GREMLIN Database
DUF320 - Small secreted domain (DUF320)
PFAM: PF03777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (55)
Sequences: 3080 (1730)
Seq/√Len: 233.3
META: 0.401

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_C54_C8.4341.00
41_N44_G3.1941.00
18_G21_S2.8731.00
11_G24_V2.3091.00
13_A24_V2.1181.00
39_T49_A1.8461.00
39_T48_P1.7951.00
39_T46_L1.7331.00
5_A8_G1.5991.00
9_A26_Q1.5391.00
23_N36_C1.3141.00
50_F53_T1.2931.00
3_A6_G1.2871.00
25_V28_P1.2071.00
24_V55_V1.1481.00
11_G26_Q1.1071.00
16_S21_S1.1031.00
22_G38_N1.0931.00
41_N45_L1.0861.00
31_V35_V1.0431.00
17_P45_L1.0061.00
17_P21_S0.9671.00
4_A7_A0.9611.00
20_L24_V0.9441.00
25_V40_V0.9431.00
7_A10_E0.9121.00
7_A32_P0.9111.00
15_G18_G0.8980.99
19_V34_N0.8600.99
2_A5_A0.8480.99
23_N26_Q0.8250.99
8_G12_A0.8180.99
34_N40_V0.8090.99
44_G47_N0.8040.99
14_A24_V0.8030.99
2_A6_G0.7920.99
46_L50_F0.7840.99
41_N46_L0.7730.98
39_T47_N0.7710.98
3_A10_E0.7540.98
49_A53_T0.7420.98
10_E53_T0.7380.98
8_G11_G0.7260.98
11_G16_S0.7190.98
24_V31_V0.7160.97
20_L53_T0.7070.97
14_A55_V0.7020.97
34_N56_N0.7000.97
2_A8_G0.6870.97
38_N51_G0.6750.96
11_G17_P0.6670.96
26_Q30_H0.6600.96
35_V40_V0.6580.96
38_N53_T0.6550.96
10_E24_V0.6510.96
19_V29_V0.6490.96
12_A24_V0.6350.95
41_N47_N0.6350.95
48_P52_N0.6280.95
16_S30_H0.6280.95
3_A55_V0.6040.93
23_N45_L0.5990.93
29_V33_V0.5980.93
31_V36_C0.5920.93
20_L23_N0.5920.93
19_V45_L0.5920.93
37_G49_A0.5910.93
13_A17_P0.5900.93
4_A8_G0.5730.92
10_E15_G0.5570.90
44_G53_T0.5430.89
16_S34_N0.5400.89
13_A16_S0.5360.89
27_V32_P0.5350.89
12_A55_V0.5340.89
35_V38_N0.5120.86
17_P28_P0.5100.86
21_S27_V0.5090.86
4_A12_A0.5070.86
2_A20_L0.5050.86
35_V50_F0.5030.85
4_A53_T0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uqiB 1 0.3214 1.6 0.883 Contact Map
1e5xA 2 0.4464 0.6 0.91 Contact Map
4pz3A 2 0.9821 0.6 0.91 Contact Map
1o7bT 1 1 0.6 0.911 Contact Map
4hu8A 4 0.75 0.6 0.911 Contact Map
4gysA 2 0.9643 0.6 0.913 Contact Map
1m22A 1 0.9643 0.6 0.913 Contact Map
2gi3A 2 0.9643 0.5 0.914 Contact Map
4wj3A 1 0.9643 0.5 0.915 Contact Map
4nq3A 4 0.6786 0.5 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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