GREMLIN Database
Glyco_tran_WecB - Glycosyl transferase WecB/TagA/CpsF family
PFAM: PF03808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 173 (171)
Sequences: 34075 (26691)
Seq/√Len: 2041.1
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_R104_D3.0561.00
52_F79_G2.9341.00
81_Y97_R2.7201.00
119_I131_A2.6371.00
63_K144_R2.6161.00
65_A69_R2.5081.00
119_I133_G2.4761.00
99_N127_N2.3301.00
96_E100_A2.2211.00
50_R76_R2.0971.00
32_A147_R2.0471.00
118_W122_H2.0411.00
52_F97_R2.0121.00
67_R70_E2.0011.00
67_R71_R1.9941.00
150_R154_R1.9591.00
4_S120_A1.9331.00
58_P82_S1.9171.00
39_A42_E1.9021.00
58_P62_E1.8501.00
45_A74_G1.8401.00
51_V107_F1.8241.00
65_A80_T1.7881.00
49_L104_D1.7121.00
63_K66_E1.6821.00
104_D129_P1.6351.00
38_P71_R1.6301.00
44_A51_V1.5551.00
145_V166_E1.5521.00
61_A80_T1.5391.00
136_A140_F1.5311.00
151_W155_L1.4911.00
63_K67_R1.4821.00
44_A49_L1.4611.00
43_R47_R1.3911.00
150_R153_Q1.3891.00
81_Y84_P1.3751.00
108_V119_I1.3391.00
106_L128_V1.3371.00
37_M141_L1.3351.00
117_K120_A1.3251.00
50_R78_A1.3221.00
57_T144_R1.3211.00
37_M137_A1.3121.00
170_L173_R1.3071.00
161_Y165_Q1.3021.00
34_P137_A1.2901.00
91_E121_R1.2671.00
106_L131_A1.2551.00
92_E125_R1.2521.00
19_A28_P1.2501.00
152_M157_L1.2441.00
54_L94_I1.2221.00
61_A65_A1.2201.00
122_H125_R1.2181.00
13_M16_V1.2131.00
34_P140_F1.1991.00
52_F81_Y1.1971.00
152_M155_L1.1931.00
160_L164_L1.1921.00
123_R131_A1.1891.00
43_R46_E1.1891.00
62_E66_E1.1711.00
95_I125_R1.1671.00
88_P91_E1.1651.00
5_A8_V1.1601.00
13_M30_R1.1591.00
78_A101_S1.1581.00
90_E93_E1.1501.00
41_L51_V1.1421.00
53_L138_F1.1341.00
66_E70_E1.1281.00
95_I99_N1.1161.00
6_D123_R1.1121.00
147_R158_E1.1091.00
97_R101_S1.1011.00
48_G76_R1.0981.00
163_L171_W1.0971.00
37_M107_F1.0941.00
111_G115_Q1.0941.00
97_R100_A1.0911.00
50_R101_S1.0911.00
109_G134_V1.0891.00
41_L68_L1.0841.00
56_G61_A1.0841.00
18_A22_L1.0831.00
145_V165_Q1.0771.00
38_P72_Y1.0771.00
38_P141_L1.0721.00
146_K165_Q1.0651.00
35_D147_R1.0621.00
92_E96_E1.0551.00
147_R153_Q1.0431.00
42_E45_A1.0291.00
42_E72_Y1.0281.00
14_P18_A1.0231.00
139_D144_R1.0211.00
81_Y94_I1.0191.00
52_F103_P1.0001.00
86_R90_E0.9991.00
66_E69_R0.9991.00
87_T90_E0.9971.00
96_E99_N0.9951.00
14_P17_W0.9791.00
117_K121_R0.9771.00
39_A43_R0.9631.00
91_E122_H0.9601.00
109_G138_F0.9501.00
148_A153_Q0.9491.00
43_R49_L0.9471.00
157_L160_L0.9451.00
13_M17_W0.9391.00
139_D145_V0.9391.00
64_A138_F0.9341.00
149_P161_Y0.9311.00
99_N125_R0.9311.00
19_A25_K0.9261.00
168_R171_W0.9241.00
148_A158_E0.9231.00
60_V144_R0.9231.00
102_G127_N0.9221.00
40_L105_I0.9171.00
87_T91_E0.9141.00
95_I122_H0.9141.00
115_Q133_G0.8901.00
148_A161_Y0.8811.00
91_E118_W0.8711.00
67_R141_L0.8651.00
81_Y85_F0.8591.00
56_G60_V0.8591.00
42_E46_E0.8571.00
37_M41_L0.8561.00
107_F134_V0.8561.00
56_G139_D0.8531.00
