GREMLIN Database
DTW - DTW domain
PFAM: PF03942 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 198 (187)
Sequences: 6152 (4258)
Seq/√Len: 311.3
META: 0.717

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_R191_D4.8631.00
48_A169_A4.3941.00
115_L172_A3.4311.00
117_V169_A3.3691.00
28_R56_E3.3001.00
49_A55_S3.2451.00
80_P114_L2.9961.00
30_L114_L2.8071.00
83_L117_V2.6331.00
118_L128_M2.5461.00
23_D53_P2.5271.00
118_L129_L2.4241.00
60_G63_F2.3961.00
86_G140_R2.3311.00
6_R50_L2.2241.00
159_R162_C1.9811.00
84_F125_A1.8761.00
127_K131_R1.8451.00
129_L140_R1.8371.00
89_A142_S1.8081.00
157_E162_C1.7911.00
46_R50_L1.7641.00
183_A187_L1.7611.00
2_P11_L1.7331.00
28_R114_L1.7201.00
56_E68_A1.6751.00
43_N46_R1.6721.00
22_L25_R1.6701.00
78_R114_L1.6651.00
49_A57_L1.6521.00
81_V113_P1.6441.00
82_L129_L1.6181.00
81_V141_V1.6061.00
179_D182_A1.5451.00
79_Q113_P1.4941.00
69_L73_L1.4881.00
31_I45_G1.4841.00
80_P116_I1.4821.00
120_G124_Q1.4721.00
45_G57_L1.4581.00
30_L116_I1.4531.00
147_R171_L1.4491.00
36_R124_Q1.4221.00
151_Y190_F1.4121.00
29_V52_L1.3871.00
45_G55_S1.3651.00
91_P94_E1.3581.00
192_A195_E1.3401.00
174_A183_A1.3251.00
64_E134_W1.3111.00
62_R65_P1.3061.00
79_Q111_K1.2911.00
68_A71_A1.2851.00
120_G125_A1.2771.00
21_P53_P1.2761.00
164_S190_F1.2731.00
146_E171_L1.2721.00
4_C7_C1.2561.00
116_I138_L1.2551.00
192_A196_R1.2481.00
88_D140_R1.2141.00
5_P8_R1.2131.00
82_L138_L1.2111.00
30_L58_F1.1981.00
181_E184_D1.1961.00
150_R153_R1.1931.00
34_H124_Q1.1911.00
45_G120_G1.1891.00
15_L47_L1.1871.00
27_T177_E1.1841.00
171_L174_A1.1751.00
133_P136_Q1.1641.00
18_L192_A1.1521.00
29_V169_A1.1501.00
31_I169_A1.1431.00
67_P71_A1.1401.00
58_F66_D1.1361.00
27_T115_L1.1351.00
61_E64_E1.1331.00
126_R130_R1.1301.00
29_V173_L1.0981.00
128_M132_S1.0921.00
61_E65_P1.0751.00
171_L175_L1.0621.00
69_L116_I1.0541.00
33_Q45_G1.0511.00
51_S189_P1.0441.00
32_L60_G1.0321.00
78_R113_P1.0281.00
29_V115_L1.0261.00
70_L134_W1.0231.00
89_A92_L1.0171.00
158_P162_C1.0101.00
172_A176_L1.0031.00
70_L74_A0.9921.00
82_L140_R0.9851.00
66_D70_L0.9821.00
9_R15_L0.9771.00
60_G132_S0.9741.00
10_P13_L0.9741.00
170_A174_A0.9611.00
166_L190_F0.9591.00
65_P70_L0.9551.00
24_T54_N0.9481.00
38_V42_S0.9411.00
31_I49_A0.9331.00
66_D69_L0.9321.00
147_R150_R0.9261.00
180_P184_D0.9231.00
44_T190_F0.9171.00
38_V59_V0.9151.00
153_R195_E0.9151.00
174_A180_P0.9081.00
170_A183_A0.9041.00
92_L95_L0.9001.00
33_Q59_V0.8991.00
166_L186_L0.8911.00
144_P175_L0.8851.00
27_T173_L0.8831.00
189_P192_A0.8821.00
163_L168_A0.8791.00
75_D78_R0.8781.00
48_A166_L0.8761.00
170_A187_L0.8741.00
117_V168_A0.8531.00
40_K124_Q0.8531.00
184_D188_A0.8451.00
35_P39_K0.8391.00
63_F66_D0.8261.00
188_A191_D0.8241.00
38_V41_P0.8241.00
86_G89_A0.8231.00
67_P74_A0.8191.00
185_A188_A0.8141.00
24_T53_P0.8091.00
51_S186_L0.8081.00
71_A74_A0.8071.00
148_P160_P0.8011.00
189_P193_M0.7961.00
52_L173_L0.7801.00
81_V112_P0.7781.00
19_I189_P0.7770.99
28_R54_N0.7680.99
115_L176_L0.7680.99
61_E124_Q0.7670.99
171_L187_L0.7610.99
