00
30_G33_L1.9601.00
22_D28_Y1.9551.00
2_Y6_I1.9301.00
36_A40_A1.6511.00
40_A44_A1.5211.00
4_L8_L1.5011.00
37_A41_V1.4561.00
38_L42_V1.4451.00
45_A49_T1.4321.00
43_L47_Y1.4061.00
20_L35_F1.3551.00
29_L33_L1.3001.00
21_A31_G1.2701.00
12_L16_L1.2331.00
19_F24_L1.2221.00
6_I10_T1.2091.00
43_L46_W1.2021.00
7_I11_T1.1821.00
28_Y32_S1.1541.00
41_V45_A1.1521.00
20_L31_G1.1481.00
6_I14_T1.0851.00
15_T18_D1.0751.00
29_L32_S1.0661.00
27_G30_G1.0441.00
30_G34_I1.0251.00
17_G21_A0.9951.00
20_L26_L0.9721.00
44_A47_Y0.9281.00
26_L30_G0.8851.00
26_L34_I0.8571.00
2_Y14_T0.8241.00
9_T15_T0.8161.00
14_T47_Y0.8151.00
17_G31_G0.8041.00
20_L24_L0.8021.00
1_L10_T0.8011.00
39_L46_W0.7921.00
28_Y31_G0.7631.00
21_A28_Y0.7621.00
26_L31_G0.7571.00
2_Y46_W0.7061.00
32_S36_A0.7021.00
5_A14_T0.6961.00
11_T15_T0.6891.00
16_L19_F0.6821.00
27_G31_G0.6811.00
9_T12_L0.6651.00
1_L4_L0.6641.00
16_L20_L0.6521.00
5_A9_T0.6441.00
12_L15_T0.6261.00
35_F38_L0.6241.00
38_L41_V0.6191.00
39_L43_L0.6131.00
34_I37_A0.6051.00
1_L6_I0.5941.00
45_A48_R0.5881.00
5_A15_T0.5801.00
9_T17_G0.5771.00
10_T14_T0.5711.00
21_A27_G0.5541.00
33_L36_A0.5501.00
41_V44_A0.5491.00
20_L34_I0.5481.00
46_W50_R0.5271.00
6_I15_T0.5211.00
22_D25_G0.5131.00
20_L23_G0.5051.00
1_L9_T0.5021.00
8_L12_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.9808 24.3 0.75 Contact Map
4i0uA 4 0.9615 24.2 0.75 Contact Map
4g1uA 2 0.8654 7.9 0.799 Contact Map
4twkA 2 0.9038 5.9 0.811 Contact Map
2nq2A 2 0.9038 5 0.817 Contact Map
2qksA 4 0.9423 3.5 0.831 Contact Map
4wgvA 2 0.9423 3.1 0.834 Contact Map
1lnqA 6 0.8462 2.7 0.839 Contact Map
2qi9A 2 0.9038 2.6 0.841 Contact Map
1p7bA 3 0.9423 2.5 0.843 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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