GREMLIN Database
CBF - CBF/Mak21 family
PFAM: PF03914 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 155 (146)
Sequences: 1648 (1113)
Seq/√Len: 92.1
META: 0.24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_F51_S5.6061.00
63_A130_S5.0791.00
15_Q18_L4.9291.00
68_L83_V3.5671.00
131_N134_A3.4091.00
66_K139_E3.1071.00
24_R126_D2.4191.00
57_P128_E2.3091.00
30_L48_L2.2721.00
30_L68_L2.2151.00
126_D129_Y2.1531.00
125_R129_Y1.9401.00
77_P80_A1.8691.00
120_Y132_A1.7481.00
132_A135_S1.7371.00
49_D89_N1.7091.00
65_V97_L1.7021.00
65_V87_I1.6491.00
62_A133_L1.6111.00
11_L15_Q1.6071.00
12_L15_Q1.5661.00
48_L64_F1.5541.00
26_L51_S1.5521.00
150_S154_F1.5411.00
59_Y133_L1.5201.00
98_R101_L1.5171.00
29_L44_F1.4901.00
63_A132_A1.4721.00
69_L137_L1.4721.00
69_L87_I1.4721.00
70_Q120_Y1.4551.00
3_L11_L1.4481.00
54_S73_L1.4220.99
45_L48_L1.4000.99
67_R122_P1.3890.99
89_N92_K1.3810.99
6_N43_L1.3570.99
59_Y130_S1.3440.99
34_R44_F1.3310.99
66_K137_L1.3280.99
9_F54_S1.3180.99
45_L82_G1.3150.99
130_S141_E1.3150.99
30_L71_L1.2980.99
10_Q14_G1.2870.99
124_E129_Y1.2770.99
79_F83_V1.2540.99
121_D130_S1.2510.99
144_R148_H1.2460.98
67_R70_Q1.2170.98
88_S154_F1.2140.98
120_Y130_S1.1690.98
109_T112_E1.1590.98
59_Y128_E1.1430.97
52_L56_V1.1360.97
81_L150_S1.1280.97
77_P148_H1.1260.97
146_H151_V1.0880.96
109_T115_K1.0450.95
84_L155_A1.0350.95
5_L8_L1.0340.95
55_D60_R1.0300.95
42_A45_L1.0300.95
88_S92_K1.0270.95
23_Y47_L1.0100.95
72_A83_V1.0030.94
84_L143_L1.0000.94
30_L35_L0.9860.94
124_E130_S0.9860.94
53_K89_N0.9840.94
58_A96_K0.9730.93
40_K45_L0.9680.93
86_L89_N0.9660.93
121_D125_R0.9650.93
80_A83_V0.9650.93
28_S125_R0.9610.93
39_S43_L0.9600.93
41_R79_F0.9510.93
13_S48_L0.9330.92
108_V113_E0.9310.92
9_F13_S0.9270.92
114_R117_D0.9240.92
90_L120_Y0.9210.91
2_L5_L0.9130.91
67_R127_P0.9120.91
9_F12_L0.9070.91
60_R127_P0.8960.90
49_D86_L0.8870.90
25_K29_L0.8790.89
48_L82_G0.8520.88
51_S55_D0.8470.88
9_F47_L0.8470.88
101_L140_L0.8420.87
46_R49_D0.8320.87
75_A79_F0.8210.86
4_A8_L0.8180.86
117_D128_E0.8160.86
113_E117_D0.8120.85
12_L96_K0.8010.84
3_L10_Q0.7920.84
121_D124_E0.7900.84
2_L13_S0.7850.83
127_P130_S0.7850.83
24_R124_E0.7830.83
9_F14_G0.7820.83
12_L68_L0.7800.83
76_P136_S0.7780.83
8_L12_L0.7780.83
41_R47_L0.7770.83
141_E144_R0.7770.83
26_L61_V0.7740.82
45_L49_D0.7730.82
38_S41_R0.7700.82
65_V113_E0.7660.82
61_V94_H0.7660.82
91_L101_L0.7630.81
35_L38_S0.7630.81
