Mtc - PFAM28P - GREMLIN Contacts

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Mtc - Tricarboxylate carrier

PFAM:	PF03820	Sequences: YDQSTFWGRVKHFFDITDPRTLLVSEAELEEAKKLVEDYKAGKVPPGLTDEELWRAKKLYDSAFHPDTGEKIFLPFRMSAFVPGNMPITGGMLTPYKTTPAVIFWQWVNQSFNAAVNYTNRNASSPLSTSQLGTSYVAATTAACSTALGLNSLVKRLKKPATPPLLGRLVPFAAVAAANCVNVPLMRQNELRNGIDVFDENGNVVGKSKKAAKKAVSETALSRVLMAAPGMVLPPLIMNRLEKTAFLKRRPRLHAPVQLGLIGLTLGFALPLACALFPQRSSISVSSLEPEFQEKIKKGPITEVYFNKGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	310 (310)
Sequences:	754 (494)
Seq/√Len:	28.0
META:	0.127

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_D	203_N	5.236	1.00
205_V	304_V	4.465	1.00
57_K	61_D	3.986	1.00
80_A	84_G	3.627	1.00
34_K	38_D	3.574	1.00
24_V	59_L	3.554	1.00
195_I	215_A	3.424	1.00
251_P	256_P	3.416	1.00
27_A	31_E	3.284	1.00
18_D	58_K	3.227	1.00
25_S	28_E	3.226	1.00
10_V	272_L	3.162	1.00
32_A	59_L	2.898	1.00
253_L	256_P	2.845	1.00
38_D	43_K	2.827	1.00
197_V	292_F	2.743	1.00
171_P	175_V	2.614	0.99
21_T	58_K	2.591	0.99
283_I	304_V	2.554	0.99
30_E	33_K	2.485	0.99
292_F	295_K	2.452	0.99
196_D	204_V	2.443	0.99
49_T	52_E	2.441	0.99
107_W	136_Y	2.371	0.99
283_I	306_F	2.364	0.99
18_D	21_T	2.210	0.98
35_L	56_A	2.191	0.98
138_A	185_L	2.177	0.98
67_D	122_N	2.156	0.98
72_I	119_T	2.134	0.98
209_K	291_E	2.110	0.97
148_L	152_S	2.107	0.97
285_V	304_V	2.068	0.97
225_L	276_L	2.040	0.97
294_E	297_K	2.036	0.97
135_S	138_A	2.025	0.97
91_G	105_W	2.005	0.96
142_A	181_V	1.904	0.95
240_R	244_T	1.888	0.95
98_T	103_I	1.828	0.94
6_F	10_V	1.814	0.94
15_D	58_K	1.812	0.94
191_L	212_A	1.781	0.93
130_S	134_T	1.769	0.93
13_F	17_T	1.762	0.93
28_E	31_E	1.746	0.92
282_S	303_E	1.664	0.90
216_V	219_T	1.661	0.90
279_Q	307_N	1.649	0.90
104_F	107_W	1.639	0.90
1_Y	15_D	1.638	0.90
290_P	293_Q	1.626	0.89
294_E	299_G	1.613	0.89
118_Y	121_R	1.585	0.88
182_N	187_R	1.567	0.88
98_T	101_A	1.551	0.87
137_V	141_T	1.523	0.86
219_T	226_M	1.510	0.85
133_G	137_V	1.501	0.85
219_T	222_S	1.491	0.85
26_E	30_E	1.487	0.85
54_W	57_K	1.475	0.84
210_K	213_K	1.475	0.84
282_S	305_Y	1.472	0.84
197_V	304_V	1.472	0.84
76_F	119_T	1.464	0.84
36_V	50_D	1.450	0.83
238_M	242_E	1.448	0.83
44_V	48_L	1.415	0.81
76_F	115_A	1.407	0.81
35_L	48_L	1.396	0.81
7_W	11_K	1.393	0.80
152_S	155_K	1.389	0.80
30_E	64_F	1.388	0.80
64_F	71_K	1.376	0.80
141_T	144_C	1.373	0.79
