GREMLIN Database
TRAM_LAG1_CLN8 - TLC domain
PFAM: PF03798 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 198 (194)
Sequences: 4117 (3064)
Seq/√Len: 220.0
META: 0.298

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_F193_F4.6091.00
191_Y195_L4.3901.00
113_L139_F3.8841.00
145_V149_V3.2261.00
52_Q56_F2.8601.00
139_F196_I2.7011.00
49_Y90_S2.5601.00
19_G48_Y2.5151.00
53_L84_L2.4751.00
28_E31_E2.3291.00
144_F149_V2.3251.00
140_A196_I2.3011.00
158_S162_E2.2681.00
136_G139_F2.1851.00
21_Y25_D2.1011.00
157_W161_D2.0521.00
156_L160_L2.0381.00
55_Y59_D1.9661.00
11_H52_Q1.9421.00
144_F148_L1.9121.00
152_P190_I1.9091.00
130_C134_F1.8601.00
187_V191_Y1.8061.00
29_L32_G1.7811.00
36_R39_G1.7711.00
117_K121_Y1.7691.00
148_L193_F1.7331.00
158_S161_D1.7081.00
49_Y99_G1.6771.00
11_H15_S1.6701.00
17_I21_Y1.6691.00
159_T179_L1.6611.00
109_S143_F1.6421.00
107_E110_D1.6141.00
53_L87_I1.6041.00
167_L170_G1.5921.00
8_S114_N1.5821.00
106_H151_F1.5781.00
185_L189_N1.5721.00
157_W162_E1.5451.00
29_L33_Y1.5311.00
106_H110_D1.5281.00
1_K5_R1.4871.00
63_L66_Y1.4751.00
124_G127_K1.4561.00
56_F59_D1.4481.00
120_K136_G1.4451.00
56_F107_E1.4261.00
112_F138_L1.4231.00
34_P37_P1.4001.00
193_F197_L1.3831.00
8_S12_Y1.3801.00
32_G35_D1.3681.00
75_E188_L1.3591.00
78_L184_V1.3551.00
64_L77_L1.3071.00
37_P40_Y1.3031.00
52_Q59_D1.2931.00
8_S11_H1.2871.00
154_L157_W1.2871.00
149_V152_P1.2621.00
109_S146_T1.2561.00
186_Q190_I1.2511.00
188_L192_W1.2441.00
35_D38_L1.2431.00
172_F175_Y1.2291.00
14_V18_L1.2261.00
52_Q107_E1.2251.00
106_H189_N1.1971.00
90_S99_G1.1921.00
5_R114_N1.1891.00
140_A143_F1.1851.00
128_K132_Y1.1841.00
156_L159_T1.1841.00
191_Y194_Y1.1771.00
13_L111_P1.1601.00
178_F183_L1.1521.00
76_M80_H1.1511.00
53_L88_S1.1461.00
155_I163_S1.1331.00
127_K131_L1.1211.00
109_S142_S1.1121.00
50_L54_G1.1081.00
148_L186_Q1.0991.00
20_L24_Y1.0991.00
142_S146_T1.0891.00
183_L187_V1.0881.00
182_L185_L1.0881.00
62_V66_Y1.0641.00
125_K129_S1.0611.00
140_A197_L1.0601.00
20_L104_L1.0381.00
42_S45_L1.0351.00
12_Y107_E1.0341.00
129_S132_Y1.0321.00
9_L114_N1.0251.00
12_Y110_D1.0171.00
110_D117_K1.0151.00
190_I194_Y1.0081.00
13_L17_I1.0081.00
114_N117_K1.0041.00
61_L65_F1.0011.00
14_V17_I0.9901.00
83_T185_L0.9901.00
159_T162_E0.9811.00
6_G118_L0.9801.00
143_F148_L0.9791.00
112_F139_F0.9591.00
5_R8_S0.9571.00
116_R132_Y0.9501.00
138_L142_S0.9491.00
175_Y178_F0.9451.00
75_E191_Y0.9411.00
63_L80_H0.9371.00
137_V141_V0.9351.00
148_L152_P0.9321.00
117_K120_K0.9280.99
60_L80_H0.9280.99
12_Y56_F0.9220.99
74_W77_L0.9210.99
83_T86_L0.9090.99
161_D165_L0.9060.99
113_L116_R0.9060.99
139_F143_F0.9040.99
116_R120_K0.9040.99
60_L77_L0.8990.99
174_L177_I0.8920.99
173_P177_I0.8800.99
127_K132_Y0.8740.99
36_R40_Y0.8710.99
56_F83_T0.8710.99
159_T163_S0.8660.99
186_Q189_N0.8660.99
145_V150_L0.8610.99
139_F192_W0.8600.99
146_T150_L0.8580.99
59_D114_N0.8560.99
108_L146_T0.8510.99
74_W78_L0.8480.99
12_Y55_Y0.8400.99
161_D164_R0.8320.99
30_W33_Y0.8260.99
116_R136_G0.8230.99
87_I103_L0.8200.99
79_H192_W0.8170.99
18_L48_Y0.8170.99
172_F176_Y0.8080.99
168_P171_P0.7980.98
143_F193_F0.7970.98
67_E70_R0.7950.98
76_M79_H0.7950.98
130_C133_L0.7920.98
