GREMLIN Database
MadL - Malonate transporter MadL subunit
PFAM: PF03817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (116)
Sequences: 967 (581)
Seq/√Len: 53.9
META: 0.82

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_D32_N4.7521.00
49_Y53_R3.0361.00
38_I79_A2.8321.00
108_L111_L2.5861.00
89_S92_P2.5001.00
21_D29_V2.4581.00
62_S65_L2.4551.00
15_L42_L2.1681.00
22_L26_L2.1461.00
86_A90_G1.9371.00
69_A101_A1.9191.00
59_P105_C1.8930.99
13_M17_V1.8820.99
2_I31_A1.8490.99
50_L54_G1.8460.99
56_L61_E1.8340.99
79_A97_A1.8190.99
18_F22_L1.7610.99
27_L33_V1.6950.99
41_L86_A1.6790.99
41_L45_L1.6710.99
12_C42_L1.6240.98
2_I6_V1.6110.98
11_F46_A1.5960.98
103_V107_A1.5240.98
15_L46_A1.5160.97
107_A110_P1.5100.97
101_A105_C1.4910.97
6_V66_F1.4570.97
65_L69_A1.4450.97
17_V32_N1.3940.96
29_V33_V1.3710.95
45_L48_N1.3430.95
95_I99_V1.3040.94
72_I86_A1.2910.94
57_S60_T1.2880.94
6_V13_M1.2860.94
58_P61_E1.2520.93
48_N68_S1.2470.92
7_A10_A1.2420.92
60_T65_L1.2230.92
98_G110_P1.2130.91
13_M81_Q1.1760.90
50_L55_L1.1620.89
9_L14_L1.1520.89
102_V108_L1.1320.88
51_R61_E1.1090.87
11_F15_L1.1070.87
82_Q85_V1.1050.87
46_A49_Y1.0780.86
19_L68_S1.0280.83
76_V86_A1.0260.83
52_K58_P1.0140.82
98_G101_A1.0110.82
8_L116_G1.0050.81
45_L88_L0.9970.81
68_S110_P0.9960.81
48_N52_K0.9960.81
72_I78_M0.9950.81
21_D30_K0.9890.80
9_L67_W0.9890.80
66_F70_M0.9880.80
47_S79_A0.9720.79
17_V27_L0.9670.79
96_L99_V0.9480.77
24_G83_N0.9310.76
19_L42_L0.9270.76
13_M74_I0.9260.76
83_N113_S0.9240.75
29_V74_I0.9230.75
69_A75_V0.9170.75
8_L74_I0.8990.73
41_L44_I0.8950.73
42_L76_V0.8950.73
104_V108_L0.8940.73
1_M5_G0.8900.73
38_I47_S0.8860.72
47_S69_A0.8840.72
6_V57_S0.8810.72
6_V21_D0.8610.70
104_V107_A0.8560.70
21_D112_L0.8530.69
11_F75_V0.8520.69
98_G106_F0.8520.69
15_L22_L0.8520.69
7_A75_V0.8410.68
17_V75_V0.8390.68
27_L66_F0.8280.67
70_M109_V0.8240.67
89_S93_V0.8150.66
16_G20_G0.8130.66
23_L27_L0.7940.64
55_L59_P0.7930.64
51_R115_I0.7930.64
6_V9_L0.7880.63
21_D25_V0.7820.63
27_L70_M0.7600.61
29_V69_A0.7570.60
25_V30_K0.7550.60
92_P96_L0.7500.59
18_F25_V0.7500.59
49_Y52_K0.7490.59
53_R86_A0.7490.59
19_L95_I0.7270.57
31_A102_V0.7260.57
8_L80_A0.7250.57
99_V105_C0.7150.56
97_A102_V0.7140.56
81_Q92_P0.7080.55
74_I93_V0.7010.54
54_G92_P0.6990.54
49_Y61_E0.6990.54
90_G95_I0.6960.54
92_P95_I0.6900.53
50_L56_L0.6890.53
46_A50_L0.6860.53
61_E93_V0.6790.52
2_I85_V0.6760.52
42_L45_L0.6650.51
110_P113_S0.6570.50
86_A100_L0.6450.48
83_N86_A0.6420.48
80_A97_A0.6240.46
109_V113_S0.6220.46
90_G101_A0.6160.45
51_R54_G0.6160.45
1_M4_Y0.6150.45
72_I113_S0.6140.45
38_I101_A0.6060.44
46_A55_L0.6050.44
10_A47_S0.6030.44
2_I69_A0.5930.43
66_F116_G0.5910.43
81_Q85_V0.5890.43
32_N67_W0.5830.42
25_V41_L0.5830.42
66_F113_S0.5810.42
13_M102_V0.5780.41
15_L18_F0.5780.41
8_L107_A0.5730.41
54_G105_C0.5730.41
1_M7_A0.5720.41
62_S69_A0.5720.41
33_V57_S0.5650.40
48_N105_C0.5640.40
4_Y60_T0.5630.40
38_I81_Q0.5630.40
14_L42_L0.5570.39
41_L62_S0.5560.39
12_C40_M0.5540.39
94_A108_L0.5520.39
97_A101_A0.5500.39
33_V85_V0.5490.38
3_I70_M0.5440.38
50_L59_P0.5430.38
60_T94_A0.5420.38
56_L60_T0.5360.37
74_I98_G0.5350.37
44_I90_G0.5340.37
109_V112_L0.5340.37
57_S72_I0.5300.37
99_V106_F0.5260.36
45_L62_S0.5260.36
6_V67_W0.5240.36
17_V74_I0.5150.35
22_L88_L0.5120.35
25_V74_I0.5110.35
11_F14_L0.5090.34
70_M93_V0.5060.34
59_P65_L0.5040.34
75_V84_V0.5030.34
33_V64_I0.5010.34
95_I114_R0.5010.34
14_L31_A0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.3846 13.9 0.943 Contact Map
4djkA 2 0.4615 7.7 0.949 Contact Map
2wswA 3 0.5641 3.6 0.956 Contact Map
2qjyC 2 0.265 3.2 0.957 Contact Map
4i0uA 4 0.4615 3.2 0.957 Contact Map
4qncA 2 0.2991 2.7 0.959 Contact Map
4p6vB 1 0.3675 2.5 0.96 Contact Map
4ev6A 3 0.4786 2.5 0.96 Contact Map
3j9tb 1 0 2.4 0.96 Contact Map
2l9uA 2 0.2564 1.9 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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