GREMLIN Database
PepSY_TM - PepSY-associated TM region
PFAM: PF03929 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 197 (175)
Sequences: 13779 (9394)
Seq/√Len: 710.1
META: 0.621

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_A183_G2.5851.00
27_F177_F2.5201.00
23_A177_F2.5041.00
170_L174_I2.4071.00
16_L184_A2.3411.00
30_E173_R2.2491.00
18_L72_V2.2361.00
47_D50_T2.1961.00
130_A143_P2.1881.00
17_L62_L2.1511.00
151_A155_L2.1401.00
67_T70_L2.1361.00
80_L115_A2.0361.00
70_L74_L2.0341.00
191_L195_W1.9891.00
192_L196_R1.9521.00
107_A182_A1.9471.00
61_R65_S1.9341.00
47_D52_E1.9021.00
23_A180_G1.8911.00
60_Y64_R1.8491.00
114_L176_W1.8311.00
160_Y164_T1.8241.00
27_F170_L1.8021.00
145_D148_D1.8001.00
37_A46_V1.7991.00
23_A184_A1.7731.00
170_L173_R1.6451.00
94_R98_D1.6441.00
168_G172_G1.6431.00
12_G187_S1.6391.00
47_D54_L1.6331.00
188_V192_L1.6131.00
76_A119_L1.6111.00
27_F174_I1.5891.00
83_L112_L1.5541.00
103_L182_A1.5221.00
83_L115_A1.5181.00
80_L112_L1.5071.00
79_L115_A1.5051.00
20_L184_A1.5021.00
162_L167_F1.4971.00
12_G191_L1.4571.00
24_L59_L1.4531.00
58_F62_L1.4381.00
110_F179_L1.4361.00
14_F75_A1.4101.00
83_L108_L1.3911.00
96_W192_L1.3831.00
185_L189_T1.3701.00
150_P153_D1.3591.00
67_T71_I1.3581.00
27_F30_E1.3521.00
103_L107_A1.3451.00
74_L77_L1.3291.00
107_A111_L1.3121.00
153_D157_R1.2921.00
111_L183_G1.2761.00
73_G123_F1.2751.00
74_L78_L1.2711.00
113_V162_L1.2691.00
60_Y63_H1.2651.00
77_L119_L1.2521.00
171_P174_I1.2461.00
87_L108_L1.2271.00
109_P113_V1.2241.00
99_L185_L1.2091.00
97_R101_N1.2081.00
82_L85_S1.1931.00
74_L123_F1.1761.00
102_V106_W1.1741.00
172_G176_W1.1691.00
126_Y129_A1.1581.00
33_A36_N1.1531.00
105_F108_L1.1391.00
93_R96_W1.1311.00
73_G122_S1.1271.00
32_D36_N1.1031.00
59_L62_L1.1021.00
93_R196_R1.1011.00
28_R32_D1.0971.00
56_F59_L1.0961.00
167_F176_W1.0921.00
184_A187_S1.0781.00
103_L185_L1.0731.00
90_W105_F1.0701.00
64_R69_R1.0671.00
192_L195_W1.0611.00
28_R60_Y1.0601.00
15_L79_L1.0571.00
92_G95_F1.0561.00
149_L154_R1.0531.00
93_R97_R1.0531.00
2_R5_L1.0471.00
149_L157_R1.0231.00
58_F61_R1.0191.00
7_L78_L1.0191.00
66_D70_L1.0011.00
114_L179_L0.9991.00
120_Y159_L0.9981.00
70_L123_F0.9971.00
58_F63_H0.9841.00
16_L187_S0.9791.00
84_L88_V0.9731.00
96_W196_R0.9731.00
68_G72_V0.9641.00
183_G187_S0.9641.00
117_T159_L0.9611.00
149_L153_D0.9601.00
94_R97_R0.9461.00
123_F126_Y0.9381.00
105_F109_P0.9351.00
72_V76_A0.9341.00
99_L103_L0.9301.00
157_R161_P0.9251.00
172_G175_L0.9051.00
11_L75_A0.9051.00
110_F114_L0.9001.00
181_L185_L0.8961.00
107_A110_F0.8951.00
57_R61_R0.8831.00
80_L116_L0.8811.00
20_L24_L0.8781.00
25_L60_Y0.8761.00
23_A26_V0.8751.00
95_F99_L0.8721.00
61_R64_R0.8661.00
19_A184_A0.8651.00
72_V118_G0.8651.00
17_L21_T0.8581.00
25_L28_R0.8441.00
98_D102_V0.8281.00
146_P154_R0.8221.00
59_L64_R0.8171.00
18_L75_A0.8151.00
155_L159_L0.8131.00
26_V177_F0.8131.00
124_P127_F0.8071.00
