GREMLIN Database
YicC_N - YicC-like family, N-terminal region
PFAM: PF03755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 151 (149)
Sequences: 37046 (26915)
Seq/√Len: 2205.0
META: 0.919

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_L132_E2.9001.00
84_K96_E2.5041.00
80_E96_E2.4881.00
24_S138_L2.4581.00
124_W128_L2.3141.00
54_R136_D2.2261.00
80_E92_E2.1851.00
103_S106_D2.1841.00
2_K139_V2.0991.00
46_E124_W1.9401.00
54_R139_V1.9191.00
87_L91_R1.8831.00
55_L138_L1.8781.00
27_H59_K1.8591.00
2_K143_E1.8521.00
139_V143_E1.7631.00
48_R52_R1.7341.00
128_L132_E1.7311.00
54_R132_E1.7241.00
50_L128_L1.7141.00
12_G130_A1.6921.00
20_V64_L1.6781.00
80_E84_K1.6321.00
55_L60_V1.5911.00
137_A140_A1.5431.00
46_E128_L1.5281.00
140_A144_R1.5281.00
11_E17_T1.5131.00
50_L53_E1.5011.00
12_G133_E1.4991.00
33_S59_K1.4921.00
92_E96_E1.4881.00
49_E53_E1.4781.00
17_T67_E1.4731.00
133_E137_A1.4261.00
13_E17_T1.4011.00
83_L93_L1.3551.00
20_V130_A1.3501.00
50_L54_R1.3411.00
84_K97_L1.3241.00
45_P49_E1.3201.00
100_G103_S1.3191.00
91_R94_A1.2961.00
84_K88_A1.2881.00
47_I131_L1.2861.00
10_A133_E1.2861.00
43_L124_W1.2841.00
51_L135_L1.2831.00
94_A100_G1.2771.00
10_A130_A1.2771.00
144_R147_A1.2321.00
46_E49_E1.2131.00
34_L47_I1.2131.00
9_R19_T1.2121.00
11_E19_T1.2091.00
106_D109_R1.2011.00
89_A92_E1.1911.00
147_A150_A1.1911.00
83_L113_V1.1871.00
129_A133_E1.1871.00
23_R61_D1.1751.00
143_E147_A1.1741.00
144_R148_A1.1691.00
87_L97_L1.1671.00
30_L52_R1.1601.00
12_G129_A1.1541.00
62_V131_L1.1511.00
140_A143_E1.1401.00
132_E136_D1.1401.00
88_A92_E1.1321.00
85_A88_A1.1121.00
24_S60_V1.1081.00
10_A137_A1.1001.00
85_A89_A1.0871.00
51_L62_V1.0851.00
133_E136_D1.0651.00
53_E132_E1.0621.00
90_L108_L1.0581.00
20_V131_L1.0571.00
54_R135_L1.0541.00
33_S61_D1.0491.00
41_R61_D1.0231.00
77_R115_E1.0201.00
16_G66_L1.0151.00
80_E89_A1.0111.00
49_E52_R1.0011.00
136_D140_A1.0011.00
75_A85_A0.9941.00
81_E84_K0.9931.00
105_S109_R0.9881.00
22_I62_V0.9851.00
126_A129_A0.9821.00
10_A134_A0.9811.00
32_L51_L0.9781.00
31_D59_K0.9761.00
31_D48_R0.9711.00
35_R63_S0.9611.00
55_L139_V0.9531.00
86_Y110_L0.9491.00
18_I66_L0.9431.00
34_L62_V0.9401.00
64_L127_L0.9381.00
125_A128_L0.9371.00
141_M144_R0.9341.00
79_N115_E0.9341.00
42_A124_W0.9231.00
40_L66_L0.9191.00
12_G126_A0.9141.00
125_A129_A0.9091.00
38_R41_R0.8981.00
50_L135_L0.8961.00
91_R95_E0.8941.00
43_L46_E0.8891.00
79_N82_L0.8841.00
93_L97_L0.8781.00
94_A101_P0.8701.00
130_A133_E0.8571.00
