GREMLIN Database
CitX - Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
PFAM: PF03802 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (162)
Sequences: 1766 (1521)
Seq/√Len: 119.5
META: 0.711

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_E148_R3.0441.00
157_K160_E3.0251.00
41_N46_R3.0201.00
138_E142_E2.7071.00
27_P92_L2.6411.00
31_L52_G2.5761.00
157_K161_L2.5491.00
56_L96_A2.5201.00
36_P158_I2.5011.00
57_E70_E2.4381.00
96_A111_I2.3421.00
77_T80_E2.2461.00
3_L7_L2.2191.00
30_S82_L2.0801.00
139_P142_E2.0011.00
5_E76_A1.9911.00
53_L81_A1.9431.00
130_P139_P1.9331.00
52_G109_F1.9181.00
42_N45_I1.8861.00
24_Y84_V1.8751.00
48_L162_L1.8281.00
141_K144_A1.8261.00
16_R71_E1.7931.00
41_N79_P1.7841.00
17_Q114_L1.7811.00
55_A103_H1.7051.00
33_L48_L1.6991.00
134_L157_K1.6761.00
37_G40_K1.6491.00
8_A12_R1.6181.00
33_L45_I1.6161.00
29_V96_A1.5991.00
115_D119_R1.5541.00
87_A92_L1.5141.00
35_I45_I1.5061.00
132_K137_G1.4561.00
90_E94_R1.4391.00
20_L84_V1.4361.00
135_L157_K1.4271.00
56_L111_I1.4221.00
108_L161_L1.3861.00
41_N74_D1.3531.00
34_N107_R1.3271.00
17_Q28_L1.3231.00
29_V85_V1.2961.00
151_L155_Q1.2931.00
14_A18_Q1.2811.00
4_E8_A1.2530.99
57_E83_L1.2520.99
6_I9_A1.2440.99
98_E102_S1.2300.99
9_A75_L1.2170.99
26_L86_D1.2080.99
39_V155_Q1.1890.99
154_L158_I1.1870.99
95_L98_E1.1830.99
12_R75_L1.1810.99
9_A32_T1.1740.99
26_L68_L1.1690.99
67_I85_V1.1570.99
121_L126_L1.1440.99
152_E156_A1.1410.99
53_L57_E1.1290.99
33_L49_F1.1280.99
88_D91_E1.1040.99
19_E23_R1.0900.98
53_L83_L1.0890.98
60_L85_V1.0850.98
31_L56_L1.0770.98
32_T80_E1.0770.98
150_S153_E1.0740.98
26_L84_V1.0690.98
24_Y69_E1.0640.98
31_L83_L1.0610.98
34_N109_F1.0510.98
24_Y27_P1.0450.98
142_E146_S1.0410.98
114_L120_P1.0370.98
59_A99_I1.0350.98
99_I109_F1.0310.98
32_T77_T0.9970.97
31_L109_F0.9840.97
97_V128_L0.9820.97
60_L95_L0.9760.97
45_I79_P0.9730.97
159_E163_E0.9710.97
34_N37_G0.9650.97
122_S125_D0.9570.97
33_L162_L0.9540.96
85_V92_L0.9530.96
74_D79_P0.9530.96
7_L11_E0.9480.96
17_Q21_L0.9430.96
87_A91_E0.9420.96
3_L11_E0.9380.96
65_I95_L0.9360.96
135_L154_L0.9310.96
142_E148_R0.9290.96
119_R125_D0.9230.96
38_P151_L0.9220.96
46_R79_P0.9140.95
155_Q159_E0.9020.95
108_L134_L0.9000.95
96_A113_V0.8980.95
123_R131_R0.8960.95
132_K139_P0.8870.95
92_L96_A0.8840.95
20_L82_L0.8810.94
115_D118_G0.8700.94
49_F53_L0.8630.94
40_K107_R0.8600.94
9_A80_E0.8600.94
9_A77_T0.8590.94
133_C136_C0.8580.94
34_N40_K0.8510.93
16_R82_L0.8480.93
53_L72_E0.8470.93
17_Q30_S0.8450.93
144_A147_R0.8350.93
15_A19_E0.8320.93
147_R151_L0.8280.92
45_I49_F0.8160.92
29_V56_L0.8140.92
35_I158_I0.8080.92
105_L109_F0.8070.91
8_A11_E0.7980.91
9_A13_R0.7980.91
48_L109_F0.7940.91
