GREMLIN Database
Cgr1 - Cgr1 family
PFAM: PF03879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 108 (105)
Sequences: 521 (366)
Seq/√Len: 35.7
META: 0.253

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_K55_E3.1091.00
55_E59_A3.0241.00
66_E70_E2.7431.00
68_R72_R2.6421.00
37_M40_R2.5301.00
33_W36_R2.3100.99
61_R65_R2.2790.99
38_E41_A2.2720.99
65_R69_K2.1020.99
76_E79_E1.9650.98
1_K13_P1.9380.98
41_A45_A1.9200.98
63_R67_R1.8880.98
32_S35_K1.8100.97
62_Q66_E1.7970.97
43_K47_K1.7750.96
58_E62_Q1.7590.96
67_R71_R1.6930.95
89_N93_V1.6790.95
70_E74_R1.6770.95
41_A44_K1.6590.95
38_E42_E1.6450.95
52_E56_E1.5900.93
92_K96_M1.5530.93
59_A63_R1.5410.92
80_R83_E1.5290.92
60_E63_R1.4970.91
18_R21_S1.4510.90
101_K105_L1.4210.89
97_K102_R1.4190.89
78_N81_K1.3810.87
75_K79_E1.3500.86
56_E59_A1.3360.86
46_V50_E1.3120.85
72_R76_E1.2870.83
19_S22_G1.2440.81
19_S24_V1.1300.74
6_S10_W1.1170.74
35_K59_A1.1140.73
69_K73_K1.0940.72
81_K85_A1.0920.72
4_R8_R1.0680.70
65_R68_R1.0640.70
31_T39_E1.0560.69
26_K72_R1.0340.68
64_K72_R1.0300.67
2_G5_K1.0200.67
67_R75_K1.0010.65
62_Q65_R1.0010.65
18_R25_K0.9980.65
53_L56_E0.9880.64
99_K105_L0.9710.63
35_K38_E0.9580.62
7_G10_W0.9530.61
94_K98_K0.9450.61
63_R66_E0.9370.60
55_E58_E0.9350.60
78_N82_E0.9270.59
3_K6_S0.9230.59
81_K88_M0.9200.58
78_N88_M0.9180.58
17_F21_S0.9130.58
50_E54_K0.9090.58
47_K54_K0.9060.57
81_K84_M0.8960.56
20_S23_K0.8950.56
59_A62_Q0.8920.56
95_R102_R0.8820.55
6_S11_K0.8790.55
24_V56_E0.8730.54
82_E85_A0.8620.54
44_K48_E0.8550.53
100_E104_K0.8530.53
66_E73_K0.8510.53
70_E73_K0.8490.52
101_K104_K0.8480.52
94_K101_K0.8470.52
99_K102_R0.8440.52
19_S23_K0.8340.51
74_R78_N0.8270.50
47_K53_L0.8230.50
68_R71_R0.8210.50
83_E86_Q0.7910.47
31_T36_R0.7810.47
51_K62_Q0.7800.46
26_K68_R0.7800.46
84_M88_M0.7700.46
8_R11_K0.7660.45
34_E38_E0.7590.45
77_E80_R0.7540.44
39_E42_E0.7510.44
92_K100_E0.7500.44
11_K96_M0.7440.43
97_K101_K0.7430.43
17_F20_S0.7360.43
94_K100_E0.7340.43
46_V49_L0.7330.42
86_Q94_K0.7220.41
89_N92_K0.7190.41
48_E90_A0.7160.41
88_M94_K0.7140.41
66_E69_K0.7100.40
78_N105_L0.7090.40
2_G40_R0.7030.40
78_N99_K0.6860.38
60_E64_K0.6780.38
45_A71_R0.6570.36
90_A93_V0.6560.36
49_L52_E0.6530.36
44_K51_K0.6530.36
80_R95_R0.6520.36
96_M100_E0.6500.36
34_E51_K0.6430.35
28_G33_W0.6420.35
88_M95_R0.6360.34
41_A55_E0.6360.34
14_K95_R0.6350.34
15_K22_G0.6330.34
86_Q90_A0.6330.34
38_E44_K0.6320.34
37_M41_A0.6300.34
42_E46_V0.6290.34
89_N95_R0.6240.34
100_E103_N0.6180.33
85_A91_K0.6170.33
14_K17_F0.6170.33
90_A94_K0.6130.33
8_R78_N0.6130.33
73_K79_E0.6130.33
97_K100_E0.6120.33
20_S24_V0.6100.32
15_K57_K0.6090.32
50_E71_R0.6080.32
16_A20_S0.6070.32
45_A52_E0.5990.32
6_S33_W0.5950.31
22_G25_K0.5830.30
96_M101_K0.5800.30
2_G6_S0.5790.30
78_N86_Q0.5700.30
76_E80_R0.5690.29
40_R93_V0.5670.29
85_A104_K0.5590.29
54_K58_E0.5590.29
24_V50_E0.5590.29
14_K102_R0.5580.29
93_V101_K0.5520.28
94_K105_L0.5410.27
81_K86_Q0.5400.27
71_R74_R0.5380.27
11_K19_S0.5310.27
26_K29_L0.5290.27
33_W69_K0.5160.26
95_R100_E0.5120.26
35_K39_E0.5110.25
2_G75_K0.5080.25
50_E98_K0.5080.25
12_A53_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3suiB 1 0.1111 18.2 0.892 Contact Map
3f1iH 1 0.6759 1.4 0.937 Contact Map
3vogA 1 0.25 1.1 0.942 Contact Map
3sdeA 1 0.6852 0.9 0.945 Contact Map
4uera 1 0 0.8 0.946 Contact Map
1vw48 1 0.5926 0.8 0.947 Contact Map
3j7yY 1 0.6667 0.8 0.948 Contact Map
3hzpA 2 0.3148 0.7 0.949 Contact Map
1eyoA 1 0.0926 0.7 0.949 Contact Map
4cpyA 2 0.2963 0.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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