GREMLIN Database
YIF1 - YIF1
PFAM: PF03878 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 231 (228)
Sequences: 505 (361)
Seq/√Len: 23.9
META: 0.17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_N51_K4.7181.00
37_Y81_A3.7861.00
216_F221_A3.6571.00
214_R222_A3.6261.00
64_R78_D3.3791.00
86_I156_V3.0361.00
164_A177_V2.8390.99
52_L55_F2.8240.99
45_Y49_K2.8210.99
214_R221_A2.5490.99
163_L167_L2.4380.98
45_Y86_I2.3670.98
12_Q65_K2.3480.98
168_F173_G2.2490.97
54_L181_T2.1940.97
81_A109_S2.1820.96
75_P78_D2.1310.96
64_R75_P2.0960.96
124_V155_F2.0480.95
21_Y25_N2.0220.95
90_A156_V2.0070.94
75_P81_A1.9800.94
118_S122_A1.9680.94
10_Y14_A1.9310.93
210_R218_F1.9190.93
49_K86_I1.9030.93
100_L150_Y1.8920.92
22_V130_L1.8130.91
157_G161_T1.8110.91
20_E24_K1.7970.90
64_R72_Y1.7660.89
125_I129_L1.7660.89
40_A81_A1.7020.88
210_R214_R1.6800.87
23_Q28_R1.6800.87
120_A191_R1.6780.87
45_Y83_D1.6350.85
175_Y180_Y1.6180.85
22_V26_F1.5600.82
23_Q127_E1.5430.82
194_K198_L1.5310.81
134_G137_L1.5020.80
39_F56_P1.5000.80
216_F220_Y1.4940.80
74_P78_D1.4670.78
118_S136_Y1.4620.78
214_R220_Y1.4110.75
161_T181_T1.4080.75
67_E77_D1.3730.73
133_L137_L1.3660.73
57_F70_E1.3610.73
59_H80_N1.3610.73
99_G113_L1.3550.72
43_N154_K1.3430.72
75_P80_N1.3170.70
99_G103_G1.3170.70
216_F222_A1.3000.69
134_G218_F1.2940.69
218_F222_A1.2900.69
92_V113_L1.2790.68
77_D184_A1.2790.68
193_L198_L1.2730.68
6_M12_Q1.2710.67
51_K223_V1.2660.67
114_G148_V1.2610.67
134_G216_F1.2610.67
101_V104_L1.2600.67
62_W81_A1.2550.66
103_G113_L1.2480.66
146_D193_L1.2410.65
52_L59_H1.2390.65
78_D81_A1.2350.65
50_L227_L1.2330.65
84_L105_Q1.2190.64
86_I150_Y1.2090.63
82_P150_Y1.2050.63
9_Q17_A1.1980.63
45_Y94_Y1.1940.62
18_G25_N1.1880.62
157_G229_M1.1780.61
91_F146_D1.1650.60
64_R80_N1.1600.60
13_S29_Y1.1430.59
126_L162_L1.1380.59
137_L210_R1.1330.58
99_G182_S1.1230.58
136_Y154_K1.1210.57
189_L194_K1.1180.57
65_K140_I1.1180.57
160_V181_T1.1170.57
51_K167_L1.1110.57
60_K115_I1.1070.56
93_T99_G1.1050.56
6_M23_Q1.1030.56
215_Q218_F1.0960.56
129_L176_L1.0850.55
62_W75_P1.0730.54
14_A19_Q1.0640.53
88_L100_L1.0580.53
86_I90_A1.0560.53
119_S228_L1.0550.53
23_Q29_Y1.0510.53
27_G228_L1.0500.52
21_Y54_L1.0410.52
62_W80_N1.0380.52
98_A152_G1.0380.52
82_P96_L1.0360.51
213_R220_Y1.0320.51
127_E154_K1.0310.51
210_R217_L1.0270.51
46_V225_Q1.0170.50
72_Y119_S1.0110.50
57_F230_W1.0030.49
197_L213_R1.0030.49
111_E220_Y0.9930.48
55_F90_A0.9830.48
