GREMLIN Database
LrgA - LrgA family
PFAM: PF03788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (92)
Sequences: 8566 (6060)
Seq/√Len: 631.8
META: 0.734

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_E74_P3.0691.00
8_V20_I2.8071.00
35_K38_W2.5941.00
40_E44_D2.4871.00
5_E9_R2.4331.00
74_P78_A2.2011.00
65_L69_A2.1891.00
4_G17_G2.0431.00
88_A92_L1.9971.00
26_F30_L1.9511.00
66_D69_A1.9191.00
86_V90_T1.9141.00
7_L24_L1.9081.00
44_D48_A1.8871.00
72_G76_L1.8511.00
6_L10_L1.7811.00
66_D70_A1.7251.00
77_V81_V1.6641.00
78_A82_S1.5861.00
32_R35_K1.5671.00
27_L31_L1.5641.00
36_L40_E1.5581.00
33_G36_L1.5251.00
67_L71_E1.5011.00
89_V93_V1.4601.00
39_V43_A1.4531.00
51_S58_G1.4291.00
6_L9_R1.3811.00
62_M65_L1.3211.00
5_E8_V1.2901.00
64_H67_L1.2891.00
41_E44_D1.2761.00
28_L34_V1.2361.00
5_E17_G1.1931.00
8_V17_G1.1841.00
7_L11_L1.1721.00
68_L75_I1.1351.00
24_L28_L1.1341.00
42_A45_F1.1191.00
38_W41_E1.1031.00
31_L34_V1.0941.00
8_V11_L1.0731.00
28_L33_G1.0671.00
71_E75_I1.0581.00
63_L66_D1.0541.00
25_L39_V1.0411.00
49_H53_L1.0011.00
51_S55_V0.9941.00
16_P57_A0.9731.00
41_E48_A0.9711.00
37_E40_E0.9661.00
17_G20_I0.9441.00
15_I20_I0.9311.00
49_H52_L0.9271.00
3_L24_L0.8941.00
70_A74_P0.8941.00
8_V12_G0.8861.00
4_G8_V0.8851.00
34_V38_W0.8841.00
81_V85_L0.8811.00
7_L20_I0.8631.00
44_D47_L0.8561.00
8_V13_L0.8401.00
59_V62_M0.8331.00
11_L20_I0.8291.00
86_V89_V0.8241.00
8_V15_I0.8211.00
81_V84_V0.8111.00
36_L39_V0.8081.00
48_A51_S0.8021.00
23_L27_L0.7951.00
89_V92_L0.7861.00
39_V47_L0.7831.00
28_L32_R0.7751.00
18_P79_L0.7691.00
50_L54_F0.7691.00
79_L83_T0.7671.00
3_L28_L0.7641.00
88_A91_G0.7571.00
43_A47_L0.7571.00
61_V64_H0.7531.00
79_L86_V0.7391.00
57_A60_G0.7351.00
64_H68_L0.7251.00
38_W42_A0.7151.00
20_I24_L0.7121.00
9_R12_G0.7101.00
27_L30_L0.7091.00
67_L70_A0.7091.00
22_M75_I0.7051.00
2_L6_L0.6761.00
36_L43_A0.6731.00
87_L91_G0.6551.00
56_P60_G0.6501.00
28_L31_L0.6351.00
28_L35_K0.6321.00
30_L33_G0.6311.00
45_F48_A0.6301.00
80_V84_V0.6241.00
25_L43_A0.6221.00
78_A87_L0.6211.00
76_L79_L0.6161.00
73_L76_L0.6131.00
32_R36_L0.6091.00
25_L34_V0.6061.00
82_S86_V0.6011.00
18_P53_L0.5931.00
41_E45_F0.5831.00
84_V88_A0.5801.00
22_M87_L0.5791.00
45_F49_H0.5731.00
58_G63_L0.5661.00
63_L71_E0.5631.00
34_V39_V0.5621.00
35_K40_E0.5591.00
55_V64_H0.5581.00
72_G78_A0.5521.00
26_F29_L0.5501.00
2_L5_E0.5501.00
58_G65_L0.5491.00
23_L26_F0.5471.00
5_E18_P0.5471.00
22_M84_V0.5451.00
22_M26_F0.5441.00
83_T86_V0.5431.00
85_L88_A0.5431.00
76_L80_V0.5420.99
43_A46_L0.5340.99
10_L13_L0.5260.99
77_V80_V0.5240.99
42_A46_L0.5220.99
68_L72_G0.5190.99
69_A72_G0.5070.99
54_F58_G0.5060.99
15_I19_V0.5040.99
58_G75_I0.5040.99
4_G20_I0.5000.99
28_L36_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cz8A 2 0.9574 19.9 0.87 Contact Map
4czbA 2 0.9574 16.6 0.875 Contact Map
4b4aA 1 0.3404 5.3 0.9 Contact Map
4bwzA 2 0.9255 3.9 0.906 Contact Map
4httA 1 0.3404 3.8 0.907 Contact Map
1a87A 1 0.5426 3.1 0.91 Contact Map
4gh4D 3 0.2553 2.5 0.915 Contact Map
2nq2A 2 0.3511 2.3 0.917 Contact Map
4hsuA 1 0.3404 2 0.92 Contact Map
2nwlA 3 0.8723 1.7 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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