GREMLIN Database
Mtc - Tricarboxylate carrier
PFAM: PF03820 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 310 (310)
Sequences: 754 (494)
Seq/√Len: 28.0
META: 0.127

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_D203_N5.2361.00
205_V304_V4.4651.00
57_K61_D3.9861.00
80_A84_G3.6271.00
34_K38_D3.5741.00
24_V59_L3.5541.00
195_I215_A3.4241.00
251_P256_P3.4161.00
27_A31_E3.2841.00
18_D58_K3.2271.00
25_S28_E3.2261.00
10_V272_L3.1621.00
32_A59_L2.8981.00
253_L256_P2.8451.00
38_D43_K2.8271.00
197_V292_F2.7431.00
171_P175_V2.6140.99
21_T58_K2.5910.99
283_I304_V2.5540.99
30_E33_K2.4850.99
292_F295_K2.4520.99
196_D204_V2.4430.99
49_T52_E2.4410.99
107_W136_Y2.3710.99
283_I306_F2.3640.99
18_D21_T2.2100.98
35_L56_A2.1910.98
138_A185_L2.1770.98
67_D122_N2.1560.98
72_I119_T2.1340.98
209_K291_E2.1100.97
148_L152_S2.1070.97
285_V304_V2.0680.97
225_L276_L2.0400.97
294_E297_K2.0360.97
135_S138_A2.0250.97
91_G105_W2.0050.96
142_A181_V1.9040.95
240_R244_T1.8880.95
98_T103_I1.8280.94
6_F10_V1.8140.94
15_D58_K1.8120.94
191_L212_A1.7810.93
130_S134_T1.7690.93
13_F17_T1.7620.93
28_E31_E1.7460.92
282_S303_E1.6640.90
216_V219_T1.6610.90
279_Q307_N1.6490.90
104_F107_W1.6390.90
1_Y15_D1.6380.90
290_P293_Q1.6260.89
294_E299_G1.6130.89
118_Y121_R1.5850.88
182_N187_R1.5670.88
98_T101_A1.5510.87
137_V141_T1.5230.86
219_T226_M1.5100.85
133_G137_V1.5010.85
219_T222_S1.4910.85
26_E30_E1.4870.85
54_W57_K1.4750.84
210_K213_K1.4750.84
282_S305_Y1.4720.84
197_V304_V1.4720.84
76_F119_T1.4640.84
36_V50_D1.4500.83
238_M242_E1.4480.83
44_V48_L1.4150.81
76_F115_A1.4070.81
35_L48_L1.3960.81
7_W11_K1.3930.80
152_S155_K1.3890.80
30_E64_F1.3880.80
64_F71_K1.3760.80
141_T144_C1.3730.79
215_A234_P1.3710.79
84_G112_F1.3660.79
129_T133_G1.3650.79
107_W114_A1.3500.78
30_E71_K1.3450.78
199_D202_G1.3340.77
33_K60_Y1.3300.77
197_V206_G1.3290.77
53_L59_L1.3180.77
195_I218_E1.3110.76
6_F272_L1.3070.76
249_R282_S1.2940.75
72_I76_F1.2750.74
278_P281_S1.2680.74
177_A180_C1.2660.74
67_D123_A1.2490.73
250_R256_P1.2430.72
191_L213_K1.2410.72
286_S302_T1.2310.71
260_G264_L1.2290.71
195_I234_P1.2230.71
81_F179_N1.2190.71
128_S131_Q1.2160.70
31_E34_K1.1990.69
124_S215_A1.1810.68
214_K218_E1.1760.68
22_L150_L1.1740.68
247_L257_V1.1730.68
45_P48_L1.1680.67
70_E141_T1.1560.66
98_T108_V1.1510.66
270_L274_C1.1500.66
106_Q175_V1.1460.66
259_L276_L1.1430.66
291_E295_K1.1430.66
283_I303_E1.1260.64
30_E34_K1.1250.64
143_A179_N1.1190.64
