GREMLIN Database
DUF310 - Protein of unknown function (DUF310)
PFAM: PF03750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 115 (109)
Sequences: 3333 (2812)
Seq/√Len: 269.4
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_K86_D3.9091.00
89_K94_D2.3601.00
61_K82_D2.3181.00
35_V99_V2.2431.00
23_L74_V2.2361.00
35_V98_F2.2091.00
68_A75_K2.1761.00
25_T110_K2.1591.00
41_K56_E2.0521.00
75_K79_E2.0471.00
34_E56_E2.0191.00
39_E96_K2.0101.00
68_A78_V1.9741.00
32_Y36_K1.8671.00
78_V82_D1.8511.00
59_M63_K1.8461.00
36_K39_E1.8081.00
12_E112_Y1.7201.00
27_Q67_A1.7191.00
30_K67_A1.7171.00
34_E63_K1.7101.00
12_E16_K1.6791.00
36_K99_V1.6681.00
31_F64_L1.6461.00
80_F101_F1.5521.00
35_V102_F1.5441.00
90_D94_D1.5051.00
11_A15_A1.4531.00
34_E37_R1.4231.00
15_A18_L1.3921.00
94_D97_N1.3911.00
57_L88_V1.3871.00
39_E99_V1.3451.00
9_E13_K1.3001.00
57_L85_I1.2871.00
83_E86_D1.2701.00
10_K13_K1.2681.00
16_K20_K1.2601.00
35_V60_L1.2341.00
91_S94_D1.2061.00
11_A14_I1.2031.00
39_E43_K1.1951.00
38_I53_I1.1771.00
51_E54_L1.1291.00
65_A82_D1.1121.00
73_V77_F1.1061.00
84_A98_F1.1041.00
42_V57_L1.0941.00
84_A101_F1.0911.00
27_Q30_K1.0861.00
98_F102_F1.0521.00
59_M100_D1.0501.00
64_L81_L1.0301.00
14_I18_L1.0211.00
31_F67_A1.0101.00
45_G48_E1.0041.00
82_D86_D0.9971.00
7_L15_A0.9841.00
15_A105_I0.9721.00
37_R41_K0.9711.00
77_F81_L0.9691.00
66_Y70_R0.9641.00
81_L85_I0.9601.00
64_L78_V0.9441.00
57_L95_F0.9331.00
109_H114_G0.9301.00
6_L10_K0.9281.00
42_V53_I0.9241.00
16_K112_Y0.9131.00
23_L106_V0.9121.00
32_Y103_E0.9101.00
97_N100_D0.8981.00
11_A104_A0.8961.00
32_Y102_F0.8911.00
93_E97_N0.8701.00
100_D103_E0.8691.00
65_A69_G0.8541.00
12_E15_A0.8531.00
59_M62_P0.8441.00
54_L58_K0.8401.00
62_P107_A0.8391.00
17_E76_E0.8381.00
15_A19_A0.8330.99
72_L75_K0.8320.99
63_K103_E0.8090.99
64_L102_F0.7990.99
6_L9_E0.7970.99
9_E12_E0.7930.99
42_V95_F0.7880.99
7_L14_I0.7790.99
6_L15_A0.7570.99
17_E20_K0.7530.99
17_E21_K0.7530.99
102_F106_V0.7490.99
38_I56_E0.7390.99
45_G49_E0.7220.99
87_Q90_D0.7210.99
28_I106_V0.7200.98
75_K78_V0.7160.98
69_G74_V0.7140.98
84_A87_Q0.7020.98
32_Y106_V0.7000.98
88_V98_F0.6880.98
68_A74_V0.6850.98
11_A18_L0.6820.98
74_V77_F0.6810.98
8_V12_E0.6760.98
38_I57_L0.6750.98
7_L11_A0.6710.98
41_K53_I0.6690.98
58_K62_P0.6660.97
105_I109_H0.6660.97
13_K16_K0.6610.97
24_T72_L0.6600.97
96_K100_D0.6570.97
23_L73_V0.6540.97
37_R56_E0.6490.97
64_L84_A0.6460.97
54_L90_D0.6360.97
32_Y62_P0.6350.97
111_Y114_G0.6340.97
58_K61_K0.6340.97
80_F84_A0.6330.97
80_F105_I0.6330.97
58_K89_K0.6250.96
31_F81_L0.6250.96
22_K76_E0.6220.96
26_S66_Y0.6210.96
13_K17_E0.6180.96
85_I88_V0.6180.96
10_K15_A0.6150.96
106_V109_H0.6150.96
76_E79_E0.6060.96
34_E60_L0.6030.96
55_P100_D0.6020.95
21_K76_E0.6020.95
30_K63_K0.6010.95
23_L77_F0.5930.95
18_L22_K0.5810.95
100_D107_A0.5710.94
26_S30_K0.5600.93
69_G111_Y0.5600.93
30_K34_E0.5560.93
35_V95_F0.5490.93
79_E83_E0.5480.93
46_K49_E0.5440.92
33_D37_R0.5440.92
14_I17_E0.5430.92
44_R47_E0.5410.92
50_F54_L0.5340.92
9_E17_E0.5290.91
67_A70_R0.5270.91
8_V15_A0.5270.91
61_K108_Y0.5250.91
64_L85_I0.5230.91
7_L10_K0.5220.91
37_R40_N0.5200.91
8_V18_L0.5130.90
83_E87_Q0.5110.90
99_V103_E0.5050.89
40_N43_K0.5010.89
61_K85_I0.5010.89
101_F105_I0.5010.89
15_A21_K0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cekA 1 0.5304 7.7 0.909 Contact Map
1x4pA 1 0.4696 7.2 0.91 Contact Map
1dquA 4 0.8783 6.5 0.912 Contact Map
3qmlC 1 0.8087 5.6 0.915 Contact Map
4fp9B 2 0.8783 4.9 0.917 Contact Map
3ghgA 2 0.7913 4.7 0.918 Contact Map
1m9iA 1 0.9565 4.7 0.918 Contact Map
3u0rA 1 0.8696 4.2 0.92 Contact Map
2dt7A 1 0.2783 4 0.921 Contact Map
3a4uB 1 0.5304 3.7 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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