GREMLIN Database
ArsP_1 - Predicted permease
PFAM: PF03773 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 294 (288)
Sequences: 19624 (11865)
Seq/√Len: 699.2
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_R271_P4.6341.00
262_L278_L3.0881.00
160_S163_R2.8321.00
101_I117_V2.8211.00
157_R160_S2.8091.00
169_R173_K2.6211.00
168_A171_A2.5051.00
119_G288_A2.4771.00
167_F171_A2.4571.00
221_V282_V2.4271.00
171_A174_D2.4041.00
271_P275_A2.3421.00
238_L247_A2.2331.00
160_S164_R2.0821.00
199_D202_A2.0701.00
91_I127_A2.0331.00
84_G132_G2.0141.00
234_A247_A1.9991.00
92_A124_A1.9821.00
161_L164_R1.9551.00
191_L195_Y1.9511.00
235_A239_A1.9401.00
275_A279_G1.9221.00
168_A172_V1.8981.00
199_D203_S1.8941.00
123_I284_G1.8861.00
272_R276_V1.8641.00
47_N50_L1.8561.00
114_L118_V1.8531.00
159_P162_R1.8481.00
38_R41_R1.8431.00
52_V88_A1.8351.00
159_P163_R1.8241.00
156_E159_P1.7971.00
42_Y54_L1.7811.00
198_E202_A1.7601.00
136_R139_E1.7161.00
170_E174_D1.7001.00
155_L159_P1.6811.00
133_R136_R1.6741.00
167_F170_E1.6711.00
220_G253_A1.6451.00
176_K179_W1.6431.00
157_R161_L1.6331.00
104_T108_L1.5971.00
253_A285_A1.5901.00
171_A175_W1.5881.00
77_L83_L1.5711.00
141_E144_V1.5691.00
140_L145_R1.5421.00
249_A289_G1.5311.00
73_F86_A1.5221.00
175_W179_W1.5051.00
157_R162_R1.5051.00
151_G154_G1.5051.00
38_R42_Y1.5031.00
112_F244_L1.4901.00
56_A125_I1.4781.00
103_L231_I1.4751.00
217_A249_A1.4661.00
173_K176_K1.4631.00
169_R174_D1.4581.00
200_F204_L1.4551.00
243_S246_A1.4521.00
156_E160_S1.4511.00
162_R165_R1.4391.00
208_N211_L1.4391.00
266_R274_L1.4361.00
163_R166_A1.4341.00
127_A280_L1.4311.00
82_P85_A1.4191.00
115_A292_F1.4041.00
9_F190_A1.3831.00
50_L54_L1.3751.00
155_L158_K1.3741.00
262_L274_L1.3611.00
142_D145_R1.3551.00
170_E173_K1.3531.00
87_F131_I1.3501.00
167_F174_D1.3481.00
211_L214_L1.3431.00
122_L126_V1.3401.00
217_A286_I1.3341.00
158_K161_L1.3191.00
214_L286_I1.3121.00
111_K244_L1.3071.00
158_K162_R1.3061.00
167_F175_W1.3021.00
211_L215_L1.2961.00
70_I264_I1.2951.00
214_L218_L1.2911.00
139_E142_D1.2881.00
216_A220_G1.2841.00
172_V175_W1.2811.00
285_A288_A1.2801.00
88_A128_G1.2801.00
110_W114_L1.2721.00
213_V249_A1.2711.00
132_G135_F1.2711.00
105_A113_A1.2701.00
180_P184_I1.2661.00
221_V262_L1.2541.00
105_A110_W1.2491.00
287_L291_L1.2481.00
279_G283_V1.2431.00
125_I129_L1.2431.00
162_R166_A1.2431.00
35_P38_R1.2411.00
217_A282_V1.2071.00
149_E152_S1.2061.00
136_R276_V1.2061.00
166_A170_E1.2011.00
17_L21_L1.1971.00
192_I196_V1.1931.00
184_I187_L1.1901.00
20_L24_F1.1881.00
101_I113_A1.1851.00
56_A88_A1.1841.00
168_A175_W1.1661.00
45_G48_K1.1591.00
74_A268_V1.1571.00
174_D177_K1.1561.00
284_G288_A1.1471.00
49_F53_L1.1451.00
48_K51_G1.1411.00
161_L165_R1.1401.00
140_L143_A1.1391.00
126_V130_L1.1391.00
14_L18_P1.1371.00
64_F72_L1.1371.00
169_R172_V1.1371.00
56_A121_L1.1351.00
263_L266_R1.1281.00
274_L278_L1.1221.00
213_V293_N1.1221.00
44_G47_N1.1131.00
51_G85_A1.1121.00
170_E175_W1.1081.00
124_A128_G1.0991.00
18_P22_L1.0971.00
142_D146_E1.0931.00
115_A119_G1.0871.00
37_E40_R1.0811.00