136_Y139_A1.1160.64
109_N139_A1.1150.64
153_L161_A1.1150.64
135_S188_Q1.1070.63
127_L132_L1.1050.63
111_S125_S1.0940.62
132_L147_A1.0910.62
117_N182_N1.0870.62
138_A141_T1.0870.62
114_A121_R1.0870.62
89_T231_M1.0840.61
110_Q113_N1.0800.61
271_P278_P1.0790.61
222_S227_A1.0720.60
141_T145_S1.0640.60
80_A112_F1.0640.60
249_R255_A1.0570.59
287_S302_T1.0560.59
117_N139_A1.0550.59
263_G268_F1.0440.58
3_Q13_F1.0340.58
20_R58_K1.0310.57
131_Q134_T1.0240.57
49_T53_L1.0180.56
33_K37_E1.0130.56
296_I301_I1.0130.56
69_G306_F1.0120.56
24_V29_L1.0080.56
294_E298_K1.0060.56
33_K40_K1.0060.56
85_N113_N0.9990.55
88_I108_V0.9970.55
109_N113_N0.9920.55
206_G292_F0.9900.54
84_G122_N0.9800.54
292_F296_I0.9770.53
17_T222_S0.9750.53
81_F116_V0.9750.53
131_Q189_N0.9740.53
114_A143_A0.9720.53
6_F203_N0.9700.53
293_Q297_K0.9690.53
66_P307_N0.9640.52
78_M112_F0.9620.52
295_K301_I0.9560.52
246_F254_H0.9530.52
55_R58_K0.9480.51
187_R223_R0.9470.51
284_S287_S0.9460.51
116_V263_G0.9430.51
97_K101_A0.9390.50
295_K304_V0.9380.50
96_Y270_L0.9360.50
198_F202_G0.9330.50
63_A114_A0.9260.49
209_K213_K0.9220.49
22_L80_A0.9210.49
292_F304_V0.9160.49
250_R290_P0.9130.48
90_G263_G0.9110.48
216_V220_A0.9110.48
269_A272_L0.9100.48
36_V61_D0.9090.48
245_A248_K0.9030.48
81_F89_T0.8970.47
84_G123_A0.8960.47
114_A212_A0.8930.47
128_S207_K0.8930.47
172_F227_A0.8900.47
238_M261_L0.8880.47
218_E278_P0.8860.46
27_A34_K0.8820.46
49_T215_A0.8800.46
35_L45_P0.8800.46
124_S196_D0.8740.45
43_K284_S0.8680.45
143_A258_Q0.8670.45
265_T269_A0.8650.45
31_E40_K0.8650.45
5_T8_G0.8640.45
196_D207_K0.8630.45
284_S302_T0.8620.45
179_N226_M0.8600.44
103_I152_S0.8590.44
44_V47_G0.8580.44
306_F309_G0.8560.44
65_H171_P0.8550.44
3_Q233_L0.8520.44
38_D160_P0.8500.44
135_S256_P0.8480.43
151_N167_G0.8460.43
112_F116_V0.8440.43
99_T197_V0.8410.43
201_N298_K0.8400.43
206_G289_E0.8390.43
217_S221_L0.8370.43
200_E302_T0.8330.42
76_F95_P0.8320.42
219_T270_L0.8310.42
249_R256_P0.8280.42
244_T251_P0.8190.41
1_Y130_S0.8180.41
247_L251_P0.8170.41
124_S204_V0.8160.41
292_F297_K0.8100.41
151_N156_R0.8090.41
10_V14_F0.8080.41
134_T138_A0.8030.40
253_L294_E0.8000.40
34_K193_N0.7970.40
38_D45_P0.7940.39
197_V288_L0.7910.39
6_F198_F0.7900.39
39_Y54_W0.7880.39
144_C215_A0.7870.39
92_M269_A0.7860.39
243_K253_L0.7850.39
285_V292_F0.7740.38
144_C274_C0.7690.38
72_I82_V0.7670.38
99_T146_T0.7660.37
240_R243_K0.7660.37
249_R299_G0.7650.37
295_K298_K0.7630.37
140_T146_T0.7620.37