215_A	234_P	1.371	0.79
84_G	112_F	1.366	0.79
129_T	133_G	1.365	0.79
107_W	114_A	1.350	0.78
30_E	71_K	1.345	0.78
199_D	202_G	1.334	0.77
33_K	60_Y	1.330	0.77
197_V	206_G	1.329	0.77
53_L	59_L	1.318	0.77
195_I	218_E	1.311	0.76
6_F	272_L	1.307	0.76
249_R	282_S	1.294	0.75
72_I	76_F	1.275	0.74
278_P	281_S	1.268	0.74
177_A	180_C	1.266	0.74
67_D	123_A	1.249	0.73
250_R	256_P	1.243	0.72
191_L	213_K	1.241	0.72
286_S	302_T	1.231	0.71
260_G	264_L	1.229	0.71
195_I	234_P	1.223	0.71
81_F	179_N	1.219	0.71
128_S	131_Q	1.216	0.70
31_E	34_K	1.199	0.69
124_S	215_A	1.181	0.68
214_K	218_E	1.176	0.68
22_L	150_L	1.174	0.68
247_L	257_V	1.173	0.68
45_P	48_L	1.168	0.67
70_E	141_T	1.156	0.66
98_T	108_V	1.151	0.66
270_L	274_C	1.150	0.66
106_Q	175_V	1.146	0.66
259_L	276_L	1.143	0.66
291_E	295_K	1.143	0.66
283_I	303_E	1.126	0.64
30_E	34_K	1.125	0.64
143_A	179_N	1.119	0.64
136_Y	139_A	1.116	0.64
109_N	139_A	1.115	0.64
153_L	161_A	1.115	0.64
135_S	188_Q	1.107	0.63
127_L	132_L	1.105	0.63
111_S	125_S	1.094	0.62
132_L	147_A	1.091	0.62
117_N	182_N	1.087	0.62
138_A	141_T	1.087	0.62
114_A	121_R	1.087	0.62
89_T	231_M	1.084	0.61
110_Q	113_N	1.080	0.61
271_P	278_P	1.079	0.61
222_S	227_A	1.072	0.60
141_T	145_S	1.064	0.60
80_A	112_F	1.064	0.60
249_R	255_A	1.057	0.59
287_S	302_T	1.056	0.59
117_N	139_A	1.055	0.59
263_G	268_F	1.044	0.58
3_Q	13_F	1.034	0.58
20_R	58_K	1.031	0.57
131_Q	134_T	1.024	0.57
49_T	53_L	1.018	0.56
33_K	37_E	1.013	0.56
296_I	301_I	1.013	0.56
69_G	306_F	1.012	0.56
24_V	29_L	1.008	0.56
294_E	298_K	1.006	0.56
33_K	40_K	1.006	0.56
85_N	113_N	0.999	0.55
88_I	108_V	0.997	0.55
109_N	113_N	0.992	0.55
206_G	292_F	0.990	0.54
84_G	122_N	0.980	0.54
292_F	296_I	0.977	0.53
17_T	222_S	0.975	0.53
81_F	116_V	0.975	0.53
131_Q	189_N	0.974	0.53
114_A	143_A	0.972	0.53
6_F	203_N	0.970	0.53
293_Q	297_K	0.969	0.53
66_P	307_N	0.964	0.52
78_M	112_F	0.962	0.52
295_K	301_I	0.956	0.52
246_F	254_H	0.953	0.52
55_R	58_K	0.948	0.51
187_R	223_R	0.947	0.51
284_S	287_S	0.946	0.51
116_V	263_G	0.943	0.51
97_K	101_A	0.939	0.50
295_K	304_V	0.938	0.50
96_Y	270_L	0.936	0.50
198_F	202_G	0.933	0.50
63_A	114_A	0.926	0.49
209_K	213_K	0.922	0.49
22_L	80_A	0.921	0.49
292_F	304_V	0.916	0.49
250_R	290_P	0.913	0.48
90_G	263_G	0.911	0.48
216_V	220_A	0.911	0.48
269_A	272_L	0.910	0.48
36_V	61_D	0.909	0.48
245_A	248_K	0.903	0.48
