GREMLIN Database
SpoVA - SpoVA protein
PFAM: PF03862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (114)
Sequences: 5859 (3197)
Seq/√Len: 299.4
META: 0.77

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_T71_N3.3231.00
23_T37_T3.2821.00
4_K57_F3.1711.00
43_A74_A2.6511.00
4_K7_L2.5371.00
92_G95_T2.3831.00
72_S97_A2.2781.00
52_D56_K2.1401.00
17_Q21_D2.1331.00
18_I22_L2.1151.00
55_A62_A1.9711.00
8_V58_A1.9201.00
93_M102_V1.8771.00
45_L50_L1.8451.00
8_V57_F1.5851.00
20_I34_T1.5821.00
11_L15_I1.5641.00
103_A107_F1.5401.00
46_T75_S1.5131.00
23_T33_R1.5081.00
16_G38_L1.4671.00
40_F44_L1.4611.00
42_G51_Y1.3981.00
3_L7_L1.3911.00
51_Y62_A1.3691.00
19_L23_T1.3681.00
55_A63_T1.3501.00
86_V89_V1.3431.00
37_T41_L1.3401.00
91_T99_P1.3371.00
54_L62_A1.3031.00
80_F95_T1.2981.00
80_F84_G1.2881.00
12_I38_L1.2781.00
85_G89_V1.2761.00
97_A101_I1.2631.00
45_L54_L1.2611.00
20_I24_I1.2551.00
35_L66_I1.2531.00
11_L14_V1.2411.00
55_A71_N1.2391.00
79_E83_E1.2371.00
44_L48_L1.2371.00
19_L38_L1.1931.00
90_G103_A1.1831.00
14_V18_I1.1791.00
4_K8_V1.1541.00
77_A81_K1.1531.00
24_I27_E1.1471.00
38_L67_T1.1391.00
22_L26_L1.1371.00
7_L57_F1.1211.00
107_F111_V1.1151.00
80_F83_E1.1021.00
101_I105_I1.1001.00
8_V54_L1.0901.00
84_G91_T1.0851.00
60_A64_V1.0661.00
41_L45_L1.0631.00
38_L42_G1.0611.00
7_L11_L1.0301.00
22_L25_K1.0101.00
52_D75_S1.0101.00
17_Q20_I0.9931.00
5_A59_G0.9921.00
20_I30_T0.9911.00
12_I62_A0.9791.00
27_E31_P0.9771.00
54_L58_A0.9771.00
31_P35_L0.9591.00
21_D24_I0.9351.00
20_I27_E0.9251.00
23_T34_T0.9221.00
4_K58_A0.9181.00
50_L53_K0.9151.00
19_L34_T0.8911.00
77_A93_M0.8911.00
96_I99_P0.8901.00
85_G103_A0.8791.00
43_A70_G0.8781.00
78_I81_K0.8771.00
71_N75_S0.8761.00
47_G74_A0.8731.00
75_S79_E0.8681.00
52_D71_N0.8641.00
78_I82_S0.8561.00
75_S78_I0.8511.00
14_V21_D0.8441.00
5_A60_A0.8371.00
32_A35_L0.8351.00
109_F113_L0.8301.00
58_A62_A0.8301.00
19_L37_T0.8261.00
70_G74_A0.8151.00
106_V109_F0.8041.00
46_T78_I0.7920.99
46_T74_A0.7910.99
86_V90_G0.7840.99
20_I31_P0.7800.99
19_L22_L0.7730.99
90_G102_V0.7730.99
79_E82_S0.7670.99
53_K56_K0.7630.99
19_L33_R0.7610.99
49_G52_D0.7360.99
24_I29_T0.7350.99
29_T32_A0.7320.99
93_M98_G0.7290.99
24_I30_T0.7290.99
81_K89_V0.7220.99
94_F97_A0.7180.99
104_G108_S0.7160.99
91_T95_T0.6990.99
24_I28_E0.6980.99
21_D25_K0.6910.99
94_F98_G0.6870.99
7_L14_V0.6780.98
106_V110_L0.6650.98
77_A89_V0.6630.98
33_R36_V0.6630.98
85_G90_G0.6580.98
18_I25_K0.6580.98
80_F89_V0.6570.98
73_L101_I0.6550.98
73_L93_M0.6470.98
23_T26_L0.6360.98
30_T35_L0.6350.98
40_F48_L0.6330.98
16_G67_T0.6110.97
16_G19_L0.6080.97
60_A63_T0.6010.97
53_K57_F0.5970.97
15_I19_L0.5950.96
6_F14_V0.5950.96
15_I41_L0.5910.96
31_P34_T0.5880.96
28_E32_A0.5860.96
8_V12_I0.5790.96
63_T73_L0.5780.96
42_G70_G0.5770.96
94_F102_V0.5740.96
33_R37_T0.5680.95
102_V106_V0.5680.95
81_K86_V0.5660.95
50_L54_L0.5630.95
26_L29_T0.5610.95
87_L90_G0.5600.95
39_V66_I0.5600.95
98_G102_V0.5590.95
19_L24_I0.5550.95
100_V103_A0.5470.94
9_G65_P0.5470.94
101_I104_G0.5440.94
8_V11_L0.5380.94
8_V62_A0.5360.94
79_E84_G0.5350.94
36_V40_F0.5320.94
4_K11_L0.5210.93
99_P102_V0.5210.93
84_G97_A0.5200.93
20_I33_R0.5150.92
80_F92_G0.5150.92
67_T71_N0.5140.92
44_L47_G0.5130.92
51_Y71_N0.5120.92
24_I33_R0.5070.92
68_G71_N0.5050.92
53_K62_A0.5030.92
7_L28_E0.5010.91
15_I38_L0.5010.91
46_T72_S0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqjA 2 0.1842 1.6 0.943 Contact Map
1lnqA 6 0.6404 1.5 0.944 Contact Map
3wxwA 1 0.3158 1.4 0.945 Contact Map
3wu2X 1 0.2719 1.3 0.946 Contact Map
3bz1X 1 0.2632 1.3 0.946 Contact Map
4dx5A 3 0.9123 1.3 0.946 Contact Map
4mt1A 3 0.9386 1 0.949 Contact Map
1u7gA 3 1 1 0.949 Contact Map
2qi9A 2 0.4386 1 0.95 Contact Map
2onkC 2 0.4561 1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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