116_V274_C0.7610.37
112_F212_A0.7600.37
33_K64_F0.7590.37
139_A182_N0.7560.37
86_M90_G0.7560.37
247_L250_R0.7490.36
92_M174_A0.7460.36
265_T308_K0.7440.36
104_F199_D0.7420.36
24_V32_A0.7410.36
299_G303_E0.7410.36
200_E284_S0.7390.36
99_T152_S0.7360.35
253_L302_T0.7350.35
219_T274_C0.7330.35
64_F81_F0.7310.35
81_F112_F0.7300.35
97_K144_C0.7300.35
200_E305_Y0.7300.35
248_K251_P0.7280.35
91_G101_A0.7260.35
297_K301_I0.7250.35
267_G278_P0.7230.34
122_N143_A0.7210.34
54_W70_E0.7190.34
183_V219_T0.7170.34
276_L279_Q0.7150.34
86_M267_G0.7150.34
292_F305_Y0.7140.34
137_V149_G0.7120.34
6_F193_N0.7110.34
10_V275_A0.7110.34
111_S238_M0.7090.33
246_F257_V0.7090.33
50_D53_L0.7060.33
30_E37_E0.7040.33
88_I250_R0.7020.33
6_F9_R0.7020.33
83_P88_I0.7010.33
233_L243_K0.7000.33
86_M112_F0.6970.33
145_S277_F0.6970.33
43_K46_P0.6970.33
7_W10_V0.6970.33
80_A83_P0.6930.32
226_M274_C0.6930.32
99_T148_L0.6920.32
80_A122_N0.6920.32
174_A178_A0.6900.32
88_I98_T0.6870.32
184_P216_V0.6850.32
109_N178_A0.6840.32
144_C197_V0.6820.32
18_D149_G0.6810.32
81_F226_M0.6800.31
86_M266_L0.6780.31
109_N136_Y0.6780.31
57_K167_G0.6780.31
66_P229_P0.6770.31
281_S306_F0.6760.31
123_A307_N0.6750.31
176_A180_C0.6730.31
265_T306_F0.6690.31
3_Q8_G0.6690.31
194_G208_S0.6680.31
69_G111_S0.6660.31
151_N224_V0.6650.31
109_N117_N0.6650.31
169_L210_K0.6640.30
26_E71_K0.6600.30
98_T155_K0.6580.30
78_M147_A0.6550.30
298_K301_I0.6510.30
60_Y71_K0.6480.29
127_L306_F0.6470.29
204_V207_K0.6460.29
161_A203_N0.6440.29
191_L216_V0.6430.29
30_E41_A0.6420.29
22_L54_W0.6420.29
187_R190_E0.6380.29
23_L63_A0.6360.29
140_T255_A0.6360.29
27_A38_D0.6340.29
111_S136_Y0.6330.28
241_L247_L0.6330.28
285_V301_I0.6310.28
56_A199_D0.6310.28
237_I260_G0.6310.28
35_L43_K0.6300.28
25_S193_N0.6290.28
167_G212_A0.6280.28
6_F269_A0.6270.28
80_A123_A0.6270.28
28_E34_K0.6260.28
23_L34_K0.6240.28
136_Y143_A0.6230.28
135_S231_M0.6230.28
241_L291_E0.6220.28
122_N196_D0.6220.28
16_I20_R0.6200.28
8_G12_H0.6190.28
67_D267_G0.6180.28
150_L173_A0.6180.28
245_A281_S0.6170.27
99_T231_M0.6160.27
95_P226_M0.6160.27
87_P90_G0.6150.27
85_N109_N0.6140.27
76_F211_A0.6120.27
37_E41_A0.6110.27
119_T143_A0.6100.27
108_V125_S0.6090.27
100_P151_N0.6050.27
8_G109_N0.6030.27
280_R305_Y0.6030.27
35_L49_T0.6020.27
222_S226_M0.6010.27
103_I192_R0.6010.27
11_K33_K0.6000.26
93_L102_V0.5980.26
97_K100_P0.5960.26
93_L278_P0.5940.26
23_L267_G0.5930.26
43_K232_V0.5910.26
62_S184_P0.5890.26
137_V146_T0.5880.26
