GREMLIN Database
BioW - 6-carboxyhexanoate--CoA ligase
PFAM: PF03744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 239 (239)
Sequences: 590 (513)
Seq/√Len: 33.2
META: 0.708

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_I167_S6.0461.00
19_R138_D5.0721.00
175_I228_L3.5271.00
41_S186_D3.3861.00
40_H43_G3.0901.00
126_P229_I3.0861.00
139_I164_V3.0831.00
4_R136_R2.9661.00
110_M125_E2.8771.00
33_L138_D2.7081.00
130_R233_E2.6841.00
189_T202_I2.6801.00
116_L216_V2.6741.00
27_E35_E2.6371.00
169_V217_F2.6281.00
51_T136_R2.4871.00
170_A194_S2.4671.00
19_R33_L2.4250.99
73_V79_G2.3940.99
219_V228_L2.3740.99
188_T204_H2.3390.99
30_V34_L2.2780.99
104_L181_W2.2380.99
93_S96_A2.1710.99
4_R51_T2.1450.99
171_S231_Y2.1270.99
188_T203_P2.0940.98
37_A48_I2.0910.98
114_M216_V1.9920.98
110_M127_D1.8060.96
111_R123_R1.7890.96
3_V52_I1.7780.96
147_L151_L1.7710.96
28_E32_E1.7710.96
97_I101_L1.7480.95
103_L114_M1.7420.95
125_E128_K1.7120.95
187_Y199_Y1.7020.94
194_S198_G1.6770.94
115_L219_V1.6720.94
164_V239_I1.6560.94
134_V217_F1.6510.93
20_I55_I1.6250.93
17_A36_R1.6060.93
111_R125_E1.5850.92
231_Y237_V1.5370.91
47_F51_T1.5290.91
194_S200_V1.5170.90
66_L167_S1.5140.90
100_A218_F1.4820.89
80_R105_A1.4750.89
149_L153_G1.4500.88
125_E130_R1.4360.88
117_D221_G1.4270.87
121_G218_F1.4220.87
123_R130_R1.4180.87
115_L228_L1.3980.86
83_A192_V1.3890.86
111_R127_D1.3720.85
82_A85_K1.3600.84
55_I236_P1.3570.84
223_A228_L1.3540.84
96_A100_A1.3150.82
13_H16_G1.3140.82
119_D220_R1.3000.82
111_R130_R1.2980.82
23_E44_K1.2730.80
96_A118_A1.2680.80
4_R53_E1.2580.79
117_D124_L1.2510.79
110_M123_R1.2300.78
21_V29_V1.2270.78
36_R165_L1.2180.77
14_I47_F1.2120.77
166_A193_A1.1990.76
172_A228_L1.1970.76
13_H18_E1.1940.76
80_R205_L1.1850.75
111_R233_E1.1740.74
30_V38_L1.1710.74
165_L184_D1.1690.74
75_S78_E1.1650.74
222_G228_L1.1610.74
137_M164_V1.1590.74
4_R135_S1.1520.73
14_I40_H1.1480.73
156_N159_V1.1470.73
1_Y4_R1.1460.73
68_V154_L1.1340.72
166_A170_A1.1230.71
6_R14_I1.1210.71
6_R46_D1.1170.71
174_G181_W1.1160.71
137_M165_L1.1090.70
53_E136_R1.1080.70
121_G219_V1.0950.69
83_A181_W1.0940.69
175_I193_A1.0870.69
181_W205_L1.0870.69
230_D234_K1.0850.68
26_I38_L1.0750.68
167_S171_S1.0600.67
107_G125_E1.0400.65
84_R98_E1.0300.64
224_D228_L1.0300.64
21_V33_L1.0280.64
56_K59_P1.0270.64
179_L218_F1.0210.64
79_G189_T1.0150.63
107_G127_D1.0030.62
22_P89_S1.0020.62
185_P209_G0.9990.62
134_V169_V0.9960.62
119_D221_G0.9900.61
73_V204_H0.9900.61
167_S205_L0.9850.61
8_S11_G0.9790.60
79_G192_V0.9780.60
55_I145_A0.9770.60
137_M217_F0.9740.60
