GREMLIN Database
RecT - RecT family
PFAM: PF03837 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 199 (186)
Sequences: 11077 (9270)
Seq/√Len: 679.7
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_Y62_G3.7281.00
43_Q68_K3.1791.00
119_A170_A3.1291.00
136_K140_E2.9141.00
158_P162_A2.8421.00
46_L57_A2.7651.00
49_Y60_Q2.7261.00
44_A59_F2.6531.00
68_K72_R2.4091.00
122_K128_E2.3641.00
77_K124_K2.3431.00
16_K19_K2.3341.00
86_E113_K2.2151.00
116_G133_V2.1901.00
77_K127_G1.9181.00
140_E158_P1.8791.00
152_G156_T1.8691.00
139_I162_A1.8691.00
66_L168_R1.8621.00
67_I167_I1.8571.00
82_E94_L1.8541.00
7_A29_L1.8311.00
134_M166_A1.8241.00
50_N53_G1.7881.00
145_K157_D1.7611.00
80_N120_V1.7351.00
132_E169_R1.7201.00
135_S138_E1.7071.00
77_K122_K1.6871.00
28_A46_L1.6511.00
157_D160_E1.6081.00
136_K162_A1.5901.00
117_A162_A1.5691.00
85_Y114_I1.5631.00
49_Y58_Q1.5571.00
152_G155_K1.5551.00
61_I66_L1.5231.00
142_H169_R1.5131.00
21_T24_S1.4931.00
147_S150_N1.4871.00
81_A163_K1.4731.00
75_Q124_K1.4681.00
70_A171_L1.4561.00
117_A166_A1.4261.00
117_A139_I1.4211.00
12_K22_P1.4131.00
160_E169_R1.4101.00
160_E163_K1.4071.00
99_P103_H1.4051.00
134_M138_E1.4021.00
121_V170_A1.3991.00
121_V175_F1.3941.00
32_A44_A1.3931.00
83_V114_I1.3871.00
87_G112_G1.3581.00
47_V60_Q1.3351.00
136_K158_P1.3311.00
153_P161_M1.3271.00
97_E101_H1.3211.00
83_V163_K1.3211.00
32_A39_P1.3131.00
19_K55_G1.3001.00
114_I162_A1.2781.00
138_E159_D1.2711.00
63_Y67_I1.2441.00
76_Y79_I1.2331.00
37_L65_G1.2241.00
42_G64_K1.2171.00
38_D41_K1.1931.00
16_K55_G1.1921.00
48_P55_G1.1821.00
109_G112_G1.1781.00
140_E143_R1.1651.00
51_K54_G1.1581.00
91_E102_E1.1481.00
83_V117_A1.1471.00
146_S149_A1.1411.00
20_C57_A1.1081.00
99_P102_E1.0941.00
134_M169_R1.0871.00
153_P157_D1.0811.00
77_K125_D1.0571.00
32_A59_F1.0561.00
83_V159_D1.0521.00
114_I117_A1.0501.00
64_K177_L1.0481.00
91_E100_E1.0451.00
5_R9_T1.0451.00
101_H105_P1.0391.00
140_E150_N1.0221.00
25_L57_A1.0211.00
100_E103_H1.0041.00
92_Y133_V1.0041.00
10_A13_R0.9981.00
50_N54_G0.9951.00
153_P156_T0.9821.00
140_E144_K0.9811.00
122_K127_G0.9691.00
28_A57_A0.9631.00
16_K48_P0.9591.00
42_G62_G0.9581.00
148_K151_S0.9571.00
37_L61_I0.9551.00
97_E100_E0.9541.00
97_E103_H0.9491.00
38_D43_Q0.9471.00
91_E104_K0.9461.00
21_T56_E0.9411.00
71_R75_Q0.9411.00
35_L59_F0.9351.00
101_H104_K0.9341.00
9_T13_R0.9311.00
34_Q38_D0.9291.00
82_E118_Y0.9281.00
31_Q34_Q0.9181.00
114_I158_P0.9121.00
35_L61_I0.9081.00
111_R137_E0.8921.00
141_K157_D0.8921.00
24_S57_A0.8911.00
171_L175_F0.8771.00
123_L129_P0.8751.00
20_C46_L0.8741.00
76_Y175_F0.8731.00
96_T99_P0.8661.00
30_L33_A0.8631.00
134_M139_I0.8631.00
117_A159_D0.8621.00
75_Q125_D0.8541.00
99_P104_K0.8541.00
90_F133_V0.8491.00
167_I174_A0.8481.00
98_E103_H0.8421.00
181_G185_A0.8371.00
183_Y188_M0.8361.00
67_I174_A0.8361.00
114_I159_D0.8251.00
93_D102_E0.8201.00
75_Q123_L0.8191.00
89_E102_E0.8121.00
78_G122_K0.8111.00
96_T102_E0.7961.00
48_P57_A0.7961.00
3_F33_A0.7951.00
26_L30_L0.7911.00
67_I79_I0.7911.00
126_G129_P0.7881.00
168_R172_R0.7871.00