1_Y44_V0.5870.26
1_Y37_E0.5840.25
169_L243_K0.5830.25
85_N123_A0.5820.25
24_V145_S0.5820.25
86_M263_G0.5810.25
3_Q276_L0.5810.25
246_F256_P0.5800.25
168_R212_A0.5790.25
110_Q118_Y0.5790.25
270_L275_A0.5790.25
192_R241_L0.5770.25
195_I261_L0.5760.25
197_V301_I0.5760.25
113_N136_Y0.5750.25
212_A231_M0.5750.25
106_Q171_P0.5740.25
82_V215_A0.5740.25
76_F156_R0.5730.25
67_D126_P0.5730.25
177_A233_L0.5730.25
1_Y87_P0.5720.25
73_F84_G0.5710.25
116_V310_L0.5690.25
128_S213_K0.5690.25
128_S293_Q0.5660.24
17_T29_L0.5640.24
46_P290_P0.5620.24
78_M222_S0.5590.24
54_W61_D0.5590.24
110_Q178_A0.5580.24
140_T180_C0.5570.24
225_L241_L0.5550.24
178_A182_N0.5540.24
165_L176_A0.5540.24
17_T21_T0.5530.24
45_P52_E0.5520.24
197_V204_V0.5520.24
114_A125_S0.5470.23
112_F143_A0.5460.23
245_A249_R0.5450.23
147_A151_N0.5450.23
152_S156_R0.5450.23
9_R19_P0.5440.23
39_Y49_T0.5440.23
206_G262_I0.5430.23
241_L260_G0.5420.23
44_V257_V0.5420.23
67_D306_F0.5410.23
48_L52_E0.5410.23
137_V302_T0.5380.23
153_L288_L0.5380.23
95_P112_F0.5370.23
34_K46_P0.5370.23
23_L293_Q0.5370.23
86_M179_N0.5360.23
137_V177_A0.5360.23
23_L28_E0.5360.23
76_F81_F0.5350.23
226_M270_L0.5350.23
225_L275_A0.5350.23
6_F290_P0.5330.23
112_F121_R0.5290.22
147_A270_L0.5270.22
226_M281_S0.5270.22
80_A239_N0.5260.22
113_N139_A0.5260.22
189_N292_F0.5250.22
80_A92_M0.5250.22
224_V263_G0.5240.22
145_S288_L0.5240.22
45_P98_T0.5230.22
16_I232_V0.5220.22
221_L283_I0.5210.22
63_A71_K0.5210.22
138_A188_Q0.5210.22
117_N120_N0.5190.22
218_E265_T0.5190.22
141_T228_A0.5190.22
139_A178_A0.5190.22
114_A118_Y0.5170.22
213_K217_S0.5170.22
189_N212_A0.5150.22
59_L63_A0.5140.22
234_P281_S0.5140.22
23_L287_S0.5140.22
134_T181_V0.5130.22
11_K98_T0.5130.22
21_T36_V0.5110.21
107_W111_S0.5080.21
208_S223_R0.5080.21
48_L53_L0.5080.21
193_N205_V0.5070.21
67_D220_A0.5060.21
68_T206_G0.5050.21
142_A146_T0.5040.21
246_F251_P0.5020.21
220_A231_M0.5010.21
41_A293_Q0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2npuA 1 0.2097 26.4 0.973 Contact Map
2ys8A 1 0.2548 22.8 0.973 Contact Map
1ff3A 5 0.2742 17.6 0.975 Contact Map
2hfvA 1 0.1484 16.4 0.975 Contact Map
4d7lA 3 0.2677 15.1 0.975 Contact Map
3ucsC 1 0.2065 14.1 0.976 Contact Map
4rwuA 1 0.2581 12.5 0.976 Contact Map
4driB 1 0.2032 11.9 0.977 Contact Map
4gwbA 2 0.2742 10.2 0.977 Contact Map
1n4cA 1 0.3194 9.1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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