GREMLIN Database
Competence - Competence protein
PFAM: PF03772 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 271 (264)
Sequences: 40330 (32111)
Seq/√Len: 1976.3
META: 0.845

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_A82_A4.1581.00
133_G167_A3.4451.00
66_L86_A3.3481.00
125_Q175_Y3.1741.00
16_A234_E3.0531.00
108_A128_F2.9721.00
100_P135_L2.8591.00
62_L86_A2.8031.00
17_F230_L2.7181.00
40_L64_A2.6641.00
111_L128_F2.6641.00
122_V175_Y2.3941.00
227_A231_A2.3441.00
66_L82_A2.3251.00
186_A236_L2.1551.00
130_A168_T2.1331.00
15_E19_R2.1181.00
231_A235_W2.0641.00
134_I160_V2.0631.00
14_R18_R2.0181.00
70_L74_A1.9841.00
137_L163_A1.9731.00
231_A234_E1.9671.00
189_L192_P1.9571.00
111_L118_A1.9341.00
133_G164_A1.9021.00
69_A74_A1.8491.00
112_L118_A1.8461.00
28_I78_V1.8421.00
37_A85_A1.8281.00
101_L136_L1.8211.00
69_A78_V1.8081.00
65_L82_A1.8001.00
223_G227_A1.7961.00
115_D118_A1.7871.00
220_W224_L1.7751.00
18_R23_A1.7701.00
217_L221_L1.7411.00
44_L60_L1.7411.00
83_I107_A1.7341.00
108_A124_F1.7041.00
16_A233_A1.6781.00
193_L228_L1.6481.00
101_L132_A1.6391.00
178_Q243_S1.6231.00
75_S78_V1.6031.00
250_P253_A1.5991.00
104_L132_A1.5991.00
129_A171_L1.5731.00
164_A168_T1.5481.00
234_E238_S1.5401.00
53_P56_L1.5311.00
19_R237_A1.5291.00
216_A220_W1.5241.00
38_G42_F1.5231.00
98_A103_A1.5041.00
10_D13_L1.4831.00
224_L228_L1.4791.00
15_E18_R1.4791.00
33_V82_A1.4571.00
72_T75_S1.4491.00
58_A89_L1.4271.00
14_R23_A1.4131.00
6_R27_A1.3891.00
107_A128_F1.3821.00
27_A77_S1.3781.00
105_A109_L1.3751.00
22_L233_A1.3661.00
22_L190_A1.3661.00
150_R154_L1.3621.00
99_D102_N1.3621.00
230_L234_E1.3411.00
190_A229_L1.3181.00
90_L94_L1.3091.00
33_V85_A1.3071.00
211_L214_L1.2991.00
55_R95_G1.2931.00
16_A237_A1.2901.00
181_L244_L1.2841.00
42_F46_R1.2841.00
88_V92_R1.2741.00
13_L230_L1.2621.00
13_L17_F1.2601.00
224_L227_A1.2491.00
131_V135_L1.2491.00
126_L172_L1.2211.00
217_L220_W1.2191.00
107_A111_L1.2131.00
182_V239_L1.2131.00
72_T78_V1.1951.00
263_L267_L1.1941.00
79_V111_L1.1861.00
221_L224_L1.1791.00
177_G248_A1.1741.00
197_V225_L1.1701.00
27_A32_H1.1691.00
182_V236_L1.1601.00
102_N105_A1.1571.00
19_R243_S1.1561.00
133_G163_A1.1551.00
40_L61_A1.1541.00
204_L219_A1.1501.00
58_A93_L1.1501.00
37_A41_F1.1491.00
104_L108_A1.1421.00
3_L71_L1.1371.00
84_M107_A1.1301.00
20_T236_L1.1291.00
52_P56_L1.1281.00
221_L225_L1.1241.00
87_L106_L1.1221.00
181_L185_L1.1191.00
235_W239_L1.1141.00
142_R153_R1.1091.00
38_G41_F1.1041.00
138_A160_V1.1001.00
254_L258_Y1.0991.00
22_L186_A1.0971.00
17_F26_L1.0951.00
200_P204_L1.0951.00
182_V242_A1.0751.00
19_R178_Q1.0681.00
57_A61_A1.0661.00
6_R14_R1.0621.00
5_D8_G1.0591.00
20_T233_A1.0521.00
28_I72_T1.0511.00
25_L194_V1.0481.00
74_A79_V1.0441.00
102_N106_L1.0431.00
112_L119_L1.0331.00
235_W238_S1.0321.00
85_A89_L1.0311.00