81_V85_S0.8031.00
167_F172_G0.8021.00
168_G171_P0.7961.00
174_I178_L0.7951.00
59_L63_H0.7931.00
155_L158_W0.7911.00
56_F60_Y0.7851.00
174_I177_F0.7821.00
108_L111_L0.7771.00
164_T168_G0.7751.00
21_T62_L0.7741.00
84_L112_L0.7701.00
125_W129_A0.7691.00
120_Y156_L0.7691.00
87_L105_F0.7691.00
7_L10_V0.7671.00
91_K94_R0.7661.00
153_D156_L0.7611.00
15_L19_A0.7601.00
47_D51_G0.7601.00
144_Y149_L0.7541.00
29_P32_D0.7511.00
171_P175_L0.7501.00
79_L183_G0.7491.00
10_V14_F0.7491.00
14_F18_L0.7471.00
69_R122_S0.7371.00
184_A192_L0.7341.00
124_P128_G0.7311.00
169_G172_G0.7291.00
26_V176_W0.7291.00
50_T53_V0.7201.00
90_W101_N0.7181.00
8_G176_W0.7171.00
23_A181_L0.7161.00
152_G156_L0.7141.00
177_F180_G0.7081.00
49_Y53_V0.7071.00
158_W167_F0.7031.00
75_A79_L0.6991.00
26_V172_G0.6961.00
11_L78_L0.6901.00
48_P51_G0.6791.00
144_Y147_A0.6791.00
154_R158_W0.6791.00
151_A154_R0.6781.00
66_D69_R0.6721.00
79_L83_L0.6711.00
98_D101_N0.6671.00
116_L120_Y0.6641.00
16_L20_L0.6591.00
79_L111_L0.6581.00
11_L15_L0.6581.00
165_G168_G0.6551.00
158_W161_P0.6521.00
73_G77_L0.6401.00
85_S88_V0.6371.00
123_F128_G0.6371.00
125_W128_G0.6341.00
123_F129_A0.6321.00
148_D151_A0.6261.00
193_L196_R0.6211.00
51_G54_L0.6171.00
120_Y127_F0.6171.00
7_L82_L0.6151.00
30_E170_L0.6121.00
19_A180_G0.6121.00
57_R60_Y0.6111.00
14_F72_V0.6111.00
19_A23_A0.6111.00
92_G96_W0.6041.00
65_S69_R0.6041.00
68_G76_A0.6011.00
186_L189_T0.6001.00
19_A187_S0.5961.00
71_I75_A0.5931.00
108_L112_L0.5911.00
180_G184_A0.5881.00
83_L89_L0.5881.00
72_V75_A0.5851.00
182_A185_L0.5841.00
96_W189_T0.5831.00
164_T176_W0.5821.00
52_E55_G0.5801.00
152_G155_L0.5751.00
111_L186_L0.5731.00
73_G119_L0.5731.00
33_A46_V0.5661.00
26_V165_G0.5601.00
15_L115_A0.5591.00
59_L65_S0.5571.00
179_L183_G0.5561.00
80_L83_L0.5531.00
68_G73_G0.5531.00
26_V173_R0.5501.00
156_L160_Y0.5451.00
187_S191_L0.5431.00
72_V122_S0.5421.00
16_L19_A0.5411.00
49_Y55_G0.5381.00
25_L121_W0.5351.00
156_L161_P0.5351.00
13_L17_L0.5311.00
68_G71_I0.5311.00
161_P166_D0.5301.00
160_Y166_D0.5281.00
91_K97_R0.5281.00
99_L189_T0.5261.00
127_F156_L0.5211.00
68_G90_W0.5171.00
10_V13_L0.5171.00
121_W160_Y0.5161.00
128_G153_D0.5141.00
93_R197_R0.5111.00
188_V194_W0.5100.99
107_A179_L0.5100.99
12_G190_G0.5100.99
175_L179_L0.5090.99
182_A186_L0.5050.99
119_L123_F0.5050.99
56_F61_R0.5040.99
6_W10_V0.5010.99
121_W127_F0.5000.99
189_T193_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gd3A 2 0.4924 78.5 0.896 Contact Map
4o6yA 2 0.5025 70.6 0.903 Contact Map
1kqfC 3 0.6091 68.5 0.904 Contact Map
2qjyA 2 0.8782 40.9 0.919 Contact Map
1pp9C 2 0.8426 37.9 0.92 Contact Map
3cx5C 2 0.8528 32.8 0.923 Contact Map
4ogqA 2 0.8731 15.9 0.933 Contact Map
2wdqC 1 0.4061 11.4 0.938 Contact Map
2m20A 2 0.1472 5.6 0.946 Contact Map
2l9uA 2 0.1574 4.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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