GREMLIN Database
ATP-synt_I - ATP synthase I chain
PFAM: PF03899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (98)
Sequences: 16975 (12228)
Seq/√Len: 1235.2
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_T33_G4.1801.00
81_Y85_K3.3151.00
91_S94_A2.9711.00
17_A21_G2.3611.00
39_N76_T2.2731.00
25_A94_A2.0691.00
31_L83_A2.0531.00
80_L95_L1.9701.00
84_F92_P1.9491.00
21_G25_A1.8771.00
17_A20_L1.8581.00
24_R27_L1.7871.00
29_A98_G1.7771.00
35_I79_L1.7711.00
23_W27_L1.7181.00
42_L71_L1.7161.00
69_E73_L1.6691.00
35_I39_N1.5471.00
42_L46_R1.5141.00
17_A29_A1.4941.00
82_L86_L1.4621.00
17_A25_A1.4301.00
24_R28_S1.4211.00
14_A30_L1.4161.00
28_S91_S1.3941.00
36_A99_L1.3701.00
80_L99_L1.3701.00
57_S60_A1.3691.00
73_L77_A1.3491.00
13_A29_A1.3401.00
41_A45_R1.3391.00
28_S90_L1.3091.00
51_A54_L1.3021.00
28_S94_A1.3011.00
50_L53_A1.2631.00
83_A95_L1.2471.00
4_R8_V1.2421.00
44_A47_V1.1781.00
36_A39_N1.1741.00
48_F51_A1.1401.00
7_L37_V1.1301.00
25_A29_A1.1231.00
3_L37_V1.1001.00
86_L89_P1.0951.00
22_G25_A1.0891.00
52_G56_A1.0721.00
83_A88_L1.0501.00
68_G72_K1.0471.00
46_R72_K1.0371.00
18_L26_A1.0311.00
53_A56_A1.0101.00
52_G55_A0.9971.00
94_A98_G0.9781.00
66_Y70_A0.9661.00
49_R52_G0.9591.00
93_L97_A0.9411.00
58_A62_L0.9321.00
25_A91_S0.9291.00
45_R68_G0.9271.00
58_A61_A0.9021.00
59_G63_R0.8961.00
46_R71_L0.8961.00
10_T37_V0.8931.00
50_L54_L0.8751.00
5_L9_L0.8591.00
63_R67_L0.8461.00
60_A63_R0.8231.00
84_F95_L0.8201.00
57_S62_L0.8181.00
13_A98_G0.8141.00
85_K88_L0.8131.00
29_A94_A0.8101.00
7_L11_A0.8081.00
69_E72_K0.8021.00
46_R68_G0.8011.00
2_I6_Q0.7991.00
27_L31_L0.7951.00
5_L8_V0.7931.00
35_I83_A0.7921.00
14_A33_G0.7841.00
48_F52_G0.7771.00
57_S63_R0.7761.00
39_N72_K0.7671.00
18_L21_G0.7671.00
18_L23_W0.7571.00
14_A26_A0.7561.00
7_L10_T0.7511.00
39_N42_L0.7511.00
16_A20_L0.7451.00
43_L65_F0.7301.00
59_G62_L0.7291.00
39_N75_L0.7241.00
66_Y69_E0.7151.00
61_A64_G0.7141.00
67_L71_L0.7011.00
62_L66_Y0.7001.00
76_T80_L0.6981.00
29_A33_G0.6951.00
76_T79_L0.6871.00
37_V41_A0.6841.00
26_A30_L0.6831.00
64_G67_L0.6821.00
35_I80_L0.6791.00
84_F88_L0.6761.00
42_L75_L0.6741.00
30_L34_L0.6661.00
81_Y86_L0.6661.00
95_L98_G0.6631.00
43_L68_G0.6461.00
90_L93_L0.6441.00
10_T14_A0.6401.00
51_A55_A0.6321.00
46_R67_L0.6291.00
39_N43_L0.6211.00
77_A81_Y0.6201.00
92_P96_L0.6181.00
15_L19_L0.5981.00
32_G98_G0.5971.00
40_F46_R0.5801.00
71_L75_L0.5801.00
81_Y84_F0.5691.00
83_A90_L0.5691.00
17_A97_A0.5651.00
39_N69_E0.5611.00
56_A60_A0.5591.00
88_L91_S0.5561.00
59_G66_Y0.5521.00
71_L74_A0.5511.00
25_A97_A0.5491.00
50_L55_A0.5441.00
11_A14_A0.5441.00
65_F68_G0.5441.00
6_Q37_V0.5411.00
50_L60_A0.5371.00
94_A97_A0.5341.00
16_A19_L0.5341.00
34_L39_N0.5311.00
83_A86_L0.5231.00
42_L45_R0.5201.00
85_K89_P0.5131.00
13_A16_A0.5131.00
24_R89_P0.5131.00
35_I95_L0.5111.00
14_A18_L0.5101.00
13_A17_A0.5011.00
12_V16_A0.5001.00
17_A94_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4av3A 2 1 11.5 0.817 Contact Map
3ne5A 3 0.56 3.5 0.856 Contact Map
4a01A 2 1 2.7 0.865 Contact Map
3ze3A 4 0.9 2.3 0.87 Contact Map
2nq2A 2 0.5 2.2 0.871 Contact Map
4pgrA 1 0.46 2.1 0.873 Contact Map
4hyjA 2 0.97 2 0.873 Contact Map
5ajiA 3 0.78 1.9 0.876 Contact Map
3w4tA 1 0.53 1.6 0.88 Contact Map
4hw9A 3 0.72 1.6 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.