111_E115_I0.9830.48
124_V152_G0.9830.48
82_P108_F0.9760.47
44_S88_L0.9730.47
50_L86_I0.9710.47
43_N95_I0.9550.46
27_G131_L0.9530.46
104_L111_E0.9530.46
81_A91_F0.9500.45
205_V208_S0.9490.45
180_Y184_A0.9460.45
213_R222_A0.9450.45
98_A104_L0.9440.45
183_L201_A0.9430.45
179_L219_L0.9430.45
133_L141_S0.9400.45
218_F221_A0.9350.44
9_Q26_F0.9330.44
37_Y42_S0.9310.44
59_H76_R0.9270.44
140_I191_R0.9250.44
165_G186_A0.9220.43
120_A127_E0.9220.43
53_L157_G0.9170.43
107_R170_S0.9160.43
13_S17_A0.9160.43
57_F184_A0.9130.43
11_G109_S0.9110.43
131_L228_L0.9060.42
84_L99_G0.8990.42
83_D86_I0.8970.42
49_K110_P0.8960.42
38_Y145_L0.8890.41
120_A149_A0.8840.41
223_V230_W0.8820.41
50_L156_V0.8780.40
50_L203_Q0.8760.40
157_G177_V0.8740.40
41_V56_P0.8690.40
70_E125_I0.8650.40
131_L201_A0.8640.39
160_V168_F0.8600.39
118_S159_I0.8590.39
98_A102_L0.8550.39
18_G41_V0.8540.39
53_L169_G0.8510.39
27_G30_V0.8510.39
53_L122_A0.8500.39
89_M153_Y0.8500.39
110_P155_F0.8500.39
171_G186_A0.8500.39
62_W78_D0.8490.38
86_I94_Y0.8390.38
104_L148_V0.8350.38
16_G177_V0.8330.37
112_L151_S0.8320.37
18_G34_A0.8310.37
35_L105_Q0.8280.37
82_P110_P0.8250.37
133_L224_L0.8210.37
5_Q185_N0.8190.36
94_Y153_Y0.8170.36
10_Y160_V0.8110.36
96_L150_Y0.8110.36
96_L155_F0.8100.36
94_Y150_Y0.8100.36
3_T74_P0.8090.36
47_L79_I0.8070.36
159_I192_S0.8030.35
145_L181_T0.7950.35
131_L170_S0.7920.35
51_K130_L0.7910.35
84_L149_A0.7910.35
54_L160_V0.7910.35
81_A97_L0.7870.34
53_L230_W0.7770.34
26_F149_A0.7750.34
84_L131_L0.7700.33
131_L181_T0.7690.33
103_G108_F0.7680.33
5_Q135_L0.7680.33
78_D83_D0.7670.33
43_N67_E0.7550.32
88_L104_L0.7500.32
97_L104_L0.7500.32
199_P217_L0.7500.32
31_S170_S0.7440.32
87_P153_Y0.7390.31
24_K95_I0.7330.31
122_A167_L0.7300.31
27_G38_Y0.7280.31
28_R200_E0.7270.31
96_L217_L0.7230.30
41_V78_D0.7230.30
42_S86_I0.7220.30
144_L167_L0.7160.30
41_V46_V0.7160.30
4_A194_K0.7150.30
88_L165_G0.7070.29
129_L148_V0.7070.29
131_L190_L0.7070.29
138_L142_L0.7030.29
195_Y227_L0.7010.29
92_V96_L0.7000.29
53_L177_V0.6990.29
107_R144_L0.6980.29
205_V219_L0.6910.29
36_K127_E0.6880.28
95_I191_R0.6850.28
18_G33_S0.6830.28
114_G193_L0.6810.28
203_Q206_S0.6800.28
117_A121_L0.6780.28
186_A223_V0.6720.27
86_I192_S0.6720.27
124_V151_S0.6710.27
96_L108_F0.6700.27
189_L213_R0.6680.27
167_L223_V0.6650.27
92_V154_K0.6620.27
180_Y190_L0.6610.27
125_I143_P0.6600.27
15_L36_K0.6590.27
80_N146_D0.6550.26
49_K146_D0.6540.26
32_V208_S0.6530.26