119_L129_S0.7920.98
58_Y62_V0.7850.98
156_L183_L0.7800.98
192_W196_I0.7690.98
109_S114_N0.7660.98
83_T87_I0.7650.98
80_H84_L0.7630.98
129_S133_L0.7570.98
153_Y156_L0.7410.98
96_T111_P0.7370.97
118_L122_L0.7370.97
110_D113_L0.7330.97
148_L190_I0.7270.97
75_E78_L0.7240.97
114_N118_L0.7220.97
80_H83_T0.7210.97
8_S59_D0.7170.97
115_L133_L0.7140.97
112_F142_S0.7100.97
166_I169_T0.7060.97
62_V65_F0.7060.97
43_P47_F0.7060.97
175_Y179_L0.7030.97
155_I182_L0.7010.97
102_V110_D0.6900.96
38_L43_P0.6890.96
22_V25_D0.6870.96
60_L84_L0.6840.96
174_L179_L0.6820.96
7_V11_H0.6780.96
57_L84_L0.6760.96
35_D39_G0.6750.96
153_Y157_W0.6740.96
79_H83_T0.6720.96
80_H106_H0.6640.95
157_W164_R0.6630.95
5_R11_H0.6600.95
88_S92_L0.6600.95
167_L171_P0.6590.95
173_P179_L0.6590.95
181_L184_V0.6590.95
34_P38_L0.6590.95
166_I170_G0.6570.95
18_L44_L0.6560.95
144_F197_L0.6540.95
56_F110_D0.6520.95
50_L91_Y0.6520.95
162_E165_L0.6510.95
19_G22_V0.6500.95
116_R133_L0.6490.95
86_L90_S0.6470.95
111_P114_N0.6380.94
21_Y44_L0.6350.94
160_L163_S0.6330.94
28_E32_G0.6330.94
73_F143_F0.6330.94
176_Y180_V0.6320.94
63_L77_L0.6250.94
140_A193_F0.6240.94
41_T44_L0.6230.93
114_N143_F0.6220.93
172_F197_L0.6200.93
87_I185_L0.6200.93
23_L26_E0.6190.93
117_K136_G0.6190.93
179_L183_L0.6170.93
99_G102_V0.6120.93
19_G104_L0.6120.93
23_L27_P0.6110.93
18_L22_V0.6080.93
85_L89_L0.6060.93
10_V13_L0.6050.92
113_L136_G0.6040.92
2_F118_L0.6010.92
119_L133_L0.5970.92
119_L125_K0.5950.92
33_Y37_P0.5940.92
76_M143_F0.5900.92
16_G108_L0.5890.91
160_L164_R0.5880.91
103_L151_F0.5840.91
15_S18_L0.5800.91
76_M110_D0.5800.91
115_L164_R0.5750.90
26_E44_L0.5750.90
129_S134_F0.5750.90
6_G9_L0.5720.90
57_L194_Y0.5720.90
9_L115_L0.5690.90
99_G103_L0.5670.90
49_Y91_Y0.5660.90
4_E7_V0.5620.89
7_V58_Y0.5600.89
152_P192_W0.5580.89
77_L84_L0.5580.89
164_R167_L0.5530.89
113_L196_I0.5530.89
79_H113_L0.5510.89
16_G19_G0.5480.88
108_L142_S0.5480.88
3_N115_L0.5480.88
9_L13_L0.5460.88
24_Y27_P0.5460.88
106_H117_K0.5410.88
16_G20_L0.5410.88
58_Y80_H0.5400.88
5_R12_Y0.5380.87
151_F186_Q0.5340.87
8_S55_Y0.5330.87
168_P173_P0.5310.87
49_Y100_L0.5310.87
110_D114_N0.5290.86
152_P186_Q0.5260.86
12_Y16_G0.5250.86
9_L118_L0.5240.86
73_F77_L0.5240.86
53_L91_Y0.5240.86
130_C137_V0.5240.86
151_F155_I0.5220.86
67_E71_K0.5220.86
60_L81_I0.5220.86
20_L25_D0.5200.86
59_D64_L0.5170.85
33_Y36_R0.5170.85
52_Q103_L0.5150.85
150_L153_Y0.5140.85
183_L186_Q0.5140.85
159_T165_L0.5130.85
132_Y136_G0.5130.85
143_F151_F0.5130.85
111_P142_S0.5120.85
106_H188_L0.5110.85
165_L171_P0.5100.84
166_I171_P0.5080.84
170_G177_I0.5060.84
159_T164_R0.5040.84
119_L132_Y0.5040.84
106_H148_L0.5040.84
104_L108_L0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a63D 1 0.1919 1.7 0.944 Contact Map
4izzA 2 0.298 0.6 0.957 Contact Map
2irfG 1 0.1919 0.6 0.958 Contact Map
4d2gD 1 0.0606 0.6 0.959 Contact Map
4pgrA 1 0.4495 0.6 0.959 Contact Map
3qu6A 1 0.1818 0.6 0.959 Contact Map
2nr9A 2 0.3788 0.5 0.961 Contact Map
2k2wA 1 0.202 0.5 0.961 Contact Map
3ap1A 2 0.2576 0.5 0.961 Contact Map
2xovA 1 0.3687 0.5 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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