149_P152_L1.0301.00
118_A121_D1.0221.00
165_Q168_T1.0181.00
220_W223_G1.0181.00
132_A136_L1.0181.00
13_L16_A1.0141.00
58_A62_L1.0121.00
122_V176_F1.0111.00
189_L232_V1.0061.00
16_A230_L1.0031.00
41_F61_A0.9991.00
125_Q129_A0.9981.00
65_L85_A0.9931.00
172_L176_F0.9911.00
32_H75_S0.9901.00
76_P118_A0.9871.00
110_V114_L0.9871.00
37_A61_A0.9821.00
218_L221_L0.9771.00
140_P143_R0.9721.00
56_L59_L0.9711.00
249_P253_A0.9711.00
181_L184_L0.9611.00
178_Q181_L0.9571.00
194_V229_L0.9561.00
138_A142_R0.9551.00
82_A86_A0.9531.00
140_P144_R0.9531.00
149_P153_R0.9461.00
25_L190_A0.9461.00
51_G56_L0.9441.00
111_L124_F0.9381.00
31_L34_G0.9331.00
154_L158_L0.9301.00
103_A107_A0.9261.00
153_R157_A0.9111.00
213_P217_L0.9071.00
204_L222_A0.9041.00
249_P258_Y0.8991.00
104_L135_L0.8981.00
173_L246_V0.8961.00
53_P57_A0.8941.00
18_R178_Q0.8921.00
171_L175_Y0.8821.00
23_A27_A0.8771.00
191_V194_V0.8741.00
35_I195_S0.8701.00
129_A167_A0.8671.00
126_L168_T0.8631.00
249_P252_W0.8631.00
137_L167_A0.8601.00
213_P216_A0.8551.00
200_P208_L0.8531.00
219_A222_A0.8491.00
86_A90_L0.8471.00
164_A167_A0.8451.00
94_L97_R0.8441.00
130_A164_A0.8381.00
87_L103_A0.8371.00
40_L44_L0.8331.00
154_L157_A0.8321.00
198_V225_L0.8301.00
84_M131_V0.8251.00
59_L63_L0.8241.00
11_P15_E0.8121.00
258_Y261_L0.8111.00
37_A89_L0.8071.00
228_L231_A0.8061.00
36_V64_A0.8041.00
160_V164_A0.7991.00
125_Q171_L0.7971.00
27_A75_S0.7961.00
228_L232_V0.7941.00
227_A230_L0.7911.00
182_V241_G0.7861.00
109_L113_L0.7861.00
31_L35_I0.7851.00
41_F45_R0.7811.00
137_L265_L0.7781.00
45_R57_A0.7781.00
172_L175_Y0.7751.00
37_A65_L0.7721.00
1_L194_V0.7691.00
59_L93_L0.7671.00
199_V202_A0.7661.00
252_W255_L0.7641.00
232_V236_L0.7641.00
210_L213_P0.7601.00
44_L57_A0.7591.00
165_Q183_G0.7581.00
196_L200_P0.7521.00
250_P258_Y0.7511.00
187_N191_V0.7501.00
200_P222_A0.7451.00
152_L156_W0.7431.00
151_L154_L0.7431.00
66_L69_A0.7421.00
28_I33_V0.7411.00
168_T172_L0.7361.00
2_L202_A0.7331.00
171_L258_Y0.7301.00
138_A163_A0.7301.00
253_A256_L0.7301.00
61_A65_L0.7281.00
52_P55_R0.7271.00
155_A159_A0.7271.00
34_G38_G0.7271.00
184_L187_N0.7271.00
195_S199_V0.7261.00
76_P121_D0.7261.00
62_L66_L0.7241.00
58_A92_R0.7221.00
12_E16_A0.7211.00
90_L93_L0.7201.00
32_H198_V0.7201.00
193_L225_L0.7181.00
20_T237_A0.7161.00
63_L67_L0.7161.00
169_L179_V0.7141.00
247_P253_A0.7091.00
54_R57_A0.7081.00
205_A208_L0.7081.00
254_L257_Y0.7051.00
77_S123_G0.7031.00
215_A219_A0.7031.00
174_Y254_L0.6991.00
58_A61_A0.6981.00
182_V240_P0.6961.00
232_V235_W0.6951.00
167_A170_P0.6921.00
251_L255_L0.6901.00
33_V65_L0.6901.00
9_L14_R0.6891.00
161_S164_A0.6871.00
139_P143_R0.6851.00
262_L266_L0.6841.00
29_S32_H0.6811.00
161_S165_Q0.6801.00
31_L191_V0.6791.00
129_A175_Y0.6761.00
33_V78_V0.6731.00
178_Q245_R0.6721.00
206_L209_L0.6681.00
42_F45_R0.6671.00
83_I111_L0.6641.00