92_E95_E0.8571.00
77_R116_E0.8561.00
81_E85_A0.8441.00
82_L86_Y0.8431.00
88_A91_R0.8431.00
9_R21_E0.8341.00
22_I138_L0.8331.00
51_L55_L0.8221.00
129_A132_E0.8201.00
43_L127_L0.8181.00
44_E48_R0.8171.00
102_L105_S0.8041.00
90_L104_L0.8031.00
90_L102_L0.7971.00
23_R27_H0.7951.00
55_L135_L0.7921.00
83_L107_L0.7761.00
20_V134_A0.7761.00
22_I134_A0.7701.00
136_D139_V0.7651.00
130_A134_A0.7641.00
22_I51_L0.7621.00
82_L85_A0.7611.00
19_T67_E0.7531.00
82_L113_V0.7511.00
50_L131_L0.7501.00
78_I83_L0.7471.00
38_R65_S0.7461.00
16_G68_R0.7451.00
34_L44_E0.7451.00
103_S107_L0.7401.00
13_E69_A0.7381.00
30_L60_V0.7371.00
15_G69_A0.7351.00
106_D110_L0.7341.00
12_G18_I0.7321.00
94_A104_L0.7301.00
8_G134_A0.7291.00
27_H61_D0.7271.00
46_E50_L0.7271.00
76_V89_A0.7141.00
94_A97_L0.7111.00
18_I130_A0.6921.00
94_A99_A0.6881.00
78_I89_A0.6851.00
51_L131_L0.6821.00
18_I127_L0.6751.00
116_E119_E0.6641.00
134_A138_L0.6611.00
19_T65_S0.6531.00
39_E66_L0.6491.00
1_I150_A0.6471.00
94_A102_L0.6461.00
84_K87_L0.6401.00
126_A130_A0.6401.00
112_G115_E0.6301.00
137_A144_R0.6261.00
91_R100_G0.6251.00
49_E148_A0.6251.00
36_L47_I0.6181.00
137_A141_M0.6161.00
90_L107_L0.6121.00
78_I93_L0.6121.00
110_L113_V0.6101.00
36_L64_L0.6101.00
18_I126_A0.6061.00
111_P114_L0.6061.00
102_L106_D0.5971.00
23_R41_R0.5951.00
27_H35_R0.5891.00
124_W129_A0.5841.00
31_D38_R0.5831.00
20_V62_V0.5821.00
40_L123_L0.5821.00
17_T69_A0.5751.00
89_A114_L0.5741.00
120_D123_L0.5741.00
87_L102_L0.5721.00
22_I135_L0.5681.00
87_L90_L0.5631.00
37_P40_L0.5611.00
91_R101_P0.5611.00
100_G106_D0.5611.00
107_L113_V0.5551.00
99_A102_L0.5451.00
47_I127_L0.5441.00
74_A79_N0.5431.00
31_D34_L0.5401.00
18_I40_L0.5361.00
30_L34_L0.5351.00
80_E83_L0.5341.00
32_L48_R0.5281.00
100_G104_L0.5271.00
51_L60_V0.5271.00
90_L110_L0.5181.00
9_R137_A0.5181.00
131_L135_L0.5161.00
127_L130_A0.5141.00
27_H31_D0.5131.00
78_I114_L0.5121.00
86_Y90_L0.5121.00
95_E98_G0.5091.00
123_L127_L0.5071.00
36_L44_E0.5071.00
51_L54_R0.5051.00
87_L107_L0.5011.00
10_A20_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ghgA 2 0.6821 30.1 0.915 Contact Map
4qgkA 2 0.3642 15.4 0.925 Contact Map
4i14A 2 0.0927 13.2 0.928 Contact Map
2gqpA 1 0.5099 11.3 0.93 Contact Map
4w6yA 2 0.404 10.5 0.931 Contact Map
1rlzA 4 0.894 10.1 0.932 Contact Map
3h90A 3 0.4305 9.3 0.933 Contact Map
1deqA 1 0.8212 8.8 0.933 Contact Map
3n9uC 1 0.3444 6.3 0.937 Contact Map
2j42A 1 0 6.2 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.