53_E205_L0.9560.59
224_D227_E0.9540.58
127_D130_R0.9530.58
114_M125_E0.9470.58
140_T143_A0.9460.58
35_E39_S0.9380.57
144_R160_R0.9320.57
79_G205_L0.9260.56
14_I43_G0.9190.55
44_K54_K0.9160.55
15_S18_E0.9130.55
80_R83_A0.9080.55
163_L182_S0.9070.54
55_I61_R0.9030.54
68_V161_E0.9000.54
65_A106_S0.8950.53
115_L175_I0.8860.53
83_A90_A0.8860.53
8_S47_F0.8810.52
42_R92_I0.8790.52
36_R48_I0.8780.52
80_R181_W0.8690.51
207_E210_S0.8660.51
139_I147_L0.8660.51
100_A121_G0.8650.51
6_R237_V0.8530.50
85_K104_L0.8490.50
53_E67_P0.8460.49
87_L203_P0.8430.49
161_E165_L0.8420.49
219_V223_A0.8380.49
107_G218_F0.8350.48
87_L192_V0.8260.48
88_E94_E0.8200.47
1_Y157_E0.8180.47
92_I96_A0.8150.47
96_A99_K0.8130.47
43_G137_M0.8110.46
41_S99_K0.8070.46
138_D164_V0.8050.46
20_I56_K0.8050.46
137_M161_E0.8040.46
136_R234_K0.8040.46
119_D239_I0.8020.46
65_A139_I0.7980.45
194_S197_L0.7950.45
21_V138_D0.7920.45
26_I118_A0.7900.45
30_V101_L0.7890.45
158_R184_D0.7880.45
201_R206_K0.7850.44
114_M233_E0.7850.44
33_L139_I0.7840.44
15_S40_H0.7820.44
50_I132_V0.7810.44
25_E52_I0.7740.43
76_P207_E0.7730.43
101_L105_A0.7720.43
8_S181_W0.7720.43
159_V218_F0.7700.43
29_V34_L0.7690.43
102_E230_D0.7680.43
65_A167_S0.7650.43
114_M123_R0.7640.43
75_S146_K0.7630.43
143_A147_L0.7620.42
4_R100_A0.7600.42
143_A151_L0.7530.42
80_R210_S0.7510.42
109_N158_R0.7500.41
100_A116_L0.7420.41
114_M138_D0.7410.41
20_I108_G0.7360.40
81_K226_E0.7360.40
24_E98_E0.7350.40
122_E221_G0.7320.40
155_N158_R0.7320.40
75_S192_V0.7260.40
22_P25_E0.7240.39
158_R219_V0.7240.39
70_T203_P0.7180.39
36_R110_M0.7170.39
124_L193_A0.7170.39
64_P167_S0.7160.39
37_A45_P0.7140.39
189_T201_R0.7140.39
74_S78_E0.7140.39
86_L197_L0.7110.38
220_R224_D0.7110.38
100_A179_L0.7100.38
105_A129_E0.7060.38
43_G184_D0.6990.37
92_I176_V0.6960.37
110_M130_R0.6940.37
84_R95_E0.6920.37
175_I219_V0.6910.37
96_A216_V0.6900.37
104_L109_N0.6880.37
5_M13_H0.6860.36
20_I60_I0.6860.36
33_L114_M0.6860.36
93_S118_A0.6840.36
231_Y235_Q0.6830.36
65_A239_I0.6820.36
71_V200_V0.6810.36
107_G116_L0.6800.36
50_I89_S0.6790.36
161_E217_F0.6760.36
73_V101_L0.6730.35
6_R13_H0.6720.35
147_L159_V0.6720.35
188_T202_I0.6710.35
40_H156_N0.6700.35
159_V163_L0.6690.35
39_S186_D0.6690.35
37_A177_A0.6680.35
29_V141_D0.6670.35
55_I204_H0.6650.35
17_A147_L0.6640.35
206_K213_G0.6620.35
111_R114_M0.6610.34
92_I100_A0.6570.34
135_S169_V0.6550.34
83_A179_L0.6540.34
79_G83_A0.6510.34
37_A169_V0.6500.34
214_G218_F0.6490.34
107_G114_M0.6470.33
123_R233_E0.6400.33
37_A43_G0.6380.33
100_A151_L0.6380.33
100_A107_G0.6360.33