57_T60_V0.8511.00
19_A27_L0.8501.00
153_Q158_E0.8491.00
60_V139_D0.8461.00
30_R153_Q0.8341.00
9_L36_L0.8321.00
49_L105_I0.8151.00
42_E71_R0.8151.00
44_A105_I0.8091.00
93_E96_E0.8081.00
88_P92_E0.8071.00
16_V20_R0.8061.00
38_P42_E0.8051.00
57_T139_D0.8021.00
45_A75_L0.7991.00
32_A35_D0.7951.00
83_P86_R0.7921.00
126_L131_A0.7871.00
17_W21_L0.7871.00
51_V105_I0.7861.00
86_R89_E0.7831.00
16_V30_R0.7831.00
166_E169_R0.7791.00
93_E97_R0.7681.00
64_A68_L0.7671.00
146_K161_Y0.7631.00
20_R26_P0.7621.00
33_G134_V0.7541.00
16_V27_L0.7341.00
106_L129_P0.7341.00
34_P38_P0.7291.00
13_M156_G0.7271.00
50_R102_G0.7271.00
89_E92_E0.7231.00
54_L110_L0.7231.00
128_V131_A0.7211.00
52_F98_I0.7081.00
140_F145_V0.7081.00
89_E93_E0.7071.00
59_G62_E0.7071.00
2_L8_V0.7041.00
41_L75_L0.6971.00
35_D153_Q0.6961.00
33_G137_A0.6951.00
68_L141_L0.6941.00
57_T61_A0.6851.00
152_M160_L0.6851.00
17_W20_R0.6841.00
53_L68_L0.6831.00
67_R142_A0.6801.00
62_E65_A0.6771.00
82_S85_F0.6731.00
61_A82_S0.6711.00
64_A141_L0.6701.00
19_A23_G0.6631.00
160_L163_L0.6601.00
52_F106_L0.6581.00
107_F138_F0.6581.00
62_E80_T0.6561.00
134_V137_A0.6551.00
140_F147_R0.6501.00
88_P93_E0.6471.00
60_V63_K0.6471.00
153_Q156_G0.6451.00
10_P16_V0.6391.00
45_A72_Y0.6381.00
98_I106_L0.6191.00
168_R173_R0.6111.00
3_N8_V0.6051.00
103_P106_L0.6031.00
94_I97_R0.6001.00
91_E95_I0.5991.00
60_V142_A0.5971.00
114_K117_K0.5971.00
113_P117_K0.5961.00
120_A123_R0.5961.00
149_P152_M0.5881.00
140_F148_A0.5871.00
37_M134_V0.5851.00
122_H126_L0.5841.00
34_P147_R0.5821.00
41_L45_A0.5801.00
64_A67_R0.5791.00
10_P27_L0.5781.00
134_V138_F0.5761.00
78_A103_P0.5751.00
87_T92_E0.5751.00
152_M164_L0.5741.00
17_W156_G0.5711.00
71_R141_L0.5671.00
53_L65_A0.5641.00
69_R76_R0.5631.00
63_K142_A0.5621.00
44_A48_G0.5621.00
59_G63_K0.5571.00
68_L75_L0.5571.00
44_A47_R0.5541.00
151_W154_R0.5511.00
84_P110_L0.5481.00
10_P19_A0.5461.00
52_F101_S0.5451.00
79_G97_R0.5411.00
99_N126_L0.5391.00
152_M161_Y0.5351.00
48_G74_G0.5251.00
126_L129_P0.5241.00
30_R34_P0.5241.00
16_V29_E0.5231.00
147_R161_Y0.5221.00
35_D150_R0.5201.00
69_R74_G0.5191.00
59_G144_R0.5151.00
58_P61_A0.5131.00
141_L145_V0.5101.00
142_A145_V0.5101.00
148_A152_M0.5101.00
40_L107_F0.5081.00
83_P114_K0.5081.00
53_L64_A0.5081.00
10_P14_P0.5061.00
88_P121_R0.5061.00
79_G101_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qsjA 2 0.6301 59 0.91 Contact Map
3cnbA 1 0.6532 58.1 0.911 Contact Map
3g40A 2 0.6821 57.7 0.911 Contact Map
4lzlA 1 0.659 55.6 0.912 Contact Map
1a2oA 1 0.6532 55 0.912 Contact Map
2qv0A 2 0.6763 52.2 0.914 Contact Map
4r3uC 1 0.6705 51.9 0.914 Contact Map
1qkkA 2 0.659 51.6 0.914 Contact Map
4xaqA 2 0.9827 49.7 0.915 Contact Map
4cbvA 2 0.6474 48 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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