209_S212_A1.0751.00
139_E272_R1.0691.00
129_L132_G1.0681.00
102_V106_G1.0661.00
46_K50_L1.0621.00
60_A121_L1.0571.00
160_S165_R1.0511.00
155_L160_S1.0481.00
207_G210_L1.0391.00
156_E162_R1.0391.00
150_A153_A1.0351.00
36_P40_R1.0351.00
50_L53_L1.0341.00
135_F138_R1.0281.00
285_A289_G1.0271.00
190_A194_G1.0181.00
276_V280_L1.0141.00
282_V286_I1.0061.00
175_W178_V1.0051.00
53_L125_I0.9991.00
198_E240_K0.9971.00
95_L120_G0.9911.00
236_A240_K0.9901.00
245_G289_G0.9891.00
286_I290_L0.9891.00
158_K163_R0.9861.00
104_T116_R0.9851.00
248_L292_F0.9801.00
112_F248_L0.9761.00
156_E161_L0.9741.00
193_H198_E0.9701.00
144_V147_A0.9631.00
52_V84_G0.9611.00
45_G49_F0.9601.00
130_L280_L0.9561.00
132_G136_R0.9511.00
129_L133_R0.9501.00
168_A173_K0.9401.00
167_F172_V0.9331.00
123_I288_A0.9311.00
210_L214_L0.9301.00
46_K51_G0.9221.00
134_L276_V0.9151.00
283_V287_L0.9131.00
141_E145_R0.9121.00
245_G293_N0.9091.00
55_A88_A0.9091.00
218_L222_P0.9081.00
13_L17_L0.9081.00
148_A151_G0.9051.00
123_I127_A0.8991.00
135_F139_E0.8941.00
136_R140_L0.8931.00
10_L14_L0.8841.00
28_G32_A0.8841.00
165_R169_R0.8831.00
140_L144_V0.8781.00
133_R137_E0.8691.00
88_A92_A0.8681.00
53_L57_L0.8681.00
213_V290_L0.8621.00
149_E154_G0.8591.00
185_G189_A0.8491.00
159_P164_R0.8471.00
217_A253_A0.8441.00
83_L87_F0.8431.00
261_E265_L0.8421.00
155_L162_R0.8411.00
172_V176_K0.8361.00
57_L61_V0.8341.00
150_A154_G0.8311.00
145_R148_A0.8311.00
206_G209_S0.8311.00
147_A150_A0.8281.00
74_A78_K0.8251.00
124_A127_A0.8241.00
166_A169_R0.8221.00
142_D270_G0.8191.00
19_L23_G0.8191.00
270_G274_L0.8161.00
200_F203_S0.8141.00
9_F187_L0.8141.00
143_A146_E0.8141.00
48_K52_V0.8141.00
281_V285_A0.8081.00
147_A152_S0.8081.00
14_L17_L0.8081.00
7_T10_L0.8061.00
12_D15_E0.8041.00
49_F52_V0.8041.00
269_L273_L0.8031.00
86_A269_L0.8021.00
157_R163_R0.7991.00
249_A253_A0.7941.00
155_L161_L0.7931.00
225_V250_F0.7871.00
207_G211_L0.7851.00
155_L163_R0.7841.00
187_L191_L0.7831.00
287_L290_L0.7821.00
168_A174_D0.7801.00
37_E41_R0.7781.00
259_L263_L0.7771.00
192_I236_A0.7761.00
276_V279_G0.7751.00
114_L117_V0.7751.00
171_A177_K0.7741.00
77_L86_A0.7731.00
41_R44_G0.7691.00
139_E143_A0.7681.00
160_S166_A0.7651.00
138_R141_E0.7651.00
275_A278_L0.7631.00
213_V286_I0.7551.00
231_I252_M0.7551.00
59_G92_A0.7541.00
138_R142_D0.7511.00
158_K166_A0.7501.00
238_L244_L0.7501.00
130_L134_L0.7471.00
174_D178_V0.7471.00
187_L190_A0.7391.00
182_L185_G0.7361.00
257_L262_L0.7351.00
171_A178_V0.7321.00
96_L121_L0.7321.00
131_I134_L0.7321.00
60_A96_L0.7321.00
103_L107_L0.7311.00
117_V121_L0.7301.00
157_R166_A0.7271.00
76_L81_A0.7231.00
146_E149_E0.7201.00
29_L33_F0.7151.00
131_I135_F0.7131.00
6_L9_F0.7121.00
21_L25_F0.7121.00
108_L238_L0.7121.00
196_V200_F0.7091.00
46_K49_F0.7091.00
146_E150_A0.7091.00
118_V122_L0.7081.00
75_G78_K0.7061.00
256_A281_V0.7061.00
148_A154_G0.7061.00
53_L56_A0.7051.00
28_G171_A0.7041.00
149_E153_A0.7021.00
213_V289_G0.6981.00
111_K115_A0.6951.00
237_L241_G0.6941.00
183_L187_L0.6931.00
156_E164_R0.6931.00
159_P166_A0.6921.00
143_A147_A0.6911.00
