GREMLIN Database
Asp23 - Asp23 family, cell envelope-related function
PFAM: PF03780 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (105)
Sequences: 16951 (10615)
Seq/√Len: 1035.9
META: 0.824

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_E97_A3.1881.00
60_A97_A2.8441.00
72_N75_E2.6161.00
62_D100_N2.5041.00
64_Y102_H2.3611.00
60_A98_E2.2721.00
64_Y104_Q2.2411.00
66_V105_G2.1231.00
58_E95_E2.1041.00
67_V76_V2.0211.00
21_E83_N1.9031.00
15_A61_I1.8721.00
65_V80_V1.8671.00
83_N87_A1.8211.00
26_V68_E1.8201.00
86_Y90_R1.8011.00
67_V73_I1.7791.00
75_E78_R1.7771.00
89_E95_E1.7601.00
87_A90_R1.7211.00
79_N83_N1.6591.00
63_L84_V1.6451.00
85_K89_E1.5631.00
75_E79_N1.5291.00
19_A80_V1.4651.00
61_I88_V1.4341.00
71_V76_V1.4261.00
54_G58_E1.4221.00
14_I91_M1.3801.00
78_R81_Q1.3781.00
52_E60_A1.3331.00
62_D102_H1.3181.00
73_I103_V1.3101.00
54_G60_A1.3061.00
19_A63_L1.2971.00
8_D53_V1.2721.00
78_R82_E1.2711.00
79_N82_E1.2411.00
21_E87_A1.2371.00
23_Y71_V1.2051.00
53_V59_V1.2041.00
88_V96_V1.1801.00
18_A87_A1.1641.00
68_E71_V1.1421.00
59_V94_L1.1011.00
50_K62_D1.0651.00
25_V80_V1.0621.00
74_P78_R1.0571.00
17_L20_L1.0551.00
81_Q85_K1.0391.00
16_G20_L1.0301.00
29_A66_V1.0251.00
83_N86_Y1.0231.00
14_I92_T1.0041.00
82_E86_Y0.9861.00
87_A91_M0.9691.00
22_V80_V0.9501.00
51_V61_I0.9451.00
27_G66_V0.9371.00
23_Y79_N0.9321.00
96_V99_V0.9271.00
7_S10_V0.9271.00
54_G97_A0.9271.00
81_Q100_N0.9181.00
85_K99_V0.9081.00
77_A103_V0.9071.00
23_Y68_E0.9051.00
17_L21_E0.9051.00
5_T8_D0.9031.00
1_L4_I0.9001.00
22_V83_N0.8811.00
28_M48_G0.8781.00
6_I10_V0.8561.00
80_V84_V0.8521.00
60_A100_N0.8431.00
11_I92_T0.8401.00
35_G39_L0.8371.00
26_V66_V0.8361.00
18_A22_V0.8161.00
33_A39_L0.8131.00
38_E47_K0.8121.00
67_V71_V0.8111.00
12_A16_G0.8111.00
88_V92_T0.8101.00
11_I61_I0.8051.00
85_K96_V0.8001.00
53_V57_D0.7991.00
25_V65_V0.7811.00
57_D95_E0.7731.00
81_Q101_V0.7641.00
16_G45_L0.7591.00
24_G71_V0.7551.00
11_I94_L0.7491.00
19_A28_M0.7431.00
6_I92_T0.7391.00
32_L37_A0.7381.00
52_E62_D0.7321.00
77_A101_V0.7231.00
17_L91_M0.7151.00
54_G57_D0.7081.00
23_Y86_Y0.7071.00
19_A25_V0.7001.00
12_A51_V0.6961.00
22_V79_N0.6951.00
20_L27_G0.6881.00
89_E96_V0.6751.00
29_A104_Q0.6691.00
67_V77_A0.6691.00
18_A21_E0.6661.00
37_A42_R0.6631.00
11_I53_V0.6551.00
79_N86_Y0.6521.00
14_I87_A0.6491.00
9_E12_A0.6371.00
16_G46_S0.6371.00
15_A88_V0.6281.00
35_G38_E0.6261.00
61_I96_V0.6211.00
33_A37_A0.6171.00
15_A51_V0.6121.00
31_G50_K0.6091.00
4_I81_Q0.6091.00
72_N104_Q0.5991.00
69_Y73_I0.5951.00
16_G49_V0.5911.00
15_A19_A0.5891.00
73_I77_A0.5861.00
38_E43_K0.5851.00
61_I84_V0.5851.00
72_N76_V0.5841.00
32_L41_G0.5821.00
30_G44_N0.5821.00
30_G47_K0.5771.00
20_L45_L0.5761.00
39_L42_R0.5741.00
80_V101_V0.5691.00
87_A92_T0.5661.00
72_N77_A0.5601.00
84_V88_V0.5541.00
32_L35_G0.5531.00
29_A64_Y0.5461.00
59_V92_T0.5421.00
81_Q98_E0.5361.00
20_L25_V0.5311.00
65_V101_V0.5301.00
13_T46_S0.5301.00
30_G38_E0.5211.00
53_V94_L0.5211.00
66_V104_Q0.5181.00
11_I88_V0.5151.00
15_A84_V0.5141.00
43_K46_S0.5141.00
19_A83_N0.5091.00
76_V79_N0.5091.00
17_L45_L0.5061.00
85_K95_E0.5051.00
63_L101_V0.5041.00
50_K64_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wh9A 1 0.7757 40.7 0.828 Contact Map
3zeyX 1 0.8318 24.7 0.846 Contact Map
3h90A 3 0.7944 18.8 0.855 Contact Map
4lkbF 4 0.8411 14.3 0.862 Contact Map
3j20C 1 0.8037 13.2 0.864 Contact Map
3j1zP 8 0.7944 12.7 0.866 Contact Map
4ujpE 1 0.8411 12.5 0.866 Contact Map
3m20A 5 0.4206 12 0.867 Contact Map
3bbnC 1 0.8598 11.8 0.867 Contact Map
4w23D 1 0.8505 10.4 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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