178_G182_A0.7560.99
129_L136_Q0.7520.99
149_S190_F0.7510.99
31_I48_A0.7510.99
66_D71_A0.7510.99
76_P79_Q0.7430.99
69_L72_L0.7380.99
149_S157_E0.7380.99
3_R8_R0.7330.99
188_A192_A0.7300.99
68_A72_L0.7240.99
19_I50_L0.7210.99
135_L138_L0.7200.99
28_R112_P0.7190.99
58_F62_R0.7190.99
42_S124_Q0.7190.99
75_D111_K0.7170.99
29_V117_V0.7160.99
82_L85_P0.7160.99
124_Q130_R0.7120.99
90_A99_E0.7120.99
35_P63_F0.7110.99
42_S154_L0.7080.99
48_A51_S0.7070.99
123_R127_K0.7040.99
56_E72_L0.7000.99
172_A175_L0.6990.99
126_R158_P0.6990.99
191_D195_E0.6980.99
182_A185_A0.6930.99
33_Q164_S0.6890.99
9_R43_N0.6890.99
79_Q109_L0.6870.99
91_P144_P0.6810.99
145_P148_P0.6810.99
47_L166_L0.6770.99
177_E183_A0.6740.99
124_Q127_K0.6740.99
120_G155_R0.6710.99
24_T28_R0.6700.99
24_T52_L0.6700.99
95_L98_S0.6680.98
92_L175_L0.6670.98
5_P11_L0.6650.98
89_A140_R0.6650.98
96_A99_E0.6600.98
157_E163_L0.6580.98
52_L55_S0.6560.98
40_K43_N0.6560.98
186_L189_P0.6520.98
185_A189_P0.6490.98
19_I51_S0.6460.98
117_V120_G0.6450.98
3_R13_L0.6430.98
174_A178_G0.6410.98
9_R42_S0.6390.98
189_P197_Q0.6380.98
124_Q131_R0.6300.98
25_R54_N0.6290.98
151_Y163_L0.6290.98
74_A78_R0.6280.98
82_L116_I0.6270.98
150_R187_L0.6260.98
70_L73_L0.6230.98
81_V84_F0.6230.98
8_R11_L0.6210.98
48_A55_S0.6150.97
44_T149_S0.6150.97
42_S47_L0.6110.97
9_R13_L0.6070.97
90_A93_S0.6040.97
143_L171_L0.6030.97
59_V63_F0.6010.97
164_S167_E0.5950.97
118_L125_A0.5940.97
31_I55_S0.5930.97
32_L63_F0.5930.97
153_R191_D0.5900.97
15_L18_L0.5880.97
78_R111_K0.5870.97
77_G112_P0.5810.96
61_E123_R0.5790.96
62_R134_W0.5760.96
174_A182_A0.5740.96
51_S166_L0.5720.96
32_L132_S0.5710.96
17_A196_R0.5690.96
61_E131_R0.5660.96
79_Q139_P0.5650.96
71_A94_E0.5640.96
91_P142_S0.5640.96
18_L196_R0.5640.96
74_A137_A0.5610.96
151_Y154_L0.5590.96
13_L19_I0.5580.95
156_R164_S0.5560.95
81_V115_L0.5550.95
60_G65_P0.5520.95
57_L60_G0.5500.95
61_E127_K0.5470.95
162_C168_A0.5460.95
149_S158_P0.5450.95
18_L21_P0.5450.95
125_A129_L0.5400.95
81_V95_L0.5390.95
156_R159_R0.5370.94
181_E185_A0.5360.94
83_L141_V0.5360.94
58_F68_A0.5350.94
179_D183_A0.5310.94
43_N151_Y0.5300.94
143_L172_A0.5300.94
143_L147_R0.5290.94
148_P161_G0.5290.94
17_A20_P0.5220.94
83_L172_A0.5220.94
174_A187_L0.5220.94
57_L61_E0.5180.93
179_D185_A0.5180.93
35_P61_E0.5180.93
43_N51_S0.5170.93
78_R112_P0.5160.93
69_L134_W0.5150.93
187_L191_D0.5150.93
20_P188_A0.5140.93
34_H120_G0.5110.93
16_C155_R0.5110.93
123_R131_R0.5110.93
6_R11_L0.5110.93
144_P147_R0.5070.93
178_G183_A0.5070.93
6_R21_P0.5060.93
81_V85_P0.5030.92
93_S96_A0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wkxA 2 0.4192 18 0.942 Contact Map
4mo0A 1 0.3586 11.4 0.947 Contact Map
3j7y1 1 0.1111 6.2 0.953 Contact Map
4rb66 1 0.0909 6 0.953 Contact Map
4tp91 1 0.0859 5.7 0.954 Contact Map
3j6pD 1 0.5051 5.6 0.954 Contact Map
3ugsB 2 0.303 4.1 0.957 Contact Map
1wgmA 1 0.2121 4 0.957 Contact Map
4cayB 1 0.1869 3.5 0.958 Contact Map
1mf7A 1 0.4192 3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.