77_K126_G0.7831.00
126_G130_F0.7771.00
151_S155_K0.7771.00
138_E141_K0.7741.00
24_S48_P0.7721.00
10_A40_F0.7701.00
123_L126_G0.7691.00
15_P18_A0.7691.00
23_E27_L0.7681.00
149_A155_K0.7681.00
132_E163_K0.7571.00
163_K173_K0.7561.00
80_N129_P0.7561.00
15_P19_K0.7541.00
85_Y113_K0.7511.00
167_I173_K0.7501.00
102_E105_P0.7411.00
114_I136_K0.7401.00
72_R178_S0.7401.00
84_V116_G0.7361.00
70_A76_Y0.7291.00
31_Q59_F0.7291.00
87_G111_R0.7281.00
81_A167_I0.7221.00
66_L171_L0.7221.00
68_K178_S0.7211.00
138_E169_R0.7161.00
120_V128_E0.7121.00
50_N55_G0.7121.00
90_F95_G0.7111.00
98_E102_E0.7081.00
145_K156_T0.7081.00
8_L12_K0.7041.00
100_E104_K0.7011.00
143_R158_P0.6991.00
82_E163_K0.6981.00
24_S28_A0.6931.00
144_K149_A0.6931.00
11_I18_A0.6931.00
132_E166_A0.6931.00
184_T187_E0.6921.00
113_K136_K0.6921.00
71_R76_Y0.6891.00
80_N122_K0.6871.00
160_E173_K0.6861.00
83_V118_Y0.6841.00
109_G137_E0.6831.00
150_N155_K0.6811.00
149_A152_G0.6781.00
137_E140_E0.6771.00
73_S76_Y0.6771.00
86_E115_I0.6761.00
70_A175_F0.6661.00
13_R23_E0.6661.00
31_Q35_L0.6601.00
129_P170_A0.6541.00
124_K127_G0.6531.00
63_Y167_I0.6531.00
146_S150_N0.6511.00
134_M165_T0.6501.00
98_E101_H0.6481.00
117_A158_P0.6441.00
67_I71_R0.6401.00
146_S157_D0.6371.00
87_G110_D0.6361.00
65_G69_L0.6331.00
23_E26_L0.6271.00
181_G184_T0.6261.00
98_E104_K0.6171.00
135_S159_D0.6131.00
89_E104_K0.6121.00
145_K148_K0.6121.00
84_V90_F0.6121.00
129_P174_A0.6121.00
97_E102_E0.6111.00
14_N41_K0.6061.00
182_A185_A0.6061.00
119_A166_A0.6011.00
143_R150_N0.6001.00
6_S38_D0.5981.00
61_I69_L0.5911.00
123_L127_G0.5911.00
4_I7_A0.5901.00
93_D100_E0.5881.00
49_Y147_S0.5821.00
110_D137_E0.5801.00
28_A32_A0.5771.00
51_K55_G0.5751.00
80_N128_E0.5731.00
85_Y111_R0.5721.00
170_A175_F0.5721.00
139_I143_R0.5721.00
9_T12_K0.5701.00
144_K150_N0.5651.00
35_L182_A0.5611.00
21_T54_G0.5591.00
69_L72_R0.5571.00
163_K167_I0.5551.00
27_L31_Q0.5531.00
47_V58_Q0.5491.00
52_K56_E0.5471.00
171_L177_L0.5461.00
31_Q40_F0.5451.00
143_R155_K0.5441.00
133_V138_E0.5391.00
96_T103_H0.5371.00
77_K128_E0.5361.00
43_Q62_G0.5361.00
144_K151_S0.5351.00
78_G129_P0.5311.00
163_K169_R0.5271.00
35_L69_L0.5271.00
184_T188_M0.5261.00
88_D94_L0.5241.00
86_E112_G0.5210.99
116_G119_A0.5210.99
85_Y88_D0.5200.99
132_E170_A0.5190.99
79_I167_I0.5180.99
134_M142_H0.5180.99
104_K107_D0.5150.99
146_S151_S0.5140.99
116_G135_S0.5130.99
103_H106_F0.5120.99
52_K55_G0.5100.99
76_Y121_V0.5090.99
100_E105_P0.5080.99
22_P26_L0.5050.99
20_C25_L0.5030.99
141_K145_K0.5010.99
17_L25_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dmpA 1 0.3618 14.1 0.93 Contact Map
2d5vA 1 0.2714 13 0.931 Contact Map
4ndlB 1 0.2261 8.5 0.937 Contact Map
3a03A 1 0.2663 8.2 0.937 Contact Map
3rkqA 1 0.2613 7.1 0.939 Contact Map
3d1nI 2 0.2714 6.9 0.939 Contact Map
3a02A 1 0.2563 6.7 0.94 Contact Map
4uzzB 1 0.3065 6.6 0.94 Contact Map
3l1pA 2 0.2714 6.5 0.94 Contact Map
2e19A 1 0.2864 6.4 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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