156_A160_E0.7910.91
28_L32_T0.7900.91
21_L28_L0.7900.91
48_L105_L0.7880.90
72_E81_A0.7840.90
23_R69_E0.7800.90
69_E84_V0.7780.90
29_V111_I0.7720.90
107_R145_R0.7700.89
145_R148_R0.7670.89
65_I87_A0.7640.89
55_A99_I0.7500.88
37_G107_R0.7480.88
49_F52_G0.7390.87
63_N91_E0.7390.87
91_E94_R0.7370.87
28_L84_V0.7330.87
65_I85_V0.7290.87
54_E58_E0.7240.86
55_A58_E0.7240.86
150_S154_L0.7210.86
39_V42_N0.7110.85
21_L114_L0.7100.85
89_A128_L0.7070.85
36_P134_L0.7060.85
59_A98_E0.7040.85
132_K138_E0.7010.85
66_K86_D0.6990.84
134_L140_A0.6970.84
20_L24_Y0.6950.84
39_V77_T0.6940.84
89_A115_D0.6940.84
75_L80_E0.6910.84
13_R80_E0.6900.84
16_R19_E0.6860.83
94_R98_E0.6860.83
102_S106_G0.6840.83
20_L69_E0.6830.83
35_I49_F0.6830.83
17_Q80_E0.6820.83
97_V126_L0.6820.83
14_A17_Q0.6810.83
147_R150_S0.6800.83
132_K140_A0.6750.82
6_I33_L0.6720.82
16_R73_L0.6700.82
38_P155_Q0.6610.81
27_P84_V0.6600.81
20_L28_L0.6590.81
134_L137_G0.6540.80
80_E114_L0.6540.80
107_R110_D0.6520.80
92_L113_V0.6470.80
52_G111_I0.6440.79
144_A154_L0.6400.79
31_L111_I0.6360.78
60_L92_L0.6330.78
110_D145_R0.6320.78
103_H106_G0.6260.77
41_N45_I0.6250.77
37_G145_R0.6250.77
134_L144_A0.6200.77
28_L82_L0.6030.75
143_C149_H0.6020.75
91_E95_L0.5940.74
14_A147_R0.5940.74
27_P85_V0.5930.73
67_I86_D0.5930.73
30_S80_E0.5900.73
17_Q32_T0.5780.72
14_A120_P0.5770.71
140_A144_A0.5770.71
45_I155_Q0.5760.71
10_R13_R0.5690.70
29_V113_V0.5670.70
101_E132_K0.5670.70
93_K110_D0.5640.70
36_P154_L0.5640.70
136_C143_C0.5620.69
52_G77_T0.5580.69
17_Q77_T0.5560.69
7_L10_R0.5540.68
35_I77_T0.5520.68
49_F74_D0.5500.68
103_H109_F0.5490.68
134_L154_L0.5490.68
115_D121_L0.5480.68
44_L159_E0.5440.67
60_L65_I0.5430.67
15_A18_Q0.5430.67
36_P124_S0.5410.67
32_T114_L0.5380.66
134_L161_L0.5340.66
47_R162_L0.5320.65
35_I40_K0.5300.65
6_I32_T0.5280.65
44_L162_L0.5270.65
40_K77_T0.5270.65
39_V80_E0.5260.64
46_R50_E0.5230.64
58_E90_E0.5220.64
97_V129_P0.5200.63
136_C149_H0.5200.63
45_I154_L0.5190.63
50_E98_E0.5190.63
38_P106_G0.5160.63
40_K145_R0.5130.62
32_T109_F0.5040.61
17_Q20_L0.5040.61
30_S92_L0.5020.61
80_E144_A0.5020.61
6_I77_T0.5020.61
11_E34_N0.5010.61
49_F79_P0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hc7A 2 0.6768 20.2 0.941 Contact Map
2pt7G 2 0.4512 11.6 0.947 Contact Map
3j65n 1 0.9939 10.8 0.947 Contact Map
3l0iB 1 0.3293 9.2 0.949 Contact Map
1nj1A 2 0.6646 8.9 0.949 Contact Map
3h5nA 3 0.7378 8.6 0.95 Contact Map
4s3qA 1 0.3171 8.5 0.95 Contact Map
2cg8A 4 0.8537 8.2 0.95 Contact Map
2kw0A 1 0.3232 7.4 0.951 Contact Map
1x1nA 2 0.3171 7.1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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