236_L239_L0.6641.00
47_L51_G0.6641.00
169_L172_L0.6621.00
88_V98_A0.6591.00
202_A208_L0.6591.00
41_F57_A0.6591.00
255_L258_Y0.6571.00
16_A19_R0.6571.00
208_L211_L0.6561.00
197_V226_L0.6541.00
6_R32_H0.6541.00
4_G75_S0.6541.00
114_L118_A0.6531.00
239_L242_A0.6531.00
234_E237_A0.6531.00
69_A79_V0.6531.00
54_R92_R0.6511.00
182_V185_L0.6501.00
51_G55_R0.6491.00
55_R93_L0.6481.00
177_G247_P0.6461.00
139_P142_R0.6451.00
92_R95_G0.6351.00
253_A258_Y0.6311.00
255_L259_L0.6301.00
28_I32_H0.6301.00
222_A225_L0.6281.00
62_L89_L0.6281.00
134_I163_A0.6221.00
195_S200_P0.6211.00
229_L233_A0.6201.00
226_L230_L0.6191.00
67_L70_L0.6191.00
249_P257_Y0.6131.00
256_L260_G0.6061.00
20_T186_A0.6051.00
170_P258_Y0.6041.00
198_V202_A0.6001.00
66_L70_L0.6001.00
174_Y178_Q0.5991.00
245_R248_A0.5981.00
188_L192_P0.5971.00
156_W159_A0.5931.00
161_S187_N0.5931.00
184_L188_L0.5931.00
106_L110_V0.5901.00
31_L195_S0.5891.00
219_A223_G0.5881.00
91_A98_A0.5881.00
87_L110_V0.5871.00
206_L210_L0.5861.00
33_V69_A0.5851.00
214_L217_L0.5831.00
21_G183_G0.5831.00
212_P216_A0.5801.00
163_A167_A0.5801.00
144_R148_L0.5801.00
208_L212_P0.5791.00
205_A209_L0.5781.00
247_P250_P0.5781.00
67_L71_L0.5771.00
98_A102_N0.5761.00
257_Y261_L0.5731.00
197_V222_A0.5731.00
17_F22_L0.5721.00
192_P196_L0.5711.00
227_A234_E0.5701.00
39_L42_F0.5671.00
208_L218_L0.5661.00
54_R58_A0.5631.00
147_R152_L0.5621.00
122_V125_Q0.5611.00
197_V229_L0.5601.00
160_V191_V0.5591.00
195_S198_V0.5581.00
149_P155_A0.5571.00
151_L156_W0.5571.00
207_L211_L0.5551.00
13_L26_L0.5551.00
79_V83_I0.5531.00
56_L60_L0.5491.00
251_L254_L0.5461.00
99_D103_A0.5441.00
100_P103_A0.5431.00
151_L155_A0.5421.00
142_R146_R0.5411.00
44_L52_P0.5391.00
150_R153_R0.5381.00
260_G263_L0.5371.00
142_R157_A0.5371.00
174_Y251_L0.5351.00
216_A219_A0.5351.00
201_G205_A0.5341.00
207_L210_L0.5321.00
25_L191_V0.5321.00
69_A72_T0.5311.00
131_V134_I0.5301.00
27_A81_A0.5291.00
51_G57_A0.5271.00
31_L75_S0.5241.00
260_G264_L0.5231.00
144_R147_R0.5221.00
252_W256_L0.5201.00
253_A257_Y0.5181.00
194_V198_V0.5171.00
191_V195_S0.5131.00
205_A219_A0.5131.00
258_Y262_L0.5131.00
152_L155_A0.5121.00
169_L173_L0.5091.00
6_R31_L0.5091.00
189_L228_L0.5081.00
141_L144_R0.5081.00
32_H78_V0.5061.00
24_H187_N0.5041.00
46_R53_P0.5031.00
155_A158_L0.5031.00
211_L215_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c0kA 1 0.1771 3 0.956 Contact Map
3j7aW 1 0.0517 3 0.956 Contact Map
2uz0A 4 0.2177 2.9 0.956 Contact Map
2oyoA 4 0.2214 2.7 0.957 Contact Map
4rotA 4 0.2214 2.6 0.957 Contact Map
3c1lA 5 0.2214 2.6 0.957 Contact Map
4exqA 2 0.2066 2.5 0.958 Contact Map
2pfxA 3 0.2214 2.4 0.958 Contact Map
3qkgA 1 0.155 2.3 0.959 Contact Map
2oilA 1 0.2214 2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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