81_F	89_T	0.897	0.47
84_G	123_A	0.896	0.47
114_A	212_A	0.893	0.47
128_S	207_K	0.893	0.47
172_F	227_A	0.890	0.47
238_M	261_L	0.888	0.47
218_E	278_P	0.886	0.46
27_A	34_K	0.882	0.46
49_T	215_A	0.880	0.46
35_L	45_P	0.880	0.46
124_S	196_D	0.874	0.45
43_K	284_S	0.868	0.45
143_A	258_Q	0.867	0.45
265_T	269_A	0.865	0.45
31_E	40_K	0.865	0.45
5_T	8_G	0.864	0.45
196_D	207_K	0.863	0.45
284_S	302_T	0.862	0.45
179_N	226_M	0.860	0.44
103_I	152_S	0.859	0.44
44_V	47_G	0.858	0.44
306_F	309_G	0.856	0.44
65_H	171_P	0.855	0.44
3_Q	233_L	0.852	0.44
38_D	160_P	0.850	0.44
135_S	256_P	0.848	0.43
151_N	167_G	0.846	0.43
112_F	116_V	0.844	0.43
99_T	197_V	0.841	0.43
201_N	298_K	0.840	0.43
206_G	289_E	0.839	0.43
217_S	221_L	0.837	0.43
200_E	302_T	0.833	0.42
76_F	95_P	0.832	0.42
219_T	270_L	0.831	0.42
249_R	256_P	0.828	0.42
244_T	251_P	0.819	0.41
1_Y	130_S	0.818	0.41
247_L	251_P	0.817	0.41
124_S	204_V	0.816	0.41
292_F	297_K	0.810	0.41
151_N	156_R	0.809	0.41
10_V	14_F	0.808	0.41
134_T	138_A	0.803	0.40
253_L	294_E	0.800	0.40
34_K	193_N	0.797	0.40
38_D	45_P	0.794	0.39
197_V	288_L	0.791	0.39
6_F	198_F	0.790	0.39
39_Y	54_W	0.788	0.39
144_C	215_A	0.787	0.39
92_M	269_A	0.786	0.39
243_K	253_L	0.785	0.39
285_V	292_F	0.774	0.38
144_C	274_C	0.769	0.38
72_I	82_V	0.767	0.38
99_T	146_T	0.766	0.37
240_R	243_K	0.766	0.37
249_R	299_G	0.765	0.37
295_K	298_K	0.763	0.37
140_T	146_T	0.762	0.37
116_V	274_C	0.761	0.37
112_F	212_A	0.760	0.37
33_K	64_F	0.759	0.37
139_A	182_N	0.756	0.37
86_M	90_G	0.756	0.37
247_L	250_R	0.749	0.36
92_M	174_A	0.746	0.36
265_T	308_K	0.744	0.36
104_F	199_D	0.742	0.36
24_V	32_A	0.741	0.36
299_G	303_E	0.741	0.36
200_E	284_S	0.739	0.36
99_T	152_S	0.736	0.35
253_L	302_T	0.735	0.35
219_T	274_C	0.733	0.35
64_F	81_F	0.731	0.35
81_F	112_F	0.730	0.35
97_K	144_C	0.730	0.35
200_E	305_Y	0.730	0.35
248_K	251_P	0.728	0.35
91_G	101_A	0.726	0.35
297_K	301_I	0.725	0.35
267_G	278_P	0.723	0.34
122_N	143_A	0.721	0.34
54_W	70_E	0.719	0.34
183_V	219_T	0.717	0.34
276_L	279_Q	0.715	0.34
86_M	267_G	0.715	0.34
292_F	305_Y	0.714	0.34
137_V	149_G	0.712	0.34
6_F	193_N	0.711	0.34
10_V	275_A	0.711	0.34
111_S	238_M	0.709	0.33
246_F	257_V	0.709	0.33
50_D	53_L	0.706	0.33
30_E	37_E	0.704	0.33
88_I	250_R	0.702	0.33
6_F	9_R	0.702	0.33
83_P	88_I	0.701	0.33
233_L	243_K	0.700	0.33
86_M	112_F	0.697	0.33
145_S	277_F	0.697	0.33