53_K93_R0.7610.81
81_L151_V0.7590.81
30_L33_P0.7540.81
147_Y151_V0.7520.81
24_R125_R0.7490.80
29_L34_R0.7390.79
11_L76_P0.7370.79
2_L138_W0.7340.79
78_S130_S0.7310.79
25_K146_H0.7260.78
75_A83_V0.7230.78
28_S145_S0.7230.78
5_L52_L0.7220.78
50_K61_V0.7190.77
72_A154_F0.7170.77
82_G149_P0.7150.77
6_N10_Q0.7070.76
64_F136_S0.7040.76
72_A143_L0.7040.76
28_S124_E0.7030.76
86_L90_L0.7020.76
54_S100_L0.6980.75
102_H155_A0.6960.75
53_K56_V0.6940.75
49_D87_I0.6930.75
67_R97_L0.6930.75
72_A80_A0.6900.75
64_F68_L0.6860.74
74_H81_L0.6850.74
115_K118_D0.6840.74
51_S54_S0.6730.73
100_L143_L0.6720.73
60_R82_G0.6650.72
71_L99_A0.6590.71
28_S65_V0.6570.71
70_Q132_A0.6560.71
58_A92_K0.6550.71
8_L15_Q0.6550.71
84_L88_S0.6540.71
50_K55_D0.6510.70
22_F25_K0.6480.70
49_D93_R0.6450.70
62_A76_P0.6450.70
52_L90_L0.6380.69
88_S94_H0.6370.69
4_A7_L0.6360.68
57_P133_L0.6320.68
82_G96_K0.6310.68
23_Y137_L0.6250.67
31_L34_R0.6170.66
5_L150_S0.6150.66
21_R24_R0.6150.66
7_L14_G0.6070.65
118_D134_A0.6070.65
66_K136_S0.6050.65
5_L23_Y0.6050.65
69_L101_L0.6040.64
91_L137_L0.5960.63
9_F15_Q0.5940.63
13_S140_L0.5930.63
42_A46_R0.5870.62
9_F17_N0.5850.62
22_F26_L0.5850.62
67_R72_A0.5830.62
21_R25_K0.5810.62
21_R125_R0.5800.61
17_N113_E0.5770.61
109_T113_E0.5700.60
45_L83_V0.5680.60
47_L69_L0.5670.60
37_H150_S0.5610.59
60_R148_H0.5600.59
44_F47_L0.5600.59
77_P147_Y0.5570.58
30_L148_H0.5550.58
131_N139_E0.5550.58
62_A94_H0.5530.58
60_R70_Q0.5490.57
47_L55_D0.5480.57
11_L119_P0.5450.57
48_L96_K0.5440.57
34_R38_S0.5340.55
80_A87_I0.5330.55
152_A155_A0.5330.55
150_S153_T0.5320.55
90_L96_K0.5280.54
69_L140_L0.5270.54
24_R35_L0.5250.54
116_G119_P0.5240.54
3_L146_H0.5230.54
112_E115_K0.5220.53
9_F72_A0.5210.53
37_H52_L0.5170.53
46_R81_L0.5160.53
98_R102_H0.5160.53
120_Y129_Y0.5090.52
76_P131_N0.5060.51
11_L42_A0.5050.51
108_V116_G0.5030.51
63_A128_E0.5000.50
21_R60_R0.5000.50
38_S83_V0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pjwA 1 0.8516 22 0.922 Contact Map
1dgwX 1 0.2452 8.7 0.935 Contact Map
1b3uA 1 0.6839 8.1 0.936 Contact Map
4uvkA 1 0.8645 7.6 0.937 Contact Map
5a1uE 1 0.8968 4.2 0.944 Contact Map
4uqiB 1 0.7742 3.5 0.946 Contact Map
4l7mA 1 0.7484 3.5 0.946 Contact Map
2nppB 1 0.7935 3.4 0.946 Contact Map
4p6zG 1 0.8839 3.4 0.946 Contact Map
3tjzB 1 0.5355 3.1 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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