3_V29_V0.6340.32
189_T199_Y0.6330.32
22_P141_D0.6280.32
68_V163_L0.6240.32
222_G227_E0.6180.31
136_R236_P0.6160.31
26_I239_I0.6150.31
5_M43_G0.6140.31
75_S142_E0.6130.31
90_A194_S0.6120.31
115_L229_I0.6110.31
4_R139_I0.6110.31
107_G110_M0.6090.31
225_L234_K0.6080.31
27_E52_I0.6040.30
109_N115_L0.6040.30
202_I205_L0.6030.30
193_A198_G0.6030.30
36_R158_R0.5980.30
35_E236_P0.5970.30
115_L217_F0.5970.30
199_Y206_K0.5960.30
229_I233_E0.5940.30
4_R20_I0.5930.30
155_N161_E0.5920.29
37_A40_H0.5920.29
20_I150_K0.5910.29
64_P176_V0.5890.29
5_M8_S0.5850.29
20_I212_R0.5840.29
95_E99_K0.5840.29
86_L200_V0.5800.29
124_L174_G0.5780.29
60_I94_E0.5770.28
92_I218_F0.5770.28
117_D120_T0.5760.28
62_Y145_A0.5750.28
206_K209_G0.5730.28
52_I188_T0.5720.28
122_E219_V0.5720.28
121_G228_L0.5710.28
181_W189_T0.5700.28
174_G231_Y0.5690.28
92_I210_S0.5680.28
89_S115_L0.5670.28
25_E141_D0.5660.28
135_S161_E0.5660.28
132_V234_K0.5650.28
109_N114_M0.5630.27
101_L114_M0.5620.27
65_A68_V0.5610.27
30_V50_I0.5600.27
79_G188_T0.5590.27
101_L195_K0.5590.27
79_G202_I0.5580.27
103_L163_L0.5570.27
83_A205_L0.5560.27
115_L197_L0.5540.27
37_A135_S0.5520.27
136_R159_V0.5510.27
173_P238_L0.5500.27
33_L96_A0.5490.27
121_G135_S0.5490.27
35_E63_I0.5460.26
218_F223_A0.5460.26
126_P130_R0.5450.26
93_S216_V0.5450.26
226_E239_I0.5430.26
49_N205_L0.5420.26
228_L232_L0.5420.26
115_L184_D0.5410.26
188_T205_L0.5400.26
84_R237_V0.5370.26
44_K101_L0.5370.26
230_D235_Q0.5360.26
218_F228_L0.5360.26
134_V204_H0.5360.26
34_L52_I0.5360.26
67_P198_G0.5350.26
9_K12_R0.5340.26
87_L166_A0.5310.25
23_E34_L0.5290.25
221_G225_L0.5280.25
21_V26_I0.5280.25
67_P208_K0.5260.25
95_E209_G0.5260.25
5_M40_H0.5250.25
82_A202_I0.5240.25
36_R127_D0.5230.25
77_E134_V0.5190.25
179_L216_V0.5190.25
64_P67_P0.5180.25
187_Y191_Y0.5180.25
78_E82_A0.5130.24
208_K230_D0.5120.24
132_V212_R0.5100.24
55_I102_E0.5100.24
104_L212_R0.5090.24
121_G179_L0.5070.24
182_S201_R0.5070.24
27_E38_L0.5060.24
34_L186_D0.5050.24
20_I51_T0.5050.24
6_R15_S0.5030.24
120_T151_L0.5030.24
23_E236_P0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3do6A 3 0.6569 18.6 0.969 Contact Map
2px0A 4 0.569 12.9 0.972 Contact Map
3dy5A 1 0.3891 10.8 0.973 Contact Map
4rptA 2 0.2176 9.4 0.973 Contact Map
3rh9A 2 0.9247 8.6 0.974 Contact Map
3bh1A 4 0.5565 8.5 0.974 Contact Map
2iruA 1 0.2008 8.2 0.974 Contact Map
4f3xA 4 0.8117 7.8 0.974 Contact Map
4h7nA 2 0.9163 7.8 0.974 Contact Map
2impA 4 0.8117 7.5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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