167_F173_K0.6911.00
272_R275_A0.6881.00
263_L267_K0.6861.00
265_L274_L0.6841.00
30_I34_V0.6841.00
16_I20_L0.6841.00
40_R79_K0.6821.00
96_L101_I0.6761.00
49_F129_L0.6761.00
212_A246_A0.6741.00
210_L290_L0.6701.00
280_L284_G0.6681.00
135_F272_R0.6621.00
29_L167_F0.6591.00
55_A85_A0.6551.00
155_L164_R0.6551.00
240_K244_L0.6541.00
84_G128_G0.6511.00
119_G123_I0.6511.00
6_L10_L0.6511.00
31_Q36_P0.6511.00
24_F28_G0.6501.00
208_N212_A0.6491.00
48_K132_G0.6451.00
109_G113_A0.6421.00
23_G27_A0.6421.00
97_N100_A0.6421.00
242_M247_A0.6411.00
16_I19_L0.6391.00
205_F242_M0.6391.00
225_V228_A0.6391.00
89_F93_S0.6391.00
217_A220_G0.6391.00
253_A282_V0.6381.00
267_K271_P0.6371.00
73_F77_L0.6371.00
139_E144_V0.6371.00
25_F28_G0.6331.00
111_K114_L0.6281.00
126_V284_G0.6281.00
18_P21_L0.6271.00
125_I128_G0.6261.00
108_L235_A0.6251.00
51_G55_A0.6231.00
248_L252_M0.6211.00
113_A117_V0.6201.00
8_F11_Y0.6201.00
112_F238_L0.6191.00
197_P200_F0.6181.00
69_V93_S0.6181.00
25_F29_L0.6161.00
157_R164_R0.6151.00
34_V39_V0.6141.00
70_I261_E0.6131.00
52_V55_A0.6121.00
7_T14_L0.6111.00
100_A228_A0.6081.00
116_R255_P0.6081.00
52_V128_G0.6051.00
242_M246_A0.6051.00
83_L273_L0.6041.00
253_A281_V0.6011.00
19_L24_F0.6001.00
158_K164_R0.6001.00
174_D179_W0.5981.00
136_R144_V0.5981.00
170_E177_K0.5971.00
39_V42_Y0.5951.00
83_L135_F0.5941.00
273_L276_V0.5931.00
207_G243_S0.5881.00
27_A30_I0.5871.00
56_A124_A0.5831.00
127_A131_I0.5821.00
83_L131_I0.5811.00
29_L32_A0.5801.00
182_L186_V0.5801.00
289_G293_N0.5791.00
177_K180_P0.5771.00
164_R167_F0.5771.00
75_G79_K0.5741.00
135_F140_L0.5721.00
226_C250_F0.5711.00
7_T11_Y0.5701.00
66_S70_I0.5681.00
257_L278_L0.5671.00
22_L26_I0.5671.00
33_F161_L0.5641.00
157_R165_R0.5631.00
148_A153_A0.5631.00
225_V229_G0.5611.00
68_G72_L0.5611.00
126_V129_L0.5611.00
250_F254_G0.5591.00
22_L25_F0.5581.00
101_I105_A0.5571.00
161_L166_A0.5571.00
15_E19_L0.5561.00
74_A264_I0.5481.00
24_F178_V0.5461.00
26_I72_L0.5461.00
201_I242_M0.5451.00
73_F90_L0.5401.00
31_Q79_K0.5381.00
205_F208_N0.5361.00
136_R146_E0.5361.00
249_A286_I0.5341.00
154_G157_R0.5321.00
181_Y184_I0.5311.00
100_A227_A0.5281.00
164_R168_A0.5271.00
163_R167_F0.5261.00
121_L125_I0.5241.00
212_A215_L0.5231.00
60_A101_I0.5211.00
156_E163_R0.5211.00
186_V189_A0.5211.00
112_F292_F0.5201.00
206_G211_L0.5191.00
156_E166_A0.5181.00
35_P39_V0.5171.00
144_V148_A0.5161.00
231_I235_A0.5161.00
188_I233_I0.5161.00
99_V103_L0.5140.99
131_I277_F0.5130.99
138_R272_R0.5110.99
258_S261_E0.5110.99
32_A35_P0.5110.99
193_H236_A0.5080.99
40_R43_L0.5060.99
107_L235_A0.5040.99
20_L23_G0.5030.99
13_L183_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.9218 49.5 0.94 Contact Map
1pw4A 1 0.915 29.9 0.947 Contact Map
3zojA 3 0.4626 23.6 0.949 Contact Map
4r1iA 2 0.932 21.9 0.95 Contact Map
3llqA 3 0.3673 20.4 0.951 Contact Map
2b6oA 6 0.5034 17.4 0.952 Contact Map
3qe7A 2 0.4626 14.8 0.954 Contact Map
3zuxA 1 0.4592 12.9 0.955 Contact Map
4j05A 3 0.4966 11.3 0.956 Contact Map
3o7qA 1 0.898 11.2 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.