118_S170_S0.6520.26
98_A184_A0.6510.26
189_L217_L0.6490.26
131_L220_Y0.6470.26
7_A17_A0.6460.26
104_L165_G0.6450.26
50_L68_R0.6420.26
91_F108_F0.6410.26
12_Q16_G0.6410.26
13_S16_G0.6400.26
8_M187_F0.6390.26
101_V180_Y0.6370.25
178_L216_F0.6370.25
103_G128_V0.6360.25
124_V192_S0.6350.25
48_N174_Y0.6340.25
217_L220_Y0.6340.25
124_V202_S0.6330.25
15_L186_A0.6320.25
190_L229_M0.6310.25
160_V223_V0.6300.25
90_A101_V0.6290.25
9_Q12_Q0.6220.25
45_Y53_L0.6170.24
165_G223_V0.6150.24
113_L202_S0.6130.24
23_Q27_G0.6120.24
185_N193_L0.6120.24
130_L141_S0.6120.24
214_R217_L0.6110.24
4_A8_M0.6100.24
206_S211_S0.6080.24
31_S99_G0.6020.24
162_L212_R0.6010.24
18_G21_Y0.6000.24
136_Y152_G0.6000.24
29_Y219_L0.5990.24
28_R141_S0.5980.23
111_E121_L0.5960.23
97_L159_I0.5960.23
57_F180_Y0.5950.23
96_L166_L0.5950.23
161_T177_V0.5920.23
50_L54_L0.5920.23
130_L219_L0.5910.23
39_F87_P0.5910.23
123_V190_L0.5890.23
16_G53_L0.5880.23
18_G23_Q0.5830.23
121_L137_L0.5820.23
46_V81_A0.5810.23
66_Y125_I0.5800.23
83_D153_Y0.5780.22
173_G226_P0.5770.22
49_K53_L0.5730.22
173_G193_L0.5710.22
56_P85_Y0.5700.22
27_G141_S0.5700.22
117_A127_E0.5660.22
217_L229_M0.5660.22
39_F85_Y0.5630.22
133_L166_L0.5600.22
36_K114_G0.5590.22
16_G33_S0.5570.21
71_P125_I0.5550.21
103_G154_K0.5520.21
211_S227_L0.5520.21
94_Y158_I0.5510.21
212_R215_Q0.5510.21
60_K95_I0.5490.21
39_F49_K0.5490.21
150_Y191_R0.5490.21
64_R73_L0.5490.21
86_I110_P0.5480.21
195_Y214_R0.5480.21
94_Y108_F0.5470.21
159_I186_A0.5440.21
16_G223_V0.5430.21
16_G29_Y0.5410.21
80_N190_L0.5370.20
90_A96_L0.5360.20
213_R218_F0.5290.20
174_Y178_L0.5280.20
61_P69_D0.5240.20
58_R74_P0.5220.20
38_Y72_Y0.5220.20
110_P146_D0.5220.20
84_L174_Y0.5190.20
60_K64_R0.5170.20
180_Y189_L0.5160.20
7_A61_P0.5160.20
49_K108_F0.5140.19
8_M162_L0.5120.19
214_R218_F0.5090.19
50_L231_W0.5080.19
82_P91_F0.5060.19
132_K209_Q0.5060.19
133_L160_V0.5030.19
26_F36_K0.5010.19
72_Y102_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ar1A 1 0.2987 5.3 0.967 Contact Map
1zceA 1 0.316 4.9 0.968 Contact Map
2gbsA 1 0.3117 2.9 0.971 Contact Map
4xtrG 1 0.0823 2.8 0.972 Contact Map
2eveA 1 0.2857 2.3 0.973 Contact Map
4n7wA 2 0.8182 2.3 0.973 Contact Map
1w8xP 1 0.0996 1.9 0.974 Contact Map
3hqiA 2 0.2554 1.6 0.975 Contact Map
3eopA 1 0.2944 1.6 0.975 Contact Map
2hgaA 1 0.3593 1.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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