GREMLIN Database
Remorin_C - Remorin, C-terminal region
PFAM: PF03763 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (104)
Sequences: 645 (336)
Seq/√Len: 33.0
META: 0.025

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_A41_A2.9211.00
26_A52_K2.7281.00
30_A33_N2.4681.00
11_E17_A2.4571.00
39_A49_K2.3550.99
21_Y79_A2.3340.99
97_I100_T2.2890.99
4_S22_K2.1820.99
69_H73_E1.9980.98
81_A84_G1.9890.98
8_A77_A1.9850.98
20_R77_A1.9630.98
24_E79_A1.9560.97
10_E14_K1.8720.97
6_A21_Y1.7200.95
35_K71_K1.6500.93
6_A20_R1.6480.93
80_E83_R1.6380.93
34_L61_M1.5390.91
101_G104_P1.5270.90
24_E72_A1.5010.90
74_E77_A1.4570.88
37_A52_K1.4140.86
29_Q68_I1.4050.86
50_L76_R1.3870.85
46_I49_K1.3860.85
5_R22_K1.3530.84
76_R81_A1.3480.84
79_A102_K1.3450.84
27_K65_L1.3420.83
78_A93_K1.3340.83
4_S90_A1.3290.83
6_A103_A1.3260.83
6_A17_A1.3220.82
65_L93_K1.3080.82
84_G95_A1.2770.80
94_A101_G1.2260.77
36_K93_K1.2200.77
6_A90_A1.2160.77
10_E13_E1.2060.76
8_A15_A1.1810.75
14_K37_A1.1730.74
12_A17_A1.1470.72
16_K84_G1.1390.72
87_A93_K1.1160.70
24_E28_I1.0810.68
39_A103_A1.0770.68
11_E35_K1.0580.66
7_K11_E1.0570.66
5_R12_A1.0440.65
59_E69_H1.0320.64
2_R5_R1.0280.64
85_E89_K1.0160.63
59_E66_A1.0080.62
9_W74_E1.0070.62
39_A46_I0.9870.61
10_E99_A0.9800.60
72_A76_R0.9560.58
11_E14_K0.9510.58
26_A51_E0.9480.58
15_A79_A0.9350.57
34_L48_E0.9350.57
36_K61_M0.9320.56
33_N73_E0.9260.56
40_E52_K0.9250.56
90_A97_I0.9080.54
25_E28_I0.8940.53
50_L72_A0.8870.53
27_K102_K0.8820.52
46_I60_K0.8760.52
39_A50_L0.8610.50
9_W16_K0.8600.50
49_K68_I0.8560.50
67_R90_A0.8500.49
60_K72_A0.8440.49
68_I84_G0.8430.49
76_R102_K0.8260.47
47_E52_K0.8160.47
89_K98_R0.8120.46
27_K86_E0.7920.45
70_K79_A0.7920.45
17_A21_Y0.7870.44
41_A47_E0.7830.44
60_K66_A0.7830.44
5_R11_E0.7830.44
25_E30_A0.7830.44
80_E94_A0.7630.42
53_K58_L0.7580.42
37_A40_E0.7550.42
14_K21_Y0.7530.41
13_E89_K0.7530.41
23_R54_R0.7530.41
42_E91_E0.7500.41
56_E71_K0.7440.41
88_L99_A0.7440.41
43_L57_A0.7370.40
24_E30_A0.7320.40
44_R67_R0.7270.39
37_A78_A0.7220.39
60_K90_A0.7220.39
48_E55_A0.7150.38
42_E96_K0.7070.38
24_E42_E0.7060.38
47_E103_A0.7030.38
4_S8_A0.7030.38
39_A67_R0.7010.37
34_L46_I0.7000.37
38_K65_L0.6990.37
32_E43_L0.6950.37
51_E60_K0.6920.37
61_M68_I0.6750.35
27_K38_K0.6750.35
18_E48_E0.6730.35
67_R70_K0.6720.35
32_E36_K0.6670.35
79_A89_K0.6660.35
46_I61_M0.6650.35
6_A94_A0.6640.35
78_A82_K0.6630.34
63_N66_A0.6630.34
54_R97_I0.6620.34
28_I42_E0.6590.34
47_E51_E0.6580.34
50_L68_I0.6460.33
102_K105_K0.6460.33
65_L72_A0.6460.33
34_L39_A0.6450.33
55_A92_E0.6360.32
20_R105_K0.6260.32
13_E52_K0.6210.31
41_A103_A0.6040.30
54_R68_I0.6030.30
85_E92_E0.5990.30
23_R48_E0.5980.30
20_R24_E0.5950.30
49_K61_M0.5950.30
66_A77_A0.5940.29
44_R47_E0.5720.28
19_N66_A0.5700.28
97_I103_A0.5630.27
92_E99_A0.5610.27
50_L53_K0.5600.27
12_A46_I0.5500.26
49_K100_T0.5410.26
30_A103_A0.5390.26
45_K64_K0.5350.26
34_L75_K0.5340.25
74_E81_A0.5310.25
26_A105_K0.5290.25
45_K71_K0.5270.25
56_E80_E0.5250.25
50_L62_K0.5120.24
12_A43_L0.5080.24
25_E68_I0.5080.24
40_E48_E0.5070.24
88_L104_P0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3plwA 1 0.0566 3 0.927 Contact Map
2r32A 3 0.3868 3 0.927 Contact Map
3mq9A 4 0.717 2.6 0.93 Contact Map
3ojaB 1 0.934 2.5 0.93 Contact Map
2qagB 1 0 2.4 0.931 Contact Map
1zl8A 1 0.2642 2.2 0.933 Contact Map
4kv9A 2 0 1.6 0.938 Contact Map
4l6yA 2 0.4245 1.6 0.938 Contact Map
2wd5A 1 0.3396 1.5 0.939 Contact Map
2mpeA 1 0.3396 1.4 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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