43_K	46_P	0.697	0.33
7_W	10_V	0.697	0.33
80_A	83_P	0.693	0.32
226_M	274_C	0.693	0.32
99_T	148_L	0.692	0.32
80_A	122_N	0.692	0.32
174_A	178_A	0.690	0.32
88_I	98_T	0.687	0.32
184_P	216_V	0.685	0.32
109_N	178_A	0.684	0.32
144_C	197_V	0.682	0.32
18_D	149_G	0.681	0.32
81_F	226_M	0.680	0.31
86_M	266_L	0.678	0.31
109_N	136_Y	0.678	0.31
57_K	167_G	0.678	0.31
66_P	229_P	0.677	0.31
281_S	306_F	0.676	0.31
123_A	307_N	0.675	0.31
176_A	180_C	0.673	0.31
265_T	306_F	0.669	0.31
3_Q	8_G	0.669	0.31
194_G	208_S	0.668	0.31
69_G	111_S	0.666	0.31
151_N	224_V	0.665	0.31
109_N	117_N	0.665	0.31
169_L	210_K	0.664	0.30
26_E	71_K	0.660	0.30
98_T	155_K	0.658	0.30
78_M	147_A	0.655	0.30
298_K	301_I	0.651	0.30
60_Y	71_K	0.648	0.29
127_L	306_F	0.647	0.29
204_V	207_K	0.646	0.29
161_A	203_N	0.644	0.29
191_L	216_V	0.643	0.29
30_E	41_A	0.642	0.29
22_L	54_W	0.642	0.29
187_R	190_E	0.638	0.29
23_L	63_A	0.636	0.29
140_T	255_A	0.636	0.29
27_A	38_D	0.634	0.29
111_S	136_Y	0.633	0.28
241_L	247_L	0.633	0.28
285_V	301_I	0.631	0.28
56_A	199_D	0.631	0.28
237_I	260_G	0.631	0.28
35_L	43_K	0.630	0.28
25_S	193_N	0.629	0.28
167_G	212_A	0.628	0.28
6_F	269_A	0.627	0.28
80_A	123_A	0.627	0.28
28_E	34_K	0.626	0.28
23_L	34_K	0.624	0.28
136_Y	143_A	0.623	0.28
135_S	231_M	0.623	0.28
241_L	291_E	0.622	0.28
122_N	196_D	0.622	0.28
16_I	20_R	0.620	0.28
8_G	12_H	0.619	0.28
67_D	267_G	0.618	0.28
150_L	173_A	0.618	0.28
245_A	281_S	0.617	0.27
99_T	231_M	0.616	0.27
95_P	226_M	0.616	0.27
87_P	90_G	0.615	0.27
85_N	109_N	0.614	0.27
76_F	211_A	0.612	0.27
37_E	41_A	0.611	0.27
119_T	143_A	0.610	0.27
108_V	125_S	0.609	0.27
100_P	151_N	0.605	0.27
8_G	109_N	0.603	0.27
280_R	305_Y	0.603	0.27
35_L	49_T	0.602	0.27
222_S	226_M	0.601	0.27
103_I	192_R	0.601	0.27
11_K	33_K	0.600	0.26
93_L	102_V	0.598	0.26
97_K	100_P	0.596	0.26
93_L	278_P	0.594	0.26
23_L	267_G	0.593	0.26
43_K	232_V	0.591	0.26
62_S	184_P	0.589	0.26
137_V	146_T	0.588	0.26
1_Y	44_V	0.587	0.26
1_Y	37_E	0.584	0.25
169_L	243_K	0.583	0.25
85_N	123_A	0.582	0.25
24_V	145_S	0.582	0.25
86_M	263_G	0.581	0.25
3_Q	276_L	0.581	0.25
246_F	256_P	0.580	0.25
168_R	212_A	0.579	0.25
110_Q	118_Y	0.579	0.25
270_L	275_A	0.579	0.25
192_R	241_L	0.577	0.25
195_I	261_L	0.576	0.25
197_V	301_I	0.576	0.25
113_N	136_Y	0.575	0.25
212_A	231_M	0.575	0.25
106_Q	171_P	0.574	0.25
82_V	215_A	0.574	0.25
76_F	156_R	0.573	0.25
67_D	126_P	0.573	0.25
177_A	233_L	0.573	0.25
1_Y	87_P	0.572	0.25
73_F	84_G	0.571	0.25
116_V	310_L	0.569	0.25
128_S	213_K	0.569	0.25
128_S	293_Q	0.566	0.24
17_T	29_L	0.564	0.24
46_P	290_P	0.562	0.24
78_M	222_S	0.559	0.24
54_W	61_D	0.559	0.24
110_Q	178_A	0.558	0.24
140_T	180_C	0.557	0.24
225_L	241_L	0.555	0.24
178_A	182_N	0.554	0.24
165_L	176_A	0.554	0.24
17_T	21_T	0.553	0.24
45_P	52_E	0.552	0.24
197_V	204_V	0.552	0.24
114_A	125_S	0.547	0.23
112_F	143_A	0.546	0.23
245_A	249_R	0.545	0.23
147_A	151_N	0.545	0.23
152_S	156_R	0.545	0.23
9_R	19_P	0.544	0.23
39_Y	49_T	0.544	0.23
206_G	262_I	0.543	0.23
241_L	260_G	0.542	0.23
44_V	257_V	0.542	0.23
67_D	306_F	0.541	0.23
48_L	52_E	0.541	0.23
137_V	302_T	0.538	0.23
153_L	288_L	0.538	0.23
95_P	112_F	0.537	0.23
34_K	46_P	0.537	0.23
23_L	293_Q	0.537	0.23
86_M	179_N	0.536	0.23
137_V	177_A	0.536	0.23
23_L	28_E	0.536	0.23
76_F	81_F	0.535	0.23
226_M	270_L	0.535	0.23
225_L	275_A	0.535	0.23
6_F	290_P	0.533	0.23
112_F	121_R	0.529	0.22
147_A	270_L	0.527	0.22
226_M	281_S	0.527	0.22
80_A	239_N	0.526	0.22
113_N	139_A	0.526	0.22
189_N	292_F	0.525	0.22
80_A	92_M	0.525	0.22
224_V	263_G	0.524	0.22
145_S	288_L	0.524	0.22
45_P	98_T	0.523	0.22
16_I	232_V	0.522	0.22
221_L	283_I	0.521	0.22
63_A	71_K	0.521	0.22
138_A	188_Q	0.521	0.22
117_N	120_N	0.519	0.22
218_E	265_T	0.519	0.22
141_T	228_A	0.519	0.22
139_A	178_A	0.519	0.22
114_A	118_Y	0.517	0.22
213_K	217_S	0.517	0.22
189_N	212_A	0.515	0.22
59_L	63_A	0.514	0.22
234_P	281_S	0.514	0.22
23_L	287_S	0.514	0.22
134_T	181_V	0.513	0.22
11_K	98_T	0.513	0.22
21_T	36_V	0.511	0.21
107_W	111_S	0.508	0.21
208_S	223_R	0.508	0.21
48_L	53_L	0.508	0.21
193_N	205_V	0.507	0.21
67_D	220_A	0.506	0.21
68_T	206_G	0.505	0.21
142_A	146_T	0.504	0.21
246_F	251_P	0.502	0.21
220_A	231_M	0.501	0.21
41_A	293_Q	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2npuA	1	0.2097	26.4	0.973	Contact Map
2ys8A	1	0.2548	22.8	0.973	Contact Map
1ff3A	5	0.2742	17.6	0.975	Contact Map
2hfvA	1	0.1484	16.4	0.975	Contact Map
4d7lA	3	0.2677	15.1	0.975	Contact Map
3ucsC	1	0.2065	14.1	0.976	Contact Map
4rwuA	1	0.2581	12.5	0.976	Contact Map
4driB	1	0.2032	11.9	0.977	Contact Map
4gwbA	2	0.2742	10.2	0.977	Contact Map
1n4cA	1	0.3194	9.1	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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